{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T22:12:45Z","timestamp":1784326365456,"version":"3.55.0"},"reference-count":119,"publisher":"Tohoku University Medical Press","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tohoku J. Exp. Med."],"published-print":{"date-parts":[[2019]]},"DOI":"10.1620\/tjem.247.87","type":"journal-article","created":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T22:43:02Z","timestamp":1550184182000},"page":"87-98","source":"Crossref","is-referenced-by-count":46,"title":["Interleukin-17: The Role for Pathological Angiogenesis in Ocular Neovascular Diseases"],"prefix":"10.1620","volume":"247","author":[{"given":"Yuanjun","family":"Li","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, The Second Xiangya Hospital, Central South University"},{"name":"Department of Ophthalmology, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yedi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Second Xiangya Hospital, Central South University"},{"name":"Hunan Clinical Research Center of Ophthalmic Disease"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"622","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"Alivand, M.R., Sabouni, F. &amp; Soheili, Z.S. (2016) Probable chemical hypoxia effects on progress of CNV through induction of promoter CpG demethylation and overexpression of IL17RC in human RPE cells. <i>Curr. Eye Res<\/i>., 41, 1245-1254.","DOI":"10.3109\/02713683.2015.1095933"},{"key":"2","doi-asserted-by":"crossref","unstructured":"Amadio, M., Govoni, S. &amp; Pascale, A. (2016) Targeting VEGF in eye neovascularization: what\u2019s new?: a comprehensive review on current therapies and oligonucleotide-based interventions under development. <i>Pharmacol. Res<\/i>., 103, 253-269.","DOI":"10.1016\/j.phrs.2015.11.027"},{"key":"3","doi-asserted-by":"crossref","unstructured":"Baeten, D., Baraliakos, X., Braun, J., Sieper, J., Emery, P., van der Heijde, D., McInnes, I., van Laar, J.M., Landewe, R., Wordsworth, P., Wollenhaupt, J., Kellner, H., Paramarta, J., Wei, J.W., Brachat, A., et al. (2013) Anti-interleukin-17A monoclonal antibody secukinumab in treatment of ankylosing spondylitis: a randomised, double-blind, placebo-controlled trial. <i>Lancet<\/i>, 382, 1705-1713.","DOI":"10.1016\/S0140-6736(13)61134-4"},{"key":"4","doi-asserted-by":"crossref","unstructured":"Beurel, E., Harrington, L.E. &amp; Jope, R.S. (2013) Inflammatory T helper 17 cells promote depression-like behavior in mice. <i>Biol. Psychiatry<\/i>, 73, 622-630.","DOI":"10.1016\/j.biopsych.2012.09.021"},{"key":"5","doi-asserted-by":"crossref","unstructured":"Beurel, E. &amp; Lowell, J.A. (2018) Th17 cells in depression. <i>Brain Behav. Immun<\/i>., 69, 28-34.","DOI":"10.1016\/j.bbi.2017.08.001"},{"key":"6","doi-asserted-by":"crossref","unstructured":"Cai, Y., Tan, W., Shen, X., Zhu, Y., Gao, Y., Sui, A., Lu, Q., Zhong, Y. &amp; Xie, B. (2016) Neutralization of IL-23 depresses experimental ocular neovascularization. <i>Exp. Eye Res<\/i>., 146, 242-251.","DOI":"10.1016\/j.exer.2016.02.008"},{"key":"7","doi-asserted-by":"crossref","unstructured":"Campochiaro, P.A. (2013) Ocular neovascularization. <i>J. Mol. Med. <\/i>(<i>Berl<\/i>.), 91, 311-321.","DOI":"10.1007\/s00109-013-0993-5"},{"key":"8","doi-asserted-by":"crossref","unstructured":"Chabaud, M., Lubberts, E., Joosten, L., van Den Berg, W. &amp; Miossec, P. (2001) IL-17 derived from juxta-articular bone and synovium contributes to joint degradation in rheumatoid arthritis. <i>Arthritis Res<\/i>., 3, 168-177.","DOI":"10.1186\/ar294"},{"key":"9","doi-asserted-by":"crossref","unstructured":"Chan, C.C. &amp; Ardeljan, D. (2014) Molecular pathology of macrophages and interleukin-17 in age-related macular degeneration. <i>Adv. Exp. Med. Biol<\/i>., 801, 193-198.","DOI":"10.1007\/978-1-4614-3209-8_25"},{"key":"10","doi-asserted-by":"crossref","unstructured":"Chang, S.L., Hsiao, Y.W., Tsai, Y.N., Lin, S.F., Liu, S.H., Lin, Y.J., Lo, L.W., Chung, F.P., Chao, T.F., Hu, Y.F., Tuan, T.C., Liao, J.N., Hsieh, Y.C., Wu, T.J., Higa, S., et al. (2018) Interleukin-17 enhances cardiac ventricular remodeling via activating MAPK pathway in ischemic heart failure. <i>J. Mol. Cell. Cardiol<\/i>., 122, 69-79.","DOI":"10.1016\/j.yjmcc.2018.08.005"},{"key":"11","doi-asserted-by":"crossref","unstructured":"Chen, H., Ren, X.R., Liao, N.Y. &amp; Wen, F. (2016) Th17 cell frequency and IL-17A concentrations in peripheral blood mononuclear cells and vitreous fluid from patients with diabetic retinopathy. <i>J. Int. Med. Res<\/i>., 44, 1403-1413.","DOI":"10.1177\/0300060516672369"},{"key":"12","doi-asserted-by":"crossref","unstructured":"Chen, J.J., Wang, W.Z. &amp; Li, Q.M. (2017) Increased Th1\/Th17 responses contribute to low-grade inflammation in age-related macular degeneration. <i>Cell. Physiol. Biochem<\/i>., 44, 357-367.","DOI":"10.1159\/000484907"},{"key":"13","doi-asserted-by":"crossref","unstructured":"Chen, Y., Zhong, M., Yuan, G. &amp; Peng, H. (2018) Interleukin-17 induces angiogenesis in vitro via CXCL8 and CCL2 in retinal pigment epithelium. <i>Mol. Med. Rep<\/i>., 17, 4627-4632.","DOI":"10.3892\/mmr.2018.8460"},{"key":"14","doi-asserted-by":"crossref","unstructured":"Chen, Y., Zhong, M.R., Liang, L., Gu, F.J. &amp; Peng, H. (2014) Interleukin-17 induces angiogenesis in human choroidal endothelial cells in vitro. <i>Invest. Ophthalmol. Vis. Sci<\/i>., 55, 6968-6975.","DOI":"10.1167\/iovs.14-15029"},{"key":"15","doi-asserted-by":"crossref","unstructured":"Cipolla, E., Fisher, A.J., Gu, H., Mickler, E.A., Agarwal, M., Wilke, C.A., Kim, K.K., Moore, B.B. &amp; Vittal, R. (2017) IL-17A deficiency mitigates bleomycin-induced complement activation during lung fibrosis. <i>FASEB J<\/i>., 31, 5543-5556.","DOI":"10.1096\/fj.201700289R"},{"key":"16","doi-asserted-by":"crossref","unstructured":"Coughlin, B., Schnabolk, G., Joseph, K., Raikwar, H., Kunchithapautham, K., Johnson, K., Moore, K., Wang, Y. &amp; Rohrer, B. (2016) Connecting the innate and adaptive immune responses in mouse choroidal neovascularization via the anaphylatoxin C5a and gamma delta T-cells. <i>Sci. Rep<\/i>., 6, 23794.","DOI":"10.1038\/srep23794"},{"key":"17","doi-asserted-by":"crossref","unstructured":"Croxford, A.L., Karbach, S., Kurschus, F.C., Wortge, S., Nikolaev, A., Yogev, N., Klebow, S., Schuler, R., Reissig, S., Piotrowski, C., Brylla, E., Bechmann, I., Scheller, J., Rose-John, S., Thomas Wunderlich, F., et al. (2014) IL-6 regulates neutrophil microabscess formation in IL-17A-driven psoriasiform lesions. <i>J. Invest. Dermatol<\/i>., 134, 728-735.","DOI":"10.1038\/jid.2013.404"},{"key":"18","doi-asserted-by":"crossref","unstructured":"Dabrowska, A.M. &amp; Skopinski, P. (2017) Stem cells in regenerative medicine - from laboratory to clinical application: the eye. <i>Cent. Eur. J. Immunol<\/i>., 42, 173-180.","DOI":"10.5114\/ceji.2017.69360"},{"key":"19","doi-asserted-by":"crossref","unstructured":"Ding, X.Y., Patel, M. &amp; Chan, C.C. (2009) Molecular pathology of age-related macular degeneration. <i>Prog. Retin. Eye Res<\/i>., 28, 1-18.","DOI":"10.1016\/j.preteyeres.2008.10.001"},{"key":"20","doi-asserted-by":"crossref","unstructured":"Drutskaya, M.S., Efimov, G.A., Astrakhantseva, I.V., Kruglov, A.A. &amp; Nedospasov, S.A. (2016) Making anti-cytokine therapy more selective: studies in mice. <i>Cytokine<\/i>, 101, 33-38.","DOI":"10.1016\/j.cyto.2016.08.022"},{"key":"21","doi-asserted-by":"crossref","unstructured":"Duechting, A., Przybyla, A., Kuerten, S. &amp; Lehmann, P.V. (2017) Delayed activation kinetics of Th2 and Th17 cells compared to Th1 cells. <i>Cells<\/i>, 6, 29.","DOI":"10.3390\/cells6030029"},{"key":"22","doi-asserted-by":"crossref","unstructured":"Esteller, M. (2011) Non-coding RNAs in human disease. <i>Nat. Rev. Genet<\/i>., 12, 861-874.","DOI":"10.1038\/nrg3074"},{"key":"23","doi-asserted-by":"crossref","unstructured":"Fong, D.S., Aiello, L., Gardner, T.W., King, G.L., Blankenship, G., Cavallerano, J.D., Ferris, F.L. 3rd &amp; Klein, R.; American Diabetes Association (2004) Retinopathy in diabetes. <i>Diabetes Care<\/i>, 27 Suppl 1, S84-87.","DOI":"10.2337\/diacare.27.2007.S84"},{"key":"24","unstructured":"Garbutcheon-Singh, K.B., Carnt, N., Pattamatta, U., Samarawickrama, C., White, A. &amp; Calder, V. (2018) A review of the cytokine IL-17 in ocular surface and corneal disease. <i>Curr. Eye Res.<\/i>, 1-10."},{"key":"25","doi-asserted-by":"crossref","unstructured":"Gariano, R.F. &amp; Gardner, T.W. (2005) Retinal angiogenesis in development and disease. <i>Nature<\/i>, 438, 960-966.","DOI":"10.1038\/nature04482"},{"key":"26","doi-asserted-by":"crossref","unstructured":"Guan, X., Liu, Z., Zhang, J. &amp; Jin, X. (2018) Myeloid-derived suppressor cell accumulation in renal cell carcinoma is correlated with CCL2, IL-17 and IL-18 expression in blood and tumors. <i>Adv. Clin. Exp. Med<\/i>., 27, 947-953.","DOI":"10.17219\/acem\/70065"},{"key":"27","unstructured":"Hang, H., Yuan, S., Yang, Q., Yuan, D. &amp; Liu, Q. (2014) Multiplex bead array assay of plasma cytokines in type 2 diabetes mellitus with diabetic retinopathy. <i>Mol. Vis<\/i>., 20, 1137-1145."},{"key":"28","doi-asserted-by":"crossref","unstructured":"Hasegawa, E., Sonoda, K.H., Shichita, T., Morita, R., Sekiya, T., Kimura, A., Oshima, Y., Takeda, A., Yoshimura, T., Yoshida, S., Ishibashi, T. &amp; Yoshimura, A. (2013) IL-23-independent induction of IL-17 from gammadeltaT cells and innate lymphoid cells promotes experimental intraocular neovascularization. <i>J. Immunol<\/i>., 190, 1778-1787.","DOI":"10.4049\/jimmunol.1202495"},{"key":"29","doi-asserted-by":"crossref","unstructured":"He, Q., Li, F., Li, J., Li, R., Zhan, G., Li, G., Du, W. &amp; Tan, H. (2017) MicroRNA-26a-interleukin (IL)-6-IL-17 axis regulates the development of non-alcoholic fatty liver disease in a murine model. <i>Clin. Exp. Immunol<\/i>., 187, 174-184.","DOI":"10.1111\/cei.12838"},{"key":"30","doi-asserted-by":"crossref","unstructured":"He, S., Li, X.F., Li, R.P., Fang, L.Z., Sun, L.Y., Wang, Y.S. &amp; Wu, M. (2016) Annexin A2 modulates ROS and impacts inflammatory response via IL-17 signaling in polymicrobial sepsis mice. <i>PLoS Pathog<\/i>., 12, e1005743.","DOI":"10.1371\/journal.ppat.1005743"},{"key":"31","doi-asserted-by":"crossref","unstructured":"Herjan, T., Hong, L., Bubenik, J., Bulek, K., Qian, W., Liu, C., Li, X., Chen, X., Yang, H., Ouyang, S., Zhou, H., Zhao, J., Vasu, K., Cockman, E., Aronica, M., et al. (2018) IL-17-receptor-associated adaptor Act1 directly stabilizes mRNAs to mediate IL-17 inflammatory signaling. <i>Nat. Immunol<\/i>., 19, 354-365.","DOI":"10.1038\/s41590-018-0071-9"},{"key":"32","doi-asserted-by":"crossref","unstructured":"Hernandez-Zimbron, L.F., Zamora-Alvarado, R., Ochoa-De la Paz, L., Velez-Montoya, R., Zenteno, E., Gulias-Canizo, R., Quiroz-Mercado, H. &amp; Gonzalez-Salinas, R. (2018) Age-related macular degeneration: new paradigms for treatment and management of AMD. <i>Oxid. Med. Cell. Longev<\/i>., 2018, 8374347.","DOI":"10.1155\/2018\/8374647"},{"key":"33","doi-asserted-by":"crossref","unstructured":"Hohenberger, M., Cardwell, L.A., Oussedik, E. &amp; Feldman, S.R. (2018) Interleukin-17 inhibition: role in psoriasis and inflammatory bowel disease. <i>J. Dermatolog. Treat<\/i>., 29, 13-18.","DOI":"10.1080\/09546634.2017.1329511"},{"key":"34","doi-asserted-by":"crossref","unstructured":"Honorati, M.C., Neri, S., Cattini, L. &amp; Facchini, A. (2006) Interleukin-17, a regulator of angiogenic factor release by synovial fibroblasts. <i>Osteoarthritis Cartilage<\/i>, 14, 345-352.","DOI":"10.1016\/j.joca.2005.10.004"},{"key":"35","doi-asserted-by":"crossref","unstructured":"Hosseini, H., Khalili, M.R. &amp; Nowroozizadeh, S. (2009) Intravitreal injection of bevacizumab (Avastin) for treatment of stage 3 retinopathy of prematurity in zone I or posterior zone II. <i>Retina<\/i>, 29, 562.","DOI":"10.1097\/IAE.0b013e31819a98a9"},{"key":"36","unstructured":"Huang, X.G., Zhou, G.H., Wu, W.Y., Duan, Y.J., Ma, G.E., Song, J.Y., Xiao, R., Vandenberghe, L., Zhang, F., D\u2019Amore, P.A. &amp; Lei, H.T. (2017) Genome editing abrogates angiogenesis in vivo. <i>Nat. Commun<\/i>., 8, 112."},{"key":"37","doi-asserted-by":"crossref","unstructured":"Huppert, J., Closhen, D., Croxford, A., White, R., Kulig, P., Pietrowski, E., Bechmann, I., Becher, B., Luhmann, H.J., Waisman, A. &amp; Kuhlmann, C.R. (2010) Cellular mechanisms of IL-17-induced blood-brain barrier disruption. <i>FASEB J<\/i>., 24, 1023-1034.","DOI":"10.1096\/fj.09-141978"},{"key":"38","doi-asserted-by":"crossref","unstructured":"Iijima, H. (2018) Mechanisms of vision loss in eyes with macular edema associated with retinal vein occlusion. <i>Jpn. J. Ophthalmol<\/i>., 62, 265-273.","DOI":"10.1007\/s10384-018-0586-5"},{"key":"39","doi-asserted-by":"crossref","unstructured":"Ishida, S., Yamashiro, K., Usui, T., Kaji, Y., Ogura, Y., Hida, T., Honda, Y., Oguchi, Y. &amp; Adamis, A.P. (2003) Leukocytes mediate retinal vascular remodeling during development and vaso-obliteration in disease. <i>Nat. Med<\/i>., 9, 781-788.","DOI":"10.1038\/nm877"},{"key":"40","doi-asserted-by":"crossref","unstructured":"Jardeleza, M.S. &amp; Miller, J.W. (2009) Review of anti-VEGF therapy in proliferative diabetic retinopathy. <i>Semin. Ophthalmol<\/i>., 24, 87-92.","DOI":"10.1080\/08820530902800330"},{"key":"41","doi-asserted-by":"crossref","unstructured":"Jetten, N., Verbruggen, S., Gijbels, M.J., Post, M.J., De Winther, M.P. &amp; Donners, M.M. (2014) Anti-inflammatory M2, but not pro-inflammatory M1 macrophages promote angiogenesis in vivo. <i>Angiogenesis<\/i>, 17, 109-118.","DOI":"10.1007\/s10456-013-9381-6"},{"key":"42","doi-asserted-by":"crossref","unstructured":"Kaneda, S., Miyazaki, D., Sasaki, S., Yakura, K., Terasaka, Y., Miyake, K., Ikeda, Y., Funakoshi, T., Baba, T., Yamasaki, A. &amp; Inoue, Y. (2011) Multivariate analyses of inflammatory cytokines in eyes with branch retinal vein occlusion: relationships to bevacizumab treatment. <i>Invest. Ophth. Vis. Sci<\/i>., 52, 2982-2988.","DOI":"10.1167\/iovs.10-6299"},{"key":"43","doi-asserted-by":"crossref","unstructured":"Karbasforooshan, H. &amp; Karimi, G. (2018) The role of SIRT1 in diabetic retinopathy. <i>Biomed. Pharmacother<\/i>., 97, 190-194.","DOI":"10.1016\/j.biopha.2017.10.075"},{"key":"44","doi-asserted-by":"crossref","unstructured":"Kauppinen, A., Paterno, J.J., Blasiak, J., Salminen, A. &amp; Kaarniranta, K. (2016) Inflammation and its role in age-related macular degeneration. <i>Cell. Mol. Life Sci<\/i>., 73, 1765-1786.","DOI":"10.1007\/s00018-016-2147-8"},{"key":"45","doi-asserted-by":"crossref","unstructured":"Kebir, H., Kreymborg, K., Ifergan, I., Dodelet-Devillers, A., Cayrol, R., Bernard, M., Giuliani, F., Arbour, N., Becher, B. &amp; Prat, A. (2007) Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation. <i>Nat. Med<\/i>., 13, 1173-1175.","DOI":"10.1038\/nm1651"},{"key":"46","doi-asserted-by":"crossref","unstructured":"Klatzmann, D. &amp; Abbas, A.K. (2015) The promise of low-dose interleukin-2 therapy for autoimmune and inflammatory diseases. <i>Nat. Rev. Immunol<\/i>., 15, 283-294.","DOI":"10.1038\/nri3823"},{"key":"47","doi-asserted-by":"crossref","unstructured":"Korn, T., Bettelli, E., Oukka, M. &amp; Kuchroo, V.K. (2009) IL-17 and Th17 Cells. <i>Annu. Rev. Immunol<\/i>., 27, 485-517.","DOI":"10.1146\/annurev.immunol.021908.132710"},{"key":"48","doi-asserted-by":"crossref","unstructured":"Lawrence, S.M., Ruoss, J.L. &amp; Wynn, J.L. (2018) IL-17 in neonatal health and disease. <i>Am. J. Reprod. Immunol<\/i>., 79, e12800.","DOI":"10.1111\/aji.12800"},{"key":"49","doi-asserted-by":"crossref","unstructured":"Li, Y., Jiang, L., Zhang, S., Yin, L., Ma, L., He, D. &amp; Shen, J. (2012) Methotrexate attenuates the Th17\/IL-17 levels in peripheral blood mononuclear cells from healthy individuals and RA patients. <i>Rheumatol. Int<\/i>., 32, 2415-2422.","DOI":"10.1007\/s00296-011-1867-1"},{"key":"50","doi-asserted-by":"crossref","unstructured":"Li, Y.F., Zhang, S.X., Ma, X.W., Xue, Y.L., Gao, C. &amp; Li, X.Y. (2017) Levels of peripheral Th17 cells and serum Th17-related cytokines in patients with multiple sclerosis: a meta-analysis. <i>Mult. Scler. Relat. Disord<\/i>., 18, 20-25.","DOI":"10.1016\/j.msard.2017.09.003"},{"key":"51","doi-asserted-by":"crossref","unstructured":"Lin, K.L., Hirose, T., Kroll, A.J., Lou, P.L. &amp; Ryan, E.A. (2009) Prospects for treatment of pediatric vitreoretinal diseases with vascular endothelial growth factor inhibition. <i>Semin. Ophthalmol<\/i>., 24, 70-76.","DOI":"10.1080\/08820530902800108"},{"key":"52","doi-asserted-by":"crossref","unstructured":"Liu, B.Y., Wei, L., Meyerle, C., Tuo, J.S., Sen, H.N., Li, Z.Y., Chakrabarty, S., Agron, E., Chan, C.C., Klein, M.L., Chew, E., Ferris, F. &amp; Nussenblatt, R.B. (2011) Complement component C5a promotes expression of IL-22 and IL-17 from human T cells and its implication in age-related macular degeneration. <i>J. Transl. Med<\/i>., 9, 1-12.","DOI":"10.1186\/1479-5876-9-111"},{"key":"53","doi-asserted-by":"crossref","unstructured":"Liu, G., Wu, H., Chen, L., Xu, J., Wang, M., Li, D. &amp; Lu, P. (2017a) Effects of interleukin-17 on human retinal vascular endothelial cell capillary tube formation in vitro. <i>Mol. Med. Rep<\/i>., 16, 865-872.","DOI":"10.3892\/mmr.2017.6623"},{"key":"54","doi-asserted-by":"crossref","unstructured":"Liu, G., Wu, H., Lu, P. &amp; Zhang, X. (2017b) Interleukin (IL)-17A promotes angiogenesis in an experimental corneal neovascularization model. <i>Curr. Eye Res<\/i>., 42, 368-379.","DOI":"10.1080\/02713683.2016.1196705"},{"key":"55","doi-asserted-by":"crossref","unstructured":"Liu, S.L., Lin, Y. &amp; Liu, X. (2016) Protective effects of SIRT1 in patients with proliferative diabetic retinopathy via the inhibition of IL-17 expression. <i>Exp. Ther. Med<\/i>., 11, 257-262.","DOI":"10.3892\/etm.2015.2877"},{"key":"56","doi-asserted-by":"crossref","unstructured":"Lubberts, E. (2008) IL-17\/Th17 targeting: on the road to prevent chronic destructive arthritis? <i>Cytokine<\/i>, 41, 84-91.","DOI":"10.1016\/j.cyto.2007.09.014"},{"key":"57","doi-asserted-by":"crossref","unstructured":"Mahecha, A.M. &amp; Wang, H. (2017) The influence of vascular endothelial growth factor-A and matrix metalloproteinase-2 and -9 in angiogenesis, metastasis, and prognosis of endometrial cancer. <i>Onco Targets Ther<\/i>., 10, 4617-4624.","DOI":"10.2147\/OTT.S132558"},{"key":"58","doi-asserted-by":"crossref","unstructured":"Manel, N., Unutmaz, D. &amp; Littman, D.R. (2008) The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor ROR gammat. <i>Nat. Immunol<\/i>., 9, 641-649.","DOI":"10.1038\/ni.1610"},{"key":"59","doi-asserted-by":"crossref","unstructured":"Mantovani, A., Biswas, S.K., Galdiero, M.R., Sica, A. &amp; Locati, M. (2013) Macrophage plasticity and polarization in tissue repair and remodelling. <i>J. Pathol<\/i>., 229, 176-185.","DOI":"10.1002\/path.4133"},{"key":"60","doi-asserted-by":"crossref","unstructured":"Mantovani, A., Sica, A., Sozzani, S., Allavena, P., Vecchi, A. &amp; Locati, M. (2004) The chemokine system in diverse forms of macrophage activation and polarization. <i>Trends Immunol<\/i>., 25, 677-686.","DOI":"10.1016\/j.it.2004.09.015"},{"key":"61","doi-asserted-by":"crossref","unstructured":"Martinez, F.O., Sica, A., Mantovani, A. &amp; Locati, M. (2008) Macrophage activation and polarization. <i>Front. Biosci<\/i>., 13, 453-461.","DOI":"10.2741\/2692"},{"key":"62","doi-asserted-by":"crossref","unstructured":"Matsuzaki, G. &amp; Umemura, M. (2007) Interleukin-17 as an effector molecule of innate and acquired immunity against infections. <i>Microbiol. Immunol<\/i>., 51, 1139-1147.","DOI":"10.1111\/j.1348-0421.2007.tb04008.x"},{"key":"63","doi-asserted-by":"crossref","unstructured":"Matsuzaki, G. &amp; Umemura, M. (2018) Interleukin-17 family cytokines in protective immunity against infections: role of hematopoietic cell-derived and non-hematopoietic cell-derived interleukin-17s. <i>Microbiol. Immunol<\/i>., 62, 1-13.","DOI":"10.1111\/1348-0421.12560"},{"key":"64","doi-asserted-by":"crossref","unstructured":"Mercer, T.R., Dinger, M.E. &amp; Mattick, J.S. (2009) Long non-coding RNAs: insights into functions. <i>Nat. Rev. Genet<\/i>., 10, 155-159.","DOI":"10.1038\/nrg2521"},{"key":"65","doi-asserted-by":"crossref","unstructured":"Mulik, S., Xu, J., Reddy, P.B., Rajasagi, N.K., Gimenez, F., Sharma, S., Lu, P.Y. &amp; Rouse, B.T. (2012) Role of miR-132 in angiogenesis after ocular infection with herpes simplex virus. <i>Am. J. Pathol<\/i>., 181, 525-534.","DOI":"10.1016\/j.ajpath.2012.04.014"},{"key":"66","doi-asserted-by":"crossref","unstructured":"Murdoch, C., Muthana, M., Coffelt, S.B. &amp; Lewis, C.E. (2008) The role of myeloid cells in the promotion of tumour angiogenesis. <i>Nat. Rev. Cancer<\/i>, 8, 618-631.","DOI":"10.1038\/nrc2444"},{"key":"67","doi-asserted-by":"crossref","unstructured":"Nagashima, H., Okuyama, Y., Hayashi, T., Ishii, N. &amp; So, T. (2016) TNFR-associated factors 2 and 5 differentially regulate the instructive IL-6 receptor signaling required for Th17 development. <i>J. Immunol<\/i>., 196, 4082-4089.","DOI":"10.4049\/jimmunol.1501610"},{"key":"68","doi-asserted-by":"crossref","unstructured":"Nakayama, T., Hirahara, K., Onodera, A., Endo, Y., Hosokawa, H., Shinoda, K., Tumes, D.J. &amp; Okamoto, Y. (2017) Th2 cells in health and disease. <i>Annu. Rev. Immunol<\/i>., 35, 53-84.","DOI":"10.1146\/annurev-immunol-051116-052350"},{"key":"69","doi-asserted-by":"crossref","unstructured":"Nassar, K., Grisanti, S., Elfar, E., Luke, J., Luke, M. &amp; Grisanti, S. (2015) Serum cytokines as biomarkers for age-related macular degeneration. <i>Graefes Arch. Clin. Exp. Ophthalmol<\/i>., 253, 699-704.","DOI":"10.1007\/s00417-014-2738-8"},{"key":"70","doi-asserted-by":"crossref","unstructured":"Numasaki, M., Fukushi, J., Ono, M., Narula, S.K., Zavodny, P.J., Kudo, T., Robbins, P.D., Tahara, H. &amp; Lotze, M.T. (2003) Interleukin-17 promotes angiogenesis and tumor growth. <i>Blood<\/i>, 101, 2620-2627.","DOI":"10.1182\/blood-2002-05-1461"},{"key":"71","doi-asserted-by":"crossref","unstructured":"Onishi, R.M. &amp; Gaffen, S.L. (2010) Interleukin-17 and its target genes: mechanisms of interleukin-17 function in disease. <i>Immunology<\/i>, 129, 311-321.","DOI":"10.1111\/j.1365-2567.2009.03240.x"},{"key":"72","doi-asserted-by":"crossref","unstructured":"Osaadon, P., Fagan, X.J., Lifshitz, T. &amp; Levy, J. (2014) A review of anti-VEGF agents for proliferative diabetic retinopathy. <i>Eye <\/i>(<i>Lond.<\/i>), 28, 510-520.","DOI":"10.1038\/eye.2014.13"},{"key":"73","doi-asserted-by":"crossref","unstructured":"Ouyang, W., Kolls, J.K. &amp; Zheng, Y. (2008) The biological functions of T helper 17 cell effector cytokines in inflammation. <i>Immunity<\/i>, 28, 454-467.","DOI":"10.1016\/j.immuni.2008.03.004"},{"key":"74","doi-asserted-by":"crossref","unstructured":"Papp, K.A., Langley, R.G., Sigurgeirsson, B., Abe, M., Baker, D.R., Konno, P., Haemmerle, S., Thurston, H.J., Papavassilis, C. &amp; Richards, H.B. (2013) Efficacy and safety of secukinumab in the treatment of moderate-to-severe plaque psoriasis: a randomized, double-blind, placebo-controlled phase II dose-ranging study. <i>Br. J. Dermatol<\/i>., 168, 412-421.","DOI":"10.1111\/bjd.12110"},{"key":"75","doi-asserted-by":"crossref","unstructured":"Peng, Y.Q., Tang, L.S., Yoshida, S. &amp; Zhou, Y.D. (2017a) Applications of CRISPR\/Cas9 in retinal degenerative diseases. <i>Int. J. Ophthalmol<\/i>., 10, 646-651.","DOI":"10.18240\/ijo.2017.04.23"},{"key":"76","doi-asserted-by":"crossref","unstructured":"Peng, Y.Q., Tang, L.S. &amp; Zhou, Y.D. (2017b) Subretinal injection: a review on the novel route of therapeutic delivery for vitreoretinal diseases. <i>Ophthalmic Res<\/i>., 58, 217-226.","DOI":"10.1159\/000479157"},{"key":"77","doi-asserted-by":"crossref","unstructured":"Pickens, S.R., Volin, M.V., Mandelin, A.M. 2nd, Kolls, J.K., Pope, R.M. &amp; Shahrara, S. (2010) IL-17 contributes to angiogenesis in rheumatoid arthritis. <i>J. Immunol<\/i>., 184, 3233-3241.","DOI":"10.4049\/jimmunol.0903271"},{"key":"78","doi-asserted-by":"crossref","unstructured":"Qiu, A.W., Liu, Q.H. &amp; Wang, J.L. (2017) Blocking IL-17A alleviates diabetic retinopathy in rodents. <i>Cell Physiol. Biochem<\/i>., 41, 960-972.","DOI":"10.1159\/000460514"},{"key":"79","doi-asserted-by":"crossref","unstructured":"Rivera, J.C., Dabouz, R., Noueihed, B., Omri, S., Tahiri, H. &amp; Chemtob, S. (2017) Ischemic retinopathies: oxidative stress and inflammation. <i>Oxid. Med. Cell. Longev<\/i>., 2017, 3940241.","DOI":"10.1155\/2017\/3940241"},{"key":"80","doi-asserted-by":"crossref","unstructured":"Rizzo, S., Genovesi-Ebert, F., Di Bartolo, E., Vento, A., Miniaci, S. &amp; Williams, G. (2008) Injection of intravitreal bevacizumab (Avastin) as a preoperative adjunct before vitrectomy surgery in the treatment of severe proliferative diabetic retinopathy (PDR). <i>Graefes Arch. Clin. Exp. Ophthalmol<\/i>., 246, 837-842.","DOI":"10.1007\/s00417-008-0774-y"},{"key":"81","doi-asserted-by":"crossref","unstructured":"Sakurai, T., Yoshiga, D., Ariyoshi, W., Okinaga, T., Kiyomiya, H., Furuta, J., Yoshioka, I., Tominaga, K. &amp; Nishihara, T. (2016) Essential role of mitogen-activated protein kinases in IL-17A-induced MMP-3 expression in human synovial sarcoma cells. <i>BMC Res. Notes<\/i>, 9, 68.","DOI":"10.1186\/s13104-016-1892-y"},{"key":"82","doi-asserted-by":"crossref","unstructured":"Salam, A., Mathew, R. &amp; Sivaprasad, S. (2011) Treatment of proliferative diabetic retinopathy with anti-VEGF agents. <i>Acta Ophthalmol<\/i>., 89, 405-411.","DOI":"10.1111\/j.1755-3768.2010.02079.x"},{"key":"83","doi-asserted-by":"crossref","unstructured":"Sato, T., Kusaka, S., Shimojo, H. &amp; Fujikado, T. (2009) Simultaneous analyses of vitreous levels of 27 cytokines in eyes with retinopathy of prematurity. <i>Ophthalmology<\/i>, 116, 2165-2169.","DOI":"10.1016\/j.ophtha.2009.04.026"},{"key":"84","doi-asserted-by":"crossref","unstructured":"Shen, F., Ruddy, M.J., Plamondon, P. &amp; Gaffen, S.L. (2005) Cytokines link osteoblasts and inflammation: microarray analysis of interleukin-17- and TNF-alpha-induced genes in bone cells. <i>J. Leukoc. Biol<\/i>., 77, 388-399.","DOI":"10.1189\/jlb.0904490"},{"key":"85","doi-asserted-by":"crossref","unstructured":"Shichita, T., Sugiyama, Y., Ooboshi, H., Sugimori, H., Nakagawa, R., Takada, I., Iwaki, T., Okada, Y., Iida, M., Cua, D.J., Iwakura, Y. &amp; Yoshimura, A. (2009) Pivotal role of cerebral interleukin-17-producing gammadeltaT cells in the delayed phase of ischemic brain injury. <i>Nat. Med<\/i>., 15, 946-950.","DOI":"10.1038\/nm.1999"},{"key":"86","doi-asserted-by":"crossref","unstructured":"Sica, A., Erreni, M., Allavena, P. &amp; Porta, C. (2015) Macrophage polarization in pathology. <i>Cell. Mol. Life Sci<\/i>., 72, 4111-4126.","DOI":"10.1007\/s00018-015-1995-y"},{"key":"87","doi-asserted-by":"crossref","unstructured":"Silveira, R.C., Fortes, J.B. &amp; Procianoy, R.S. (2011) Assessment of the contribution of cytokine plasma levels to detect retinopathy of prematurity in very low birth weight infants. <i>Invest. Ophthalmol. Vis. Sci<\/i>., 52, 1297-1301.","DOI":"10.1167\/iovs.10-6279"},{"key":"88","doi-asserted-by":"crossref","unstructured":"Singh, A., Subhi, Y., Krogh Nielsen, M., Falk, M.K., Matzen, S.M.H., Sellebjerg, F. &amp; Sorensen, T.L. (2017) Systemic frequencies of T helper 1 and T helper 17 cells in patients with age-related macular degeneration: a case-control study. <i>Sci. Rep<\/i>., 7, 605.","DOI":"10.1038\/s41598-017-00741-4"},{"key":"89","doi-asserted-by":"crossref","unstructured":"Sohn, H.J., Han, D.H., Lee, D.Y. &amp; Nam, D.H. (2014) Changes in aqueous cytokines after intravitreal triamcinolone versus bevacizumab for macular oedema in branch retinal vein occlusion. <i>Acta Ophthalmol<\/i>., 92, e217-e224.","DOI":"10.1111\/aos.12219"},{"key":"90","doi-asserted-by":"crossref","unstructured":"Song, Y. &amp; Yang, J.M. (2017) Role of interleukin (IL)-17 and T-helper (Th)17 cells in cancer. <i>Biochem. Biophys. Res. Commun<\/i>., 493, 1-8.","DOI":"10.1016\/j.bbrc.2017.08.109"},{"key":"91","doi-asserted-by":"crossref","unstructured":"Sood, B.G., Madan, A., Saha, S., Schendel, D., Thorsen, P., Skogstrand, K., Hougaard, D., Shankaran, S., Carlo, W. &amp; Network, N.N.R. (2010) Perinatal systemic inflammatory response syndrome and retinopathy of prematurity. <i>Pediatr. Res<\/i>., 67, 394-400.","DOI":"10.1203\/PDR.0b013e3181d01a36"},{"key":"92","doi-asserted-by":"crossref","unstructured":"Spuls, P.I. &amp; Hooft, L. (2012) Brodalumab and ixekizumab, anti-interleukin-17-receptor antibodies for psoriasis: a critical appraisal. <i>Br. J. Dermatol<\/i>., 167, 710-713.","DOI":"10.1111\/bjd.12025"},{"key":"93","doi-asserted-by":"crossref","unstructured":"Suryawanshi, A., Veiga-Parga, T., Reddy, P.B., Rajasagi, N.K. &amp; Rouse, B.T. (2012) IL-17A differentially regulates corneal vascular endothelial growth factor (VEGF)-A and soluble VEGF receptor 1 expression and promotes corneal angiogenesis after herpes simplex virus infection. <i>J. Immunol<\/i>., 188, 3434-3446.","DOI":"10.4049\/jimmunol.1102602"},{"key":"94","doi-asserted-by":"crossref","unstructured":"Sutton, C.E., Mielke, L.A. &amp; Mills, K.H. (2012) IL-17-producing gammadelta T cells and innate lymphoid cells. <i>Eur. J. Immunol<\/i>., 42, 2221-2231.","DOI":"10.1002\/eji.201242569"},{"key":"95","doi-asserted-by":"crossref","unstructured":"Suzuki, Y., Nakazawa, M., Suzuki, K., Yamazaki, H. &amp; Miyagawa, Y. (2011) Expression profiles of cytokines and chemokines in vitreous fluid in diabetic retinopathy and central retinal vein occlusion. <i>Jpn. J. Ophthalmol<\/i>., 55, 256-263.","DOI":"10.1007\/s10384-011-0004-8"},{"key":"96","doi-asserted-by":"crossref","unstructured":"Takeuchi, M., Sato, T., Sakurai, Y., Taguchi, M., Harimoto, K., Karasawa, Y. &amp; Ito, M. (2017) Association between aqueous humor and vitreous fluid levels of Th17 cell-related cytokines in patients with proliferative diabetic retinopathy. <i>PLoS One<\/i>, 12, e0178230.","DOI":"10.1371\/journal.pone.0178230"},{"key":"97","doi-asserted-by":"crossref","unstructured":"Takeuchi, M., Sato, T., Tanaka, A., Muraoka, T., Taguchi, M., Sakurai, Y., Karasawa, Y. &amp; Ito, M. (2015) Elevated levels of cytokines associated with Th2 and Th17 cells in vitreous fluid of proliferative diabetic retinopathy patients. <i>PLoS One<\/i>, 10, e0137358.","DOI":"10.1371\/journal.pone.0137358"},{"key":"98","doi-asserted-by":"crossref","unstructured":"Talia, D.M., Deliyanti, D., Agrotis, A. &amp; Wilkinson-Berka, J.L. (2016) Inhibition of the nuclear receptor RORgamma and interleukin-17A suppresses neovascular retinopathy: involvement of immunocompetent microglia. <i>Arterioscler. Thromb. Vasc. Biol<\/i>., 36, 1186-1196.","DOI":"10.1161\/ATVBAHA.115.307080"},{"key":"99","doi-asserted-by":"crossref","unstructured":"Tan, Z., Jiang, R., Wang, X., Wang, Y., Lu, L., Liu, Q., Zheng, S.G., Sun, B. &amp; Ryffel, B. (2013) RORgammat+IL-17+ neutrophils play a critical role in hepatic ischemia-reperfusion injury. <i>J. Mol. Cell. Biol<\/i>., 5, 143-146.","DOI":"10.1093\/jmcb\/mjs065"},{"key":"100","doi-asserted-by":"crossref","unstructured":"Tang, J. &amp; Kern, T.S. (2011) Inflammation in diabetic retinopathy. <i>Prog. Retin. Eye Res<\/i>., 30, 343-358.","DOI":"10.1016\/j.preteyeres.2011.05.002"},{"key":"101","doi-asserted-by":"crossref","unstructured":"Veldhoen, M. (2017) Interleukin 17 is a chief orchestrator of immunity. <i>Nat. Immunol<\/i>., 18, 612-621.","DOI":"10.1038\/ni.3742"},{"key":"102","doi-asserted-by":"crossref","unstructured":"Velez-Montoya, R., Oliver, S.C.N., Olson, J.L., Fine, S.L., Mandava, N. &amp; Quiroz-Mercado, H. (2013) Current knowledge and trends in age-related macular degeneration today\u2019s and future treatments. <i>Retina<\/i>, 33, 1487-1502.","DOI":"10.1097\/IAE.0b013e318271f265"},{"key":"103","doi-asserted-by":"crossref","unstructured":"Wang, C., Wang, L., Liu, J., Song, J., Sun, Y., Lin, P., Liang, K., Liu, F., He, T., Sun, Z., Hou, X. &amp; Chen, L. (2016) Irisin modulates the association of interleukin-17A with the presence of non-proliferative diabetic retinopathy in patients with type 2 diabetes. <i>Endocrine<\/i>, 53, 459-464.","DOI":"10.1007\/s12020-016-0905-x"},{"key":"104","unstructured":"Wang, C., You, Q.S., Cao, X.S., Guo, H.L., Gao, X.X. &amp; Peng, X.Y. (2017) Micro RNA-19a suppresses interleukin-10 in peripheral B cells of patients with diabetic retinopathy. <i>Am. J. Transl. Res<\/i>., 9, 1410-1417."},{"key":"105","doi-asserted-by":"crossref","unstructured":"Wei, L., Liu, B.Y., Tuo, J.S., Shen, D.F., Chen, P., Li, Z.Y., Liu, X.X., Ni, J., Dagur, P., Sen, H.N., Jawad, S., Ling, D., Park, S., Chakrabarty, S., Meyerle, C., et al. (2012) Hypomethylation of the IL17RC promoter associates with age-related macular degeneration. <i>Cell Rep<\/i>., 2, 1151-1158.","DOI":"10.1016\/j.celrep.2012.10.013"},{"key":"106","doi-asserted-by":"crossref","unstructured":"Wu, L., Martinez-Castellanos, M.A., Quiroz-Mercado, H., Arevalo, J.F., Berrocal, M.H., Farah, M.E., Maia, M., Roca, J.A. &amp; Rodriguez, F.J.; Pan American Collaborative Retina Group (2008) Twelve-month safety of intravitreal injections of bevacizumab (Avastin): results of the Pan-American Collaborative Retina Study Group (PACORES). <i>Graefes Arch. Clin. Exp. Ophthalmol<\/i>., 246, 81-87.","DOI":"10.1007\/s00417-007-0660-z"},{"key":"107","doi-asserted-by":"crossref","unstructured":"Xu, H.Y., Cai, M. &amp; Zhang, X.D. (2015) Effect of the blockade of the IL-23-Th17-IL-17A pathway on streptozotocin-induced diabetic retinopathy in rats. <i>Graefes Arch. Clin. Exp. Ophthalmol<\/i>., 253, 1485-1492.","DOI":"10.1007\/s00417-014-2842-9"},{"key":"108","unstructured":"Xu, J., Li, Y. &amp; Hong, J. (2014) Progress of anti-vascular endothelial growth factor therapy for ocular neovascular disease: benefits and challenges. <i>Chin. Med. J. <\/i>(<i>Engl.<\/i>), 127, 1550-1557."},{"key":"109","doi-asserted-by":"crossref","unstructured":"Yang, B., Kang, H., Fung, A., Zhao, H., Wang, T. &amp; Ma, D. (2014) The role of interleukin 17 in tumour proliferation, angiogenesis, and metastasis. <i>Mediators Inflamm<\/i>., 2014, 623759.","DOI":"10.1155\/2014\/623759"},{"key":"110","doi-asserted-by":"crossref","unstructured":"Yang, L., Anderson, D.E., Baecher-Allan, C., Hastings, W.D., Bettelli, E., Oukka, M., Kuchroo, V.K. &amp; Hafler, D.A. (2008) IL-21 and TGF-beta are required for differentiation of human T(H)17 cells. <i>Nature<\/i>, 454, 350-352.","DOI":"10.1038\/nature07021"},{"key":"111","unstructured":"Yoshida, A., Yoshida, S., Ishibashi, T. &amp; Inomata, H. (1999) Intraocular neovascularization. <i>Histol. Histopathol<\/i>., 14, 1287-1294."},{"key":"112","doi-asserted-by":"crossref","unstructured":"Yu, H.H., Yuan, L., Zou, Y.P., Peng, L.H., Wang, Y., Li, T. &amp; Tang, S.B. (2014) Serum concentrations of cytokines in infants with retinopathy of prematurity. <i>APMIS<\/i>, 122, 818-823.","DOI":"10.1111\/apm.12223"},{"key":"113","doi-asserted-by":"crossref","unstructured":"Zandi, S., Nakao, S., Chun, K.H., Fiorina, P., Sun, D., Arita, R., Zhao, M., Kim, E., Schueller, O., Campbell, S., Taher, M., Melhorn, M.I., Schering, A., Gatti, F., Tezza, S., et al. (2015) ROCK-isoform-specific polarization of macrophages associated with age-related macular degeneration. <i>Cell Rep<\/i>., 10, 1173-1186.","DOI":"10.1016\/j.celrep.2015.01.050"},{"key":"114","doi-asserted-by":"crossref","unstructured":"Zenobia, C. &amp; Hajishengallis, G. (2015) Basic biology and role of interleukin-17 in immunity and inflammation. <i>Periodontol. 2000<\/i>, 69, 142-159.","DOI":"10.1111\/prd.12083"},{"key":"115","doi-asserted-by":"crossref","unstructured":"Zhang, S., Liu, Y., Lu, S. &amp; Cai, X. (2015) Genetic variants of interleukin 17A are functionally associated with increased risk of age-related macular degeneration. <i>Inflammation<\/i>, 38, 658-663.","DOI":"10.1007\/s10753-014-9973-3"},{"key":"116","doi-asserted-by":"crossref","unstructured":"Zhang, Z., Zheng, M., Bindas, J., Schwarzenberger, P. &amp; Kolls, J.K. (2006) Critical role of IL-17 receptor signaling in acute TNBS-induced colitis. <i>Inflamm. Bowel Dis<\/i>., 12, 382-388.","DOI":"10.1097\/01.MIB.0000218764.06959.91"},{"key":"117","doi-asserted-by":"crossref","unstructured":"Zhou, Y., Yoshida, S., Nakao, S., Yoshimura, T., Kobayashi, Y., Nakama, T., Kubo, Y., Miyawaki, K., Yamaguchi, M., Ishikawa, K., Oshima, Y., Akashi, K. &amp; Ishibashi, T. (2015) M2 macrophages enhance pathological neovascularization in the mouse model of oxygen-induced retinopathy. <i>Invest. Ophthalmol. Vis. Sci<\/i>., 56, 4767-4777.","DOI":"10.1167\/iovs.14-16012"},{"key":"118","unstructured":"Zhou, Y.D., Yoshida, S., Peng, Y.Q., Kobayashi, Y., Zhang, L.S. &amp; Tang, L.S. (2017) Diverse roles of macrophages in intraocular neovascular diseases: a review. <i>Int. J. Ophthalmol<\/i>., 10, 1902-1908."},{"key":"119","doi-asserted-by":"crossref","unstructured":"Zhu, Y., Tan, W., Demetriades, A.M., Cai, Y., Gao, Y., Sui, A., Lu, Q., Shen, X., Jiang, C., Xie, B. &amp; Sun, X. (2016) Interleukin-17A neutralization alleviated ocular neovascularization by promoting M2 and mitigating M1 macrophage polarization. <i>Immunology<\/i>, 147, 414-428.","DOI":"10.1111\/imm.12571"}],"container-title":["The Tohoku Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/tjem\/247\/2\/247_87\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,17]],"date-time":"2019-11-17T02:26:27Z","timestamp":1573957587000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/tjem\/247\/2\/247_87\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":119,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.1620\/tjem.247.87","relation":{},"ISSN":["0040-8727","1349-3329"],"issn-type":[{"value":"0040-8727","type":"print"},{"value":"1349-3329","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]}}}