{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T05:18:17Z","timestamp":1787980697314,"version":"build-2784847793"},"reference-count":27,"publisher":"Tohoku University Medical Press","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tohoku J. Exp. Med."],"published-print":{"date-parts":[[2026]]},"DOI":"10.1620\/tjem.2025.j047","type":"journal-article","created":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T22:36:18Z","timestamp":1746052578000},"page":"343-349","source":"Crossref","is-referenced-by-count":2,"title":["Anti-MDA5 Dermatomyositis Induced by COVID-19 Following Recombinant SARS-CoV-2 Vaccination: A Case Report"],"prefix":"10.1620","volume":"269","author":[{"given":"Yuya","family":"Sumichika","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Fukushima Medical University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuzo","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Fukushima Medical University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Fukushima Medical University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Fukushima Medical University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhei","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Fukushima Medical University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruki","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Fukushima Medical University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jumpei","family":"Temmoku","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Fukushima Medical University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuya","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Fukushima Medical University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Asano","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Fukushima Medical University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Fukushima Medical University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshi","family":"Migita","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Fukushima Medical University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"622","reference":[{"key":"1","doi-asserted-by":"publisher","unstructured":"Abegunde, T.B., Persad, C., Ojule, S., Colgan, J.&amp;Duncan, M. (2024)  Unveiling the Connections Between Melanoma Differentiation-Associated Gene 5 (MDA5)-Positive Dermatomyositis and Its Potential Association With COVID-19: A Report of Two Cases. <i>Cureus<\/i>, 16, e65016. https:\/\/doi.org\/10.7759\/cureus.65016","DOI":"10.7759\/cureus.65016"},{"key":"2","doi-asserted-by":"publisher","unstructured":"Anderle, K., Machold, K., Kiener, H.P., Bormann, D., Hoetzenecker, K., Geleff, S., Prosch, H., Laccone, F., Heil, P.M., Petzelbauer, P., Aletaha, D., Bluml, S.&amp;Kastrati, K. (2022)  COVID-19 as a putative trigger of anti-MDA5-associated dermatomyositis with acute respiratory distress syndrome (ARDS) requiring lung transplantation, a case report. <i>BMC Rheumatol.<\/i>, 6, 42. https:\/\/doi.org\/10.1186\/s41927-022-00271-1","DOI":"10.1186\/s41927-022-00271-1"},{"key":"3","doi-asserted-by":"publisher","unstructured":"Boitiaux, J.F., Debray, M.P., Nicaise-Roland, P., Adle-Biassette, H., Danel, C., Clerici, C., Aubier, M., Mariette, X., Cadranel, J.&amp;Crestani, B. (2011)  Idiopathic interstitial lung disease with anti-SSA antibody. <i>Rheumatology<\/i> (<i>Oxford<\/i>), 50, 2245-2250. https:\/\/doi.org\/10.1093\/rheumatology\/ker267","DOI":"10.1093\/rheumatology\/ker267"},{"key":"4","doi-asserted-by":"publisher","unstructured":"Chiale, C., Greene, T.T.&amp;Zuniga, E.I. (2022)  Interferon induction, evasion, and paradoxical roles during SARS-CoV-2 infection. <i>Immunol. Rev.<\/i>, 309, 12-24. https:\/\/doi.org\/10.1111\/imr.13113","DOI":"10.1111\/imr.13113"},{"key":"5","doi-asserted-by":"publisher","unstructured":"DeWane, M.E., Waldman, R.&amp;Lu, J. (2020)  Dermatomyositis: Clinical features and pathogenesis. <i>J. Am. Acad. Dermatol.<\/i>, 82, 267-281. https:\/\/doi.org\/10.1016\/j.jaad.2019.06.1309","DOI":"10.1016\/j.jaad.2019.06.1309"},{"key":"6","doi-asserted-by":"publisher","unstructured":"Dunkle, L.M., Kotloff, K.L., Gay, C.L., Anez, G., Adelglass, J.M., Barrat Hernandez, A.Q., Harper, W.L., Duncanson, D.M., McArthur, M.A., Florescu, D.F., McClelland, R.S., Garcia-Fragoso, V., Riesenberg, R.A., Musante, D.B., Fried, D.L., et al. (2022)  Efficacy and Safety of NVX-CoV2373 in Adults in the United States and Mexico. <i>N. Engl. J. Med.<\/i>, 386, 531-543. https:\/\/doi.org\/10.1056\/NEJMoa2116185","DOI":"10.1056\/NEJMoa2116185"},{"key":"7","doi-asserted-by":"publisher","unstructured":"Ebinger, J.E., Joung, S.Y., Wang, M., Liu, Y., Prostko, J.C., Frias, E.C., Stewart, J.L., Braun, J., McGovern, D.P.B., Melmed, G.Y., Jordan, S.C., Claggett, B.L., Sobhani, K.&amp;Cheng, S. (2023)  Long-term durability of antibody responses after SARS-CoV-2 vaccination and influencing factors. <i>J. Intern. Med.<\/i>, 293, 520-523. https:\/\/doi.org\/10.1111\/joim.13601","DOI":"10.1111\/joim.13601"},{"key":"8","doi-asserted-by":"publisher","unstructured":"Glasle, F., Uhlmann, T.&amp;Vandersee, S. (2023)  Schwere Anti-MDA5-Dermatomyositis nach nur milder Covid-19-Infektion. <i>J. Dtsch. Dermatol. Ges.<\/i>, 21 Suppl 2, 19-21. https:\/\/doi.org\/10.1111\/ddg.15092_g","DOI":"10.1111\/ddg.15092_g"},{"key":"9","doi-asserted-by":"publisher","unstructured":"Gonzalez, D., Gupta, L., Murthy, V., Gonzalez, E.B., Williamson, K.A., Makol, A., Tan, C.L., Sulaiman, F.N., Shahril, N.S., Isa, L.M., Martin-Nares, E.&amp;Aggarwal, R. (2022)  Anti-MDA5 dermatomyositis after COVID-19 vaccination: a case-based review. <i>Rheumatol. Int.<\/i>, 42, 1629-1641. https:\/\/doi.org\/10.1007\/s00296-022-05149-6","DOI":"10.1007\/s00296-022-05149-6"},{"key":"10","doi-asserted-by":"publisher","unstructured":"Guimaraes, L.E., Baker, B., Perricone, C.&amp;Shoenfeld, Y. (2015)  Vaccines, adjuvants and autoimmunity. <i>Pharmacol. Res.<\/i>, 100, 190-209. https:\/\/doi.org\/10.1016\/j.phrs.2015.08.003","DOI":"10.1016\/j.phrs.2015.08.003"},{"key":"11","doi-asserted-by":"publisher","unstructured":"Holzer, M.T., Krusche, M., Ruffer, N., Haberstock, H., Stephan, M., Huber, T.B.&amp;Kotter, I. (2022)  New-onset dermatomyositis following SARS-CoV-2 infection and vaccination: a case-based review. <i>Rheumatol. Int.<\/i>, 42, 2267-2276. https:\/\/doi.org\/10.1007\/s00296-022-05176-3","DOI":"10.1007\/s00296-022-05176-3"},{"key":"12","doi-asserted-by":"publisher","unstructured":"Jaganathan, S., Stieber, F., Rao, S.N., Nikolayevskyy, V., Manissero, D., Allen, N., Boyle, J.&amp;Howard, J. (2021)  Preliminary Evaluation of QuantiFERON SARS-CoV-2 and QIAreach Anti-SARS-CoV-2 Total Test in Recently Vaccinated Individuals. <i>Infect. Dis. Ther.<\/i>, 10, 2765-2776. https:\/\/doi.org\/10.1007\/s40121-021-00521-8","DOI":"10.1007\/s40121-021-00521-8"},{"key":"13","doi-asserted-by":"publisher","unstructured":"Keshtkarjahromi, M., Chhetri, S., Balagani, A., Tayyab, U.B.&amp;Haas, C.J. (2021)  Macrophage activation syndrome in MDA5 antibody-positive dermatomyositis and COVID-19 infection. <i>BMC Rheumatol.<\/i>, 5, 59. https:\/\/doi.org\/10.1186\/s41927-021-00225-z","DOI":"10.1186\/s41927-021-00225-z"},{"key":"14","doi-asserted-by":"publisher","unstructured":"Kitajima, T., Funauchi, A., Nakajima, T., Marumo, S., Imura, Y.&amp;Fukui, M. (2022)  Antimelanoma Differentiation-Associated Gene 5 Antibody-Positive Interstitial Lung Disease After Vaccination With COVID-19 mRNA Vaccines. <i>J. Rheumatol.<\/i>, 49, 1158-1162. https:\/\/doi.org\/10.3899\/jrheum.220259","DOI":"10.3899\/jrheum.220259"},{"key":"15","doi-asserted-by":"publisher","unstructured":"Kumar, H., Koyama, S., Ishii, K.J., Kawai, T.&amp;Akira, S. (2008)  Cutting edge: cooperation of IPS-1- and TRIF-dependent pathways in poly IC-enhanced antibody production and cytotoxic T cell responses. <i>J. Immunol.<\/i>, 180, 683-687. https:\/\/doi.org\/10.4049\/jimmunol.180.2.683","DOI":"10.4049\/jimmunol.180.2.683"},{"key":"16","doi-asserted-by":"publisher","unstructured":"Kuriyama, K., Murakami, K., Sugiura, K., Sakui, S., Schuring, R.P., Masuda, T.&amp;Mori, M. (2024)  One-year follow-up of the immunogenicity and safety of a primary series of the NVX-CoV2373 (TAK-019) vaccine in healthy Japanese adults: Final report of a phase I\/II randomized controlled trial. <i>Vaccine<\/i>, 42, 1319-1325. https:\/\/doi.org\/10.1016\/j.vaccine.2024.01.056","DOI":"10.1016\/j.vaccine.2024.01.056"},{"key":"17","doi-asserted-by":"publisher","unstructured":"Lu, X., Peng, Q.&amp;Wang, G. (2024)  Anti-MDA5 antibody-positive dermatomyositis: pathogenesis and clinical progress. <i>Nat. Rev. Rheumatol.<\/i>, 20, 48-62. https:\/\/doi.org\/10.1038\/s41584-023-01054-9","DOI":"10.1038\/s41584-023-01054-9"},{"key":"18","doi-asserted-by":"publisher","unstructured":"Lundberg, I.E., Fujimoto, M., Vencovsky, J., Aggarwal, R., Holmqvist, M., Christopher-Stine, L., Mammen, A.L.&amp;Miller, F.W. (2021)  Idiopathic inflammatory myopathies. <i>Nat. Rev. Dis. Primers<\/i>, 7, 86. https:\/\/doi.org\/10.1038\/s41572-021-00321-x","DOI":"10.1038\/s41572-021-00321-x"},{"key":"19","doi-asserted-by":"publisher","unstructured":"Marklund, J., Hanna, B., Jin, T.&amp;Pullerits, R. (2024)  Myositis-associated antibodies predict the severity of lung involvement in adult patients with inflammatory myositis - a cohort study of 70 adult patients with myositis in a single center. <i>Front. Med.<\/i> (<i>Lausanne<\/i>), 11, 1340310. https:\/\/doi.org\/10.3389\/fmed.2024.1340310","DOI":"10.3389\/fmed.2024.1340310"},{"key":"20","doi-asserted-by":"publisher","unstructured":"Nakayama, T., Ito, T., Ishiyama, R.&amp;Katayama, K. (2023)  Cytokine and Chemokine Production in Mice Inoculated with NVX-CoV2373 (Nuvaxovid((R))) in Comparison with Omicron BA.4\/5 Bivalent BNT162b2 (Comirnaty((R))). <i>Vaccines<\/i> (<i>Basel<\/i>), 11, 1677. https:\/\/doi.org\/10.3390\/vaccines11111677","DOI":"10.3390\/vaccines11111677"},{"key":"21","doi-asserted-by":"publisher","unstructured":"Nombel, A., Pin, J.J., Fabien, N., Miossec, P.&amp;Coutant, F. (2022)  Evaluation of the Performance of an Indirect Immunofluorescence Assay for the Detection of Anti-MDA5 Antibodies. <i>Biomedicines<\/i>, 10, 2969. https:\/\/doi.org\/10.3390\/biomedicines10112969","DOI":"10.3390\/biomedicines10112969"},{"key":"22","doi-asserted-by":"publisher","unstructured":"Rydyznski Moderbacher, C., Kim, C., Mateus, J., Plested, J., Zhu, M., Cloney-Clark, S., Weiskopf, D., Sette, A., Fries, L., Glenn, G.&amp;Crotty, S. (2022)  NVX-CoV2373 vaccination induces functional SARS-CoV-2-specific CD4+ and CD8+ T cell responses. <i>J. Clin. Invest.<\/i>, 132, e160898. https:\/\/doi.org\/10.1172\/JCI160898","DOI":"10.1172\/JCI160898"},{"key":"23","doi-asserted-by":"publisher","unstructured":"Sugimoto, T., Yorishima, A., Oka, N., Masuda, S., Nakamoto, N., Kidoguchi, G., Watanabe, H., Yoshida, Y., Mokuda, S.&amp;Hirata, S. (2023)  Appearance of anti-MDA5 antibody-positive dermatomyositis after COVID-19 vaccination. <i>Mod. Rheumatol. Case Rep.<\/i>, 7, 108-112. https:\/\/doi.org\/10.1093\/mrcr\/rxac064","DOI":"10.1093\/mrcr\/rxac064"},{"key":"24","doi-asserted-by":"publisher","unstructured":"Temmoku, J., Sato, S., Fujita, Y., Asano, T., Suzuki, E., Kanno, T., Furuya, M.Y., Matsuoka, N., Kobayashi, H., Watanabe, H., Koga, T., Shimizu, T., Kawakami, A.&amp;Migita, K. (2019) Clinical significance of myositis-specific autoantibody profiles in Japanese patients with polymyositis\/dermatomyositis. <i>Medicine<\/i> (<i>Baltimore<\/i>), 98, e15578. https:\/\/doi.org\/10.1097\/MD.0000000000015578","DOI":"10.1097\/MD.0000000000015578"},{"key":"25","doi-asserted-by":"publisher","unstructured":"Tonutti, A., Motta, F., Ceribelli, A., Isailovic, N., Selmi, C.&amp;De Santis, M. (2022)  Anti-MDA5 Antibody Linking COVID-19, Type I Interferon, and Autoimmunity: A Case Report and Systematic Literature Review. <i>Front. Immunol.<\/i>, 13, 937667. https:\/\/doi.org\/10.3389\/fimmu.2022.937667","DOI":"10.3389\/fimmu.2022.937667"},{"key":"26","doi-asserted-by":"publisher","unstructured":"Wang, G., Wang, Q., Wang, Y., Liu, C., Wang, L., Chen, H., Jiao, T., Hu, C., Lei, X., Guo, L., Ren, L., Li, M., Zhao, Y., Zeng, X., Zhang, D., et al. (2021)  Presence of Anti-MDA5 Antibody and Its Value for the Clinical Assessment in Patients With COVID-19: A Retrospective Cohort Study. <i>Front. Immunol.<\/i>, 12, 791348. https:\/\/doi.org\/10.3389\/fimmu.2021.791348","DOI":"10.3389\/fimmu.2021.791348"},{"key":"27","doi-asserted-by":"publisher","unstructured":"Yasui, M., Iwamoto, T.&amp;Furuta, S. (2024)  New therapies in anti-MDA5 antibody-positive dermatomyositis. <i>Curr. Opin. Rheumatol.<\/i>, 36, 61-68. https:\/\/doi.org\/10.1097\/BOR.0000000000000979","DOI":"10.1097\/BOR.0000000000000979"}],"container-title":["The Tohoku Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/tjem\/269\/3\/269_2025.J047\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T04:24:38Z","timestamp":1787977478000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/tjem\/269\/3\/269_2025.J047\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.1620\/tjem.2025.j047","relation":{},"ISSN":["0040-8727","1349-3329"],"issn-type":[{"value":"0040-8727","type":"print"},{"value":"1349-3329","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"2025.J047"}}