{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T03:53:00Z","timestamp":1791604380364,"version":"4.3.4"},"reference-count":31,"publisher":"Tohoku University Medical Press","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tohoku J. Exp. Med."],"published-print":{"date-parts":[[2026]]},"DOI":"10.1620\/tjem.2025.j169","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T22:08:13Z","timestamp":1770242893000},"page":"599-612","source":"Crossref","is-referenced-by-count":0,"title":["TAL1 Suppresses High-Grade Serous Ovarian Cancer Progression by Transcriptionally Inhibiting TPI1-Mediated Glycolysis"],"prefix":"10.1620","volume":"269","author":[{"given":"Nan","family":"Zhao","sequence":"first","affiliation":[{"name":"Gynecology Ward 1, Harbin Medical University Affiliated Cancer Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Breast Internal Medicine 1, Harbin Medical University Affiliated Cancer Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Gao","sequence":"additional","affiliation":[{"name":"Chest Radiotherapy Ward 1, Harbin Medical University Affiliated Cancer Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhe","family":"Zhou","sequence":"additional","affiliation":[{"name":"Gynecology Ward 1, Harbin Medical University Affiliated Cancer Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"622","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"Alberghina, L. (2023)  The Warburg Effect Explained: Integration of Enhanced Glycolysis with Heterogeneous Mitochondria to Promote Cancer Cell Proliferation.  <i>Int. J. Mol. Sci.<\/i>, 24, 15787. https:\/\/doi.org\/10.3390\/ijms242115787","DOI":"10.3390\/ijms242115787"},{"key":"2","doi-asserted-by":"publisher","unstructured":"Chandel, N.S. (2021)  Glycolysis.  <i>Cold Spring Harb Perspect Biol<\/i>, 13, a040535. https:\/\/doi.org\/10.1101\/cshperspect.a040535","DOI":"10.1101\/cshperspect.a040535"},{"key":"3","doi-asserted-by":"publisher","unstructured":"Dong, J., Ru, Y., Zhai, L., Gao, Y., Guo, X., Chen, B. &amp; Lv, X. (2023)  LMNB1 deletion in ovarian cancer inhibits the proliferation and metastasis of tumor cells through PI3K\/Akt pathway.  <i>Exp. Cell Res.<\/i>, 426, 113573. https:\/\/doi.org\/10.1016\/j.yexcr.2023.113573","DOI":"10.1016\/j.yexcr.2023.113573"},{"key":"4","doi-asserted-by":"publisher","unstructured":"Geng, T., Sun, Q., He, J., Chen, Y., Cheng, W., Shen, J., Liu, B., Zhang, M., Wang, S., Asan, K., Song, M., Gao, Q., Song, Y., Liu, R., Liu, X., et al. (2024)  CXXC5 drove inflammation and ovarian cancer proliferation via transcriptional activation of ZNF143 and EGR1.  <i>Cell. Signal.<\/i>, 119, 111180. https:\/\/doi.org\/10.1016\/j.cellsig.2024.111180","DOI":"10.1016\/j.cellsig.2024.111180"},{"key":"5","doi-asserted-by":"publisher","unstructured":"Huang, F., Xue, F., Wang, Q., Huang, Y., Wan, Z., Cao, X. &amp; Zhong, L. (2023)  Transcription factor-target gene regulatory network analysis in human lung adenocarcinoma.  <i>J. Thorac<\/i><i>. Dis.<\/i>, 15, 6996-7012. https:\/\/doi.org\/10.21037\/jtd-23-1688","DOI":"10.21037\/jtd-23-1688"},{"key":"6","doi-asserted-by":"publisher","unstructured":"Hundal, J., Lopetegui-Lia, N. &amp; Rabitaille, W. (2021)  Fallopian tube cancer- challenging to diagnose but not as infrequent as originally thought.  <i>J. Community Hosp. Intern. Med. Perspect.<\/i>, 11, 393-396. https:\/\/doi.org\/10.1080\/20009666.2021.1893889","DOI":"10.1080\/20009666.2021.1893889"},{"key":"7","doi-asserted-by":"publisher","unstructured":"Jiang, H., Ma, N., Shang, Y., Zhou, W., Chen, T., Guan, D., Li, J., Wang, J., Zhang, E., Feng, Y., Yin, F., Yuan, Y., Fang, Y., Qiu, L., Xie, D., et al. (2017)  Triosephosphate isomerase 1 suppresses growth, migration and invasion of hepatocellular carcinoma cells.  <i>Biochem. Biophys. Res. Commun.<\/i>, 482, 1048-1053. https:\/\/doi.org\/10.1016\/j.bbrc.2016.11.156","DOI":"10.1016\/j.bbrc.2016.11.156"},{"key":"8","doi-asserted-by":"publisher","unstructured":"Kierans, S.J. &amp; Taylor, C.T. (2024)  Glycolysis: A multifaceted metabolic pathway and signaling hub.  <i>J. Biol. Chem.<\/i>, 300, 107906. https:\/\/doi.org\/10.1016\/j.jbc.2024.107906","DOI":"10.1016\/j.jbc.2024.107906"},{"key":"9","doi-asserted-by":"publisher","unstructured":"Kooshan, Z., Cardenas-Piedra, L., Clements, J. &amp; Batra, J. (2024)  Glycolysis, the sweet appetite of the tumor microenvironment.  <i>Cancer Lett.<\/i>, 600, 217156. https:\/\/doi.org\/10.1016\/j.canlet.2024.217156","DOI":"10.1016\/j.canlet.2024.217156"},{"key":"10","doi-asserted-by":"publisher","unstructured":"Kordowitzki, P., Lange, B., Elias, K.M., Haigis, M.C., Mechsner, S., Braicu, I.E. &amp; Sehouli, J. (2025)  Transforming treatment paradigms: Focus on personalized medicine for high-grade serous ovarian cancer.  <i>CA Cancer J. Clin.<\/i>, 75, 436-460. https:\/\/doi.org\/10.3322\/caac.70008","DOI":"10.3322\/caac.70008"},{"key":"11","doi-asserted-by":"publisher","unstructured":"Li, C., Liu, F.Y., Shen, Y., Tian, Y. &amp; Han, F.J. (2023)  Research progress on the mechanism of glycolysis in ovarian cancer.  <i>Front. Immunol.<\/i>, 14, 1284853. https:\/\/doi.org\/10.3389\/fimmu.2023.1284853","DOI":"10.3389\/fimmu.2023.1284853"},{"key":"12","doi-asserted-by":"publisher","unstructured":"Li, L., Xu, H., Qu, L., Xu, K. &amp; Liu, X. (2022)  Daidzin inhibits hepatocellular carcinoma survival by interfering with the glycolytic\/gluconeogenic pathway through downregulation of TPI1.  <i>Biofactors<\/i>, 48, 883-896. https:\/\/doi.org\/10.1002\/biof.1826","DOI":"10.1002\/biof.1826"},{"key":"13","doi-asserted-by":"publisher","unstructured":"Liu, P., Sun, S.J., Ai, Y.J., Feng, X., Zheng, Y.M., Gao, Y., Zhang, J.Y., Zhang, L., Sun, Y.P., Xiong, Y., Lin, M. &amp; Yuan, H.X. (2022)  Elevated nuclear localization of glycolytic enzyme TPI1 promotes lung adenocarcinoma and enhances chemoresistance.  <i>Cell Death Dis.<\/i>, 13, 205. https:\/\/doi.org\/10.1038\/s41419-022-04655-6","DOI":"10.1038\/s41419-022-04655-6"},{"key":"14","doi-asserted-by":"publisher","unstructured":"Liu, X., Wei, Q., Yang, C., Zhao, H., Xu, J., Mobet, Y., Luo, Q., Yang, D., Zuo, X., Chen, N., Yang, Y., Li, L., Wang, W., Yu, J., Xu, J., et al. (2024)  RNA m(5)C modification upregulates E2F1 expression in a manner dependent on YBX1 phase separation and promotes tumor progression in ovarian cancer.  <i>Exp. Mol. Med.<\/i>, 56, 600-615. https:\/\/doi.org\/10.1038\/s12276-024-01184-4","DOI":"10.1038\/s12276-024-01184-4"},{"key":"15","unstructured":"Liu, Y., Lang, Z., Peng, X., Zhang, Z., Fu, J. &amp; Zhou, C. (2023)  The impact of link quality management on healthcare quality: a comparative study at The Fourth Hospital of Harbin Medical University.  <i>Am. J.<\/i><i> Transl. Res.<\/i>, 15, 5930-5939."},{"key":"16","doi-asserted-by":"publisher","unstructured":"Maruyama, K., Uematsu, S., Kondo, T., Takeuchi, O., Martino, M.M., Kawasaki, T. &amp; Akira, S. (2013)  Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP.  <i>J. Exp. Med.<\/i>, 210, 1947-1960. https:\/\/doi.org\/10.1084\/jem.20130512","DOI":"10.1084\/jem.20130512"},{"key":"17","doi-asserted-by":"publisher","unstructured":"Myers, T.D. &amp; Palladino, M.J. (2023)  Newly discovered roles of triosephosphate isomerase including functions within the nucleus.  <i>Mol. Med.<\/i>, 29, 18. https:\/\/doi.org\/10.1186\/s10020-023-00612-x","DOI":"10.1186\/s10020-023-00612-x"},{"key":"18","doi-asserted-by":"publisher","unstructured":"Nayak, A.P., Kapur, A., Barroilhet, L. &amp; Patankar, M.S. (2018)  Oxidative Phosphorylation: A Target for Novel Therapeutic Strategies Against Ovarian Cancer.  <i>Cancers <\/i>(<i>Basel<\/i>), 10, 337. https:\/\/doi.org\/10.3390\/cancers10090337","DOI":"10.3390\/cancers10090337"},{"key":"19","doi-asserted-by":"crossref","unstructured":"Polaj\u017eer, S. &amp; \u010cerne, K. (2025)  Precision Medicine in High-Grade Serous Ovarian Cancer: Targeted Therapies and the Challenge of Chemoresistance.  <i>Int. J. Mol. Sci.<\/i>, 26, 2545. https:\/\/doi.org\/10.3390\/ijms26062545","DOI":"10.3390\/ijms26062545"},{"key":"20","doi-asserted-by":"publisher","unstructured":"Porcher, C., Chagraoui, H. &amp; Kristiansen, M.S. (2017)  SCL\/TAL1: a multifaceted regulator from blood development to disease.  <i>Blood<\/i>, 129, 2051-2060. https:\/\/doi.org\/10.1182\/blood-2016-12-754051","DOI":"10.1182\/blood-2016-12-754051"},{"key":"21","doi-asserted-by":"publisher","unstructured":"Qiao, Q., Wang, J., Liu, S., Chang, J., Zhou, T., Li, C., Zhang, Y., Jiang, W., Chen, Y., Xu, X., Wu, M. &amp; Li, X. (2024)  USP28 promotes tumor progression and glycolysis by stabilizing PKM2\/Hif1-alpha in cholangiocarcinoma.  <i>Cell. Oncol. <\/i>(<i>Dordr<\/i>), 47, 2217-2231. https:\/\/doi.org\/10.1007\/s13402-024-01002-z","DOI":"10.1007\/s13402-024-01002-z"},{"key":"22","doi-asserted-by":"publisher","unstructured":"Tan, S., Yu, H., Xu, Y., Zhao, Y. &amp; Lou, G. (2023)  Hypoxia-induced PPFIA4 accelerates the progression of ovarian cancer through glucose metabolic reprogramming.  <i>Med. Oncol.<\/i>, 40, 272. https:\/\/doi.org\/10.1007\/s12032-023-02144-0","DOI":"10.1007\/s12032-023-02144-0"},{"key":"23","doi-asserted-by":"crossref","unstructured":"Vidoni, C., Ferraresi, A., Vallino, L., Salwa, A., Ha, J.H., Seca, C., Garavaglia, B., Dhanasekaran, D.N. &amp; Isidoro, C. (2023)  Glycolysis Inhibition of Autophagy Drives Malignancy in Ovarian Cancer: Exacerbation by IL-6 and Attenuation by Resveratrol.  <i>Int. J. Mol. Sci.<\/i>, 24, 1723. https:\/\/doi.org\/10.3390\/ijms24021723","DOI":"10.3390\/ijms24021723"},{"key":"24","doi-asserted-by":"publisher","unstructured":"Wang, C., Wan, S., Li, K., Chen, S., Shu, Y., Liu, S. &amp; Yang, L. (2025)  TPI1 promotes p53 ubiquitination in bladder cancer by recruiting AKT to enhance MDM2 phosphorylation.  <i>Pharmacol. Res.<\/i>, 215, 107695. https:\/\/doi.org\/10.1016\/j.phrs.2025.107695","DOI":"10.1016\/j.phrs.2025.107695"},{"key":"25","doi-asserted-by":"publisher","unstructured":"Wang, J., Xiang, F., Liu, X., Ma, X., Cai, X., Yang, Y., Shen, X., Yuan, C., Xiang, Y. &amp; Xiao, H. (2021a)  HPV E7 affects the function of cervical cancer cells via the TAL1\/lnc-EBIC\/KLHDC7B axis.  <i>Oncol<\/i><i>. Rep.<\/i>, 45, 51. https:\/\/doi.org\/10.3892\/or.2021.8002","DOI":"10.3892\/or.2021.8002"},{"key":"26","doi-asserted-by":"publisher","unstructured":"Wang, S., Wang, Z., Li, J., Qin, J., Song, J., Li, Y., Zhao, L., Zhang, X., Guo, H., Shao, C., Kong, B. &amp; Liu, Z. (2021b)  Splicing factor USP39 promotes ovarian cancer malignancy through maintaining efficient splicing of oncogenic HMGA2.  <i>Cell Death Dis.<\/i>, 12, 294. https:\/\/doi.org\/10.1038\/s41419-021-03581-3","DOI":"10.1038\/s41419-021-03581-3"},{"key":"27","doi-asserted-by":"publisher","unstructured":"Xu, D., Shao, F., Bian, X., Meng, Y., Liang, T. &amp; Lu, Z. (2021)  The Evolving Landscape of Noncanonical Functions of Metabolic Enzymes in Cancer and Other Pathologies.  <i>Cell Metab<\/i><i>.<\/i>, 33, 33-50. https:\/\/doi.org\/10.1016\/j.cmet.2020.12.015","DOI":"10.1016\/j.cmet.2020.12.015"},{"key":"28","doi-asserted-by":"publisher","unstructured":"Yoshida, A., Okamoto, N., Tozawa-Ono, A., Koizumi, H., Kiguchi, K., Ishizuka, B., Kumai, T. &amp; Suzuki, N. (2013)  Proteomic analysis of differential protein expression by brain metastases of gynecological malignancies.  <i>Hum. Cell<\/i>, 26, 56-66. https:\/\/doi.org\/10.1007\/s13577-012-0053-4","DOI":"10.1007\/s13577-012-0053-4"},{"key":"29","doi-asserted-by":"publisher","unstructured":"Zhang, L., Zhao, J., Su, C., Wu, J., Jiang, L., Chi, H. &amp; Wang, Q. (2025)  Organoid models of ovarian cancer: resolving immune mechanisms of metabolic reprogramming and drug resistance.  <i>Front.<\/i><i> Immunol.<\/i>, 16, 1573686. https:\/\/doi.org\/10.3389\/fimmu.2025.1573686","DOI":"10.3389\/fimmu.2025.1573686"},{"key":"30","doi-asserted-by":"crossref","unstructured":"Zhang, R., Siu, M.K.Y., Ngan, H.Y.S. &amp; Chan, K.K.L. (2022)  Molecular Biomarkers for the Early Detection of Ovarian Cancer.  <i>Int. J. Mol. Sci.<\/i>, 23, 12041. https:\/\/doi.org\/10.3390\/ijms231912041","DOI":"10.3390\/ijms231912041"},{"key":"31","doi-asserted-by":"publisher","unstructured":"Zheng, F., Chen, J., Zhang, X., Wang, Z., Chen, J., Lin, X., Huang, H., Fu, W., Liang, J., Wu, W., Li, B., Yao, H., Hu, H. &amp; Song, E. (2021)  The HIF-1alpha antisense long non-coding RNA drives a positive feedback loop of HIF-1alpha mediated transactivation and glycolysis.  <i>Nat. Commun.<\/i>, 12, 1341. https:\/\/doi.org\/10.1038\/s41467-021-21535-3","DOI":"10.1038\/s41467-021-21535-3"}],"container-title":["The Tohoku Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/tjem\/269\/4\/269_2025.J169\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T03:27:29Z","timestamp":1791602849000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/tjem\/269\/4\/269_2025.J169\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.1620\/tjem.2025.j169","relation":{},"ISSN":["0040-8727","1349-3329"],"issn-type":[{"value":"0040-8727","type":"print"},{"value":"1349-3329","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"2025.J169"}}