{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T16:56:06Z","timestamp":1751475366761},"reference-count":23,"publisher":"Tohoku University Medical Press","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tohoku J. Exp. Med."],"published-print":{"date-parts":[[2014]]},"DOI":"10.1620\/tjem.233.149","type":"journal-article","created":{"date-parts":[[2014,6,5]],"date-time":"2014-06-05T23:05:41Z","timestamp":1402009541000},"page":"149-153","source":"Crossref","is-referenced-by-count":9,"title":["The A&gt;T Polymorphism of the Tribbles Homolog 1 Gene Is Associated with Serum Triglyceride Concentrations in Japanese Community-Dwelling Women"],"prefix":"10.1620","volume":"233","author":[{"given":"Toshiyuki","family":"Ikeoka","sequence":"first","affiliation":[{"name":"Department of Global Health, Medicine and Welfare, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences"},{"name":"Department of Endocrinology and Metabolism, Unit of Translational Medicine, Nagasaki University Graduate School of Biomedical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomi","family":"Hayashida","sequence":"additional","affiliation":[{"name":"Department of Global Health, Medicine and Welfare, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mio","family":"Nakazato","sequence":"additional","affiliation":[{"name":"Department of Island and Community Medicine, Nagasaki University Graduate School of Biomedical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takaharu","family":"Sekita","sequence":"additional","affiliation":[{"name":"Department of Island and Community Medicine, Nagasaki University Graduate School of Biomedical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumi","family":"Murata-Mori","sequence":"additional","affiliation":[{"name":"Department of Global Health, Medicine and Welfare, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences"},{"name":"Department of Endocrinology and Metabolism, Unit of Translational Medicine, Nagasaki University Graduate School of Biomedical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takao","family":"Ando","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Unit of Translational Medicine, Nagasaki University Graduate School of Biomedical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norio","family":"Abiru","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Unit of Translational Medicine, Nagasaki University Graduate School of Biomedical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironori","family":"Yamasaki","sequence":"additional","affiliation":[{"name":"Center for Health and Community Medicine, Nagasaki University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Kudo","sequence":"additional","affiliation":[{"name":"Department of Isotope Medicine, Atomic Bomb Disease Institute, Nagasaki University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Island and Community Medicine, Nagasaki University Graduate School of Biomedical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Kawakami","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Unit of Translational Medicine, Nagasaki University Graduate School of Biomedical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noboru","family":"Takamura","sequence":"additional","affiliation":[{"name":"Department of Global Health, Medicine and Welfare, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"622","reference":[{"key":"1","unstructured":"Bots, M.L. &amp; Grobbee, D.E. (2002) Intima media thickness as a surrogate marker for generalised atherosclerosis. <i>Cardiovasc. Drugs Ther.<\/i>, 16, 341-351."},{"key":"2","doi-asserted-by":"crossref","unstructured":"Burkhardt, R., Toh, S.A., Lagor, W.R., Birkeland, A., Levin, M., Li, X., Robblee, M., Fedorov, V.D., Yamamoto, M., Satoh, T., Akira, S., Kathiresan, S., Breslow, J.L. &amp; Rader, D.J. (2010) Trib1 is a lipid- and myocardial infarction-associated gene that regulates hepatic lipogenesis and VLDL production in mice. <i>J. Clin. Invest.<\/i>, 120, 4410-4414.","DOI":"10.1172\/JCI44213"},{"key":"3","doi-asserted-by":"crossref","unstructured":"Chiba-Falek, O., Nichols, M., Suchindran, S., Guyton, J., Ginsburg, G.S., Barrett-Connor, E. &amp; McCarthy, J.J. (2010) Impact of gene variants on sex-specific regulation of human Scavenger receptor class B type 1 (SR-BI) expression in liver and association with lipid levels in a population-based study. <i>BMC Med. Genet.<\/i>, 11, 9.","DOI":"10.1186\/1471-2350-11-9"},{"key":"4","unstructured":"Gotto, A.M. Jr. &amp; Brinton, E.A. (2004) Assessing low levels of high-density lipoprotein cholesterol as a risk factor in coronary heart disease: a working group report and update. <i>J. Am. Coll. Cardiol.<\/i>, 43, 717-724."},{"key":"5","doi-asserted-by":"crossref","unstructured":"Grundy, S.M., Cleeman, J.I., Merz, C.N., Brewer, H.B. Jr., Clark, L.T., Hunninghake, D.B., Pasternak, R.C., Smith, S.C. Jr. &amp; Stone, N.J. (2004) Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines. <i>Circulation<\/i>, 110, 227-239.","DOI":"10.1161\/01.CIR.0000133317.49796.0E"},{"key":"6","unstructured":"Hegedus, Z., Czibula, A. &amp; Kiss-Toth, E. (2006) Tribbles: novel regulators of cell function; evolutionary aspects. <i>Cell. Mol. Life Sci.<\/i>, 63, 1632-1641."},{"key":"7","doi-asserted-by":"crossref","unstructured":"Kashiwagi, A., Kasuga, M., Araki, E., Oka, Y., Hanafusa, T., Ito, H., Tominaga, M., Oikawa, S., Noda, M., Kawamura, T., Sanke, T., Namba, M., Hashiramoto, M., Sasahara, T., Nishio, Y., et al. (2012) International clinical harmonization of glycated hemoglobin in Japan: from Japan Diabetes Society to National Glycohemoglobin Standardization Program values. <i>J. Diabetes Investig.<\/i>, 3, 39-40.","DOI":"10.1007\/s13340-012-0069-8"},{"key":"8","unstructured":"Kathiresan, S., Melander, O., Guiducci, C., Surti, A., Burtt, N.P., Rieder, M.J., Cooper, G.M., Roos, C., Voight, B.F., Havulinna, A.S., Wahlstrand, B., Hedner, T., Corella, D., Tai, E.S., Ordovas, J.M., et al. (2008) Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. <i>Nat. Genet.<\/i>, 40, 189-197."},{"key":"9","unstructured":"Kiss-Toth, E., Bagstaff, S.M., Sung, H.Y., Jozsa, V., Dempsey, C., Caunt, J.C., Oxley, K.M., Wyllie, D.H., Polgar, T., Harte, M., O\u2019Neill, L.A., Qwarnstrom, E.E. &amp; Dower, S.K. (2004) Human tribbles, a protein family controlling mitogen-activated protein kinase cascades. <i>J. Biol. Chem.<\/i>, 279, 42703-42708."},{"key":"10","doi-asserted-by":"crossref","unstructured":"Klos, K.L., Boerwinkle, E., Ferrell, R.E., Turner, S.T. &amp; Morrison, A.C. (2008) ESR1 polymorphism is associated with plasma lipid and apolipoprotein levels in Caucasians of the Rochester Family Heart Study. <i>J. Lipid Res.<\/i>, 49, 1701-1706.","DOI":"10.1194\/jlr.M700490-JLR200"},{"key":"11","doi-asserted-by":"crossref","unstructured":"Kraja, A.T., Vaidya, D., Pankow, J.S., Goodarzi, M.O., Assimes, T.L., Kullo, I.J., Sovio, U., Mathias, R.A., Sun, Y.V., Franceschini, N., Absher, D., Li, G., Zhang, Q., Feitosa, M.F., Glazer, N.L., et al. (2011) A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium. <i>Diabetes<\/i>, 60, 1329-1339.","DOI":"10.2337\/db10-1011"},{"key":"12","doi-asserted-by":"crossref","unstructured":"Manninen, V., Tenkanen, L., Koskinen, P., Huttunen, J.K., Manttari, M., Heinonen, O.P. &amp; Frick, M.H. (1992) Joint effects of serum triglyceride and LDL cholesterol and HDL cholesterol concentrations on coronary heart disease risk in the Helsinki Heart Study. Implications for treatment. <i>Circulation<\/i>, 85, 37-45.","DOI":"10.1161\/01.CIR.85.1.37"},{"key":"13","doi-asserted-by":"crossref","unstructured":"Mohlke, K.L., Boehnke, M. &amp; Abecasis, G.R. (2008) Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants. <i>Hum. Mol. Genet.<\/i>, 17, R102-108.","DOI":"10.1093\/hmg\/ddn275"},{"key":"14","doi-asserted-by":"crossref","unstructured":"Murata-Mori, F., Hayashida, N., Ando, T., Ikeoka, T., Nakazato, M., Sekita, H., Abiru, N., Yamasaki, H., Maeda, T., Kawakami, A. &amp; Takamura, N. (2014) Association of the GCKR rs780094 polymorphism with metabolic traits including carotid intima-media thickness in Japanese community-dwelling men, but not in women. <i>Clin. Chem. Lab. Med.<\/i>, 52, 289-295.","DOI":"10.1515\/cclm-2013-0092"},{"key":"15","unstructured":"Nakamura, K., Tomaru, T., Yamamura, S., Miyashita, Y., Shirai, K. &amp; Noike, H. (2008) Cardio-ankle vascular index is a candidate predictor of coronary atherosclerosis. <i>Circ. J.<\/i>, 72, 598-604."},{"key":"16","doi-asserted-by":"crossref","unstructured":"Satoh, T., Kidoya, H., Naito, H., Yamamoto, M., Takemura, N., Nakagawa, K., Yoshioka, Y., Morii, E., Takakura, N., Takeuchi, O. &amp; Akira, S. (2013) Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages. <i>Nature<\/i>, 495, 524-528.","DOI":"10.1038\/nature11930"},{"key":"17","unstructured":"Sung, H.Y., Guan, H., Czibula, A., King, A.R., Eder, K., Heath, E., Suvarna, S.K., Dower, S.K., Wilson, A.G., Francis, S.E., Crossman, D.C. &amp; Kiss-Toth, E. (2007) Human tribbles-1 controls proliferation and chemotaxis of smooth muscle cells via MAPK signaling pathways. <i>J. Biol. Chem.<\/i>, 282, 18379-18387."},{"key":"18","doi-asserted-by":"crossref","unstructured":"Teslovich, T.M., Musunuru, K., Smith, A.V., Edmondson, A.C., Stylianou, I.M., Koseki, M., Pirruccello, J.P., Ripatti, S., Chasman, D.I., Willer, C.J., Johansen, C.T., Fouchier, S.W., Isaacs, A., Peloso, G.M., Barbalic, M., et al. (2010) Biological, clinical and population relevance of 95 loci for blood lipids. <i>Nature<\/i>, 466, 707-713.","DOI":"10.1038\/nature09270"},{"key":"19","unstructured":"The IBC 50K CAD Consortium (2011) Large-scale gene-centric analysis identifies novel variants for coronary artery disease. <i>PLoS Genet.<\/i>, 7, e1002260."},{"key":"20","unstructured":"Varbo, A., Benn, M., Tybj\u00e6rg-Hansen, A., Grande, P. &amp; Nordestgaard, B.G. (2011) TRIB1 and GCKR polymorphisms, lipid levels, and risk of ischemic heart disease in the general population. <i>Arterioscler. Thromb. Vasc. Biol.<\/i>, 31, 451-457."},{"key":"21","unstructured":"Waterworth, D.M., Ricketts, S.L., Song, K., Chen, L., Zhao, J.H., Ripatti, S., Aulchenko, Y.S., Zhang, W., Yuan, X., Lim, N., Luan, J., Ashford, S., Wheeler, E., Young, E.H., Hadley, D., et al. (2010) Genetic variants influencing circulating lipid levels and risk of coronary artery disease. <i>Arterioscler. Thromb. Vasc. Biol.<\/i>, 30, 2264-2276."},{"key":"22","unstructured":"Willer, C.J., Sanna, S., Jackson, A.U., Scuteri, A., Bonnycastle, L.L., Clarke, R., Heath, S.C., Timpson, N.J., Najjar, S.S., Stringham, H.M., Strait, J., Duren, W.L., Maschio, A., Busonero, F., Mulas, A., et al. (2008) Newly identified loci that influence lipid concentrations and risk of coronary artery disease. <i>Nat. Genet.<\/i>, 40, 161-169."},{"key":"23","doi-asserted-by":"crossref","unstructured":"Zhang, Z., Tao, L., Chen, Z., Zhou, D., Kan, M., Zhang, D., Li, C., He, L. &amp; Liu, Y. (2011) Association of genetic loci with blood lipids in the Chinese population. <i>PLoS One<\/i>, 6, e27305.","DOI":"10.1371\/journal.pone.0027305"}],"container-title":["The Tohoku Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/tjem\/233\/2\/233_149\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T19:58:54Z","timestamp":1619639934000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/tjem\/233\/2\/233_149\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.1620\/tjem.233.149","relation":{},"ISSN":["0040-8727","1349-3329"],"issn-type":[{"value":"0040-8727","type":"print"},{"value":"1349-3329","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}