{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T03:40:21Z","timestamp":1767066021678},"reference-count":48,"publisher":"Tohoku University Medical Press","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tohoku J. Exp. Med."],"published-print":{"date-parts":[[2011]]},"DOI":"10.1620\/tjem.225.161","type":"journal-article","created":{"date-parts":[[2011,10,5]],"date-time":"2011-10-05T06:24:52Z","timestamp":1317795892000},"page":"161-169","source":"Crossref","is-referenced-by-count":19,"title":["Superantigenic Toxin Genes Coexist with Specific Staphylococcal Cassette Chromosome mec Genes in Methicillin-Resistant Staphylococcus aureus"],"prefix":"10.1620","volume":"225","author":[{"given":"Dong-Liang","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward K","family":"Maina","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuhiko","family":"Omoe","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, Faculty of Agriculture, Iwate University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumio","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Hirosaki University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minoru","family":"Yasujima","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Hirosaki University Hospital"},{"name":"Department of Laboratory Medicine, Hirosaki University Graduate School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akio","family":"Nakane","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"622","reference":[{"issue":"4","key":"1","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1128\/AAC.40.4.924","volume":"40","year":"1996","ISSN":"http:\/\/id.crossref.org\/issn\/0066-4804","issn-type":"print"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08713-5"},{"issue":"2","key":"3","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1128\/jb.165.2.373-378.1986","volume":"165","year":"1986","ISSN":"http:\/\/id.crossref.org\/issn\/0021-9193","issn-type":"print"},{"key":"4","doi-asserted-by":"crossref","unstructured":"Becker, K., Friedrich, A.W., Lubritz, G., Weilert, M., Peters, G. & Von Eiff, C. (2003) Prevalence of genes encoding pyrogenic toxin superantigens and exfoliative toxins among strains of Staphylococcus aureus<\/i> isolated from blood and nasal specimens. J. Clin. Microbiol<\/i>., 41<\/b>, 1434-1439.","DOI":"10.1128\/JCM.41.4.1434-1439.2003"},{"key":"5","doi-asserted-by":"crossref","unstructured":"Berglund, C. & Soderquist, B. (2008) The origin of a methicillin-resistant Staphylococcus aureus<\/i> isolate at a neonatal ward in Sweden-possible horizontal transfer of a staphylococcal cassette chromosome mec between methicillin-resistant Staphylococcus haemolyticus<\/i> and Staphylococcus aureus<\/i>. Clin. Microbiol. Infect<\/i>., 14<\/b>, 1048-1056.","DOI":"10.1111\/j.1469-0691.2008.02090.x"},{"key":"6","doi-asserted-by":"crossref","unstructured":"Bonventre, P.F., Thompson, M.R., Adinolfi, L.E., Gillis, Z.A. & Parsonnet, J. (1988) Neutralization of toxic shock syndrome toxin-1 by monoclonal antibodies in vitro and in vivo. Infect. Immun<\/i>., 56<\/b>, 135-141.","DOI":"10.1128\/IAI.56.1.135-141.1988"},{"key":"7","doi-asserted-by":"crossref","unstructured":"Boye, K., Bartels, M.D., Andersen, I.S., Moller, J.A. & Westh, H. (2007) A new multiplex PCR for easy screening of methicillin-resistant Staphylococcus aureus<\/i> SCCmec types I-V. Clin. Microbiol. Infect<\/i>., 13<\/b>, 725-727.","DOI":"10.1111\/j.1469-0691.2007.01720.x"},{"key":"8","doi-asserted-by":"crossref","unstructured":"Chen, C.J., Hsueh, P.R., Su, L.H., Chiu, C.H., Lin, T.Y. & Huang, Y.C. (2009) Change in the molecular epidemiology of methicillin-resistant Staphylococcus aureus<\/i> bloodstream infections in Taiwan. Diagn. Microbiol. Infect. Dis<\/i>., 65<\/b>, 199-201.","DOI":"10.1016\/j.diagmicrobio.2009.05.020"},{"key":"9","doi-asserted-by":"crossref","unstructured":"Chini, V., Dimitracopoulos, G. & Spiliopoulou, I. (2006) Occurrence of the enterotoxin gene cluster and the toxic shock syndrome toxin 1 gene among clinical isolates of methicillin-resistant Staphylococcus aureus<\/i> is related to clonal type and agr<\/i> group. J. Clin. Microbiol<\/i>., 44<\/b>, 1881-1883.","DOI":"10.1128\/JCM.44.5.1881-1883.2006"},{"key":"10","doi-asserted-by":"crossref","unstructured":"Daum, R.S., Ito, T., Hiramatsu, K., Hussain, F., Mongkolrattanothai, K., Jamklang, M. & Boyle-Vavra, S. (2002) A novel methicillin-resistance cassette in community-acquired methicillin-resistant Staphylococcus aureus<\/i> isolates of diverse genetic backgrounds. J. Infect. Dis<\/i>., 186<\/b>, 1344-1347.","DOI":"10.1086\/344326"},{"key":"11","doi-asserted-by":"crossref","unstructured":"Deurenberg, R.H. & Stobberingh, E.E. (2008) The evolution of Staphylococcus aureus<\/i>. Infect. Genet. Evol<\/i>., 8<\/b>, 747-763.","DOI":"10.1016\/j.meegid.2008.07.007"},{"key":"12","doi-asserted-by":"crossref","unstructured":"Deurenberg, R.H., Vink, C., Kalenic, S., Friedrich, A.W., Bruggeman, C.A. & Stobberingh, E.E. (2007) The molecular evolution of methicillin-resistant Staphylococcus aureus<\/i>. Clin. Microbiol. Infect<\/i>., 13<\/b>, 222-235.","DOI":"10.1111\/j.1469-0691.2006.01573.x"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1159\/000067822"},{"key":"14","doi-asserted-by":"crossref","unstructured":"Ferry, T., Thomas, D., Bouchut, J.C., Lina, G., Vasselon-Raina, M., Dauwalder, O., Gillet, Y., Vandenesch, F., Floret, D. & Etienne, J. (2008) Early diagnosis of staphylococcal toxic shock syndrome by detection of the TSST-1 Vβ signature in peripheral blood of a 12-year-old boy. Pediatr. Infect. Dis. J<\/i>., 27<\/b>, 274-277.","DOI":"10.1097\/INF.0b013e31815c93a3"},{"key":"15","doi-asserted-by":"crossref","unstructured":"Hallin, M., Denis, O., Deplano, A., De Mendonca, R., De Ryck, R., Rottiers, S. & Struelens, M.J. (2007) Genetic relatedness between methicillin-susceptible and methicillin-resistant Staphylococcus aureus<\/i>: results of a national survey. J. Antimicrob. Chemother<\/i>., 59<\/b>, 465-472.","DOI":"10.1093\/jac\/dkl535"},{"key":"16","unstructured":"Holtfreter, S. & Broker, B.M. (2005) Staphylococcal superantigens: do they play a role in sepsis? Arch. Immunol. Ther. Exp<\/i>., 53<\/b>, 13-27."},{"key":"17","doi-asserted-by":"crossref","unstructured":"Hu, D.L., Omoe, K., Inoue, F., Kasai, T., Yasujima, M., Shinagawa, K. & Nakane, A. (2008) Comparative prevalence of superantigenic toxin genes in meticillin-resistant and meticillin-susceptible Staphylococcus aureus<\/i> isolates. J. Med. Microbiol<\/i>., 57<\/b>, 1106-1112.","DOI":"10.1099\/jmm.0.2008\/002790-0"},{"key":"18","doi-asserted-by":"crossref","unstructured":"Hu, D.L., Omoe, K., Shimoda, Y., Nakane, A. & Shinagawa, K. (2003) Induction of emetic response to staphylococcal enterotoxins in the house musk shrew (Suncus murinus<\/i>). Infect. Immun<\/i>., 71<\/b>, 567-570.","DOI":"10.1128\/IAI.71.1.567-570.2003"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.5.1323-1336.2001"},{"key":"20","doi-asserted-by":"crossref","unstructured":"Ito, T., Ma, X.X., Takeuchi, F., Okuma, K., Yuzawa, H. & Hiramatsu, K. (2004) Novel type V staphylococcal cassette chromosome mec driven by a novel cassette chromosome recombinase, ccrC. Antimicrob. Agents Chemother<\/i>., 48<\/b>, 2637-2651.","DOI":"10.1128\/AAC.48.7.2637-2651.2004"},{"key":"21","doi-asserted-by":"crossref","unstructured":"Jarraud, S., Mougel, C., Thioulouse, J., Lina, G., Meugnier, H., Forey, F., Nesme, X., Etienne, J. & Vandenesch, F. (2002) Relationships between Staphylococcus aureus<\/i> genetic background, virulence factors, agr groups (alleles), and human disease. Infect. Immun<\/i>., 70<\/b>, 631-641.","DOI":"10.1128\/IAI.70.2.631-641.2002"},{"key":"22","doi-asserted-by":"crossref","unstructured":"Kansal, R., Davis, C., Hansmann, M., Seymour, J., Parsonnet, J., Modern, P., Gilbert, S. & Kotb, M. (2007) Structural and functional properties of antibodies to the superantigen TSST-1 and their relationship to menstrual toxic shock syndrome. J. Clin. Immunol<\/i>., 27<\/b>, 327-338.","DOI":"10.1007\/s10875-007-9072-4"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.6.1549-1555.2000"},{"key":"24","doi-asserted-by":"crossref","unstructured":"Klein, E., Smith, D.L. & Laxminarayan, R. (2007) Hospitalizations and deaths caused by methicillin-resistant Staphylococcus aureus<\/i>, United States, 1999-2005. Emerg. infect. Dis<\/i>., 13<\/b>, 1840-1846.","DOI":"10.3201\/eid1312.070629"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1086\/428573"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04403-2"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.5.2278-2281.2002"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.69.1.18-23.2003"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1128\/JB.188.2.669-676.2006"},{"key":"30","doi-asserted-by":"crossref","unstructured":"Llewelyn, M. & Cohen, J. (2002) Superantigens: microbial agents that corrupt immunity. Lancet Infect. Dis<\/i>., 2<\/b>, 156-162.","DOI":"10.1016\/S1473-3099(02)00222-0"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199808203390806"},{"key":"32","doi-asserted-by":"crossref","unstructured":"Ma, X.X., Ito, T., Tiensasitorn, C., Jamklang, M., Chongtrakool, P., Boyle-Vavra, S., Daum, R.S. & Hiramatsu, K. (2002) Novel type of staphylococcal cassette chromosome mec identified in community-acquired methicillin-resistant Staphylococcus aureus<\/i> strains. Antimicrob. Agents Chemother<\/i>., 46<\/b>, 1147-1152.","DOI":"10.1128\/AAC.46.4.1147-1152.2002"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.55.1.77"},{"key":"34","doi-asserted-by":"crossref","unstructured":"Melles, D.C., Gorkink, R.F., Boelens, H.A., Snijders, S.V., Peeters, J.K., Moorhouse, M.J., van der Spek, P.J., van Leeuwen, W.B., Simons, G., Verbrugh, H.A. & van Belkum, A. (2004) Natural population dynamics and expansion of pathogenic clones of Staphylococcus aureus<\/i>. J. Clin. Invest<\/i>., 114<\/b>, 1732-1740.","DOI":"10.1172\/JCI200423083"},{"key":"35","doi-asserted-by":"crossref","unstructured":"Milheirico, C., Oliveira, D.C. & de Lencastre, H. (2007) Update to the multiplex PCR strategy for assignment of mec element types in Staphylococcus aureus<\/i>. Antimicrob. Agents Chemother<\/i>., 51<\/b>, 3374-3377.","DOI":"10.1128\/AAC.00275-07"},{"key":"36","doi-asserted-by":"crossref","unstructured":"Murakami, K., Minamide, W., Wada, K., Nakamura, E., Teraoka, H. & Watanabe, S. (1991) Identification of methicillin-resistant strains of staphylococci by polymerase chain reaction. J. Clin. Microbiol<\/i>., 29<\/b>, 2240-2244.","DOI":"10.1128\/JCM.29.10.2240-2244.1991"},{"key":"37","doi-asserted-by":"crossref","unstructured":"Novotna, G., Adamkova, V., Janata, J., Melter, O. & Spizek, J. (2005) Prevalence of resistance mechanisms against macrolides and lincosamides in methicillin-resistant coagulase-negative staphylococci in the Czech Republic and occurrence of an undefined mechanism of resistance to lincosamides. Antimicrob. Agents Chemother<\/i>., 49<\/b>, 3586-3589.","DOI":"10.1128\/AAC.49.8.3586-3589.2005"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.11.4289-4294.2002"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.7.2155-2161.2002"},{"key":"40","doi-asserted-by":"crossref","unstructured":"Oliveira, D.C., Milheirico, C., Vinga, S. & de Lencastre, H. (2006) Assessment of allelic variation in the ccrAB locus in methicillin-resistant Staphylococcus aureus<\/i> clones. J. Antimicrob. Chemother<\/i>., 58<\/b>, 23-30.","DOI":"10.1093\/jac\/dkl208"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1016\/j.femsle.2005.04.007"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00045-08"},{"key":"43","doi-asserted-by":"crossref","unstructured":"Robinson, D.A. & Enright, M.C. (2003) Evolutionary models of the emergence of methicillin-resistant Staphylococcus aureus<\/i>. Antimicrob. Agents Chemother<\/i>., 47<\/b>, 3926-3934.","DOI":"10.1128\/AAC.47.12.3926-3934.2003"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00132-06"},{"key":"45","doi-asserted-by":"crossref","unstructured":"Wu, S., Piscitelli, C., de Lencastre, H. & Tomasz, A. (1996) Tracking the evolutionary origin of the methicillin resistance gene: cloning and sequencing of a homologue of mecA<\/i> from a methicillin susceptible strain of Staphylococcus sciuri<\/i>. Microb. Drug Resist<\/i>., 2<\/b>, 435-441.","DOI":"10.1089\/mdr.1996.2.435"},{"issue":"2","key":"46","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1348-0421.2007.tb03898.x","volume":"51","author":"ZARAKET HASSAN","year":"2007","ISSN":"http:\/\/id.crossref.org\/issn\/0385-5600","issn-type":"print"},{"key":"47","doi-asserted-by":"crossref","unstructured":"Zhang, K., McClure, J.A., Elsayed, S. & Conly, J.M. (2009) Novel staphylococcal cassette chromosome mec type, tentatively designated type VIII, harboring class A mec<\/i> and type 4 ccr<\/i> gene complexes in a Canadian epidemic strain of methicillin-resistant Staphylococcus aureus<\/i>. Antimicrob. Agents Chemother<\/i>., 53<\/b>, 531-540.","DOI":"10.1128\/AAC.01118-08"},{"key":"48","doi-asserted-by":"crossref","unstructured":"Zhang, K., McClure, J.A., Elsayed, S., Louie, T. & Conly, J.M. (2005) Novel multiplex PCR assay for characterization and concomitant subtyping of staphylococcal cassette chromosome mec types I to V in methicillin-resistant Staphylococcus aureus<\/i>. J. Clin. Microbiol<\/i>., 43<\/b>, 5026-5033.","DOI":"10.1128\/JCM.43.10.5026-5033.2005"}],"container-title":["The Tohoku Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.jstage.jst.go.jp\/article\/tjem\/225\/3\/225_3_161\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T19:43:28Z","timestamp":1619639008000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jstage.jst.go.jp\/article\/tjem\/225\/3\/225_3_161\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":48,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.1620\/tjem.225.161","relation":{},"ISSN":["0040-8727","1349-3329"],"issn-type":[{"value":"0040-8727","type":"print"},{"value":"1349-3329","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}