{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T16:31:43Z","timestamp":1789576303159,"version":"build-2803163510"},"reference-count":48,"publisher":"Tohoku University Medical Press","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tohoku J. Exp. Med."],"published-print":{"date-parts":[[2011]]},"DOI":"10.1620\/tjem.223.35","type":"journal-article","created":{"date-parts":[[2011,1,7]],"date-time":"2011-01-07T06:17:05Z","timestamp":1294381025000},"page":"35-44","source":"Crossref","is-referenced-by-count":42,"title":["Low Serum Levels of Pepsinogen and Gastrin 17 Are Predictive of Extensive Gastric Atrophy with High-Risk of Early Gastric Cancer"],"prefix":"10.1620","volume":"223","author":[{"given":"Ryousuke","family":"Kikuchi","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Tohoku University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiko","family":"Abe","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Tohoku University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsunori","family":"Iijima","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Tohoku University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Koike","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Tohoku University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyuki","family":"Ara","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Tohoku University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaname","family":"Uno","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Tohoku University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyotaka","family":"Asanuma","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Tohoku University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Asano","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Tohoku University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Imatani","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Tohoku University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tooru","family":"Shimosegawa","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Tohoku University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"622","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"Asaka, M., Kimura, T., Kudo, M., Takeda, H., Mitani, S., Miyazaki, T., Miki, K. &amp; Graham, D.Y. (1992) Relationship of Helicobacter pylori to serum pepsinogens in an asymptomatic Japanese population. <i>Gastroenterology<\/i>, <b>102<\/b>, 760-766.","DOI":"10.1016\/0016-5085(92)90156-S"},{"key":"2","doi-asserted-by":"crossref","unstructured":"Borch, K., Axelsson, C.K., Halgreen, H., Damkjaer, N.M.D., Ledin, T. &amp; Szesci, P.B. (1989) The ratio of pepsinogen A to pepsinogen C: a sensitive test for atrophic gastritis. <i>Scand. J. Gastroenterol.<\/i>, <b>24<\/b>, 870-876.","DOI":"10.3109\/00365528909089228"},{"key":"3","doi-asserted-by":"crossref","unstructured":"Broutet, N., Plebani, M., Sakarovitch, C., Sipponen, P. &amp; M&eacute;graud, F.; the Eurohepygast Study Group. (2003) Pepsinogen A, pepsinogen C, and gastrin as markers of atrophic chronic gastritis in European dyspeptics. <i>Br. J. Cancer<\/i>, <b>88<\/b>, 1239-1247.","DOI":"10.1038\/sj.bjc.6600877"},{"key":"4","doi-asserted-by":"crossref","unstructured":"Cao, Q., Ran, Z.H. &amp; Xiao, S.D. (2007) Screening of atrophic gastritis and gastric cancer by serum pepsinogen, gastrin-17 and Helicobacter pylori immunoglobulin G antibodies. <i>J. Dig. Dis<\/i>., <b>8<\/b>, 15-22.","DOI":"10.1111\/j.1443-9573.2007.00271.x"},{"key":"5","doi-asserted-by":"crossref","unstructured":"Cassaro, M., Rugge, M., Gutierrez, O., Leandro, G., Graham, D.Y. &amp; Genta, R.M. (2000) Topographic patterns of intestinal metaplasia and gastric cancer. <i>Am. J. Gastroenterol<\/i>., <b>95<\/b>, 1431-1438.","DOI":"10.1111\/j.1572-0241.2000.02074.x"},{"issue":"24","key":"6","first-page":"6735","volume":"52","year":"1992","ISSN":"https:\/\/id.crossref.org\/issn\/0008-5472","issn-type":"print"},{"issue":"15","key":"7","first-page":"4737","volume":"50","year":"1990","ISSN":"https:\/\/id.crossref.org\/issn\/0008-5472","issn-type":"print"},{"key":"8","doi-asserted-by":"crossref","unstructured":"Derakhshan, M.H., El-Omar, E., Oien, K., Gillen, D., Fyfe, V., Crabtree, J.E. &amp; McColl, K.E. (2006) Gastric histology, serological markers and age as predictors of gastric acid secretion in patients infected with Helicobacter pylori. <i>J. Clin. Pathol<\/i>., <b>59<\/b>, 1293-1299.","DOI":"10.1136\/jcp.2005.036111"},{"key":"9","doi-asserted-by":"crossref","unstructured":"di Mario, F. &amp; Cavallaro, L.G. (2008) Non-invasive tests in gastric disease. <i>Dig. Liver Dis<\/i>., <b>40<\/b>, 523-530.","DOI":"10.1016\/j.dld.2008.02.028"},{"key":"10","doi-asserted-by":"crossref","unstructured":"Dinis-Ribeiro, M., Yamaki, G., Miki, K., Costa-Pereira, A., Matsukawa, M. &amp; Kurihara, M. (2004) Meta-analysis on the validity of pepsinogen test for gastric carcinoma, dysplasia or chronic atrophic gastritis screening. <i>J. Med. Screen<\/i>., <b>11<\/b>, 141-147.","DOI":"10.1258\/0969141041732184"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199610000-00001"},{"key":"12","doi-asserted-by":"crossref","unstructured":"Faraji, E.I. &amp; Frank, B.B. (2002) Multifocal atrophic gastritis and gastric carcinoma. <i>Gastroenterol. Clin. North. Am<\/i>., <b>31<\/b>, 499-516.","DOI":"10.1016\/S0889-8553(02)00008-0"},{"key":"13","doi-asserted-by":"crossref","unstructured":"Fujisawa, T., Kumagai, T., Akamatsu, T., Kiyosawa, K. &amp; Matsunaga, Y. (1999) Changes in seroepidemiological pattern of <i>Helicobacter pylori<\/i> and hepatitis A virus over the last 20 years in Japan. <i>Am. J. Gastroenrerol<\/i>., <b>94<\/b>, 2094-2099.","DOI":"10.1111\/j.1572-0241.1999.01283.x"},{"key":"14","doi-asserted-by":"crossref","unstructured":"German&aacute;, B., Mario, F., Cavallaro, L.G., Moussa, A.M., Lecis, P., Liatoupolou, S., Comparato, G., Carloni, C., Bertiato, G., Battiestel, M., Papa, N., Aragona, G., Cavestro, G.M., Iori, V., Merli, R., Bertolini, S., Caruana, P. &amp; Franz&eacute;, A. (2005) Clinical usefulness of serum pepsinogens I and II, gastrin-17 and anti-Helicobacter pylori antibodies in the management of dyspeptic patients in primary care. <i>Dig. Liver Dis<\/i>., <b>37<\/b>, 501-508.","DOI":"10.1016\/j.dld.2005.01.016"},{"key":"15","doi-asserted-by":"crossref","unstructured":"Iijima, K., Abe, Y., Kikuchi, R., Koike, T., Ohara, S., Sipponen, P. &amp; Shimosegawa, T. (2009) Serum biomarker tests are useful in delineating between patients with gastric atrophy and normal, healthy stomach. <i>World J. Gastroenterol<\/i>., <b>15<\/b>, 853-859.","DOI":"10.3748\/wjg.15.853"},{"key":"16","doi-asserted-by":"crossref","unstructured":"Kimura, K. &amp; Takemoto, T. (1969) An endoscopic recognition of the atrophic border and its significance in chronic gastritis. <i>Endoscopy<\/i>, <b>3<\/b>, 87-97.","DOI":"10.1055\/s-0028-1098086"},{"key":"17","doi-asserted-by":"crossref","unstructured":"Kimura, K. (1972) Chronological transition of the fundic-pyloric border determined by stepwise biopsy of the lesser and greater curvatures of the stomach. <i>Gastroenterology<\/i>, <b>63<\/b>, 584-592.","DOI":"10.1016\/S0016-5085(19)33241-X"},{"key":"18","doi-asserted-by":"crossref","unstructured":"Kinoshita, Y., Kawanami, C., Kishi, K., Nakata, H., Seino, Y. &amp; Chiba, T. (1997) Helicobacter pylori independent chronological change in gastric acid secretion in the Japanese. <i>Gut<\/i>, <b>41<\/b>, 452-458.","DOI":"10.1136\/gut.41.4.452"},{"key":"19","doi-asserted-by":"crossref","unstructured":"Kitahara, F., Kobayashi, K., Sato, T., Kojima, Y., Araki, T. &amp; Fujino, M.A. (1999) Accuracy of screening for gastric cancer using serum pepsinogen concentrations. <i>Gut<\/i>, <b>44<\/b>, 693-697.","DOI":"10.1136\/gut.44.5.693"},{"issue":"2","key":"20","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/BF02774209","volume":"22","author":"MIKI K","year":"1987","ISSN":"https:\/\/id.crossref.org\/issn\/0435-1339","issn-type":"print"},{"key":"21","doi-asserted-by":"crossref","unstructured":"Miki, K., Morita, M., Sasajima, M., Hoshina, R., Kanda, E. &amp; Urita, Y. (2003) Usefulness of gastric cancer screening using the serum pepsinogen test method. <i>Am. J. Gastroenterol.<\/i>, <b>98<\/b>, 735-739.","DOI":"10.1111\/j.1572-0241.2003.07410.x"},{"key":"22","doi-asserted-by":"crossref","unstructured":"Oishi, Y., Kiyohara, Y., Kubo, M., Tanaka, K., Tanizaki, Y., Ninomiya, T., Doi, Y., Shikata, K., Yonemoto, K., Shirota, T., Matsumoto, T. &amp; Iida, M. (2006) The serum pepsinogen test as a predictor of gastric cancer: the Hisayama study. <i>Am. J. Epidemiol<\/i>., <b>163<\/b>, 629-637.","DOI":"10.1093\/aje\/kwj088"},{"key":"23","doi-asserted-by":"crossref","unstructured":"Palli, D., Masala, G., Del Giudice, G., Plebani, M., Basso, D., Berti, D., Numans, M.E., Ceroti, M., Peeters, P.H., Bueno, H.B., Buchner, F.L., Clavel, C.F., Boutron-Ruault, M.C., Krogh, V., Saieva, C., Vineis, P., Panico, S., Tumino, R., Nyr&eacute;n, O., Sim&aacute;n, H., Berglund, G., Hallmans, G., Sanchez, M.J., Larr&atilde;naga, N., Barricarte, A., Navarro, C., Quiros, J.R., Key, T., Allen, N., Bingham, S., Khaw, K.T., Boeing, H., Weikert, C., Linseisen, J., Nagel, G., Overvad, K., Thomsen, R.W., Tjonneland, A., Olsen, A., Trichoupoulou, A., Trichopoulos, D., Arvaniti, A., Pera, G., Kaaks, R., Jenab, M., Ferrari, P., Nesi, G., Carneiro, F., Riboli, E. &amp; Gonzalez, C.A. (2007) CagA+ Helicobacter pylori infection and gastric cancer risk in the EPIC-EURGAST study. <i>Int. J. Cancer<\/i>, <b>120<\/b>, 859-867.","DOI":"10.1002\/ijc.22435"},{"key":"24","doi-asserted-by":"crossref","unstructured":"Rollan, A., Ferreccio, C., Gederlini, A., Serrano, C., Torres, J. &amp; Harris, P. (2006) Non-invasive diagnosis of gastric mucosal atrophy in an asymptomatic population with high prevalence of gastric cancer. <i>World J. Gastroenterol<\/i>., <b>12<\/b>, 7172-7178.","DOI":"10.3748\/wjg.v12.i44.7172"},{"key":"25","doi-asserted-by":"crossref","unstructured":"Rugge, M., Meggio, A., Pennelli, G., Piscioli, F., Giacomelli, L., De Pretis, G. &amp; Graham, D.Y. (2007) Gastritis staging in clinical practice: the OLGA staging system. <i>Gut<\/i>, <b>56<\/b>, 631-636.","DOI":"10.1136\/gut.2006.106666"},{"key":"26","doi-asserted-by":"crossref","unstructured":"Ruiz, B., Garay, J., Johnosn, W., Li, D., Rugge, M., Dixon, M.F., Fiocca, R., Genta, R.M., Hattori, T., Lechago, J., Price, A.B., Sipponen, P., Solcia, E., Watanabe, H. &amp; Correa, P. (2001) Morphometric assessment of gastric antral atrophy: comparison with visual evaluation. <i>Histopathology<\/i>, <b>39<\/b>, 235-242.","DOI":"10.1046\/j.1365-2559.2001.01221.x"},{"key":"27","doi-asserted-by":"crossref","unstructured":"Samloff, I.M. (1971) Cellular localization of group I pepsinogens in human gastric mucosa by immunofluorescence. <i>Gastroenterology<\/i>, <b>61<\/b>, 185-188.","DOI":"10.1016\/S0016-5085(19)33596-6"},{"key":"28","doi-asserted-by":"crossref","unstructured":"Samloff, I.M. &amp; Liebman, W.M. (1973) Cellular localization of the group II pepsinogens in human stomach and duodenum by immunofluorescence. <i>Gastroenterology<\/i>, <b>65<\/b>, 36-42.","DOI":"10.1016\/S0016-5085(19)33138-5"},{"key":"29","doi-asserted-by":"crossref","unstructured":"Satoh, K., Kimura, K., Taniguchi, Y., Kihira, K., Takimoto, T., Saifuku, K., Kawata, H., Tokumaru, K., Kojima, T., Seki, M., Ido, K. &amp; Fujioka, T. (1998) Biopsy sites suitable for the diagnosis of Helicobacter pylori infection and the assessment of the extent of atrophic gastritis. <i>Am. J. Gastroenterol<\/i>., <b>93<\/b>, 569-573.","DOI":"10.1111\/j.1572-0241.1998.166_b.x"},{"key":"30","doi-asserted-by":"crossref","unstructured":"Shiotani, A., Iishi, H., Uedo, N., Kumamoto, M., Nakae, Y., Ishiguro, S., Tatsuta, M. &amp; Graham, D.Y. (2005) Histologic and serum risk markers for noncardia early gastric cancer. <i>Int. J. Cancer<\/i>, <b>115<\/b>, 463-469.","DOI":"10.1002\/ijc.20852"},{"key":"31","unstructured":"Sipponen, P., H&auml;rk&ouml;nen, M., Alanko, A. &amp; Suovaniemi, O. (2002a) Diagnosis of atrophic gastritis from a serum sample. <i>Clin. Lab<\/i>., <b>48<\/b>, 505-515."},{"key":"32","doi-asserted-by":"crossref","unstructured":"Sipponen, P., Ranta, P., Helske, T., K&auml;&auml;ri&auml;inen, I., M&auml;ki, T., Linnala, A., Suovaniemi, O., Alanko, A. & H&auml;rk&ouml;nen, M. (2002b) Serum levels of amidated gastrin-17 and pepsinogen I in atrophic gastritis: an observational case control study. <i>Scand. J. Gastroenterol<\/i>., <b>37<\/b>, 785-791.","DOI":"10.1080\/713786525"},{"key":"33","doi-asserted-by":"crossref","unstructured":"Sipponen, P. &amp; Stolte, M. (1997) Clinical impact of routine biopsies of the gastric antrum and body. <i>Endoscopy<\/i>, <b>29<\/b>, 671-678.","DOI":"10.1055\/s-2007-1004278"},{"key":"34","doi-asserted-by":"crossref","unstructured":"Sipponen, P., Valle, J., Varis, K., Kekki, M., Iham&auml;ki, T. &amp; Siurala, M. (1990) Fasting levels of serum gastrin in different functional and morphologic states of the antrofundal mucosa. An analysis of 860 subjects. <i>Scand. J. Gastroenterol<\/i>., <b>25<\/b>, 513-519.","DOI":"10.3109\/00365529009095523"},{"key":"35","doi-asserted-by":"crossref","unstructured":"Sipponen, P., Vauhkonen, M., Helske, T., Kaariainen, I. &amp; Harkonen, M. (2005) Low circulating levels of gastrin-17 in patients with Barrett's esophagus. <i>World J. Gastroenterol<\/i>., <b>11<\/b>, 5988-5992.","DOI":"10.3748\/wjg.v11.i38.5988"},{"key":"36","doi-asserted-by":"crossref","unstructured":"Siurala, M., Varis, K. &amp; Wiljasalo, M. (1966) Studies of patients with atrophic gastritis: a 10-15-year follow-up. <i>Scand. J. Gastroenterol<\/i>., <b>1<\/b>, 40-48.","DOI":"10.1080\/00365521.1966.11800612"},{"key":"37","unstructured":"Staibano, S., Rocco, A., Mezza, E., De Rosa, G., Budillon, G. &amp; Nardone, G. (2002) Diagnosis of chronic atrophic gastritis by morphometric image analysis. A new method to overcome the confounding effect of the inflammatory infiltrate. <i>J. Pathol<\/i>., <b>198<\/b>, 47-54."},{"key":"38","doi-asserted-by":"crossref","unstructured":"Stengel, D., Bauwens, K., Sehouli, J., Ekkernkamp, A. &amp; Porzsolt, F. (2003) A likelihood ratio approach to meta-analysis of diagnostic studies. <i>J. Med. Screen<\/i>., <b>10<\/b>, 47-51.","DOI":"10.1258\/096914103321610806"},{"key":"39","doi-asserted-by":"crossref","unstructured":"Stockbrugger, R., Larsson, L.I., Lundqvist, G. &amp; Angervall, L. (1977) Antral gastrin cells and serum gastrin in achlorhydria. <i>Scand. J. Gastroenterol<\/i>., <b>12<\/b>, 209-213.","DOI":"10.1080\/00365521.1977.12031136"},{"key":"40","doi-asserted-by":"crossref","unstructured":"Storskrubb, T., Aro, P., Ronkainen, J., Sipponen, P., Nyhlin, H., Talley, N.J., Engstrand, L., Stolte, M., Vieth, M., Walker, M. &amp; Agreus, L. (2008) Serum biomarkers provide an accurate method for diagnosis of atrophic gastritis in a general population: the Kalixanda study. <i>Scand. J. Gastroenterol<\/i>., <b>43<\/b>, 1448-1455.","DOI":"10.1080\/00365520802273025"},{"key":"41","doi-asserted-by":"crossref","unstructured":"Sugiu, K., Kamada, T., Ito, M., Kaya, S., Tanaka, A., Kusunoki, H., Hata, J. &amp; Haruma, K. (2006) Anti-parietal cell antibody and serum pepsinogen assessment in screening for gastric carcinoma. <i>Dig. Liver Dis<\/i>., <b>38<\/b>, 303-307.","DOI":"10.1016\/j.dld.2005.10.021"},{"key":"42","unstructured":"Svendsen, J.H., Dahl, C., Sevendsen, L.B. &amp; Christiansen, P.M. (1986) Gastric cancer risk in achlorhydric patients. A long-term follow-up study. <i>Scand. J. Gastroenterol<\/i>., <b>21<\/b>, 16-20."},{"key":"43","doi-asserted-by":"crossref","unstructured":"Taguchi, A., Ohmiya, N., Itoh, A., Hirooka, Y., Niwa, Y., Mori, N. &amp; Goto, H. (2006) Severity of atrophic gastritis related to antiparietal cell antibody and gastric carcinogenesis, including p53 mutations. <i>J. Gastroenterol. Hepatol<\/i>., <b>21<\/b>, 545-551.","DOI":"10.1111\/j.1440-1746.2005.03983.x"},{"key":"44","doi-asserted-by":"crossref","unstructured":"Uemura, N., Okamoto, S., Yamamoto, S., Matsumura, N., Yamaguchi, S., Yamakido, M., Taniyama, K., Sasaki, N. &amp; Schlemper, R.J. (2001) Helicobacter pylori infection and the development of gastric cancer. <i>N. Engl. J. Med<\/i>., <b>345<\/b>, 784-789.","DOI":"10.1056\/NEJMoa001999"},{"key":"45","unstructured":"Varis, K., Sipponen, P., Lax&eacute;n, F., Samloff, I.M., Huttunen, J.K., Taylor, P.R., Heinonen, O.P., Albanes, D., Sande, N., Virtamo, J. &amp; H&auml;rk&ouml;nen, M. (2000) Implications of serum pepsinogen I in early endoscopic diagnosis of gastric cancer and dysplasia. Helsinki Gastritis Study Group. <i>Scand. J. Gastroenterol<\/i>., <b>35<\/b>, 950-956."},{"key":"46","unstructured":"V&auml;&auml;n&auml;nen, H., Vauhkonen, M., Helske, T., K&auml;&auml;ri&auml;inen, I., Rasmussen, M., Tunturi, H.H., Koskenpato, J., Sotka, M., Turunen, M., Sandstr&ouml;m, R., Ristikankare, M., Jussila, A. &amp; Sipponen, P. (2003) Non-endoscopic diagnosis of atrophic gastritis with a blood test. Correlation between gastric histology and serum levels of gastrin-17 and pepsinogen I: a multicentre study. <i>Eur. J. Gastroenterol. Hepatol<\/i>., <b>15<\/b>, 885-891."},{"key":"47","doi-asserted-by":"crossref","unstructured":"Watabe, H., Mitsushima, T., Yamaji, Y., Okamoto, M., Wada, R., Kokubo, T., Doi, H., Yoshida, H., Kawabe, T. &amp; Omata, M. (2005) Predicting the development of gastric cancer from combining Helicobacter pylori antibodies and serum pepsinogen status: a prospective endoscopic cohort study. <i>Gut<\/i>, <b>54<\/b>, 764 -768.","DOI":"10.1136\/gut.2004.055400"},{"key":"48","doi-asserted-by":"crossref","unstructured":"Yanaoka, K., Oka, M., Mukoubayashi, C., Yoshimura, N., Enomoto, S., Iguchi, M., Magari, H., Utsunomiya, H., Tamai, H., Arii, K., Ohata, H., Fujishiro, M., Takeshita, T., Mohara, O. &amp; Ichinose, M. (2008) Cancer high-risk subjects identified by serum pepsinogen tests: outcomes after 10-year follow-up in asymptomatic middle-aged males. <i>Cancer Epidemiol. Biomarkers Prev<\/i>., <b>17<\/b>, 838-845.","DOI":"10.1158\/1055-9965.EPI-07-2762"}],"container-title":["The Tohoku Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.jstage.jst.go.jp\/article\/tjem\/223\/1\/223_1_35\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T19:40:20Z","timestamp":1619638820000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jstage.jst.go.jp\/article\/tjem\/223\/1\/223_1_35\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.1620\/tjem.223.35","relation":{},"ISSN":["0040-8727","1349-3329"],"issn-type":[{"value":"0040-8727","type":"print"},{"value":"1349-3329","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}