{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:51:09Z","timestamp":1785775869387,"version":"3.56.0"},"reference-count":15,"publisher":"Tohoku University Medical Press","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tohoku J. Exp. Med."],"published-print":{"date-parts":[[2014]]},"DOI":"10.1620\/tjem.234.237","type":"journal-article","created":{"date-parts":[[2014,11,6]],"date-time":"2014-11-06T23:47:30Z","timestamp":1415317650000},"page":"237-240","source":"Crossref","is-referenced-by-count":20,"title":["Efficacy of Acotiamide in Combination with Esomeprazole for Functional Dyspepsia Refractory to Proton-Pump Inhibitor Monotherapy"],"prefix":"10.1620","volume":"234","author":[{"given":"Shuhei","family":"Mayanagi","sequence":"first","affiliation":[{"name":"Oizumichuo Clinic"},{"name":"Department of Surgery, Keio University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maiko","family":"Kishino","sequence":"additional","affiliation":[{"name":"Oizumichuo Clinic"},{"name":"Institute of Gastroenterology, Tokyo Women\u2019s Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Kitagawa","sequence":"additional","affiliation":[{"name":"Department of Surgery, Keio University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Sunamura","sequence":"additional","affiliation":[{"name":"Oizumichuo Clinic"},{"name":"Digestive Surgery and Transplantation Surgery, Tokyo Medical University Hachioji Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"622","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"Blum, A.L., Arnold, R., Stolte, M., Fischer, M. &amp; Koelz, H.R. (2000) Short course acid suppressive treatment for patients with functional dyspepsia: results depend on Helicobacter pylori status. The Frosch Study Group. <i>Gut<\/i>, 47, 473-480.","DOI":"10.1136\/gut.47.4.473"},{"key":"2","unstructured":"Bolling-Sternevald, E., Lauritsen, K., Aalykke, C., Havelund, T., Knudsen, T., Unge, P., Ekstrom, P., Jaup, B., Norrby, A., Stubberod, A., Melen, K., Carlsson, R., Jerndal, P., Junghard, O. &amp; Glise, H. (2002) Effect of profound acid suppression in functional dyspepsia: a double-blind, randomized, placebo-controlled trial. <i>Scand. J. Gastroenterol.<\/i>, 37, 1395-1402."},{"key":"3","doi-asserted-by":"crossref","unstructured":"Drossman, D.A. (2006) The functional gastrointestinal disorders and the Rome III process. <i>Gastroenterology<\/i>, 130, 1377-1390.","DOI":"10.1053\/j.gastro.2006.03.008"},{"key":"4","doi-asserted-by":"crossref","unstructured":"Kusano, M., Hosaka, H., Kawada, A., Kuribayashi, S., Shimoyama, Y., Kawamura, O. &amp; Moki, F. (2012) Development and evaluation of a modified Frequency Scale for the Symptoms of Gastroesophageal Reflux Disease to distinguish functional dyspepsia from non-erosive reflux disease. <i>J. Gastroenterol. Hepatol.<\/i>, 27, 1187-1191.","DOI":"10.1111\/j.1440-1746.2012.07121.x"},{"key":"5","unstructured":"Lacy, B.E., Talley, N.J., Locke, G.R. 3rd., Bouras, E.P., DiBaise, J.K., El-Serag, H.B., Abraham, B.P., Howden, C.W., Moayyedi, P. &amp; Prather, C. (2012) Review article: current treatment options and management of functional dyspepsia. <i>Aliment. Pharmacol. Ther.<\/i>, 36, 3-15."},{"key":"6","doi-asserted-by":"crossref","unstructured":"Matsueda, K., Hongo, M., Tack, J., Saito, Y. &amp; Kato, H. (2012) A placebo-controlled trial of acotiamide for meal-related symptoms of functional dyspepsia. <i>Gut<\/i>, 61, 821-828.","DOI":"10.1136\/gutjnl-2011-301454"},{"key":"7","unstructured":"Nakajima, T., Nawata, H. &amp; Ito, Y. (2000) Z-338, a newly synthetized carboxyamide derivative, stimulates gastric motility through enhancing the excitatory neurotransmission. <i>J. Smooth Muscle Res.<\/i>, 36, 69-81."},{"key":"8","unstructured":"Ogishima, M., Kaibara, M., Ueki, S., Kurimoto, T. &amp; Taniyama, K. (2000) Z-338 facilitates acetylcholine release from enteric neurons due to blockade of muscarinic autoreceptors in guinea pig stomach. <i>J. Pharmacol. Exp. Ther.<\/i>, 294, 33-37."},{"key":"9","doi-asserted-by":"crossref","unstructured":"Peura, D.A., Kovacs, T.O., Metz, D.C., Siepman, N., Pilmer, B.L. &amp; Talley, N.J. (2004) Lansoprazole in the treatment of functional dyspepsia: two double-blind, randomized, placebo-controlled trials. <i>Am. J. Med.<\/i>, 116, 740-748.","DOI":"10.1016\/j.amjmed.2004.01.008"},{"key":"10","doi-asserted-by":"crossref","unstructured":"Seto, K., Sasaki, T., Katsunuma, K., Kobayashi, N., Tanaka, K. &amp; Tack, J. (2008) Acotiamide hydrochloride (Z-338), a novel prokinetic agent, restores delayed gastric emptying and feeding inhibition induced by restraint stress in rats. <i>Neurogastroenterol. Motil.<\/i>, 20, 1051-1059.","DOI":"10.1111\/j.1365-2982.2008.01135.x"},{"key":"11","unstructured":"Talley, N.J., Meineche-Schmidt, V., Pare, P., Duckworth, M., Raisanen, P., Pap, A., Kordecki, H. &amp; Schmid, V. (1998) Efficacy of omeprazole in functional dyspepsia: double-blind, randomized, placebo-controlled trials (the Bond and Opera studies). <i>Aliment. Pharmacol. Ther.<\/i>, 12, 1055-1065."},{"key":"12","unstructured":"van Rensburg, C., Berghofer, P., Enns, R., Dattani, I.D., Maritz, J.F., Gonzalez Carro, P., Fischer, R. &amp; Schwan, T. (2008) Efficacy and safety of pantoprazole 20 mg once daily treatment in patients with ulcer-like functional dyspepsia. <i>Curr. Med. Res. Opin.<\/i>, 24, 2009-2018."},{"key":"13","doi-asserted-by":"crossref","unstructured":"van Zanten, S.V., Armstrong, D., Chiba, N., Flook, N., White, R.J., Chakraborty, B. &amp; Gasco, A. (2006) Esomeprazole 40 mg once a day in patients with functional dyspepsia: the randomized, placebo-controlled \u201cENTER\u201d trial. <i>Am. J. Gastroenterol.<\/i>, 101, 2096-2106.","DOI":"10.1111\/j.1572-0241.2006.00751.x"},{"key":"14","unstructured":"Wang, W.H., Huang, J.Q., Zheng, G.F., Xia, H.H.X., Wong, W.M., Liu, X.G., Karlberg, J. &amp; Wong, B.C.Y. (2007) Effects of proton-pump inhibitors on functional dyspepsia: a meta-analysis of randomized placebo-controlled trials. <i>Clin. Gastroenterol. Hepatol.<\/i>, 5, 178-185."},{"key":"15","doi-asserted-by":"crossref","unstructured":"Wong, W.M., Wong, B.C., Hung, W.K., Yee, Y.K., Yip, A.W., Szeto, M.L., Fung, F.M., Tong, T.S., Lai, K.C., Hu, W.H. Yuen, M.F. &amp; Lam, S.K. (2002) Double blind, randomised, placebo controlled study of four weeks of lansoprazole for the treatment of functional dyspepsia in Chinese patients. <i>Gut<\/i>, 51, 502-506.","DOI":"10.1136\/gut.51.4.502"}],"container-title":["The Tohoku Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/tjem\/234\/3\/234_237\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T20:51:47Z","timestamp":1717534307000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/tjem\/234\/3\/234_237\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.1620\/tjem.234.237","relation":{},"ISSN":["0040-8727","1349-3329"],"issn-type":[{"value":"0040-8727","type":"print"},{"value":"1349-3329","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}