{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T03:48:57Z","timestamp":1771040937963,"version":"3.50.1"},"reference-count":14,"publisher":"Tohoku University Medical Press","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tohoku J. Exp. Med."],"published-print":{"date-parts":[[2016]]},"DOI":"10.1620\/tjem.238.311","type":"journal-article","created":{"date-parts":[[2016,4,8]],"date-time":"2016-04-08T23:03:58Z","timestamp":1460156638000},"page":"311-316","source":"Crossref","is-referenced-by-count":5,"title":["Early Onset of Diabetes Mellitus Accelerates Cognitive Decline in Japanese Patients with Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-Like Episodes"],"prefix":"10.1620","volume":"238","author":[{"given":"Takaaki","family":"Murakami","sequence":"first","affiliation":[{"name":"Department of Diabetes and Endocrinology, Osaka Red Cross Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuya","family":"Shinoto","sequence":"additional","affiliation":[{"name":"Department of Neurology, Osaka Red Cross Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin","family":"Yonemitsu","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology, Osaka Red Cross Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiji","family":"Muro","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology, Osaka Red Cross Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shogo","family":"Oki","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology, Osaka Red Cross Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasutoshi","family":"Koga","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Child Health, Kurume University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-ichi","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daita","family":"Kaneda","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"622","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"Committee of the Japan Diabetes Society on the Diagnostic Criteria of Diabetes Mellitus; Seino, Y., Nanjo, K., Tajima, N., Kadowaki, T., Kashiwagi, A., Araki, E., Ito, C., Inagaki, N., Iwamoto, Y., Kasuga, M., Hanafusa, T., Haneda, M. &amp; Ueki, K. (2010) Report of the committee on the classification and diagnostic criteria of diabetes mellitus. <i>J. Diabetes Investig.<\/i>, 1, 212-228.","DOI":"10.1111\/j.2040-1124.2010.00074.x"},{"key":"2","doi-asserted-by":"crossref","unstructured":"El-Hattab, A.W., Adesina, A.M., Jones, J. &amp; Scaglia, F. (2015) MELAS syndrome: clinical manifestations, pathogenesis, and treatment options. <i>Mol. Genet. Metab.<\/i>, 116, 4-12.","DOI":"10.1016\/j.ymgme.2015.06.004"},{"key":"3","doi-asserted-by":"crossref","unstructured":"Finsterer, J. (2009) Mitochondrial disorders, cognitive impairment and dementia. <i>J. Neurol. Sci.<\/i>, 283, 143-148.","DOI":"10.1016\/j.jns.2009.02.347"},{"key":"4","doi-asserted-by":"crossref","unstructured":"Goto, Y., Horai, S., Matsuoka, T., Koga, Y., Nihei, K., Kobayashi, M. &amp; Nonaka, I. (1992) Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS): a correlative study of the clinical features and mitochondrial DNA mutation. <i>Neurology<\/i>, 42, 545-550.","DOI":"10.1212\/WNL.42.3.545"},{"key":"5","doi-asserted-by":"crossref","unstructured":"Gudala, K., Bansal, D., Schifano, F. &amp; Bhansali, A. (2013) Diabetes mellitus and risk of dementia: a meta-analysis of prospective observational studies. <i>J. Diabetes Investig.<\/i>, 4, 640-650.","DOI":"10.1111\/jdi.12087"},{"key":"6","doi-asserted-by":"crossref","unstructured":"McDonnell, M.T., Schaefer, A.M., Blakely, E.L., McFarland, R., Chinnery, P.F., Turnbull, D.M. &amp; Taylor, R.W. (2004) Noninvasive diagnosis of the 3243A &gt; G mitochondrial DNA mutation using urinary epithelial cells. <i>Eur. J. Hum. Genet.<\/i>, 12, 778-781.","DOI":"10.1038\/sj.ejhg.5201216"},{"key":"7","doi-asserted-by":"crossref","unstructured":"Schaefer, A.M., Phoenix, C., Elson, J.L., McFarland, R., Chinnery, P.F. &amp; Turnbull, D.M. (2006) Mitochondrial disease in adults: a scale to monitor progression and treatment. <i>Neurology<\/i>, 66, 1932-1934.","DOI":"10.1212\/01.wnl.0000219759.72195.41"},{"key":"8","doi-asserted-by":"crossref","unstructured":"Seaquist, E.R., Anderson, J., Childs, B., Cryer, P., Dagogo-Jack, S., Fish, L., Heller, S.R., Rodriguez, H., Rosenzweig, J. &amp; Vigersky, R. (2013) Hypoglycemia and diabetes: a report of a workgroup of the American Diabetes Association and the Endocrine Society. <i>Diabetes Care<\/i>, 36, 1384-1395.","DOI":"10.2337\/dc12-2480"},{"key":"9","doi-asserted-by":"crossref","unstructured":"Simoncini, C., Orsucci, D., Caldarazzo Ienco, E., Siciliano, G., Bonuccelli, U. &amp; Mancuso, M. (2015) Alzheimer\u2019s pathogenesis and its link to the mitochondrion. <i>Oxid. Med. Cell. Longev.<\/i>, 2015, 803942.","DOI":"10.1155\/2015\/803942"},{"key":"10","doi-asserted-by":"crossref","unstructured":"Suzuki, S., Oka, Y., Kadowaki, T., Kanatsuka, A., Kuzuya, T., Kobayashi, M., Sanke, T., Seino, Y. &amp; Nanjo, K.; Research Committee or Specific Types of Diabetes Mellitus with Gene Mutations of the Japan Diabetes Society (2003) Clinical features of diabetes mellitus with the mitochondrial DNA 3243 (A-G) mutation in Japanese: maternal inheritance and mitochondria-related complications. <i>Diabetes Res. Clin. Pract.<\/i>, 59, 207-217.","DOI":"10.1016\/S0168-8227(02)00246-2"},{"key":"11","doi-asserted-by":"crossref","unstructured":"Tuppen, H.A., Blakely, E.L., Turnbull, D.M. &amp; Taylor, R.W. (2010) Mitochondrial DNA mutations and human disease. <i>Biochim. Biophys. Acta<\/i>, 1797, 113-128.","DOI":"10.1016\/j.bbabio.2009.09.005"},{"key":"12","doi-asserted-by":"crossref","unstructured":"van den Ouweland, J.M., Lemkes, H.H., Gerbitz, K.D. &amp; Maassen, J.A. (1995) Maternally inherited diabetes and deafness (MIDD): a distinct subtype of diabetes associated with a mitochondrial tRNA(Leu)(UUR) gene point mutation. <i>Muscle Nerve Suppl.<\/i>, 3, S124-S130.","DOI":"10.1002\/mus.880181425"},{"key":"13","doi-asserted-by":"crossref","unstructured":"Whitmer, R.A., Karter, A.J., Yaffe, K., Quesenberry, C.P. Jr. &amp; Selby, J.V. (2009) Hypoglycemic episodes and risk of dementia in older patients with type 2 diabetes mellitus. <i>JAMA<\/i>, 301, 1565-1572.","DOI":"10.1001\/jama.2009.460"},{"key":"14","doi-asserted-by":"crossref","unstructured":"Yatsuga, S., Povalko, N., Nishioka, J., Katayama, K., Kakimoto, N., Matsuishi, T., Kakuma, T., Koga, Y.; Taro Matsuoka for MELAS Study Group in Japan (2012) MELAS: a nationwide prospective cohort study of 96 patients in Japan. <i>Biochim. Biophys. Acta<\/i>, 1820, 619-624.","DOI":"10.1016\/j.bbagen.2011.03.015"}],"container-title":["The Tohoku Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/tjem\/238\/4\/238_311\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,6]],"date-time":"2019-09-06T07:18:01Z","timestamp":1567754281000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/tjem\/238\/4\/238_311\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.1620\/tjem.238.311","relation":{},"ISSN":["0040-8727","1349-3329"],"issn-type":[{"value":"0040-8727","type":"print"},{"value":"1349-3329","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}