{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:46:26Z","timestamp":1790063186680,"version":"4.0.1"},"reference-count":27,"publisher":"Tohoku University Medical Press","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tohoku J. Exp. Med."],"published-print":{"date-parts":[[2015]]},"DOI":"10.1620\/tjem.236.225","type":"journal-article","created":{"date-parts":[[2015,6,25]],"date-time":"2015-06-25T20:25:06Z","timestamp":1435263906000},"page":"225-232","source":"Crossref","is-referenced-by-count":48,"title":["Mitochonic Acid 5 (MA-5), a Derivative of the Plant Hormone Indole-3-Acetic Acid, Improves Survival of Fibroblasts from Patients with Mitochondrial Diseases"],"prefix":"10.1620","volume":"236","author":[{"given":"Takehiro","family":"Suzuki","sequence":"first","affiliation":[{"name":"Renal Division, Brigham and Women\u2019s Hospital and Harvard Medical School"},{"name":"Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Tohoku University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoi","family":"Kikusato","sequence":"additional","affiliation":[{"name":"Animal Nutrition, Life Sciences, Graduate School of Agricultural Science, Tohoku University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuro","family":"Matsuhashi","sequence":"additional","affiliation":[{"name":"Division of Pediatrics, Tohoku University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Matsuo","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeya","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Molecular Pharmacology, Tohoku University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Oba","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daichi","family":"Minaki","sequence":"additional","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences, Tohoku University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Saigusa","sequence":"additional","affiliation":[{"name":"Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Shimbo","sequence":"additional","affiliation":[{"name":"Clinical Research Institute, Kanagawa Children\u2019s Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyoshi","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Rehabilitation Science, Tohoku University Graduate School of Medicine Sendai"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eikan","family":"Mishima","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisato","family":"Shima","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasutoshi","family":"Akiyama","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichi","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akinori","family":"Yuri","sequence":"additional","affiliation":[{"name":"Laboratory of Oncology, Pharmacy Practice and Sciences, Tohoku University Graduate School of Pharmaceutical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"Department of Clinical Biology and Hormonal Regulation, Tohoku University Graduate School of Medicine"},{"name":"Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takafumi","family":"Toyohara","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chitose","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Kohzuki","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Rehabilitation Science, Tohoku University Graduate School of Medicine Sendai"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-ichi","family":"Anzai","sequence":"additional","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences, Tohoku University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nariyasu","family":"Mano","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Tohoku University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeo","family":"Kure","sequence":"additional","affiliation":[{"name":"Division of Pediatrics, Tohoku University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teruyuki","family":"Yanagisawa","sequence":"additional","affiliation":[{"name":"Department of Molecular Pharmacology, Tohoku University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihisa","family":"Tomioka","sequence":"additional","affiliation":[{"name":"Laboratory of Oncology, Pharmacy Practice and Sciences, Tohoku University Graduate School of Pharmaceutical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Toyomizu","sequence":"additional","affiliation":[{"name":"Animal Nutrition, Life Sciences, Graduate School of Agricultural Science, Tohoku University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadayoshi","family":"Ito","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Osaka","sequence":"additional","affiliation":[{"name":"Division of Pediatrics, Jichi Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken-ichiro","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Okayama University of Science"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaaki","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Medical Science, Tohoku University Graduate School of Biomedical Engineering"},{"name":"Department of Clinical Biology and Hormonal Regulation, Tohoku University Graduate School of Medicine"},{"name":"Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"622","reference":[{"key":"1","unstructured":"Abu Sinna, G. (1983) The effect of the plant hormone indole-3-acetic acid and chemically related compounds on the growth of mouse fibroblast 3T3 cells. <i>Comp. Biochem. Physiol. C<\/i>, 74, 433-436."},{"key":"2","doi-asserted-by":"crossref","unstructured":"Avula, S., Parikh, S., Demarest, S., Kurz, J. &amp; Gropman, A. (2014) Treatment of mitochondrial disorders. <i>Curr. Treat. Options Neurol.<\/i>, 16, 292.","DOI":"10.1007\/s11940-014-0292-7"},{"key":"3","doi-asserted-by":"crossref","unstructured":"Carelli, V., La Morgia, C. &amp; Sadun, A.A. (2013) Mitochondrial dysfunction in optic neuropathies: animal models and therapeutic options. <i>Curr. Opin. Neurol.<\/i>, 26, 52-58.","DOI":"10.1097\/WCO.0b013e32835c5f0b"},{"key":"4","doi-asserted-by":"crossref","unstructured":"Che, R., Yuan, Y., Huang, S. &amp; Zhang, A. (2014) Mitochondrial dysfunction in the pathophysiology of renal diseases. <i>Am. J. Physiol. Renal Physiol.<\/i>, 306, F367-F378.","DOI":"10.1152\/ajprenal.00571.2013"},{"key":"5","unstructured":"Chung, K.T., Anderson, G.M. &amp; Fulk, G.E. (1975) Formation of indoleacetic acid by intestinal anaerobes. <i>J. Bacteriol.<\/i>, 124, 573-575."},{"key":"6","unstructured":"Coskuner, O. &amp; Murray, I.V. (2014) Adenosine triphosphate (ATP) reduces amyloid-beta protein misfolding in vitro. <i>J. Alzheimers Dis.<\/i>, 41, 561-574."},{"key":"7","doi-asserted-by":"crossref","unstructured":"El-Hattab, A.W., Emrick, L.T., Chanprasert, S., Craigen, W.J. &amp; Scaglia, F. (2014) Mitochondria: role of citrulline and arginine supplementation in MELAS syndrome. <i>Int. J. Biochem. Cell Biol.<\/i>, 48, 85-91.","DOI":"10.1016\/j.biocel.2013.12.009"},{"key":"8","doi-asserted-by":"crossref","unstructured":"Enns, G.M. (2014) Treatment of mitochondrial disorders: antioxidants and beyond. <i>J. Child. Neurol.<\/i>, 29, 1235-1240.","DOI":"10.1177\/0883073814538509"},{"key":"9","doi-asserted-by":"crossref","unstructured":"Enns, G.M., Kinsman, S.L., Perlman, S.L., Spicer, K.M., Abdenur, J.E., Cohen, B.H., Amagata, A., Barnes, A., Kheifets, V., Shrader, W.D., Thoolen, M., Blankenberg, F. &amp; Miller, G. (2012) Initial experience in the treatment of inherited mitochondrial disease with EPI-743. <i>Mol. Genet. Metab.<\/i>, 105, 91-102.","DOI":"10.1016\/j.ymgme.2011.10.009"},{"key":"10","unstructured":"Gordon, S.A., Fry, R.J. &amp; Barr, S. (1972) Origin or urinary auxin in the germfree and conventional mouse. <i>Am. J. Physiol.<\/i>, 222, 399-403."},{"key":"11","doi-asserted-by":"crossref","unstructured":"Habersetzer, J., Ziani, W., Larrieu, I., Stines-Chaumeil, C., Giraud, M.F., Brethes, D., Dautant, A. &amp; Paumard, P. (2013) ATP synthase oligomerization: from the enzyme models to the mitochondrial morphology. <i>Int. J. Biochem. Cell Biol.<\/i>, 45, 99-105.","DOI":"10.1016\/j.biocel.2012.05.017"},{"key":"12","doi-asserted-by":"crossref","unstructured":"Hayashi, K., Neve, J., Hirose, M., Kuboki, A., Shimada, Y., Kepinski, S. &amp; Nozaki, H. (2012) Rational design of an auxin antagonist of the SCF(TIR1) auxin receptor complex. <i>ACS Chem. Biol.<\/i>, 7, 590-598.","DOI":"10.1021\/cb200404c"},{"key":"13","unstructured":"Imagawa, S., Nakano, Y., Obara, N., Suzuki, N., Doi, T., Kodama, T., Nagasawa, T. &amp; Yamamoto, M. (2003) A GATA-specific inhibitor (K-7174) rescues anemia induced by IL-1beta, TNF-alpha, or L-NMMA. <i>FASEB J.<\/i>, 17, 1742-1744."},{"key":"14","doi-asserted-by":"crossref","unstructured":"Jiang, Y., Zhou, X., Chen, X., Yang, G., Wang, Q., Rao, K., Xiong, W. &amp; Yuan, J. (2011) Benzo(a)pyrene-induced mitochondrial dysfunction and cell death in p53-null Hep3B cells. <i>Mutat. Res.<\/i>, 726, 75-83.","DOI":"10.1016\/j.mrgentox.2011.08.006"},{"key":"15","doi-asserted-by":"crossref","unstructured":"Kabunga, P., Lau, A.K., Phan, K., Puranik, R., Liang, C., Davis, R.L., Sue, C.M. &amp; Sy, R.W. (2015) Systematic review of cardiac electrical disease in Kearns-Sayre syndrome and mitochondrial cytopathy. <i>Int. J. Cardiol.<\/i>, 181, 303-310.","DOI":"10.1016\/j.ijcard.2014.12.038"},{"key":"16","doi-asserted-by":"crossref","unstructured":"Lim, C.K., Kalinowski, D.S. &amp; Richardson, D.R. (2008) Protection against hydrogen peroxide-mediated cytotoxicity in Friedreich\u2019s ataxia fibroblasts using novel iron chelators of the 2-pyridylcarboxaldehyde isonicotinoyl hydrazone class. <i>Mol. Pharmacol.<\/i>, 74, 225-235.","DOI":"10.1124\/mol.108.046847"},{"key":"17","doi-asserted-by":"crossref","unstructured":"Mitchell, P. (1961) Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism. <i>Nature<\/i>, 191, 144-148.","DOI":"10.1038\/191144a0"},{"key":"18","doi-asserted-by":"crossref","unstructured":"Pagnussat, G.C., Lanteri, M.L. &amp; Lamattina, L. (2003) Nitric oxide and cyclic GMP are messengers in the indole acetic acid-induced adventitious rooting process. <i>Plant Physiol.<\/i>, 132, 1241-1248.","DOI":"10.1104\/pp.103.022228"},{"key":"19","doi-asserted-by":"crossref","unstructured":"Pfeffer, G., Majamaa, K., Turnbull, D.M., Thorburn, D. &amp; Chinnery, P.F. (2012) Treatment for mitochondrial disorders. <i>Cochrane Database Syst. Rev.<\/i>, 4, CD004426.","DOI":"10.1002\/14651858.CD004426.pub3"},{"key":"20","doi-asserted-by":"crossref","unstructured":"Pieczenik, S.R. &amp; Neustadt, J. (2007) Mitochondrial dysfunction and molecular pathways of disease. <i>Exp. Mol. Pathol.<\/i>, 83, 84-92.","DOI":"10.1016\/j.yexmp.2006.09.008"},{"key":"21","doi-asserted-by":"crossref","unstructured":"Schapira, A.H. (2012) Mitochondrial diseases. <i>Lancet<\/i>, 379, 1825-1834.","DOI":"10.1016\/S0140-6736(11)61305-6"},{"key":"22","doi-asserted-by":"crossref","unstructured":"Shrader, W.D., Amagata, A., Barnes, A., Enns, G.M., Hinman, A., Jankowski, O., Kheifets, V., Komatsuzaki, R., Lee, E., Mollard, P., Murase, K., Sadun, A.A., Thoolen, M., Wesson, K. &amp; Miller, G. (2011) alpha-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. <i>Bioorg. Med. Chem. Lett.<\/i>, 21, 3693-3698.","DOI":"10.1016\/j.bmcl.2011.04.085"},{"key":"23","doi-asserted-by":"crossref","unstructured":"Strauss, M., Hofhaus, G., Schroder, R.R. &amp; Kuhlbrandt, W. (2008) Dimer ribbons of ATP synthase shape the inner mitochondrial membrane. <i>EMBO J.<\/i>, 27, 1154-1160.","DOI":"10.1038\/emboj.2008.35"},{"key":"24","doi-asserted-by":"crossref","unstructured":"Tanigawa, J., Kaneko, K., Honda, M., Harashima, H., Murayama, K., Wada, T., Takano, K., Iai, M., Yamashita, S., Shimbo, H., Aida, N., Ohtake, A. &amp; Osaka, H. (2012) Two Japanese patients with Leigh syndrome caused by novel SURF1 mutations. <i>Brain Dev.<\/i>, 34, 861-865.","DOI":"10.1016\/j.braindev.2012.02.007"},{"key":"25","doi-asserted-by":"crossref","unstructured":"Toyohara, T., Akiyama, Y., Suzuki, T., Takeuchi, Y., Mishima, E., Tanemoto, M., Momose, A., Toki, N., Sato, H., Nakayama, M., Hozawa, A., Tsuji, I., Ito, S., Soga, T. &amp; Abe, T. (2010) Metabolomic profiling of uremic solutes in CKD patients. <i>Hypertens. Res.<\/i>, 33, 944-952.","DOI":"10.1038\/hr.2010.113"},{"key":"26","doi-asserted-by":"crossref","unstructured":"Uchihashi, T., Iino, R., Ando, T. &amp; Noji, H. (2011) High-speed atomic force microscopy reveals rotary catalysis of rotorless F(1)-ATPase. <i>Science<\/i>, 333, 755-758.","DOI":"10.1126\/science.1205510"},{"key":"27","doi-asserted-by":"crossref","unstructured":"Vafai, S.B. &amp; Mootha, V.K. (2012) Mitochondrial disorders as windows into an ancient organelle. <i>Nature<\/i>, 491, 374-383.","DOI":"10.1038\/nature11707"}],"container-title":["The Tohoku Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/tjem\/236\/3\/236_225\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T10:33:42Z","timestamp":1498214022000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/tjem\/236\/3\/236_225\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.1620\/tjem.236.225","relation":{},"ISSN":["0040-8727","1349-3329"],"issn-type":[{"value":"0040-8727","type":"print"},{"value":"1349-3329","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}