{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,15]],"date-time":"2025-06-15T04:01:17Z","timestamp":1749960077662,"version":"3.41.0"},"reference-count":20,"publisher":"Tohoku University Medical Press","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tohoku J. Exp. Med."],"published-print":{"date-parts":[[2025]]},"DOI":"10.1620\/tjem.2024.j143","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T22:12:21Z","timestamp":1733955141000},"page":"121-125","source":"Crossref","is-referenced-by-count":0,"title":["Protein Z Promotes Proliferation in Vascular Endothelial Cell Mediated by Chemokine C-X-C-Motif Receptor 4"],"prefix":"10.1620","volume":"266","author":[{"given":"Peng","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, Yijishan Hospital of Wannan Medical College"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Yijishan Hospital of Wannan Medical College"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingxuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Yijishan Hospital of Wannan Medical College"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinran","family":"Ruan","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Yijishan Hospital of Wannan Medical College"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"622","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"Agalakova, N.I., Kolodkin, N.I., Adair, C.D., Trashkov, A.P. &amp; Bagrov, A.Y.(2021) Preeclampsia: Cardiotonic Steroids, Fibrosis, Fli1 and Hint to Carcinogenesis. <i>Int. J. Mol. Sci.<\/i>, 22, 1941.","DOI":"10.3390\/ijms22041941"},{"key":"2","doi-asserted-by":"crossref","unstructured":"Al-Amer, O.M. (2022) The role of thrombin in haemostasis. <i>Blood Coagul. Fibrinolysis<\/i>, 33, 145-148.","DOI":"10.1097\/MBC.0000000000001130"},{"key":"3","doi-asserted-by":"crossref","unstructured":"Brouwers, L., van der Meiden-van Roest, A.J., Savelkoul, C., Vogelvang, T.E., Lely, A.T., Franx, A. &amp; van Rijn, B.B.(2018) Recurrence of pre-eclampsia and the risk of future hypertension and cardiovascular disease: a systematic review and meta-analysis. <i>BJOG<\/i>, 125, 1642-1654.","DOI":"10.1111\/1471-0528.15394"},{"key":"4","doi-asserted-by":"crossref","unstructured":"Cheng, X., Wang, H., Zhang, X., Zhao, S., Zhou, Z., Mu, X., Zhao, C. &amp; Teng, W.(2017) The Role of SDF-1\/CXCR4\/CXCR7 in Neuronal Regeneration after Cerebral Ischemia. <i>Front. Neurosci.<\/i>, 11, 590.","DOI":"10.3389\/fnins.2017.00590"},{"key":"5","doi-asserted-by":"crossref","unstructured":"Cui, C., Cheng, X., Yan, L., Ding, H., Guan, X., Zhang, W., Tian, X. &amp; Hao, C.(2019) Downregulation of TfR1 promotes progression of colorectal cancer via the JAK\/STAT pathway. <i>Cancer Manag. Res.<\/i>, 11, 6323-6341.","DOI":"10.2147\/CMAR.S198911"},{"key":"6","doi-asserted-by":"crossref","unstructured":"Ghozlan, M.F., Mohamed, A.A.E., Eissa, D.S. &amp; Eldawy, H.S.(2019) Low Protein Z Level: A Thrombophilic Risk Biomarker for Acute Coronary Syndrome. <i>Indian J. Hematol. Blood Transfus.<\/i>, 35, 339-346.","DOI":"10.1007\/s12288-018-1002-5"},{"key":"7","unstructured":"Karakoyun, S., Ozan Gursoy, M., Kalcik, M., Yesin, M., Gunduz, S., Ali Astarcioglu, M., Bayram, Z., Cakal, B., Bayam, E. &amp; Ozkan, M.(2017) The Role of Protein Z and Protein Z-Dependent Protease Inhibitor Polymorphisms in the Development of Prosthetic Heart Valve Thrombosis. <i>J. Heart Valve Dis.<\/i>, 26, 460-466."},{"key":"8","doi-asserted-by":"crossref","unstructured":"Markowicz-Piasecka, M., Huttunen, K.M., Broncel, M. &amp; Sikora, J.(2019) Sulfenamide and Sulfonamide Derivatives of Metformin - A New Option to Improve Endothelial Function and Plasma Haemostasis. <i>Sci. Rep.<\/i>, 9, 6573.","DOI":"10.1038\/s41598-019-43083-z"},{"key":"9","doi-asserted-by":"crossref","unstructured":"Mastrolia, S.A., Mazor, M., Loverro, G., Klaitman, V. &amp; Erez, O.(2014) Placental vascular pathology and increased thrombin generation as mechanisms of disease in obstetrical syndromes. <i>PeerJ<\/i>, 2, e653.","DOI":"10.7717\/peerj.653"},{"key":"10","doi-asserted-by":"crossref","unstructured":"Medegan Fagla, B. &amp; Buhimschi, I.A.(2024) Protein Misfolding in Pregnancy: Current Insights, Potential Mechanisms, and Implications for the Pathogenesis of Preeclampsia. <i>Molecules<\/i>, 29, 610.","DOI":"10.3390\/molecules29030610"},{"key":"11","doi-asserted-by":"crossref","unstructured":"Melchiorre, K., Giorgione, V. &amp; Thilaganathan, B.(2022) The placenta and preeclampsia: villain or victim? <i>Am. J. Obstet. Gynecol.<\/i>, 226, S954-S962.","DOI":"10.1016\/j.ajog.2020.10.024"},{"key":"12","doi-asserted-by":"crossref","unstructured":"Minhas, N., Xue, M., Fukudome, K. &amp; Jackson, C.J.(2010) Activated protein C utilizes the angiopoietin\/Tie2 axis to promote endothelial barrier function. <i>FASEB J.<\/i>, 24, 873-881.","DOI":"10.1096\/fj.09-134445"},{"key":"13","doi-asserted-by":"crossref","unstructured":"Neubauer, K. &amp; Zieger, B.(2022) Endothelial cells and coagulation. <i>Cell Tissue Res.<\/i>, 387, 391-398.","DOI":"10.1007\/s00441-021-03471-2"},{"key":"14","doi-asserted-by":"crossref","unstructured":"Sfriso, R., Bongoni, A., Banz, Y., Klymiuk, N., Wolf, E. &amp; Rieben, R.(2017) Assessment of the Anticoagulant and Anti-inflammatory Properties of Endothelial Cells Using 3D Cell Culture and Non-anticoagulated Whole Blood. <i>J. Vis. Exp.<\/i>, 56277.","DOI":"10.3791\/56227-v"},{"key":"15","doi-asserted-by":"crossref","unstructured":"Uchiba, M., Okajima, K., Oike, Y., Ito, Y., Fukudome, K., Isobe, H. &amp; Suda, T.(2004) Activated protein C induces endothelial cell proliferation by mitogen-activated protein kinase activation in vitro and angiogenesis in vivo. <i>Circ. Res.<\/i>, 95, 34-41.","DOI":"10.1161\/01.RES.0000133680.87668.FA"},{"key":"16","doi-asserted-by":"crossref","unstructured":"Xue, M., Chow, S.O., Dervish, S., Chan, Y.K., Julovi, S.M. &amp; Jackson, C.J.(2011) Activated protein C enhances human keratinocyte barrier integrity via sequential activation of epidermal growth factor receptor and Tie2. <i>J. Biol. Chem.<\/i>, 286, 6742-6750.","DOI":"10.1074\/jbc.M110.181388"},{"key":"17","doi-asserted-by":"crossref","unstructured":"Yu, J.S. &amp; Cui, W.(2016) Proliferation, survival and metabolism: the role of PI3K\/AKT\/mTOR signalling in pluripotency and cell fate determination. <i>Development<\/i>, 143, 3050-3060.","DOI":"10.1242\/dev.137075"},{"key":"18","doi-asserted-by":"crossref","unstructured":"Zhang, L., Segal, A.Z., Leifer, D., Silverstein, R.L., Gerber, L.M., Devereux, R.B. &amp; Kizer, J.R.(2017a) Circulating protein Z concentration, PROZ variants, and unexplained cerebral infarction in young and middle-aged adults. <i>Thromb. Haemost.<\/i>, 117, 149-157.","DOI":"10.1160\/TH16-04-0277"},{"key":"19","doi-asserted-by":"crossref","unstructured":"Zhang, P., Wu, Q.W., Feng, G., Liu, C.S., Zhang, Y.Y. &amp; Pu, C.(2017b) Protein Z and anti-protein Z IgG levels, but not the promotor Al3G polymorphism, are associated with preeclampsia. <i>Clinical and Experimental Obstetrics &amp; Gynecology<\/i>, 44, 929-933.","DOI":"10.12891\/ceog3903.2017"},{"key":"20","doi-asserted-by":"crossref","unstructured":"Zhou, W., Li, X., Li, X., Liu, Y., Song, W. &amp; Yang, Q.(2024) The role of circular RNA in preeclampsia: From pathophysiological mechanism to clinical application. <i>Life Sci.<\/i>, 338, 122407.","DOI":"10.1016\/j.lfs.2023.122407"}],"container-title":["The Tohoku Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/tjem\/266\/2\/266_2024.J143\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T03:55:33Z","timestamp":1749873333000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/tjem\/266\/2\/266_2024.J143\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.1620\/tjem.2024.j143","relation":{},"ISSN":["0040-8727","1349-3329"],"issn-type":[{"type":"print","value":"0040-8727"},{"type":"electronic","value":"1349-3329"}],"subject":[],"published":{"date-parts":[[2025]]},"article-number":"2024.J143"}}