{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T03:56:44Z","timestamp":1781323004099,"version":"3.54.1"},"reference-count":41,"publisher":"Tohoku University Medical Press","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tohoku J. Exp. Med."],"published-print":{"date-parts":[[2026]]},"DOI":"10.1620\/tjem.2025.j174","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T22:08:13Z","timestamp":1770242893000},"page":"91-100","source":"Crossref","is-referenced-by-count":0,"title":["Adipose-derived Mesenchymal Stem Cells-Derived Exosomes Alleviate LPS-Induced Hepatocyte Injury in Sepsis by Inhibiting the JAK2\/STAT3 Signaling Pathway"],"prefix":"10.1620","volume":"269","author":[{"given":"Xiaona","family":"Yi","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine, Ningbo Medical Center Lihuili Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Ningbo Medical Center Lihuili Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingkai","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Ningbo Medical Center Lihuili Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingyang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Ningbo Medical Center Lihuili Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Ningbo Medical Center Lihuili Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meixia","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Ningbo Medical Center Lihuili Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feifei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Ningbo Medical Center Lihuili Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Ningbo Medical Center Lihuili Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhong","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Ningbo Medical Center Lihuili Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"622","reference":[{"key":"1","doi-asserted-by":"publisher","unstructured":"Beyer, D., Hoff, J., Sommerfeld, O., Zipprich, A., Gassler, N.&Press, A.T. (2022) The liver in sepsis: molecular mechanism of liver failure and their potential for clinical translation. Mol. Med.<\/i>, 28, 84. https:\/\/doi.org\/10.1186\/s10020-022-00510-8","DOI":"10.1186\/s10020-022-00510-8"},{"key":"2","doi-asserted-by":"publisher","unstructured":"Cai, J., Tang, D., Hao, X., Liu, E., Li, W.&Shi, J. (2023) Mesenchymal stem cell-derived exosome alleviates sepsis- associated acute liver injury by suppressing MALAT1 through microRNA-26a-5p: an innovative immunopharmacological intervention and therapeutic approach for sepsis. Front. Immunol.<\/i>, 14, 1157793. https:\/\/doi.org\/10.3389\/fimmu.2023.1157793","DOI":"10.3389\/fimmu.2023.1157793"},{"key":"3","doi-asserted-by":"publisher","unstructured":"Chen, J.W., Liu, C.Y., Li, S., Wu, S.W., Cai, C.&Lu, M.Q. (2024) Sepsis-associated liver injury: Mechanisms and potential therapeutic targets. World J. Gastroenterol.<\/i>, 30, 4518-4522. https:\/\/doi.org\/10.3748\/wjg.v30.i42.4518","DOI":"10.3748\/wjg.v30.i42.4518"},{"key":"4","doi-asserted-by":"publisher","unstructured":"Chen, Y., Wang, L., Liu, M., Zhao, J., Xu, X., Wei, D.&Chen, J. (2023) Mechanism of exosomes from adipose-derived mesenchymal stem cells on sepsis-induced acute lung injury by promoting TGF-beta secretion in macrophages. Surgery<\/i>, 174, 1208-1219. https:\/\/doi.org\/10.1016\/j.surg.2023.06.017","DOI":"10.1016\/j.surg.2023.06.017"},{"key":"5","doi-asserted-by":"publisher","unstructured":"Cheng, Y., Li, J., Wang, L., Wu, X., Li, Y., Xu, M., Li, Q., Huang, J., Zhao, T., Yang, Z., Zhang, H., Zuo, L., Zhang, X., Geng, Z., Wang, Y., et al. (2023) Eriocalyxin B ameliorated Crohn\u2019s disease-like colitis by restricting M1 macrophage polarization through JAK2\/STAT1 signalling. Eur. J. Pharmacol.<\/i>, 954, 175876. https:\/\/doi.org\/10.1016\/j.ejphar.2023.175876","DOI":"10.1016\/j.ejphar.2023.175876"},{"key":"6","doi-asserted-by":"publisher","unstructured":"Chu, M., Wang, H., Bian, L., Huang, J., Wu, D., Zhang, R., Fei, F., Chen, Y.&Xia, J. (2022) Nebulization Therapy with Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes for COVID-19 Pneumonia. Stem Cell Rev. Rep.<\/i>, 18, 2152-2163. https:\/\/doi.org\/10.1007\/s12015-022-10398-w","DOI":"10.1007\/s12015-022-10398-w"},{"key":"7","doi-asserted-by":"publisher","unstructured":"Civelek, E., Kabatas, S., Savrunlu, E.C., Diren, F., Kaplan, N., Ofluoglu, D.&Karaoz, E. (2024) Effects of exosomes from mesenchymal stem cells on functional recovery of a patient with total radial nerve injury: A pilot study. World J. Stem Cells<\/i>, 16, 19-32. https:\/\/doi.org\/10.4252\/wjsc.v16.i1.19","DOI":"10.4252\/wjsc.v16.i1.19"},{"key":"8","doi-asserted-by":"publisher","unstructured":"Duke, L.C., Cone, A.S., Sun, L., Dittmer, D.P., Meckes, D.G. Jr.&Tomko, R.J. Jr. (2025) Tetraspanin CD9 alters cellular trafficking and endocytosis of tetraspanin CD63, affecting CD63 packaging into small extracellular vesicles. J. Biol. Chem.<\/i>, 301, 108255. https:\/\/doi.org\/10.1016\/j.jbc.2025.108255","DOI":"10.1016\/j.jbc.2025.108255"},{"key":"9","doi-asserted-by":"publisher","unstructured":"Gao, Y., Chen, Y.&Gao, L. (2024) Evaluation of Sepsis Severity Using Combined High-Density Lipoprotein and Red Cell Distribution Width Indicators. Br. J. Hosp. Med. <\/i>(Lond.<\/i>), 85, 1-12. https:\/\/doi.org\/10.12968\/hmed.2024.0473","DOI":"10.12968\/hmed.2024.0473"},{"key":"10","doi-asserted-by":"crossref","unstructured":"Gong, T., Liu, Y.T.&Fan, J. (2024) Exosomal mediators in sepsis and inflammatory organ injury: unraveling the role of exosomes in intercellular crosstalk and organ dysfunction. Mil. Med. Res.<\/i>, 11, 24. https:\/\/doi.org\/10.1186\/s40779-024-00527-6","DOI":"10.1186\/s40779-024-00527-6"},{"key":"11","doi-asserted-by":"publisher","unstructured":"He, X., Kang, K., Pan, D., Sun, Y.&Chang, B. (2022) FTY720 attenuates APAP-induced liver injury via the JAK2\/STAT3 signaling pathway. Int. J. Mol. Med.<\/i>, 49, 67. https:\/\/doi.org\/10.3892\/ijmm.2022.5123","DOI":"10.3892\/ijmm.2022.5123"},{"key":"12","doi-asserted-by":"publisher","unstructured":"Lai, Y.J., Sung, Y.T., Lai, Y.A., Chen, L.N., Chen, T.S.&Chien, C.T. (2022) L-Theanine-Treated Adipose-Derived Mesenchymal Stem Cells Alleviate the Cytotoxicity Induced by N-Nitrosodiethylamine in Liver. Tissue Eng. Regen. Med.<\/i>, 19, 1207-1221. https:\/\/doi.org\/10.1007\/s13770-022-00472-2","DOI":"10.1007\/s13770-022-00472-2"},{"key":"13","doi-asserted-by":"publisher","unstructured":"Lee, J., Lee, D.&Kim, Y. (2021) Mathematical model of STAT signalling pathways in cancer development and optimal control approaches. R. Soc. Open Sci.<\/i>, 8, 210594. https:\/\/doi.org\/10.1098\/rsos.210594","DOI":"10.1098\/rsos.210594"},{"key":"14","doi-asserted-by":"publisher","unstructured":"Li, J., Lu, Y.&Lin, G. (2022) Blocking cGAS\/STING signaling protects against sepsis-associated acute liver injury. Int. Immunopharmacol.<\/i>, 113, 109276. https:\/\/doi.org\/10.1016\/j.intimp.2022.109276","DOI":"10.1016\/j.intimp.2022.109276"},{"key":"15","doi-asserted-by":"publisher","unstructured":"Li, Q., Tan, Y., Chen, S., Xiao, X., Zhang, M., Wu, Q.&Dong, M. (2021a) Irisin alleviates LPS-induced liver injury and inflammation through inhibition of NLRP3 inflammasome and NF-kappaB signaling. J. Recept. Signal Transduct. Res.<\/i>, 41, 294-303. https:\/\/doi.org\/10.1080\/10799893.2020.1808675","DOI":"10.1080\/10799893.2020.1808675"},{"key":"16","doi-asserted-by":"publisher","unstructured":"Li, Y., Zhang, J., Shi, J., Liu, K., Wang, X., Jia, Y., He, T., Shen, K., Wang, Y., Liu, J., Zhang, W., Wang, H., Zheng, Z.&Hu, D. (2021b) Exosomes derived from human adipose mesenchymal stem cells attenuate hypertrophic scar fibrosis by miR-192-5p\/IL-17RA\/Smad axis. Stem Cell Res. Ther.<\/i>, 12, 221. https:\/\/doi.org\/10.1186\/s13287-021-02290-0","DOI":"10.1186\/s13287-021-02290-0"},{"key":"17","doi-asserted-by":"publisher","unstructured":"Lin, F., Chen, W., Zhou, J., Zhu, J., Yao, Q., Feng, B., Feng, X., Shi, X., Pan, Q., Yu, J., Li, L.&Cao, H. (2022) Mesenchymal stem cells protect against ferroptosis via exosome-mediated stabilization of SLC7A11 in acute liver injury. Cell Death Dis.<\/i>, 13, 271. https:\/\/doi.org\/10.1038\/s41419-022-04708-w","DOI":"10.1038\/s41419-022-04708-w"},{"key":"18","doi-asserted-by":"crossref","unstructured":"Liu, D., Huang, S.Y., Sun, J.H., Zhang, H.C., Cai, Q.L., Gao, C., Li, L., Cao, J., Xu, F., Zhou, Y., Guan, C.X., Jin, S.W., Deng, J., Fang, X.M., Jiang, J.X., et al. (2022) Sepsis-induced immunosuppression: mechanisms, diagnosis and current treatment options. Mil. Med. Res.<\/i>, 9, 56. https:\/\/doi.org\/10.1186\/s40779-022-00422-y","DOI":"10.1186\/s40779-022-00422-y"},{"key":"19","doi-asserted-by":"publisher","unstructured":"Lu, Y., Li, D., Huang, Y., Sun, Y., Zhou, H., Ye, F., Yang, H., Xu, T., Quan, S.&Pan, J. (2023) Pretreatment with Eupatilin Attenuates Inflammation and Coagulation in Sepsis by Suppressing JAK2\/STAT3 Signaling Pathway. J. Inflamm. Res.<\/i>, 16, 1027-1042. https:\/\/doi.org\/10.2147\/JIR.S393850","DOI":"10.2147\/JIR.S393850"},{"key":"20","doi-asserted-by":"publisher","unstructured":"Ma, Y., Jiao, Z., Liu, X., Zhang, Q., Piao, C., Xu, J.&Wang, H. (2022) Protective effect of adipose-derived stromal cell-secretome attenuate autophagy induced by liver ischemia-reperfusion and partial hepatectomy. Stem Cell Res. Ther.<\/i>, 13, 427. https:\/\/doi.org\/10.1186\/s13287-022-03109-2","DOI":"10.1186\/s13287-022-03109-2"},{"key":"21","doi-asserted-by":"publisher","unstructured":"Nie, Y., Wang, P., Wang, S., Ma, Q.&Su, X. (2023) Accurate Capture and Identification of Exosomes: Nanoarchitecture of the MXene Heterostructure\/Engineered Lipid Layer. ACS Sens.<\/i>, 8, 1850-1857. https:\/\/doi.org\/10.1021\/acssensors.3c00370","DOI":"10.1021\/acssensors.3c00370"},{"key":"22","doi-asserted-by":"crossref","unstructured":"Piao, C., Sang, J., Kou, Z., Wang, Y., Liu, T., Lu, X., Jiao, Z.&Wang, H. (2022) Effects of Exosomes Derived from Adipose-Derived Mesenchymal Stem Cells on Pyroptosis and Regeneration of Injured Liver. Int. J. Mol. Sci.<\/i>, 23, 12065. https:\/\/doi.org\/10.3390\/ijms232012065","DOI":"10.3390\/ijms232012065"},{"key":"23","doi-asserted-by":"publisher","unstructured":"Qin, Y., Ge, G., Yang, P., Wang, L., Qiao, Y., Pan, G., Yang, H., Bai, J., Cui, W.&Geng, D. (2023) An Update on Adipose-Derived Stem Cells for Regenerative Medicine: Where Challenge Meets Opportunity. Adv. Sci. <\/i>(Weinh.<\/i>), 10, e2207334. https:\/\/doi.org\/10.1002\/advs.202207334","DOI":"10.1002\/advs.202207334"},{"key":"24","doi-asserted-by":"publisher","unstructured":"Shen, K., Wang, X., Wang, Y., Jia, Y., Zhang, Y., Wang, K., Luo, L., Cai, W., Li, J., Li, S., Du, Y., Zhang, L., Zhang, H., Chen, Y., Xu, C., et al. (2023) miR-125b-5p in adipose derived stem cells exosome alleviates pulmonary microvascular endothelial cells ferroptosis via Keap1\/Nrf2\/GPX4 in sepsis lung injury. Redox Biol.<\/i>, 62, 102655. https:\/\/doi.org\/10.1016\/j.redox.2023.102655","DOI":"10.1016\/j.redox.2023.102655"},{"key":"25","doi-asserted-by":"publisher","unstructured":"Sheng, B., Zhao, L., Zang, X., Zhen, J.&Chen, W. (2017) miR-375 ameliorates sepsis by downregulating miR-21 level via inhibiting JAK2-STAT3 signaling. Biomed. Pharmacother.<\/i>, 86, 254-261. https:\/\/doi.org\/10.1016\/j.biopha.2016.11.147","DOI":"10.1016\/j.biopha.2016.11.147"},{"key":"26","doi-asserted-by":"publisher","unstructured":"Tatullo, M., Rengo, S., Sammartino, G., Simeone, M., Valletta, A.&Gasparro, R. (2024) Inflammaging, Epigenetic Damage, Mitochondrial Dysfunctions, and Macrophage Alterations are the Main Missing Pieces in the Complex Mosaic of Stem Cell Physiology. Discov. Med.<\/i>, 36, 1772-1779. https:\/\/doi.org\/10.24976\/Discov.Med.202436188.163","DOI":"10.24976\/Discov.Med.202436188.163"},{"key":"27","doi-asserted-by":"publisher","unstructured":"Tian, Y., Zhang, J., Jia, Z., Pan, X., Hu, Z., Kang, R., Zhou, X., Luo, L., Shen, Z.&Shen, Q. (2025) Biomimetic mineralized mesenchymal stem cell-derived exosomes for dual modulation of ferroptosis and lactic acid-driven inflammation in acute liver injury therapy. J. Colloid Interface Sci.<\/i>, 687, 489-506. https:\/\/doi.org\/10.1016\/j.jcis.2025.02.078","DOI":"10.1016\/j.jcis.2025.02.078"},{"key":"28","doi-asserted-by":"publisher","unstructured":"Tu, Y., Liu, J., Kong, D., Guo, X., Li, J., Long, Z., Peng, J., Wang, Z., Wu, H., Liu, P., Liu, R., Yu, W.&Li, W. (2023) Irisin drives macrophage anti-inflammatory differentiation via JAK2-STAT6-dependent activation of PPARgamma and Nrf2 signaling. Free Radic. Biol. Med.<\/i>, 201, 98-110. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2023.03.014","DOI":"10.1016\/j.freeradbiomed.2023.03.014"},{"key":"29","doi-asserted-by":"publisher","unstructured":"van den Berg, M., van Beuningen, F.E., Ter Maaten, J.C.&Bouma, H.R. (2022) Hospital-related costs of sepsis around the world: A systematic review exploring the economic burden of sepsis. J. Crit. Care<\/i>, 71, 154096. https:\/\/doi.org\/10.1016\/j.jcrc.2022.154096","DOI":"10.1016\/j.jcrc.2022.154096"},{"key":"30","doi-asserted-by":"publisher","unstructured":"Wang, L., Li, T., Ma, X., Li, Y., Li, Z., Li, Z., Yu, N., Huang, J., Han, Q.&Long, X. (2023a) Exosomes from human adipose-derived mesenchymal stem cells attenuate localized scleroderma fibrosis by the let-7a-5p\/TGF-betaR1\/Smad axis. J. Dermatol. Sci.<\/i>, 112, 31-38. https:\/\/doi.org\/10.1016\/j.jdermsci.2023.09.001","DOI":"10.1016\/j.jdermsci.2023.09.001"},{"key":"31","doi-asserted-by":"publisher","unstructured":"Wang, Y., Chu, Y., Dai, H., Zheng, Y., Chen, R., Zhou, C., Zhong, Y., Zhan, C.&Luo, J. (2024) Protective role of pretreatment with Anisodamine against sepsis-induced diaphragm atrophy via inhibiting JAK2\/STAT3 pathway. Int. Immunopharmacol.<\/i>, 133, 112133. https:\/\/doi.org\/10.1016\/j.intimp.2024.112133","DOI":"10.1016\/j.intimp.2024.112133"},{"key":"32","doi-asserted-by":"publisher","unstructured":"Wang, Y., Liu, T., Jiao, G., Lv, Y., Piao, C., Lu, X., Ma, H.&Wang, H. (2023b) Exosomes from adipose-derived mesenchymal stem cells can attenuate liver injury caused by minimally invasive hemihepatectomy combined with ischemia-reperfusion in minipigs by modulating the endoplasmic reticulum stress response. Life Sci.<\/i>, 321, 121618. https:\/\/doi.org\/10.1016\/j.lfs.2023.121618","DOI":"10.1016\/j.lfs.2023.121618"},{"key":"33","doi-asserted-by":"publisher","unstructured":"Wu, Y.C., Wu, G.X., Chen, K.W., Shiu, L.Y., Kumar, S., Liu, G.S.&Kuo, S.M. (2022) Transplantation of 3D adipose-derived stem cell\/hepatocyte spheroids alleviates chronic hepatic damage in a rat model of thioacetamide-induced liver cirrhosis. Sci. Rep.<\/i>, 12, 1227. https:\/\/doi.org\/10.1038\/s41598-022-05174-2","DOI":"10.1038\/s41598-022-05174-2"},{"key":"34","doi-asserted-by":"publisher","unstructured":"Xie, S., Zhang, Q.&Jiang, L. (2022) Current Knowledge on Exosome Biogenesis, Cargo-Sorting Mechanism and Therapeutic Implications. Membranes<\/i> (Basel<\/i>), 12, 498. https:\/\/doi.org\/10.3390\/membranes12050498","DOI":"10.3390\/membranes12050498"},{"key":"35","doi-asserted-by":"publisher","unstructured":"Ye, J., Li, D., Jie, Y., Luo, H., Zhang, W.&Qiu, C. (2024) Exosome-based nanoparticles and cancer immunotherapy. Biomed. Pharmacother.<\/i>, 179, 117296. https:\/\/doi.org\/10.1016\/j.biopha.2024.117296","DOI":"10.1016\/j.biopha.2024.117296"},{"key":"36","doi-asserted-by":"publisher","unstructured":"Zanders, L., Kny, M., Hahn, A., Schmidt, S., Wundersitz, S., Todiras, M., Lahmann, I., Bandyopadhyay, A., Wollersheim, T., Kaderali, L., Luft, F.C., Birchmeier, C., Weber-Carstens, S.&Fielitz, J. (2022) Sepsis induces interleukin 6, gp130\/JAK2\/STAT3, and muscle wasting. J. Cachexia Sarcopenia Muscle<\/i>, 13, 713-727. https:\/\/doi.org\/10.1002\/jcsm.12867","DOI":"10.1002\/jcsm.12867"},{"key":"37","doi-asserted-by":"publisher","unstructured":"Zhang, B., Su, L., Chen, Z., Wu, M., Wei, J.&Lin, Y. (2024) Exosomes derived from Baicalin-pretreated bone mesenchymal stem cells improve Th17\/Treg imbalance after hepatic ischemia-reperfusion via FGF21 and the JAK2\/STAT3 pathway. IUBMB Life<\/i>, 76, 534-547. https:\/\/doi.org\/10.1002\/iub.2810","DOI":"10.1002\/iub.2810"},{"key":"38","doi-asserted-by":"publisher","unstructured":"Zhang, M., Wu, W., Huang, C., Cai, T., Zhao, N., Liu, S.&Yang, S. (2022) Shuxie-1 Decoction Alleviated CUMS -Induced Liver Injury via IL-6\/JAK2\/STAT3 Signaling. Front. Pharmacol.<\/i>, 13, 848355. https:\/\/doi.org\/10.3389\/fphar.2022.848355","DOI":"10.3389\/fphar.2022.848355"},{"key":"39","doi-asserted-by":"publisher","unstructured":"Zhang, W., Xu, M., Chen, F., Su, Y., Yu, M., Xing, L., Chang, Y.&Yan, T. (2023) Targeting the JAK2-STAT3 pathway to inhibit cGAS-STING activation improves neuronal senescence after ischemic stroke. Exp. Neurol.<\/i>, 368, 114474. https:\/\/doi.org\/10.1016\/j.expneurol.2023.114474","DOI":"10.1016\/j.expneurol.2023.114474"},{"key":"40","doi-asserted-by":"publisher","unstructured":"Zheng, Q., Xing, J., Li, X., Tang, X.&Zhang, D. (2024) PRDM16 suppresses ferroptosis to protect against sepsis-associated acute kidney injury by targeting the NRF2\/GPX4 axis. Redox Biol.<\/i>, 78, 103417. https:\/\/doi.org\/10.1016\/j.redox.2024.103417","DOI":"10.1016\/j.redox.2024.103417"},{"key":"41","doi-asserted-by":"publisher","unstructured":"Zhu, Z., Lian, X., Su, X., Wu, W., Zeng, Y.&Chen, X. (2022) Exosomes derived from adipose-derived stem cells alleviate cigarette smoke-induced lung inflammation and injury by inhibiting alveolar macrophages pyroptosis. Respir. Res.<\/i>, 23, 5. https:\/\/doi.org\/10.1186\/s12931-022-01926-w","DOI":"10.1186\/s12931-022-01926-w"}],"container-title":["The Tohoku Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/tjem\/269\/1\/269_2025.J174\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T03:21:45Z","timestamp":1781320905000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/tjem\/269\/1\/269_2025.J174\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.1620\/tjem.2025.j174","relation":{},"ISSN":["0040-8727","1349-3329"],"issn-type":[{"value":"0040-8727","type":"print"},{"value":"1349-3329","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"2025.J174"}}