{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T03:58:27Z","timestamp":1775275107933,"version":"3.50.1"},"reference-count":38,"publisher":"Tohoku University Medical Press","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tohoku J. Exp. Med."],"published-print":{"date-parts":[[2026]]},"DOI":"10.1620\/tjem.2025.j118","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T22:06:41Z","timestamp":1761775601000},"page":"331-343","source":"Crossref","is-referenced-by-count":0,"title":["Unraveling Shared Diagnostic Biomarkers: Integrated Bioinformatics Identification of CGB7, MYCNUT, and GPR32 in Gestational Diabetes Mellitus and Retinopathy of Prematurity"],"prefix":"10.1620","volume":"268","author":[{"given":"Lixiong","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Children\u2019s Hospital, Zhejiang University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Tongde Hospital of Zhejiang Province"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"622","reference":[{"key":"1","doi-asserted-by":"publisher","unstructured":"Andersen, L.B., Norgaard, M., Rasmussen, M., Fredsoe, J., Borre, M., Ulhoi, B.P.&amp;Sorensen, K.D. (2021)  Immune cell analyses of the tumor microenvironment in prostate cancer highlight infiltrating regulatory T cells and macrophages as adverse prognostic factors. <i>J. Pathol.<\/i>, 255, 155-165. https:\/\/doi.org\/10.1002\/path.5757","DOI":"10.1002\/path.5757"},{"key":"2","doi-asserted-by":"publisher","unstructured":"Ara, I., Maqbool, M.&amp;Gani, I. (2022)  Role of insulin resistance in gestational diabetes mellitus: a literature review. <i>Chettinad Health City Medical Journal<\/i>, 11, 69-74. https:\/\/doi.org\/10.24321\/2278.2044.202218","DOI":"10.24321\/2278.2044.202218"},{"key":"3","doi-asserted-by":"publisher","unstructured":"Arnardottir, H., Thul, S., Pawelzik, S.C., Karadimou, G., Artiach, G., Gallina, A.L., Mysdotter, V., Carracedo, M., Tarnawski, L., Caravaca, A.S., Baumgartner, R., Ketelhuth, D.F., Olofsson, P.S., Paulsson-Berne, G., Hansson, G.K., et al.(2021)  The resolvin D1 receptor GPR32 transduces inflammation resolution and atheroprotection. <i>J. Clin. Invest.<\/i>, 131, e142883. https:\/\/doi.org\/10.1172\/JCI142883","DOI":"10.1172\/JCI142883"},{"key":"4","doi-asserted-by":"publisher","unstructured":"Chen, Q., Feng, Y., Yang, H., Wu, W., Zhang, P., Wang, K., Wang, Y., Ko, J., Shen, J., Guo, L., Zhao, F., Du, W., Ru, S., Wang, S.&amp;Zhang, Y. (2019)  A Vitamin Pattern Diet Is Associated with Decreased Risk of Gestational Diabetes Mellitus in Chinese Women: Results from a Case Control Study in Taiyuan, China. <i>J. Diabetes Res.<\/i>, 2019, 5232308. https:\/\/doi.org\/10.1155\/2019\/5232308","DOI":"10.1155\/2019\/5232308"},{"key":"5","doi-asserted-by":"publisher","unstructured":"Choudhury, A.A.&amp;Devi Rajeswari, V. (2021)  Gestational diabetes mellitus - A metabolic and reproductive disorder. <i>Biomed. Pharmacother.<\/i>, 143, 112183. https:\/\/doi.org\/10.1016\/j.biopha.2021.112183","DOI":"10.1016\/j.biopha.2021.112183"},{"key":"6","doi-asserted-by":"publisher","unstructured":"Fuchs, S., Danssmann, C., Klironomos, F., Winkler, A., Fallmann, J., Kruetzfeldt, L.M., Szymansky, A., Naderi, J., Bernhart, S.H., Grunewald, L., Helmsauer, K., Rodriguez-Fos, E., Kirchner, M., Mertins, P., Astrahantseff, K., et al.(2023)  Defining the landscape of circular RNAs in neuroblastoma unveils a global suppressive function of MYCN. <i>Nat. Commun.<\/i>, 14, 3936. https:\/\/doi.org\/10.1038\/s41467-023-38747-4","DOI":"10.1038\/s41467-023-38747-4"},{"key":"7","doi-asserted-by":"publisher","unstructured":"Hellstr\u00f6m, A., Smith, L.E.H.&amp;Hard, A.L. (2024)  ROP: 80 Years after Its Detection - Where Do We Stand and How Long Will We Continue to Laser? <i>Neonatology<\/i>, 121, 608-615. https:\/\/doi.org\/10.1159\/000538907","DOI":"10.1159\/000538907"},{"key":"8","doi-asserted-by":"publisher","unstructured":"Iu, L.P.L., Yip, W.W.K., Lok, J.Y.C., Fan, M.C.Y., Lai, C.H.Y., Ho, M.&amp;Young, A.L. (2023)  Prediction model to predict type 1 retinopathy of prematurity using gestational age and birth weight (PW-ROP). <i>Br. J. Ophthalmol.<\/i>, 107, 1007-1011. https:\/\/doi.org\/10.1136\/bjophthalmol-2021-320670","DOI":"10.1136\/bjophthalmol-2021-320670"},{"key":"9","doi-asserted-by":"publisher","unstructured":"James, A., Ke, H., Yao, T.&amp;Wang, Y. (2023)  The Role of Probiotics in Purine Metabolism, Hyperuricemia and Gout: Mechanisms and Interventions. <i>Food Reviews International<\/i>, 39, 261-277. https:\/\/doi.org\/10.1080\/87559129.2021.1904412","DOI":"10.1080\/87559129.2021.1904412"},{"key":"10","doi-asserted-by":"publisher","unstructured":"Khoshtinat, N., Moayeri, M., Fakhredin, H., Farahani, A.D., Ghassemi, F., Mahmoudi, A., Bazvand, F.&amp;Nabavi, A. (2025)  Association of hypertensive disorders of pregnancy and gestational diabetes mellitus with developing severe retinopathy of prematurity. <i>Int. J. Retina Vitreous<\/i>, 11, 52. https:\/\/doi.org\/10.1186\/s40942-025-00635-y","DOI":"10.1186\/s40942-025-00635-y"},{"key":"11","doi-asserted-by":"publisher","unstructured":"Kunysz, M., Mora-Janiszewska, O.&amp;Darmochwal-Kolarz, D. (2021)  Epigenetic Modifications Associated with Exposure to Endocrine Disrupting Chemicals in Patients with Gestational Diabetes Mellitus. <i>Int. J. Mol. Sci.<\/i>, 22, 4693. https:\/\/doi.org\/10.3390\/ijms22094693","DOI":"10.3390\/ijms22094693"},{"key":"12","doi-asserted-by":"publisher","unstructured":"Law, K.P., Han, T.L., Mao, X.&amp;Zhang, H. (2017)  Tryptophan and purine metabolites are consistently upregulated in the urinary metabolome of patients diagnosed with gestational diabetes mellitus throughout pregnancy: A longitudinal metabolomics study of Chinese pregnant women part 2. <i>Clin. Chim. Acta<\/i>, 468, 126-139. https:\/\/doi.org\/10.1016\/j.cca.2017.02.018","DOI":"10.1016\/j.cca.2017.02.018"},{"key":"13","doi-asserted-by":"publisher","unstructured":"Loganathan, P.K., Nair, V.&amp;Lal, M.K. (2022)  Retinopathy of prematurity: overview of new global problem. <i>Paediatrics and Child Health<\/i>, 32, 311-323. https:\/\/doi.org\/10.1016\/j.paed.2022.07.001","DOI":"10.1016\/j.paed.2022.07.001"},{"key":"14","doi-asserted-by":"publisher","unstructured":"Lu, S., Wang, J., Kakongoma, N., Hua, W., Xu, J., Wang, Y., He, S., Gu, H., Shi, J.&amp;Hu, W. (2022)  DNA methylation and expression profiles of placenta and umbilical cord blood reveal the characteristics of gestational diabetes mellitus patients and offspring. <i>Clin. Epigenetics<\/i>, 14, 69. https:\/\/doi.org\/10.1186\/s13148-022-01289-5","DOI":"10.1186\/s13148-022-01289-5"},{"key":"15","unstructured":"Madi, A.A.M.(2024)  Development and homeostasis of memory CD8+ T cells and implications for cancer immunotherapy. <i>Heidelberg Dokumentenserver, Doctoral dissertation<\/i>, https:\/\/doi.org\/10.11588\/heidok.00032848"},{"key":"16","doi-asserted-by":"crossref","unstructured":"Meinhardt, G., Haider, S., Kunihs, V., Saleh, L., Pollheimer, J., Fiala, C., Hetey, S., Feher, Z., Szilagyi, A., Than, N.G.&amp;Knofler, M. (2020)  Pivotal role of the transcriptional co-activator YAP in trophoblast stemness of the developing human placenta. <i>Proc. Natl. Acad. Sci. U. S. A.<\/i>, 117, 13562-13570. https:\/\/doi.org\/10.1073\/pnas.2002630117","DOI":"10.1073\/pnas.2002630117"},{"key":"17","doi-asserted-by":"publisher","unstructured":"Modzelewski, R., Stefanowicz-Rutkowska, M.M., Matuszewski, W.&amp;Bandurska-Stankiewicz, E.M. (2022)  Gestational Diabetes Mellitus-Recent Literature Review. <i>J. Clin. Med.<\/i>, 11, 5736. https:\/\/doi.org\/10.3390\/jcm11195736","DOI":"10.3390\/jcm11195736"},{"key":"18","doi-asserted-by":"publisher","unstructured":"Opara, C.N., Akintorin, M., Byrd, A., Cirignani, N., Akintorin, S.&amp;Soyemi, K. (2020)  Maternal diabetes mellitus as an independent risk factor for clinically significant retinopathy of prematurity severity in neonates less than 1500g. <i>PLoS One<\/i>, 15, e0236639. https:\/\/doi.org\/10.1371\/journal.pone.0236639","DOI":"10.1371\/journal.pone.0236639"},{"key":"19","doi-asserted-by":"publisher","unstructured":"Owen, L.A., Zhang, C., Shirer, K., Carroll, L., Wood, B., Szczotka, K., Cornia, C., Stubben, C., Fung, C., Yost, C.C., Katikaneni, L.D., DeAngelis, M.M.&amp;Comstock, J. (2023)  Placental Inflammation Significantly Correlates with Reduced Risk for Retinopathy of Prematurity. <i>Am. J. Pathol.<\/i>, 193, 1776-1788. https:\/\/doi.org\/10.1016\/j.ajpath.2023.02.003","DOI":"10.1016\/j.ajpath.2023.02.003"},{"key":"20","doi-asserted-by":"publisher","unstructured":"Ozgur Gursoy, O., Gurer, H.G., Yildiz Eren, C., Erdogan Ozgur, P.&amp;Gursoy, H. (2022)  The association of various obstetric and perinatal factors with retinopathy of prematurity. <i>Int. Ophthalmol.<\/i>, 42, 2719-2728. https:\/\/doi.org\/10.1007\/s10792-022-02260-2","DOI":"10.1007\/s10792-022-02260-2"},{"key":"21","unstructured":"Tashtemirova, I. M.&amp;Qosimov, I.S. (2024)  Features of Purine Metabolism and Microalbuminuria of Ischemic Heart Disease in Patients with Metabolic Syndrome. <i>World Bulletin of Public Health<\/i>, 32, 192-195. https:\/\/scholarexpress.net\/index.php\/wbph\/article\/view\/4000"},{"key":"22","doi-asserted-by":"publisher","unstructured":"Quaresima, P., Visconti, F., Interlandi, F., Puccio, L., Caroleo, P., Amendola, G., Morelli, M., Venturella, R.&amp;Di Carlo, C. (2021)  Awareness of gestational diabetes mellitus foetal-maternal risks: an Italian cohort study on pregnant women. <i>BMC Pregnancy Childbirth<\/i>, 21, 692. https:\/\/doi.org\/10.1186\/s12884-021-04172-y","DOI":"10.1186\/s12884-021-04172-y"},{"key":"23","doi-asserted-by":"publisher","unstructured":"Rao, A., Gupta, A., Kain, V.&amp;Halade, G.V. (2023)  Extrinsic and intrinsic modulators of inflammation-resolution signaling in heart failure. <i>Am. J. Physiol. Heart Circ. Physiol.<\/i>, 325, H433-H448. https:\/\/doi.org\/10.1152\/ajpheart.00276.2023","DOI":"10.1152\/ajpheart.00276.2023"},{"key":"24","doi-asserted-by":"publisher","unstructured":"Raskov, H., Orhan, A., Christensen, J.P.&amp;Gogenur, I. (2021)  Cytotoxic CD8(+) T cells in cancer and cancer immunotherapy. <i>Br. J. Cancer<\/i>, 124, 359-367. https:\/\/doi.org\/10.1038\/s41416-020-01048-4","DOI":"10.1038\/s41416-020-01048-4"},{"key":"25","doi-asserted-by":"publisher","unstructured":"Reina-Campos, M., Scharping, N.E.&amp;Goldrath, A.W. (2021)  CD8(+) T cell metabolism in infection and cancer. <i>Nat. Rev. Immunol.<\/i>, 21, 718-738. https:\/\/doi.org\/10.1038\/s41577-021-00537-8","DOI":"10.1038\/s41577-021-00537-8"},{"key":"26","doi-asserted-by":"publisher","unstructured":"Rivero-M\u00fcller, A.&amp;Huhtaniemi, I. (2022)  Genetic variants of gonadotrophins and their receptors: Impact on the diagnosis and management of the infertile patient. <i>Best Pract. Res. Clin. Endocrinol. Metab.<\/i>, 36, 101596. https:\/\/doi.org\/10.1016\/j.beem.2021.101596","DOI":"10.1016\/j.beem.2021.101596"},{"key":"27","doi-asserted-by":"publisher","unstructured":"Romero-Maldonado, S., Montoya-Estrada, A., Reyes-Munoz, E., Guzman-Grenfell, A.M., Torres-Ramos, Y.D., Sanchez-Mendez, M.D., Tolentino-Dolores, M., Salgado-Valladares, M.B., Belmont-Gomez, A., Najera, N., Ceballos, G., Cardona-Perez, J.A., Hicks, J.J.&amp;Mancilla-Ramirez, J. (2021)  Efficacy of water-based vitamin E solution versus placebo in the prevention of retinopathy of prematurity in very low birth weight infants: A randomized clinical trial. <i>Medicine (Baltimore)<\/i>, 100, e26765. https:\/\/doi.org\/10.1097\/MD.0000000000026765","DOI":"10.1097\/MD.0000000000026765"},{"key":"28","doi-asserted-by":"publisher","unstructured":"Sabri, K., Ells, A.L., Lee, E.Y., Dutta, S.&amp;Vinekar, A. (2022)  Retinopathy of Prematurity: A Global Perspective and Recent Developments. <i>Pediatrics<\/i>, 150, e2021053924. https:\/\/doi.org\/10.1542\/peds.2021-053924","DOI":"10.1542\/peds.2021-053924"},{"key":"29","doi-asserted-by":"publisher","unstructured":"Saito, Y., Tanaka, A., Node, K.&amp;Kobayashi, Y. (2021)  Uric acid and cardiovascular disease: A clinical review. <i>J. Cardiol.<\/i>, 78, 51-57. https:\/\/doi.org\/10.1016\/j.jjcc.2020.12.013","DOI":"10.1016\/j.jjcc.2020.12.013"},{"key":"30","doi-asserted-by":"publisher","unstructured":"Saucedo, R., Ortega-Camarillo, C., Ferreira-Hermosillo, A., Diaz-Velazquez, M.F., Meixueiro-Calderon, C.&amp;Valencia-Ortega, J. (2023)  Role of Oxidative Stress and Inflammation in Gestational Diabetes Mellitus. <i>Antioxidants (Basel)<\/i>, 12, 1812. https:\/\/doi.org\/10.3390\/antiox12101812","DOI":"10.3390\/antiox12101812"},{"key":"31","doi-asserted-by":"publisher","unstructured":"Shattnawi, K.K., Khader, Y.S., Alyahya, M.S., Al-Sheyab, N.&amp;Batieha, A. (2020)  Rate, determinants, and causes of stillbirth in Jordan: Findings from the Jordan Stillbirth and Neonatal Deaths Surveillance (JSANDS) system. <i>BMC Pregnancy Childbirth<\/i>, 20, 571. https:\/\/doi.org\/10.1186\/s12884-020-03267-2","DOI":"10.1186\/s12884-020-03267-2"},{"key":"32","doi-asserted-by":"publisher","unstructured":"Singh, C., Arya, S., Chellani, H., Anand, P.&amp;Singhal, R. (2024)  Effect of Kangaroo Mother Care on Retinopathy of Prematurity in Neonates Less Than 1,800 g or Below 34 Weeks of Gestation. <i>Journal of Neonatology<\/i>, 38, 182-190. https:\/\/doi.org\/10.1177\/09732179241244567","DOI":"10.1177\/09732179241244567"},{"key":"33","doi-asserted-by":"publisher","unstructured":"Wu, T., Hu, E., Xu, S., Chen, M., Guo, P., Dai, Z., Feng, T., Zhou, L., Tang, W., Zhan, L., Fu, X., Liu, S., Bo, X.&amp;Yu, G. (2021)  clusterProfiler 4. <i>0: A universal enrichment tool for interpreting omics data. Innovation (Camb.)<\/i>, 2, 100141. https:\/\/doi.org\/10.1016\/j.xinn.2021.100141","DOI":"10.1016\/j.xinn.2021.100141"},{"key":"34","doi-asserted-by":"publisher","unstructured":"Xu, M., Zhou, H., Hu, P., Pan, Y., Wang, S., Liu, L.&amp;Liu, X. (2023)  Identification and validation of immune and oxidative stress-related diagnostic markers for diabetic nephropathy by WGCNA and machine learning. <i>Front. Immunol.<\/i>, 14, 1084531. https:\/\/doi.org\/10.3389\/fimmu.2023.1084531","DOI":"10.3389\/fimmu.2023.1084531"},{"key":"35","doi-asserted-by":"publisher","unstructured":"Xue, D., Peng, H., Li, Z., Xu, J., Ma, H., Dang, Y., Li, F., Wang, G.&amp;Sun, Q. (2024)  Comprehensive analysis reveals TSPEAR as a prognostic biomarker in colorectal cancer. <i>J. Cancer<\/i>, 15, 809-824. https:\/\/doi.org\/10.7150\/jca.90028","DOI":"10.7150\/jca.90028"},{"key":"36","doi-asserted-by":"publisher","unstructured":"Yang, K., Li, J.&amp;Tao, L. (2022)  Purine metabolism in the development of osteoporosis. <i>Biomed. Pharmacother.<\/i>, 155, 113784. https:\/\/doi.org\/10.1016\/j.biopha.2022.113784","DOI":"10.1016\/j.biopha.2022.113784"},{"key":"37","doi-asserted-by":"crossref","unstructured":"Yang, Y., Dong, L., Qi, H., Zhang, Y., Lu, X., Fan, Z., Wu, D., Zhang, G.&amp;Lei, H. (2023)  Kidney-eye metabolomics in a mouse mode of oxygen-induced retinopathy correlates with those in retinopathy of prematurity. <i>Research Square<\/i>, https:\/\/doi.org\/10.21203\/rs.3.rs-2532885\/v1.","DOI":"10.21203\/rs.3.rs-2532885\/v1"},{"key":"38","doi-asserted-by":"publisher","unstructured":"Zhao, G.Q., Cheng, T., Wang, P.Y., Mo, J., Yu, F., Dong, Y., Li, Y.F., Feng, Y., Xu, P.F.&amp;Shu, L.P. (2025)  Mycn regulates vascular development through PI3K signaling pathway in zebrafish. <i>Dev. Dyn<\/i>., https:\/\/doi.org\/10.1002\/dvdy.70104 [Epub ahead of print].","DOI":"10.1002\/dvdy.70104"}],"container-title":["The Tohoku Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/tjem\/268\/3\/268_2025.J118\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T03:18:45Z","timestamp":1775272725000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/tjem\/268\/3\/268_2025.J118\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.1620\/tjem.2025.j118","relation":{},"ISSN":["0040-8727","1349-3329"],"issn-type":[{"value":"0040-8727","type":"print"},{"value":"1349-3329","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"2025.J118"}}