{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T11:50:06Z","timestamp":1788522606878,"version":"build-2803163510"},"reference-count":34,"publisher":"Tohoku University Medical Press","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tohoku J. Exp. Med."],"published-print":{"date-parts":[[2025]]},"DOI":"10.1620\/tjem.2025.j042","type":"journal-article","created":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T18:05:29Z","timestamp":1743012329000},"page":"203-216","source":"Crossref","is-referenced-by-count":2,"title":["LncRNA ACTA2-AS1 Inhibits Tumorigenesis of Prostate Cancer by Maintaining ACTA2 Expression"],"prefix":"10.1620","volume":"267","author":[{"given":"Chang-wei","family":"Peng","sequence":"first","affiliation":[{"name":"Department of Urology, First Affiliated Hospital of Yangtze University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-li","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Urology, First Affiliated Hospital of Yangtze University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-tao","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Urology, First Affiliated Hospital of Yangtze University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"622","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R.L., Torre, L.A.&Jemal, A. (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin.<\/i>, 68, 394-424.","DOI":"10.3322\/caac.21492"},{"key":"2","doi-asserted-by":"crossref","unstructured":"Cuzick, J., Thorat, M.A., Andriole, G., Brawley, O.W., Brown, P.H., Culig, Z., Eeles, R.A., Ford, L.G., Hamdy, F.C., Holmberg, L., Ilic, D., Key, T.J., La Vecchia, C., Lilja, H., Marberger, M., et al.(2014) Prevention and early detection of prostate cancer. Lancet Oncol.<\/i>, 15, e484-492.","DOI":"10.1016\/S1470-2045(14)70211-6"},{"key":"3","doi-asserted-by":"crossref","unstructured":"Eggener, S.E., Rumble, R.B., Armstrong, A.J., Morgan, T.M., Crispino, T., Cornford, P., van der Kwast, T., Grignon, D.J., Rai, A.J., Agarwal, N., Klein, E.A., Den, R.B.&Beltran, H. (2020) Molecular Biomarkers in Localized Prostate Cancer: ASCO Guideline. J. Clin. Oncol.<\/i>, 38, 1474-1494.","DOI":"10.1200\/JCO.19.02768"},{"key":"4","doi-asserted-by":"crossref","unstructured":"Guo, W., Liu, S., Cheng, Y., Lu, L., Shi, J., Xu, G., Li, N., Cheng, K., Wu, M., Cheng, S.&Liu, S. (2016) ICAM-1-Related Noncoding RNA in Cancer Stem Cells Maintains ICAM-1 Expression in Hepatocellular Carcinoma. Clin. Cancer Res.<\/i>, 22, 2041-2050.","DOI":"10.1158\/1078-0432.CCR-14-3106"},{"key":"5","doi-asserted-by":"crossref","unstructured":"Hu, Z., Chen, Z., Jiang, W., Fang, D., Peng, P., Yao, S., Luo, M., Wang, L., Sun, Z., Wang, W., Wang, X., Mao, H., Ai, F.&Zhou, P. (2023) Long Noncoding RNA ACTA2-AS1 Inhibits Cell Growth and Facilitates Apoptosis in Gastric Cancer by Binding with miR-6720-5p to Regulate ESRRB. Biochem. Genet.<\/i>, 61, 2672-2690.","DOI":"10.1007\/s10528-023-10399-5"},{"key":"6","doi-asserted-by":"crossref","unstructured":"Knudsen, E.S., Witkiewicz, A.K.&Rubin, S.M. (2024) Cancer takes many paths through G1\/S. Trends Cell Biol.<\/i>, 34, 636-645.","DOI":"10.1016\/j.tcb.2023.10.007"},{"key":"7","doi-asserted-by":"crossref","unstructured":"Kurihara, M., Shiraishi, A., Satake, H.&Kimura, A.P. (2014) A conserved noncoding sequence can function as a spermatocyte-specific enhancer and a bidirectional promoter for a ubiquitously expressed gene and a testis-specific long noncoding RNA. J. Mol. Biol.<\/i>, 426, 3069-3093.","DOI":"10.1016\/j.jmb.2014.06.018"},{"key":"8","doi-asserted-by":"crossref","unstructured":"Lecerf, C., Le Bourhis, X.&Adriaenssens, E. (2019) The long non-coding RNA H19: an active player with multiple facets to sustain the hallmarks of cancer. Cell. Mol. Life Sci.<\/i>, 76, 4673-4687.","DOI":"10.1007\/s00018-019-03240-z"},{"key":"9","doi-asserted-by":"crossref","unstructured":"Lee, H.W., Park, Y.M., Lee, S.J., Cho, H.J., Kim, D.H., Lee, J.I., Kang, M.S., Seol, H.J., Shim, Y.M., Nam, D.H., Kim, H.H.&Joo, K.M. (2013) Alpha-smooth muscle actin (ACTA2) is required for metastatic potential of human lung adenocarcinoma. Clin. Cancer Res.<\/i>, 19, 5879-5889.","DOI":"10.1158\/1078-0432.CCR-13-1181"},{"key":"10","unstructured":"Li, Y., Yang, Z.&Chen, J. (2021) Mechanism underlying the regulation of lncRNA ACTA2-AS1 on CXCL2 by absorbing miRNA-532-5p as ceRNA in the development of ovarian cancer. Int. J. Clin. Exp. Pathol.<\/i>, 14, 596-607."},{"key":"11","doi-asserted-by":"crossref","unstructured":"Li, Z., Wang, J., Wu, J., Li, N.&Jiang, C. (2022) Long Noncoding RNA LEMD1-AS1 Increases LEMD1 Expression and Activates PI3K-AKT Pathway to Promote Metastasis in Oral Squamous Cell Carcinoma. Biomed Res. Int.<\/i>, 2022, 3543948.","DOI":"10.1155\/2022\/3543948"},{"key":"12","doi-asserted-by":"crossref","unstructured":"Liu, X., Zhang, X.&Du, S. (2022) Long non-coding RNA ACTA2-AS1 inhibits the cisplatin resistance of non-small cell lung cancer cells through inhibiting autophagy by suppressing TSC2. Cell Cycle<\/i>, 21, 368-378.","DOI":"10.1080\/15384101.2021.2020433"},{"key":"13","doi-asserted-by":"crossref","unstructured":"Liu, Y.W., Xia, R., Lu, K., Xie, M., Yang, F., Sun, M., De, W., Wang, C.&Ji, G. (2017) LincRNAFEZF1-AS1 represses p21 expression to promote gastric cancer proliferation through LSD1-Mediated H3K4me2 demethylation. Mol. Cancer<\/i>, 16, 39.","DOI":"10.1186\/s12943-017-0588-9"},{"key":"14","doi-asserted-by":"crossref","unstructured":"Luo, J., Qu, J., Wu, D.K., Lu, Z.L., Sun, Y.S.&Qu, Q. (2017) Long non-coding RNAs: a rising biotarget in colorectal cancer. Oncotarget<\/i>, 8, 22187-22202.","DOI":"10.18632\/oncotarget.14728"},{"key":"15","doi-asserted-by":"crossref","unstructured":"Melegh, Z.&Oltean, S. (2019) Targeting Angiogenesis in Prostate Cancer. Int. J. Mol. Sci.<\/i>, 20, 2676.","DOI":"10.3390\/ijms20112676"},{"key":"16","doi-asserted-by":"crossref","unstructured":"Mohler, J., Bahnson, R.R., Boston, B., Busby, J.E., D\u2019Amico, A., Eastham, J.A., Enke, C.A., George, D., Horwitz, E.M., Huben, R.P., Kantoff, P., Kawachi, M., Kuettel, M., Lange, P.H., Macvicar, G., et al.(2010) NCCN clinical practice guidelines in oncology: prostate cancer. J. Natl. Compr. Canc. Netw.<\/i>, 8, 162-200.","DOI":"10.6004\/jnccn.2010.0012"},{"key":"17","doi-asserted-by":"crossref","unstructured":"Nachiyappan, A., Gupta, N.&Taneja, R. (2022) EHMT1\/EHMT2 in EMT, cancer stemness and drug resistance: emerging evidence and mechanisms. FEBS J.<\/i>, 289, 1329-1351.","DOI":"10.1111\/febs.16334"},{"key":"18","doi-asserted-by":"crossref","unstructured":"Pan, Q., Huang, Y., Wang, Y., Li, D.&Lei, C. (2021) LncRNA ACTA2-AS1 suppress colon adenocarcinoma progression by sponging miR-4428 upregulation BCL2L11. Cancer Cell Int.<\/i>, 21, 203.","DOI":"10.1186\/s12935-021-01769-3"},{"key":"19","doi-asserted-by":"crossref","unstructured":"Park, S., Karalis, J.D., Hong, C., Clemenceau, J.R., Porembka, M.R., Kim, I.H., Lee, S.H., Wang, S.C., Cheong, J.H.&Hwang, T.H. (2023) ACTA2 Expression Predicts Survival and Is Associated with Response to Immune Checkpoint Inhibitors in Gastric Cancer. Clin. Cancer Res.<\/i>, 29, 1077-1085.","DOI":"10.1158\/1078-0432.CCR-22-1897"},{"key":"20","doi-asserted-by":"crossref","unstructured":"Peng, Y., Huang, X.&Wang, H. (2022) lncRNA ACTA2-AS1 predicts malignancy and poor prognosis of triple-negative breast cancer and regulates tumor progression via modulating miR-532-5p. BMC Mol. Cell Biol.<\/i>, 23, 34.","DOI":"10.1186\/s12860-022-00432-7"},{"key":"21","doi-asserted-by":"crossref","unstructured":"Pistritto, G., Trisciuoglio, D., Ceci, C., Garufi, A.&D\u2019Orazi, G. (2016) Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies. Aging<\/i> (Albany NY<\/i>), 8, 603-619.","DOI":"10.18632\/aging.100934"},{"key":"22","doi-asserted-by":"crossref","unstructured":"Qu, L., Wu, Z., Li, Y., Xu, Z., Liu, B., Liu, F., Bao, Y., Wu, D., Liu, J., Wang, A., Chu, X., Sun, Y., Chen, C., Zhang, Z.&Wang, L. (2016) A feed-forward loop between lncARSR and YAP activity promotes expansion of renal tumour-initiating cells. Nat. Commun.<\/i>, 7, 12692.","DOI":"10.1038\/ncomms12692"},{"key":"23","doi-asserted-by":"crossref","unstructured":"Qu, X., Alsager, S., Zhuo, Y.&Shan, B. (2019) HOX transcript antisense RNA (HOTAIR) in cancer. Cancer Lett.<\/i>, 454, 90-97.","DOI":"10.1016\/j.canlet.2019.04.016"},{"key":"24","doi-asserted-by":"crossref","unstructured":"Suer, I., Guzel, E., Karatas, O.F., Creighton, C.J., Ittmann, M.&Ozen, M. (2019) MicroRNAs as prognostic markers in prostate cancer. Prostate<\/i>, 79, 265-271.","DOI":"10.1002\/pros.23731"},{"key":"25","doi-asserted-by":"crossref","unstructured":"Sun, Y.&Ma, L. (2019) New Insights into Long Non-Coding RNA MALAT1 in Cancer and Metastasis. Cancers<\/i> (Basel<\/i>), 11, 216.","DOI":"10.3390\/cancers11020216"},{"key":"26","doi-asserted-by":"crossref","unstructured":"Tang, Y., He, Y., Zhang, P., Wang, J., Fan, C., Yang, L., Xiong, F., Zhang, S., Gong, Z., Nie, S., Liao, Q., Li, X., Li, X., Li, Y., Li, G., et al.(2018) LncRNAs regulate the cytoskeleton and related Rho\/ROCK signaling in cancer metastasis. Mol. Cancer<\/i>, 17, 77.","DOI":"10.1186\/s12943-018-0825-x"},{"key":"27","doi-asserted-by":"crossref","unstructured":"Wang, Y., Li, D., Lu, J., Chen, L., Zhang, S., Qi, W., Li, W.&Xu, H. (2020) Long noncoding RNA TTN-AS1 facilitates tumorigenesis and metastasis by maintaining TTN expression in skin cutaneous melanoma. Cell Death Dis.<\/i>, 11, 664.","DOI":"10.1038\/s41419-020-02895-y"},{"key":"28","doi-asserted-by":"crossref","unstructured":"Wang, Y., Li, Z., Zhang, Z.&Chen, X. (2021) Identification ACTA2 and KDR as key proteins for prognosis of PD-1\/PD-L1 blockade therapy in melanoma. Animal Model. Exp. Med.<\/i>, 4, 138-150.","DOI":"10.1002\/ame2.12154"},{"key":"29","doi-asserted-by":"crossref","unstructured":"Wu, S., Zhu, J., Jiang, T., Cui, T., Zuo, Q., Zheng, G., Li, G., Zhou, J.&Chen, X. (2024) Long non-coding RNA ACTA2-AS1 suppresses metastasis of papillary thyroid cancer via regulation of miR-4428\/KLF9 axis. Clin. Epigenetics<\/i>, 16, 10.","DOI":"10.1186\/s13148-023-01622-6"},{"key":"30","doi-asserted-by":"crossref","unstructured":"Yang, M.H., Zhao, L., Wang, L., Ou-Yang, W., Hu, S.S., Li, W.L., Ai, M.L., Wang, Y.Q., Han, Y., Li, T.T., Ding, Y.Q.&Wang, S. (2019) Nuclear lncRNA HOXD-AS1 suppresses colorectal carcinoma growth and metastasis via inhibiting HOXD3-induced integrin beta3 transcriptional activating and MAPK\/AKT signalling. Mol. Cancer<\/i>, 18, 31.","DOI":"10.1186\/s12943-019-0955-9"},{"key":"31","doi-asserted-by":"crossref","unstructured":"Ying, K., Wang, L., Long, G., Lian, C., Chen, Z.&Lin, W. (2020) ACTA2-AS1 suppresses lung adenocarcinoma progression via sequestering miR-378a-3p and miR-4428 to elevate SOX7 expression. Cell Biol. Int.<\/i>, 44, 2438-2449.","DOI":"10.1002\/cbin.11451"},{"key":"32","doi-asserted-by":"crossref","unstructured":"Yuan, J.H., Liu, X.N., Wang, T.T., Pan, W., Tao, Q.F., Zhou, W.P., Wang, F.&Sun, S.H. (2017) The MBNL3 splicing factor promotes hepatocellular carcinoma by increasing PXN expression through the alternative splicing of lncRNA-PXN-AS1. Nat. Cell Biol.<\/i>, 19, 820-832.","DOI":"10.1038\/ncb3538"},{"key":"33","doi-asserted-by":"crossref","unstructured":"Zeng, A.L., Yan, W., Liu, Y.W., Wang, Z., Hu, Q., Nie, E., Zhou, X., Li, R., Wang, X.F., Jiang, T.&You, Y.P. (2017) Tumour exosomes from cells harbouring PTPRZ1-MET fusion contribute to a malignant phenotype and temozolomide chemoresistance in glioblastoma. Oncogene<\/i>, 36, 5369-5381.","DOI":"10.1038\/onc.2017.134"},{"key":"34","doi-asserted-by":"crossref","unstructured":"Zhou, R.J.&Lv, H.Z. (2019) Knockdown of ACTA2-AS1 promotes liver cancer cell proliferation, migration and invasion. Mol. Med. Rep.<\/i>, 19, 2263-2270.","DOI":"10.3892\/mmr.2019.9856"}],"container-title":["The Tohoku Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/tjem\/267\/2\/267_2025.J042\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T04:22:56Z","timestamp":1761366176000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/tjem\/267\/2\/267_2025.J042\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.1620\/tjem.2025.j042","relation":{},"ISSN":["0040-8727","1349-3329"],"issn-type":[{"value":"0040-8727","type":"print"},{"value":"1349-3329","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]},"article-number":"2025.J042"}}