{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T09:26:49Z","timestamp":1782552409202,"version":"3.54.5"},"reference-count":38,"publisher":"Tohoku University Medical Press","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tohoku J. Exp. Med."],"published-print":{"date-parts":[[2014]]},"DOI":"10.1620\/tjem.234.229","type":"journal-article","created":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:03:16Z","timestamp":1414800196000},"page":"229-236","source":"Crossref","is-referenced-by-count":10,"title":["Sipjeondaebo-Tang, a Traditional Herbal Formula, Inhibits Retinal Neovascularization in a Mouse Model of Oxygen-Induced Retinopathy"],"prefix":"10.1620","volume":"234","author":[{"given":"Yun Mi","family":"Lee","sequence":"first","affiliation":[{"name":"Korean Medicine Based Herbal Drug Development Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan-Sik","family":"Kim","sequence":"additional","affiliation":[{"name":"Korean Medicine Based Herbal Drug Development Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunjin","family":"Sohn","sequence":"additional","affiliation":[{"name":"Korean Medicine Based Herbal Drug Development Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyuhyung","family":"Jo","sequence":"additional","affiliation":[{"name":"Korean Medicine Based Herbal Drug Development Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye Ryeng","family":"Lim","sequence":"additional","affiliation":[{"name":"Korean Medicine Based Herbal Drug Development Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun Ki","family":"Kim","sequence":"additional","affiliation":[{"name":"Korean Medicine Based Herbal Drug Development Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Sook","family":"Kim","sequence":"additional","affiliation":[{"name":"Korean Medicine Based Herbal Drug Development Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junghyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Korean Medicine Based Herbal Drug Development Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"622","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"Aiello, L.P. (1997) Vascular endothelial growth factor and the eye: biochemical mechanisms of action and implications for novel therapies. <i>Ophthalmic. Res.<\/i>, 29, 354-362.","DOI":"10.1159\/000268033"},{"key":"2","unstructured":"Aiello, L.P., Avery, R.L., Arrigg, P.G., Keyt, B.A., Jampel, H.D., Shah, S.T., Pasquale, L.R., Thieme, H., Iwamoto, M.A., Park, J.E., Nguyen, H.V., Aiello, L.M., Ferrara, N. &amp; King, G.L. (1994) Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. <i>N. Engl. J. Med.<\/i>, 331, 1480-1487."},{"key":"3","unstructured":"Alvarez, R.H., Kantarjian, H.M. &amp; Cortes, J.E. (2006) Biology of platelet-derived growth factor and its involvement in disease. <i>Mayo Clin. Proc.<\/i>, 81, 1241-1257."},{"key":"4","unstructured":"Appelmann, I., Liersch, R., Kessler, T., Mesters, R.M. &amp; Berdel, W.E. (2010) Angiogenesis inhibition in cancer therapy: platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF) and their receptors: biological functions and role in malignancy. <i>Recent Results Cancer Res.<\/i>, 180, 51-81."},{"key":"5","doi-asserted-by":"crossref","unstructured":"Benjamin, L.E., Hemo, I. &amp; Keshet, E. (1998) A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF. <i>Development<\/i>, 125, 1591-1598.","DOI":"10.1242\/dev.125.9.1591"},{"key":"6","unstructured":"Butchbach, M.E., Edwards, J.D., Schussler, K.R. &amp; Burghes, A.H. (2007) A novel method for oral delivery of drug compounds to the neonatal SMNDelta7 mouse model of spinal muscular atrophy. <i>J. Neurosci. Methods<\/i>, 161, 285-290."},{"key":"7","unstructured":"Campochiaro, P.A. (2013) Ocular neovascularization. <i>J. Mol. Med. <\/i>(<i>Berl<\/i>), 91, 311-321."},{"key":"8","unstructured":"Cao, L., Liu, H., Lam, D.S., Yam, G.H. &amp; Pang, C.P. (2010) In vitro screening for angiostatic potential of herbal chemicals. <i>Invest. Ophthalmol. Vis. Sci.<\/i>, 51, 6658-6664."},{"key":"9","unstructured":"Castellon, R., Hamdi, H.K., Sacerio, I., Aoki, A.M., Kenney, M.C. &amp; Ljubimov, A.V. (2002) Effects of angiogenic growth factor combinations on retinal endothelial cells. <i>Exp. Eye Res.<\/i>, 74, 523-535."},{"key":"10","unstructured":"Giddabasappa, A., Eswaraka, J.R., Barrett, C.M., Bauler, M.N., Wu, Z., Yepuru, M., Miller, D.D. &amp; Dalton, J.T. (2012) <i>\u03b2<\/i>-LGND2, an ER<i>\u03b2<\/i> selective agonist, inhibits pathologic retinal neovascularization. <i>Invest. Ophthalmol. Vis. Sci.<\/i>, 53, 5066-5075."},{"key":"11","unstructured":"Haranaka, K., Satomi, N., Sakurai, A., Haranaka, R., Okada, N. &amp; Kobayashi, M. (1985) Antitumor activities and tumor necrosis factor producibility of traditional Chinese medicines and crude drugs. <i>Cancer Immunol. Immunother.<\/i>, 20, 1-5."},{"key":"12","doi-asserted-by":"crossref","unstructured":"Heldin, C.H., Ostman, A. &amp; Ronnstrand, L. (1998) Signal transduction via platelet-derived growth factor receptors. <i>Biochim. Biophys. Acta<\/i>, 1378, F79-113.","DOI":"10.1016\/S0304-419X(98)00015-8"},{"key":"13","unstructured":"Heldin, C.H. &amp; Westermark, B. (1999) Mechanism of action and in vivo role of platelet-derived growth factor. <i>Physiol. Rev.<\/i>, 79, 1283-1316."},{"key":"14","unstructured":"Hsiu, S.L., Lin, Y.T., Wen, K.C., Hou, Y.C. &amp; Chao, P.D. (2003) A deglucosylated metabolite of paeoniflorin of the root of Paeonia lactiflora and its pharmacokinetics in rats. <i>Planta Med.<\/i>, 69, 1113-1118."},{"key":"15","unstructured":"Hua, J., Guerin, K.I., Chen, J., Michan, S., Stahl, A., Krah, N.M., Seaward, M.R., Dennison, R.J., Juan, A.M., Hatton, C.J., Sapieha, P., Sinclair, D.A. &amp; Smith, L.E. (2011) Resveratrol inhibits pathologic retinal neovascularization in Vldlr(\u2212\/\u2212) mice. <i>Invest. Ophthalmol. Vis. Sci.<\/i>, 52, 2809-2816."},{"key":"16","doi-asserted-by":"crossref","unstructured":"Ji, B., Geng, P., Liu, J.G., Shi, D.Z. &amp; Wang, Y.Y. (2006) Effects of active components extracted from Qixue Bingzhi Recipe on proliferation of vascular smooth muscle cells and expressions of platelet-derived growth factor and its receptor genes. <i>Zhong Xi Yi Jie He Xue Bao<\/i>, 4, 30-34.","DOI":"10.3736\/jcim20060109"},{"key":"17","unstructured":"Kamiyama, H., Takano, S., Ishikawa, E., Tsuboi, K. &amp; Matsumura, A. (2005) Anti-angiogenic and immunomodulatory effect of the herbal medicine \u201cJuzen-taiho-to\u201d on malignant glioma. <i>Biol. Pharm. Bull.<\/i>, 28, 2111-2116."},{"key":"18","unstructured":"Kim, K.J., Choi, J.S., Kim, K.W. &amp; Jeong, J.W. (2013) The anti-angiogenic activities of glycyrrhizic acid in tumor progression. <i>Phytother. Res.<\/i>, 27, 841-846."},{"key":"19","unstructured":"Kiyohara, H., Matsumoto, T. &amp; Yamada, H. (2004) Combination Effects of Herbs in a Multi-herbal Formula: Expression of Juzen-taiho-to\u2019s Immuno-modulatory Activity on the Intestinal Immune System. <i>Evid. Based Complement. Alternat. Med.<\/i>, 1, 83-91."},{"key":"20","unstructured":"Kociok, N., Radetzky, S., Krohne, T.U., Gavranic, C. &amp; Joussen, A.M. (2006) Pathological but not physiological retinal neovascularization is altered in TNF-Rp55-receptor-deficient mice. <i>Invest. Ophthalmol. Vis. Sci.<\/i>, 47, 5057-5065."},{"key":"21","unstructured":"Kogure, T., Hoshino, A., Ito, K., Sato, H., Tatsumi, T., Ohyama, Y., Kawata, E., Fujita, K. &amp; Tamura, J. (2005) Beneficial effect of complementary alternative medicine on lymphedema with rheumatoid arthritis. <i>Mod. Rheumatol.<\/i>, 15, 445-449."},{"key":"22","unstructured":"Kumar Gupta, S., Kumar, B., Srinivasan, B.P., Nag, T.C., Srivastava, S., Saxena, R. &amp; Aggarwal, A. (2013) Retinoprotective effects of Moringa oleifera via antioxidant, anti-inflammatory, and anti-angiogenic mechanisms in streptozotocin-induced diabetic rats. <i>J. Ocul. Pharmacol. Ther.<\/i>, 29, 419-426."},{"key":"23","unstructured":"Lee, J.J., Hsiao, C.C., Yang, I.H., Chou, M.H., Wu, C.L., Wei, Y.C., Chen, C.H. &amp; Chuang, J.H. (2012) High-mobility group box 1 protein is implicated in advanced glycation end products-induced vascular endothelial growth factor A production in the rat retinal ganglion cell line RGC-5. <i>Mol. Vis.<\/i>, 18, 838-850."},{"key":"24","unstructured":"Lee, Y.M., Kim, J., Jo, K., Shin, S.D., Kim, C.S., Sohn, E.J., Kim, S.G. &amp; Kim, J.S. (2013) Ethyl pyruvate inhibits retinal pathogenic neovascularization by downregulating HMGB1 expression. <i>J. Diabetes Res.<\/i>, 2013, 245271."},{"key":"25","doi-asserted-by":"crossref","unstructured":"Lee, H.J., Lee, E.O., Rhee, Y.H., Ahn, K.S., Li, G.X., Jiang, C., Lu, J. &amp; Kim, S.H. (2006) An oriental herbal cocktail, ka-mi-kae-kyuk-tang, exerts anti-cancer activities by targeting angiogenesis, apoptosis and metastasis. <i>Carcinogenesis<\/i>, 27, 2455-2463.","DOI":"10.1093\/carcin\/bgl104"},{"key":"26","doi-asserted-by":"crossref","unstructured":"McClain, R.M., Keller, D., Casciano, D., Fu, P., MacDonald, J., Popp, J. &amp; Sagartz, J. (2001) Neonatal mouse model: review of methods and results. <i>Toxicol. Pathol.<\/i>, 29 Suppl, 128-137.","DOI":"10.1080\/019262301753178537"},{"key":"27","doi-asserted-by":"crossref","unstructured":"Miki, K., Miki, A., Matsuoka, M., Muramatsu, D., Hackett, S.F. &amp; Campochiaro, P.A. (2009) Effects of intraocular ranibizumab and bevacizumab in transgenic mice expressing human vascular endothelial growth factor. <i>Ophthalmology<\/i>, 116, 1748-1754.","DOI":"10.1016\/j.ophtha.2009.05.020"},{"key":"28","unstructured":"Raines, E.W. (2004) PDGF and cardiovascular disease. <i>Cytokine Growth Factor Rev.<\/i>, 15, 237-254."},{"key":"29","doi-asserted-by":"crossref","unstructured":"Ross, R., Glomset, J., Kariya, B. &amp; Harker, L. (1974) A platelet-dependent serum factor that stimulates the proliferation of arterial smooth muscle cells in vitro. <i>Proc. Natl. Acad. Sci. USA<\/i>, 71, 1207-1210.","DOI":"10.1073\/pnas.71.4.1207"},{"key":"30","unstructured":"Ruma, I.M., Putranto, E.W., Kondo, E., Watanabe, R., Saito, K., Inoue, Y., Yamamoto, K., Nakata, S., Kaihata, M., Murata, H. &amp; Sakaguchi, M. (2014) Extract of Cordyceps militaris inhibits angiogenesis and suppresses tumor growth of human malignant melanoma cells. <i>Int. J. Oncol.<\/i>, 45, 209-218."},{"key":"31","unstructured":"Shin, I.S., Yu, Y.B., Seo, C.S., Ha, H.K., Lee, M.Y., Huang, D.S., Kim, J.H. &amp; Shin, H.K. (2011) Subchronic toxicity of Sipjeondaebo-tang (SDT) in Sprague-Dawley rats. <i>Regul. Toxicol. Pharmacol.<\/i>, 59, 375-384."},{"key":"32","unstructured":"Tagami, K., Niwa, K., Lian, Z., Gao, J., Mori, H. &amp; Tamaya, T. (2004) Preventive effect of Juzen-taiho-to on endometrial carcinogenesis in mice is based on Shimotsu-to constituent. <i>Biol. Pharm. Bull.<\/i>, 27, 156-161."},{"key":"33","unstructured":"Tanaka, J., Nakamura, S., Tsuruma, K., Shimazawa, M., Shimoda, H. &amp; Hara, H. (2012) Purple rice (Oryza sativa L.) extract and its constituents inhibit VEGF-induced angiogenesis. <i>Phytother. Res.<\/i>, 26, 214-222."},{"key":"34","unstructured":"Vassbotn, F.S., Havnen, O.K., Heldin, C.H. &amp; Holmsen, H. (1994) Negative feedback regulation of human platelets via autocrine activation of the platelet-derived growth factor alpha-receptor. <i>J. Biol. Chem.<\/i>, 269, 13874-13879."},{"key":"35","unstructured":"Wankun, X., Wenzhen, Y., Min, Z., Weiyan, Z., Huan, C., Wei, D., Lvzhen, H., Xu, Y. &amp; Xiaoxin, L. (2011) Protective effect of paeoniflorin against oxidative stress in human retinal pigment epithelium in vitro. <i>Mol. Vis.<\/i>, 17, 3512-3522."},{"key":"36","unstructured":"Yance, D.R. Jr. &amp; Sagar, S.M. (2006) Targeting angiogenesis with integrative cancer therapies. <i>Integr. Cancer Ther.<\/i>, 5, 9-29."},{"key":"37","unstructured":"Zehetner, C., Kirchmair, R., Neururer, S.B., Kralinger, M.T., Bechrakis, N.E. &amp; Kieselbach, G.F. (2014) Systemic upregulation of PDGF-B in patients with neovascular AMD. <i>Invest. Ophthalmol. Vis. Sci.<\/i>, 55, 337-344."},{"key":"38","unstructured":"Zheng, Y.Q., Wei, W., Zhu, L. &amp; Liu, J.X. (2007) Effects and mechanisms of Paeoniflorin, a bioactive glucoside from paeony root, on adjuvant arthritis in rats. <i>Inflamm. Res.<\/i>, 56, 182-188."}],"container-title":["The Tohoku Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/tjem\/234\/3\/234_229\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T01:08:24Z","timestamp":1650503304000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/tjem\/234\/3\/234_229\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.1620\/tjem.234.229","relation":{},"ISSN":["0040-8727","1349-3329"],"issn-type":[{"value":"0040-8727","type":"print"},{"value":"1349-3329","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}