{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T16:10:08Z","timestamp":1768925408598,"version":"3.49.0"},"reference-count":27,"publisher":"Tohoku University Medical Press","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tohoku J. Exp. Med."],"published-print":{"date-parts":[[2018]]},"DOI":"10.1620\/tjem.245.239","type":"journal-article","created":{"date-parts":[[2018,8,8]],"date-time":"2018-08-08T18:59:46Z","timestamp":1533754786000},"page":"239-243","source":"Crossref","is-referenced-by-count":5,"title":["Serum Osteocalcin Levels in Girls with Central Precocious Puberty: Relation to the Onset of Puberty"],"prefix":"10.1620","volume":"245","author":[{"given":"Won Young","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Korea University College of Medicine"},{"name":"Department of Pediatrics, Korea University Ansan Hospital, Korea University College of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geehae","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Korea University College of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hye Ryun","family":"Kim","sequence":"additional","affiliation":[{"name":"Woorisoa Children\u2019s Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyo-Kyoung","family":"Nam","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Korea University College of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Jun","family":"Rhie","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Korea University College of Medicine"},{"name":"Department of Pediatrics, Korea University Ansan Hospital, Korea University College of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kee-Hyoung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Korea University College of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"622","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"Abrams, S.A., Copeland, K.C., Gunn, S.K., Gundberg, C.M., Klein, K.O. &amp; Ellis, K.J. (2000)  Calcium absorption, bone mass accumulation, and kinetics increase during early pubertal development in girls.  <i>J. Clin. Endocrinol. Metab<\/i>., 85, 1805-1809.","DOI":"10.1210\/jc.85.5.1805"},{"key":"2","doi-asserted-by":"crossref","unstructured":"Booth, S.L., Centi, A., Smith, S.R. &amp; Gundberg, C. (2013)  The role of osteocalcin in human glucose metabolism: marker or mediator?  <i>Nat. Rev. Endocrinol<\/i>., 9, 43-55.","DOI":"10.1038\/nrendo.2012.201"},{"key":"3","doi-asserted-by":"crossref","unstructured":"Carel, J.C. &amp; Leger, J. (2008)  Clinical Practice.  Precocious puberty. <i>N. Engl. J. Med<\/i>., 358, 2366-2377.","DOI":"10.1056\/NEJMcp0800459"},{"key":"4","unstructured":"Cioffi, M., Molinari, A.M., Gazzerro, P., Di Finizio, B., Fratta, M., Deufemia, A. &amp; Puca, G.A. (1997)  Serum osteocalcin in 1634 healthy children.  <i>Clin. Chem<\/i>., 43, 543-545."},{"key":"5","doi-asserted-by":"crossref","unstructured":"Delmas, P.D.  (1993)  Biochemical markers of bone turnover.  <i>J. Bone Miner. Res.<\/i>, 8 Supple 2, S549-555.","DOI":"10.1002\/jbmr.5650081323"},{"key":"6","doi-asserted-by":"crossref","unstructured":"Federico, G., Baroncelli, G.I., Vanacore, T., Fiore, L. &amp; Saggese, G. (2003)  Pubertal changes in biochemical markers of growth.  <i>Horm. Res<\/i>., 60, 46-51.","DOI":"10.1159\/000071225"},{"key":"7","doi-asserted-by":"crossref","unstructured":"Ferron, M., McKee, M.D., Levine, R.L., Ducy, P. &amp; Karsenty, G. (2012)  Intermittent injections of osteocalcin improve glucose metabolism and prevent type 2 diabetes in mice.  <i>Bone<\/i>, 50, 568-575.","DOI":"10.1016\/j.bone.2011.04.017"},{"key":"8","doi-asserted-by":"crossref","unstructured":"Hannon, T.S., Janosky, J. &amp; Arslanian, S.A. (2006)  Longitudinal study of physiologic insulin resistance and metabolic changes of puberty.  <i>Pediatr. Res<\/i>., 60, 759-763.","DOI":"10.1203\/01.pdr.0000246097.73031.27"},{"key":"9","doi-asserted-by":"crossref","unstructured":"Im, J.A., Yu, B.P., Jeon, J.Y. &amp; Kim, S.H. (2008)  Relationship between osteocalcin and glucose metabolism in postmenopausal women.  <i>Clin. Chim. Acta<\/i>, 396, 66-69.","DOI":"10.1016\/j.cca.2008.07.001"},{"key":"10","doi-asserted-by":"crossref","unstructured":"J\u00fcrim\u00e4e, J., L\u00e4tt, E., M\u00e4estu, J., Saar, M., Purge, P., Maasalu, K. &amp; J\u00fcrim\u00e4e, T. (2015)  Osteocalcin is inversely associated with adiposity and leptin in adolescent boys.  <i>J. Pediatr. Endocrinol. Metab<\/i>., 28, 571-577.","DOI":"10.1515\/jpem-2014-0432"},{"key":"11","doi-asserted-by":"crossref","unstructured":"Kelsey, M.M. &amp; Zeitler, P.S. (2016)  Insulin resistance of puberty.  <i>Curr. Diab. Rep<\/i>., 16, 64.","DOI":"10.1007\/s11892-016-0751-5"},{"key":"12","doi-asserted-by":"crossref","unstructured":"Kindblom, J.M., Ohlsson, C., Ljunggren, \u00d6., Karlsson, M.K., Tivesten, \u00c5., Smith, U. &amp; Mellstr\u00f6m, D. (2009)  Plasma osteocalcin is inversely related to fat mass and plasma glucose in elderly Swedish men.  <i>J. Bone Miner. Res<\/i>., 24, 785-791.","DOI":"10.1359\/jbmr.081234"},{"key":"13","doi-asserted-by":"crossref","unstructured":"Klein, K.O.  (1999)  Precocious puberty: who has it?  Who should be treated?  <i>J. Clin. Endocrinol. Metab<\/i>., 84, 411-414.","DOI":"10.1210\/jcem.84.2.5533"},{"key":"14","doi-asserted-by":"crossref","unstructured":"Lee, N.K., Sowa, H., Hinoi, E., Ferron, M., Ahn, J.D., Confavreux, C., Dacquin, R., Mee, P.J., McKee, M.D., Jung, D.Y., Zhang, Z., Kim, J.K., Mauvais-Jarvis, F., Ducy, P., &amp; Karsenty, G. (2007)  Endocrine regulation of energy metabolism by the skeleton.  <i>Cell<\/i>, 130, 456-469.","DOI":"10.1016\/j.cell.2007.05.047"},{"key":"15","doi-asserted-by":"crossref","unstructured":"Magnusson, P., H\u00e4ger, A. &amp; Larsson, L. (1995)  Serum osteocalcin and bone and liver alkaline phosphatase isoforms in healthy children and adolescents.  <i>Pediatr. Res<\/i>., 38, 955-961.","DOI":"10.1203\/00006450-199512000-00021"},{"key":"16","doi-asserted-by":"crossref","unstructured":"Moran, A., Jacobs, D.R. Jr., Steinberger, J., Hong, C.P., Prineas, R., Luepker, R. &amp; Sinaiko, A.R. (1999)  Insulin resistance during puberty: results from clamp studies in 357 children.  <i>Diabetes<\/i>, 48, 2039-2044.","DOI":"10.2337\/diabetes.48.10.2039"},{"key":"17","doi-asserted-by":"crossref","unstructured":"Nimptsch, K., Hailer, S., Rohrmann, S., Gedrich, K., Wolfram, G. &amp; Linseisen, J. (2007)  Determinants and correlates of serum undercarboxylated osteocalcin.  <i>Ann. Nutr. Metab<\/i>., 51, 563-570.","DOI":"10.1159\/000114211"},{"key":"18","doi-asserted-by":"crossref","unstructured":"Oury, F., Sumara, G., Sumara, O., Ferron, M., Chang, H., Smith, C.E., Hermo, L., Suarez, S., Roth, B.L., Ducy, P &amp; Karsenty, G. (2011)  Endocrine regulation of male fertility by the skeleton.  <i>Cell<\/i>, 144, 796-809.","DOI":"10.1016\/j.cell.2011.02.004"},{"key":"19","doi-asserted-by":"crossref","unstructured":"Parent, A.S., Rasier, G., Gerard, A., Heger, S., Roth, C., Mastronardi, C., Jung, H., Ojeda, S.R. &amp; Bourguignon, J.P. (2005)  Early onset of puberty: tracking genetic and environmental factors.  <i>Horm. Res<\/i>., 64 Supple 2, 41-47.","DOI":"10.1159\/000087753"},{"key":"20","doi-asserted-by":"crossref","unstructured":"Rotteveel, J., Schoute, E. &amp; Delemarre-van de Waal, H.A. (1997)  Serum procollagen I carboxyterminal propeptide (PICP) levels through puberty: relation to height velocity and serum hormone levels.  <i>Acta Paediatr<\/i>., 86, 143-147.","DOI":"10.1111\/j.1651-2227.1997.tb08855.x"},{"key":"21","doi-asserted-by":"crossref","unstructured":"Saggese, G., Baroncelli, G.I. &amp; Bertelloni, S. (2002)  Puberty and bone development.  <i>Best Pract. Res. Clin. Endocrinol. Metab<\/i>., 16, 53-64.","DOI":"10.1053\/beem.2001.0180"},{"key":"22","doi-asserted-by":"crossref","unstructured":"Sch\u00fcndeln, M.M., B\u00e4der, L., Kiewert, C., Herrmann, R., F\u00fchrer, D., Hauffa, B.P. &amp; Grasemann, C. (2017)  Plasma concentrations of osteocalcin are associated with the timing of pubertal progress in boys.  <i>J. Pediatr. Endocrinol. Metab<\/i>., 30, 141-147.","DOI":"10.1515\/jpem-2016-0243"},{"key":"23","doi-asserted-by":"crossref","unstructured":"Shalitin, S. &amp; Phillip, M. (2003)  Role of obesity and leptin in the pubertal process and pubertal growth: a review.  <i>Int. J. Obes. Relat. Metab. Disord<\/i>., 27, 869-874.","DOI":"10.1038\/sj.ijo.0802328"},{"key":"24","doi-asserted-by":"crossref","unstructured":"Slyper, A.H. (2006)  The pubertal timing controversy in the USA, and a review of possible causative factors for the advance in timing of onset of puberty.  <i>Clin. Endocrinol<\/i>. (<i>Oxf<\/i>.), 65, 1-8.","DOI":"10.1111\/j.1365-2265.2006.02539.x"},{"key":"25","doi-asserted-by":"crossref","unstructured":"Szulc, P., Seeman, E. &amp; Delmas, P.D. (2000)  Biochemical measurements of bone turnover in children and adolescents.  <i>Osteoporos. Int<\/i>., 11, 281-294.","DOI":"10.1007\/s001980070116"},{"key":"26","doi-asserted-by":"crossref","unstructured":"Wei, J. &amp; Karsenty, G. (2015)  An overview of the metabolic functions of osteocalcin.  <i>Rev. Endocr. Metab. Disord<\/i>., 16, 93-98.","DOI":"10.1007\/s11154-014-9307-7"},{"key":"27","doi-asserted-by":"crossref","unstructured":"Zhou, M., Ma, X., Li, H., Pan, X., Tang, J., Gao, Y., Hou, X., Lu, H., Bao, Y. &amp; Jia, W. (2009)  Serum osteocalcin concentrations in relation to glucose and lipid metabolism in Chinese individuals.  <i>Eur. J. Endocrinol<\/i>., 161, 723-729.","DOI":"10.1530\/EJE-09-0585"}],"container-title":["The Tohoku Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/tjem\/245\/4\/245_239\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,8,11]],"date-time":"2018-08-11T00:51:01Z","timestamp":1533948661000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/tjem\/245\/4\/245_239\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.1620\/tjem.245.239","relation":{},"ISSN":["0040-8727","1349-3329"],"issn-type":[{"value":"0040-8727","type":"print"},{"value":"1349-3329","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}