{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T15:29:52Z","timestamp":1781796592985,"version":"3.54.5"},"reference-count":50,"publisher":"Tohoku University Medical Press","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tohoku J. Exp. Med."],"published-print":{"date-parts":[[2026]]},"DOI":"10.1620\/tjem.2025.j040","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T18:12:40Z","timestamp":1742407960000},"page":"19-28","source":"Crossref","is-referenced-by-count":2,"title":["Tubacin Decelerates TGF-<i>\u03b2<\/i>1-Induced Pro-Fibrotic Effects on Human Dermal Fibroblasts by Regulating HDAC6-Mediated Deacetylation of <i>\u03b1<\/i>-Tubulin and Hsp90"],"prefix":"10.1620","volume":"268","author":[{"given":"Yanli","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery, Zibo Central Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Zibo Central Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Zibo Central Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuli","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Zibo Central Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Zibo Central Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"622","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"Bharadia, S.K., Burnett, L.&Gabriel, V. (2023) Hypertrophic Scar. Phys. Med. Rehabil. Clin. N. Am.<\/i>, 34, 783-798. https:\/\/doi.org\/10.1016\/j.pmr.2023.05.002","DOI":"10.1016\/j.pmr.2023.05.002"},{"key":"2","doi-asserted-by":"crossref","unstructured":"Bonanni, D., Citarella, A., Moi, D., Pinzi, L., Bergamini, E.&Rastelli, G. (2022) Dual Targeting Strategies on Histone Deacetylase 6 (HDAC6) and Heat Shock Protein 90 (Hsp90). Curr. Med. Chem.<\/i>, 29, 1474-1502. https:\/\/doi.org\/10.2174\/0929867328666210902145102","DOI":"10.2174\/0929867328666210902145102"},{"key":"3","doi-asserted-by":"crossref","unstructured":"Budi, E.H., Schaub, J.R., Decaris, M., Turner, S.&Derynck, R. (2021) TGF-beta as a driver of fibrosis: physiological roles and therapeutic opportunities. J. Pathol.<\/i>, 254, 358-373. https:\/\/doi.org\/10.1002\/path.5680","DOI":"10.1002\/path.5680"},{"key":"4","doi-asserted-by":"crossref","unstructured":"Calogero, A.M., Basellini, M.J., Isilgan, H.B., Longhena, F., Bellucci, A., Mazzetti, S., Rolando, C., Pezzoli, G.&Cappelletti, G. (2023) Acetylated alpha-Tubulin and alpha-Synuclein: Physiological Interplay and Contribution to alpha-Synuclein Oligomerization. Int. J. Mol. Sci.<\/i>, 24, 12287. https:\/\/doi.org\/10.3390\/ijms241512287","DOI":"10.3390\/ijms241512287"},{"key":"5","doi-asserted-by":"crossref","unstructured":"Chen, J., Zhang, J., Shaik, N.F., Yi, B., Wei, X., Yang, X.F., Naik, U.P., Summer, R., Yan, G., Xu, X.&Sun, J. (2019) The histone deacetylase inhibitor tubacin mitigates endothelial dysfunction by up-regulating the expression of endothelial nitric oxide synthase. J. Biol. Chem.<\/i>, 294, 19565-19576. https:\/\/doi.org\/10.1074\/jbc.RA119.011317","DOI":"10.1074\/jbc.RA119.011317"},{"key":"6","doi-asserted-by":"crossref","unstructured":"Chen, X., Yu, C., Hou, X., Li, J., Li, T., Qiu, A., Liu, N.&Zhuang, S. (2020) Histone deacetylase 6 inhibition mitigates renal fibrosis by suppressing TGF-beta and EGFR signaling pathways in obstructive nephropathy. Am. J. Physiol. Renal Physiol.<\/i>, 319, F1003-F1014. https:\/\/doi.org\/10.1152\/ajprenal.00261.2020","DOI":"10.1152\/ajprenal.00261.2020"},{"key":"7","doi-asserted-by":"crossref","unstructured":"Choi, S.Y., Ryu, Y., Kee, H.J., Cho, S.N., Kim, G.R., Cho, J.Y., Kim, H.S., Kim, I.K.&Jeong, M.H. (2015) Tubastatin A suppresses renal fibrosis via regulation of epigenetic histone modification and Smad3-dependent fibrotic genes. Vascul. Pharmacol.<\/i>, 72, 130-140. https:\/\/doi.org\/10.1016\/j.vph.2015.04.006","DOI":"10.1016\/j.vph.2015.04.006"},{"key":"8","doi-asserted-by":"crossref","unstructured":"Cui, J., Zhang, S., Acharya, K., Xu, Y., Guo, H., Li, T., Fu, D., Yang, Z., Hou, L., Xing, X.&Hu, X. (2024) Decorin attenuates hypertrophic scar fibrosis via TGFbeta\/Smad signalling. Exp. Dermatol.<\/i>, 33, e15133. https:\/\/doi.org\/10.1111\/exd.15133","DOI":"10.1111\/exd.15133"},{"key":"9","doi-asserted-by":"crossref","unstructured":"Dees, C., Chakraborty, D.&Distler, J.H.W. (2021) Cellular and molecular mechanisms in fibrosis. Exp. Dermatol.<\/i>, 30, 121-131. https:\/\/doi.org\/10.1111\/exd.14193","DOI":"10.1111\/exd.14193"},{"key":"10","doi-asserted-by":"crossref","unstructured":"Deskin, B., Lasky, J., Zhuang, Y.&Shan, B. (2016) Requirement of HDAC6 for activation of Notch1 by TGF-beta1. Sci. Rep.<\/i>, 6, 31086. https:\/\/doi.org\/10.1038\/srep31086","DOI":"10.1038\/srep31086"},{"key":"11","doi-asserted-by":"crossref","unstructured":"Du, Y., Yang, X., Li, Z., Le, W., Hao, Y., Song, Y., Wang, F.&Guan, Y. (2021) HDAC6-mediated Hsp90 deacetylation reduces aggregation and toxicity of the protein alpha-synuclein by regulating chaperone-mediated autophagy. Neurochem. Int.<\/i>, 149, 105141. https:\/\/doi.org\/10.1016\/j.neuint.2021.105141","DOI":"10.1016\/j.neuint.2021.105141"},{"key":"12","doi-asserted-by":"crossref","unstructured":"Edwards, J. (2022) Hypertrophic scar management. Br. J. Nurs.<\/i>, 31, S24-S31. https:\/\/doi.org\/10.12968\/bjon.2022.31.20.S24","DOI":"10.12968\/bjon.2022.31.20.S24"},{"key":"13","doi-asserted-by":"crossref","unstructured":"Fei, H., Qian, Y., Pan, T., Wei, Y.&Hu, Y. (2024) Curcumin alleviates hypertrophic scarring by inhibiting fibroblast activation and regulating tissue inflammation. J. Cosmet. Dermatol.<\/i>, 23, 227-235. https:\/\/doi.org\/10.1111\/jocd.15905","DOI":"10.1111\/jocd.15905"},{"key":"14","doi-asserted-by":"crossref","unstructured":"Ho, T.C.S., Chan, A.H.Y.&Ganesan, A. (2020) Thirty Years of HDAC Inhibitors: 2020 Insight and Hindsight. J. Med. Chem.<\/i>, 63, 12460-12484. https:\/\/doi.org\/10.1021\/acs.jmedchem.0c00830","DOI":"10.1021\/acs.jmedchem.0c00830"},{"key":"15","doi-asserted-by":"crossref","unstructured":"Ihrig, C.M., Montgomery, M.M., Nomura, Y., Nakano, M., Pandey, D.&La Favor, J.D. (2024) Histone deacetylase 6 inhibition prevents hypercholesterolemia-induced erectile dysfunction independent of changes in markers of autophagy. Sex. Med.<\/i>, 12, qfae096. https:\/\/doi.org\/10.1093\/sexmed\/qfae096","DOI":"10.1093\/sexmed\/qfae096"},{"key":"16","doi-asserted-by":"crossref","unstructured":"Karppinen, S.M., Heljasvaara, R., Gullberg, D., Tasanen, K.&Pihlajaniemi, T. (2019) Toward understanding scarless skin wound healing and pathological scarring. F1000Res.<\/i>, 8, F1000 Faculty Rev-787. https:\/\/doi.org\/10.12688\/f1000research.18293.1","DOI":"10.12688\/f1000research.18293.1"},{"key":"17","doi-asserted-by":"crossref","unstructured":"Knowles, A.&Glass, D.A.2nd (2023) Keloids and Hypertrophic Scars. Dermatol. Clin.<\/i>, 41, 509-517. https:\/\/doi.org\/10.1016\/j.det.2023.02.010","DOI":"10.1016\/j.det.2023.02.010"},{"key":"18","doi-asserted-by":"crossref","unstructured":"Kukushkin, A.N., Svetlikova, S.B., Aksenov, N.D.&Pospelov, V.A. (2023) Tubacin Histone Deacetylase 6 Inhibitor Produced \u03b1<\/i>-Tubulin Acetylation, Cell Cycle Arrest, Aging, and Suppression of Migration of Mouse Fibroblasts Transformed by E1A and cHa-ras Oncogenes. Cell Tiss. Biol.<\/i>, 17, 133-145.","DOI":"10.1134\/S1990519X23020098"},{"key":"19","unstructured":"Li, S., Fan, H., Liu, L., Ling, J.&Wu, Y. (2021) Inhibition of Notch signaling pathway reduces angiogenesis in hypertrophic scar. Zhong Nan Da Xue Xue Bao Yi Xue Ban<\/i>, 46, 1195-1202. https:\/\/doi.org\/10.11817\/j.issn.1672-7347.2021.210234"},{"key":"20","doi-asserted-by":"crossref","unstructured":"Li, T., Xiong, X., Wang, Y., Li, Y., Liu, Y., Zhang, M., Li, C., Yu, T., Cao, W., Chen, S., Zhang, H., Wang, X., Lv, L., Zhou, Y., Liang, H., et al.(2023) Neuroepithelial cell-transforming 1 promotes cardiac fibrosis via the Wnt\/beta-catenin signaling pathway. iScience<\/i>, 26, 107888. https:\/\/doi.org\/10.1016\/j.isci.2023.107888","DOI":"10.1016\/j.isci.2023.107888"},{"key":"21","doi-asserted-by":"crossref","unstructured":"Liu, X., Chen, W., Zeng, Q., Ma, B., Li, Z., Meng, T., Chen, J., Yu, N., Zhou, Z.&Long, X. (2022) Single-Cell RNA-Sequencing Reveals Lineage-Specific Regulatory Changes of Fibroblasts and Vascular Endothelial Cells in Keloids. J. Invest. Dermatol.<\/i>, 142, 124-135 e111. https:\/\/doi.org\/10.1016\/j.jid.2021.06.010","DOI":"10.1016\/j.jid.2021.06.010"},{"key":"22","doi-asserted-by":"crossref","unstructured":"Liu, X.J., Gao, X.X., Li, H., Li, Z.D., Wang, X.E., Zhang, L., Wang, B., Chen, X.X., Meng, X.L.&Yu, J.A. (2021) Ellagic acid exerts anti-fibrotic effects on hypertrophic scar fibroblasts via inhibition of TGF-\u03b2<\/i>1\/Smad2\/3 pathway. Applied Biological Chemistry<\/i>, 64, 67. https:\/\/doi.org\/10.1186\/s13765-021-00641-2","DOI":"10.1186\/s13765-021-00641-2"},{"key":"23","doi-asserted-by":"crossref","unstructured":"Magupalli, V.G., Negro, R., Tian, Y., Hauenstein, A.V., Di Caprio, G., Skillern, W., Deng, Q., Orning, P., Alam, H.B., Maliga, Z., Sharif, H., Hu, J.J., Evavold, C.L., Kagan, J.C., Schmidt, F.I., et al.(2020) HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation. Science<\/i>, 369, eaas8995. https:\/\/doi.org\/10.1126\/science.aas8995","DOI":"10.1126\/science.aas8995"},{"key":"24","doi-asserted-by":"crossref","unstructured":"Meng, X., Gao, X., Chen, X.&Yu, J. (2021) Umbilical cord-derived mesenchymal stem cells exert anti-fibrotic action on hypertrophic scar-derived fibroblasts in co-culture by inhibiting the activation of the TGF beta1\/Smad3 pathway. Exp. Ther. Med.<\/i>, 21, 210. https:\/\/doi.org\/10.3892\/etm.2021.9642","DOI":"10.3892\/etm.2021.9642"},{"key":"25","doi-asserted-by":"crossref","unstructured":"Miyake, Y., Keusch, J.J., Wang, L., Saito, M., Hess, D., Wang, X., Melancon, B.J., Helquist, P., Gut, H.&Matthias, P. (2016) Structural insights into HDAC6 tubulin deacetylation and its selective inhibition. Nat. Chem. Biol.<\/i>, 12, 748-754. https:\/\/doi.org\/10.1038\/nchembio.2140","DOI":"10.1038\/nchembio.2140"},{"key":"26","doi-asserted-by":"crossref","unstructured":"Peng, J., Xie, F., Qin, P., Liu, Y., Niu, H., Sun, J., Xue, H., Zhao, Q., Liu, J.&Wu, J. (2023) Recent development of selective inhibitors targeting the HDAC6 as anti-cancer drugs: Structure, function and design. Bioorg. Chem.<\/i>, 138, 106622. https:\/\/doi.org\/10.1016\/j.bioorg.2023.106622","DOI":"10.1016\/j.bioorg.2023.106622"},{"key":"27","doi-asserted-by":"crossref","unstructured":"Pulya, S., Amin, S.A., Adhikari, N., Biswas, S., Jha, T.&Ghosh, B. (2021) HDAC6 as privileged target in drug discovery: A perspective. Pharmacol. Res.<\/i>, 163, 105274. https:\/\/doi.org\/10.1016\/j.phrs.2020.105274","DOI":"10.1016\/j.phrs.2020.105274"},{"key":"28","unstructured":"Qin, Y.M., Li, P., Mu, X.P., Li, Z.M., Sun, C., Xue, W.L., Sun, J., Bai, J.J., Zhu, Y.C.&Wang, M.J. (2022) Histone deacetylase 6 promotes skin wound healing by regulating fibroblast migration and differentiation in aged mice. Sheng Li Xue Bao<\/i>, 74, 979-992."},{"key":"29","doi-asserted-by":"crossref","unstructured":"Saito, S., Zhuang, Y., Shan, B., Danchuk, S., Luo, F., Korfei, M., Guenther, A.&Lasky, J.A. (2017) Tubastatin ameliorates pulmonary fibrosis by targeting the TGFbeta-PI3K-Akt pathway. PLoS One<\/i>, 12, e0186615. https:\/\/doi.org\/10.1371\/journal.pone.0186615","DOI":"10.1371\/journal.pone.0186615"},{"key":"30","doi-asserted-by":"crossref","unstructured":"Schuster, R., Younesi, F., Ezzo, M.&Hinz, B. (2023) The Role of Myofibroblasts in Physiological and Pathological Tissue Repair. Cold Spring Harb. Perspect. Biol.<\/i>, 15, a041231. https:\/\/doi.org\/10.1101\/cshperspect.a041231","DOI":"10.1101\/cshperspect.a041231"},{"key":"31","doi-asserted-by":"crossref","unstructured":"Shan, B., Yao, T.P., Nguyen, H.T., Zhuo, Y., Levy, D.R., Klingsberg, R.C., Tao, H., Palmer, M.L., Holder, K.N.&Lasky, J.A. (2008) Requirement of HDAC6 for transforming growth factor-beta1-induced epithelial-mesenchymal transition. J. Biol. Chem.<\/i>, 283, 21065-21073. https:\/\/doi.org\/10.1074\/jbc.M802786200","DOI":"10.1074\/jbc.M802786200"},{"key":"32","doi-asserted-by":"crossref","unstructured":"Shen, Y., Jin, R., Liang, X., Deng, Z., He, J., Ding, Y., Ding, F., Lu, L., Liu, F.&Yang, J. (2023) Angiogenesis modulation-mediated inhibitory effects of tacrolimus on hypertrophic scar formation. Microvasc. Res.<\/i>, 145, 104446. https:\/\/doi.org\/10.1016\/j.mvr.2022.104446","DOI":"10.1016\/j.mvr.2022.104446"},{"key":"33","doi-asserted-by":"crossref","unstructured":"Shi, Y., Li, J., Chen, H., Hu, Y., Tang, L., Zhou, X., Tao, M., Lv, Z., Chen, S., Qiu, A.&Liu, N. (2022) Pharmacologic Inhibition of Histone Deacetylase 6 Prevents the Progression of Chlorhexidine Gluconate-Induced Peritoneal Fibrosis by Blockade of M2 Macrophage Polarization. Front. Immunol.<\/i>, 13, 899140. https:\/\/doi.org\/10.3389\/fimmu.2022.899140","DOI":"10.3389\/fimmu.2022.899140"},{"key":"34","doi-asserted-by":"crossref","unstructured":"Siow, D.&Wattenberg, B. (2014) The histone deacetylase-6 inhibitor tubacin directly inhibits de novo sphingolipid biosynthesis as an off-target effect. Biochem. Biophys. Res. Commun.<\/i>, 449, 268-271. https:\/\/doi.org\/10.1016\/j.bbrc.2014.05.016","DOI":"10.1016\/j.bbrc.2014.05.016"},{"key":"35","doi-asserted-by":"crossref","unstructured":"\u0160tork\u00e1nov\u00e1, H., \u0160tork\u00e1nov\u00e1, L., Navr\u00e1tilov\u00e1, A., Be\u010dv\u00e1\u0159, V., Hulejov\u00e1, H., Oresk\u00e1, S., He\u0159m\u00e1nkov\u00e1, B., \u0160piritovi\u0107, M., Be\u010dv\u00e1\u0159, R., Pavelka, K., Vencovsk\u00fd, J., Distler, J.H.W., \u0160enolt, L.&Tom\u010d\u00edk, M. (2021) Inhibition of Hsp90 Counteracts the Established Experimental Dermal Fibrosis Induced by Bleomycin. Biomedicines<\/i>, 9, 650. https:\/\/doi.org\/10.3390\/biomedicines9060650","DOI":"10.3390\/biomedicines9060650"},{"key":"36","doi-asserted-by":"crossref","unstructured":"Tao, H., Yang, J.J., Hu, W., Shi, K.H.&Li, J. (2016a) HDAC6 Promotes Cardiac Fibrosis Progression through Suppressing RASSF1A Expression. Cardiology<\/i>, 133, 18-26. https:\/\/doi.org\/10.1159\/000438781","DOI":"10.1159\/000438781"},{"key":"37","doi-asserted-by":"crossref","unstructured":"Tao, H., Yang, J.J., Shi, K.H.&Li, J. (2016b) Epigenetic factors MeCP2 and HDAC6 control alpha-tubulin acetylation in cardiac fibroblast proliferation and fibrosis. Inflamm. Res.<\/i>, 65, 415-426. https:\/\/doi.org\/10.1007\/s00011-016-0925-2","DOI":"10.1007\/s00011-016-0925-2"},{"key":"38","doi-asserted-by":"crossref","unstructured":"Tao, L., Wu, L.&Ge, Y. (2024) Tubastatin alleviates epidural fibrosis via negatively targeting TGFbeta\/PI3K\/Akt pathway. Cell. Mol. Biol. (Noisy-le-grand)<\/i>, 70, 231-236. https:\/\/doi.org\/10.14715\/cmb\/2024.70.4.36","DOI":"10.14715\/cmb\/2024.70.4.36"},{"key":"39","doi-asserted-by":"crossref","unstructured":"Verma, P., Yalavarthi, B., Bhattacharyya, S., Khanna, D., Gudjonsson, J.E., Tsoi, L.C., Wells, R., Ross, R.L., Riobo-Del Galdo, N.&Del Galdo, F. (2024) Morphological Reprogramming of Primary Cilia Length Mitigates the Fibrotic Phenotype in fibroblasts across diverse fibrotic conditions. bioRxiv<\/i>, 2024.01.06.574461. https:\/\/doi.org\/10.1242\/jcs.264191","DOI":"10.1101\/2024.01.06.574461"},{"key":"40","doi-asserted-by":"crossref","unstructured":"Wang, X., Wang, L., Sun, Y., Chen, B., Xiong, L., Chen, J., Huang, M., Wu, J., Tan, X., Zheng, Y., Huang, S.&Liu, Y. (2020) MiR-22-3p inhibits fibrotic cataract through inactivation of HDAC6 and increase of alpha-tubulin acetylation. Cell Prolif.<\/i>, 53, e12911. https:\/\/doi.org\/10.1111\/cpr.12911","DOI":"10.1111\/cpr.12911"},{"key":"41","doi-asserted-by":"crossref","unstructured":"Wen, D., Gao, Y., Liu, Y., Ho, C., Sun, J., Huang, L., Liu, Y., Li, Q.&Zhang, Y. (2023) Matrix stiffness-induced alpha-tubulin acetylation is required for skin fibrosis formation through activation of Yes-associated protein. MedComm (2020)<\/i>, 4, e319. https:\/\/doi.org\/10.1002\/mco2.319","DOI":"10.1002\/mco2.319"},{"key":"42","doi-asserted-by":"crossref","unstructured":"Xu, W., Yan, P., Zhou, Z., Yao, J., Pan, H., Jiang, L., Bo, Z., Ni, B., Sun, M., Gao, S.&Huan, C. (2023) HDAC6 Triggers the ATM-Dependent DNA Damage Response To Promote PRV Replication. Microbiol. Spectr.<\/i>, 11, e0213222. https:\/\/doi.org\/10.1128\/spectrum.02132-22","DOI":"10.1128\/spectrum.02132-22"},{"key":"43","doi-asserted-by":"crossref","unstructured":"Yang, Y., Sangwung, P., Kondo, R., Jung, Y., McConnell, M.J., Jeong, J., Utsumi, T., Sessa, W.C.&Iwakiri, Y. (2021) Alcohol-induced Hsp90 acetylation is a novel driver of liver sinusoidal endothelial dysfunction and alcohol-related liver disease. J. Hepatol.<\/i>, 75, 377-386. https:\/\/doi.org\/10.1016\/j.jhep.2021.02.028","DOI":"10.1016\/j.jhep.2021.02.028"},{"key":"44","doi-asserted-by":"crossref","unstructured":"Yimiti, M., Fei, X., Yang, H., Yang, X., Li, S., Tuoheniyazi, H., Liu, D., Ma, J., Xie, J., Zheng, J., Song, Z., Li, Q., Xu, D., Zhao, Y.&Gu, Z. (2024) HDAC6 inhibitor promotes reactive oxygen species-meditated clearance of Staphylococcus aureus in macrophage. Clin. Exp. Pharmacol. Physiol.<\/i>, 51, e13866. https:\/\/doi.org\/10.1111\/1440-1681.13866","DOI":"10.1111\/1440-1681.13866"},{"key":"45","doi-asserted-by":"crossref","unstructured":"Yu, H., Liu, S., Wang, S.&Gu, X. (2024) A narrative review of the role of HDAC6 in idiopathic pulmonary fibrosis. J. Thorac. Dis.<\/i>, 16, 688-695. https:\/\/doi.org\/10.21037\/jtd-23-1183","DOI":"10.21037\/jtd-23-1183"},{"key":"46","doi-asserted-by":"crossref","unstructured":"Yu, S., Cai, X., Wu, C., Liu, Y., Zhang, J., Gong, X., Wang, X., Wu, X., Zhu, T., Mo, L., Gu, J., Yu, Z., Chen, J., Thiery, J.P., Chai, R., et al.(2017) Targeting HSP90-HDAC6 Regulating Network Implicates Precision Treatment of Breast Cancer. Int. J. Biol. Sci.<\/i>, 13, 505-517. https:\/\/doi.org\/10.7150\/ijbs.18834","DOI":"10.7150\/ijbs.18834"},{"key":"47","doi-asserted-by":"crossref","unstructured":"Yu, W.C., Yeh, T.Y., Ye, C.H., Chong, P.C.T., Ho, Y.H., So, D.K., Yap, K.Y., Peng, G.R., Shao, C.H., Jagtap, A.D., Chern, J.W., Lin, C.S., Lin, S.P., Lin, S.L., Yu, S.H., et al.(2023) Discovery of HDAC6, HDAC8, and 6\/8 Inhibitors and Development of Cell-Based Drug Screening Models for the Treatment of TGF-beta-Induced Idiopathic Pulmonary Fibrosis. J. Med. Chem.<\/i>, 66, 10528-10557. https:\/\/doi.org\/10.1021\/acs.jmedchem.3c00644","DOI":"10.1021\/acs.jmedchem.3c00644"},{"key":"48","doi-asserted-by":"crossref","unstructured":"Zhai, X.X., Tang, Z.M., Ding, J.C.&Lu, X.L. (2017) Expression of TGF-beta1\/mTOR signaling pathway in pathological scar fibroblasts. Mol. Med. Rep.<\/i>, 15, 3467-3472. https:\/\/doi.org\/10.3892\/mmr.2017.6437","DOI":"10.3892\/mmr.2017.6437"},{"key":"49","unstructured":"Zhang, C., Zhang, Q., Zhang, J.H., Wang, F.&Zhang, J.P. (2021) Effects and molecular mechanism of histone deacetylase 6 inhibitor Tubastatin A on the prolifera- tion and movement of human skin fibroblasts. Zhonghua Shao Shang Za Zhi<\/i>, 37, 853-859. https:\/\/doi.org\/10.3760\/cma.j.cn501120-20200519-00274"},{"key":"50","doi-asserted-by":"crossref","unstructured":"Zhang, Y.F., Zhou, S.Z., Cheng, X.Y., Yi, B., Shan, S.Z., Wang, J.&Li, Q.F. (2016) Baicalein attenuates hypertrophic scar formation via inhibition of the transforming growth factor-beta\/Smad2\/3 signalling pathway. Br. J. Dermatol.<\/i>, 174, 120-130. https:\/\/doi.org\/10.1111\/bjd.14108","DOI":"10.1111\/bjd.14108"}],"container-title":["The Tohoku Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/tjem\/268\/1\/268_2025.J040\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T03:27:05Z","timestamp":1769830025000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/tjem\/268\/1\/268_2025.J040\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.1620\/tjem.2025.j040","relation":{},"ISSN":["0040-8727","1349-3329"],"issn-type":[{"value":"0040-8727","type":"print"},{"value":"1349-3329","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"2025.J040"}}