{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T04:20:42Z","timestamp":1775622042018,"version":"3.50.1"},"reference-count":15,"publisher":"Tohoku University Medical Press","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tohoku J. Exp. Med."],"published-print":{"date-parts":[[2018]]},"DOI":"10.1620\/tjem.244.243","type":"journal-article","created":{"date-parts":[[2018,3,19]],"date-time":"2018-03-19T22:48:53Z","timestamp":1521499733000},"page":"243-248","source":"Crossref","is-referenced-by-count":23,"title":["Vitamin B&lt;sub&gt;3&lt;\/sub&gt; Nicotinamide: A Promising Candidate for Treating Preeclampsia and Improving Fetal Growth"],"prefix":"10.1620","volume":"244","author":[{"given":"Nobuyuki","family":"Takahashi","sequence":"first","affiliation":[{"name":"Division of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences"},{"name":"Department of Medicine, Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University"},{"name":"Department of Pathology and Laboratory Medicine, The University of North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, The University of North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomofumi","family":"Fushima","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gen","family":"Oyanagi","sequence":"additional","affiliation":[{"name":"Tohoku University Hospital Pharmaceutical Department"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emiko","family":"Sato","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences"},{"name":"Department of Medicine, Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Oe","sequence":"additional","affiliation":[{"name":"Division of Feto-Maternal Medical Science, Tohoku Medical Megabank Organization, Tohoku University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiyo","family":"Sekimoto","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences"},{"name":"Department of Medicine, Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Saigusa","sequence":"additional","affiliation":[{"name":"Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Sato","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences"},{"name":"Department of Medicine, Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadayoshi","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"622","reference":[{"key":"1","unstructured":"Arendshorst, W.J. &amp; Thai, T.L. (2009)  Regulation of the renal microcirculation by ryanodine receptors and calcium-induced calcium release.  <i>Curr. Opin. Nephrol. Hypertens.<\/i>, 18, 40-49."},{"key":"2","unstructured":"Dulak, J., Loboda, A., Zagorska, A. &amp; Jozkowicz, A. (2004)  Complex role of heme oxygenase-1 in angiogenesis.  <i>Antioxid. Redox Signal.<\/i>, 6, 858-866."},{"key":"3","unstructured":"Fushima, T., Sekimoto, A., Minato, T., Ito, T., Oe, Y., Kisu, K., Sato, E., Funamoto, K., Hayase, T., Kimura, Y., Ito, S., Sato, H. &amp; Takahashi, N. (2016)  Reduced uterine perfusion pressure (RUPP) model of preeclampsia in mice.  <i>PLoS One<\/i>, 11, e0155426."},{"key":"4","unstructured":"Fushima, T., Sekimoto, A., Oe, Y., Sato, E., Ito, S., Sato, H. &amp; Takahashi, N. (2017)  Nicotinamide ameliorates a preeclampsia-like condition in mice with reduced uterine perfusion pressure.  <i>Am. J. Physiol. Renal Physiol.<\/i>, 312, F366-F372."},{"key":"5","unstructured":"Kingman, M., Ruggiero, R. &amp; Torres, F. (2009)  Ambrisentan, an endothelin receptor type A-selective endothelin receptor antagonist, for the treatment of pulmonary arterial hypertension.  <i>Expert Opin. Pharmacother.<\/i>, 10, 1847-1858."},{"key":"6","unstructured":"Knip, M., Douek, I.F., Moore, W.P., Gillmor, H.A., McLean, A.E., Bingley, P.J. &amp; Gale, E.A. (2000)  Safety of high-dose nicotinamide: a review.  <i>Diabetologia<\/i>, 43, 1337-1345."},{"key":"7","unstructured":"Levine, R.J., Maynard, S.E., Qian, C., Lim, K.H., England, L.J., Yu, K.F., Schisterman, E.F., Thadhani, R., Sachs, B.P., Epstein, F.H., Sibai, B.M., Sukhatme, V.P. &amp; Karumanchi, S.A. (2004)  Circulating angiogenic factors and the risk of preeclampsia.  <i>N. Engl. J. Med.<\/i>, 350, 672-683."},{"key":"8","unstructured":"Li, F., Fushima, T., Oyanagi, G., Townley-Tilson, H.W., Sato, E., Nakada, H., Oe, Y., Hagaman, J.R., Wilder, J., Li, M., Sekimoto, A., Saigusa, D., Sato, H., Ito, S., Jennette, J.C., et al. (2016)  Nicotinamide benefits both mothers and pups in two contrasting mouse models of preeclampsia.  <i>Proc. Natl. Acad. Sci. USA<\/i>, 113, 13450-13455."},{"key":"9","unstructured":"Li, F., Hagaman, J.R., Kim, H.S., Maeda, N., Jennette, J.C., Faber, J.E., Karumanchi, S.A., Smithies, O. &amp; Takahashi, N. (2012)  eNOS deficiency acts through endothelin to aggravate sFlt-1-induced pre-eclampsia-like phenotype.  <i>J. Am. Soc. Nephrol.<\/i>, 23, 652-660."},{"key":"10","unstructured":"Murphy, S.R., LaMarca, B.B., Cockrell, K. &amp; Granger, J.P. (2010)  Role of endothelin in mediating soluble fms-like tyrosine kinase 1-induced hypertension in pregnant rats.  <i>Hypertension<\/i>, 55, 394-398."},{"key":"11","unstructured":"Nuyt, A.M., Lavoie, J.C., Mohamed, I., Paquette, K. &amp; Luu, T.M. (2017)  Adult consequences of extremely preterm birth: cardiovascular and metabolic diseases risk factors, mechanisms, and prevention avenues.  <i>Clin. Perinatol.<\/i>, 44, 315-332."},{"key":"12","unstructured":"Sutton, P.S. &amp; Darmstadt, G.L. (2013)  Preterm birth and neurodevelopment: a review of outcomes and recommendations for early identification and cost-effective interventions.  <i>J. Trop. Pediatr.<\/i>, 59, 258-265."},{"key":"13","unstructured":"Thai, T.L. &amp; Arendshorst, W.J. (2008)  ADP-ribosyl cyclase and ryanodine receptors mediate endothelin ETA and ETB receptor-induced renal vasoconstriction in vivo.  <i>Am. J. Physiol. Renal Physiol.<\/i>, 295, F360-368."},{"key":"14","unstructured":"Townley-Tilson, W.H., Wu, Y., Ferguson, J.E. 3rd &amp; Patterson, C. (2014)  The ubiquitin ligase ASB4 promotes trophoblast differentiation through the degradation of ID2.  <i>PLoS One<\/i>, 9, e89451."},{"key":"15","unstructured":"von Dadelszen, P., Ornstein, M.P., Bull, S.B., Logan, A.G., Koren, G. &amp; Magee, L.A. (2000)  Fall in mean arterial pressure and fetal growth restriction in pregnancy hypertension: a meta-analysis.  <i>Lancet<\/i>, 355, 87-92."}],"container-title":["The Tohoku Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/tjem\/244\/3\/244_243\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,3,24]],"date-time":"2018-03-24T05:16:33Z","timestamp":1521868593000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/tjem\/244\/3\/244_243\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.1620\/tjem.244.243","relation":{},"ISSN":["0040-8727","1349-3329"],"issn-type":[{"value":"0040-8727","type":"print"},{"value":"1349-3329","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}