{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T08:32:57Z","timestamp":1784709177708,"version":"3.55.0"},"reference-count":24,"publisher":"Tohoku University Medical Press","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tohoku J. Exp. Med."],"published-print":{"date-parts":[[2019]]},"DOI":"10.1620\/tjem.248.193","type":"journal-article","created":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T22:04:59Z","timestamp":1564092299000},"page":"193-200","source":"Crossref","is-referenced-by-count":5,"title":["Idiopathic Short Stature Phenotypes among Korean Children: Cluster Analysis"],"prefix":"10.1620","volume":"248","author":[{"given":"Hyo-Kyoung","family":"Nam","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Korea University Guro Hospital, Korea University College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye Ryun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Korea University Anam Hospital, Korea University College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kee-Hyoung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Korea University Anam Hospital, Korea University College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Jun","family":"Rhie","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Korea University Ansan Hospital, Korea University College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"622","reference":[{"key":"1","unstructured":"Bakker, B., Frane, J., Anhalt, H., Lippe, B. &amp; Rosenfeld, R.G. (2008)  Height velocity targets from the national cooperative growth study for first-year growth hormone responses in short children.  <i>J. Clin. Endocrinol. Metab<\/i>., 93, 352-357."},{"key":"2","unstructured":"Brusco, M.J., Shireman, E. &amp; Steinley, D. (2017)  A comparison of latent class, K-means, and K-median methods for clustering dichotomous data.  <i>Psychol. Methods<\/i>, 22, 563-580."},{"key":"3","unstructured":"Chung, S., Yoo, J.H., Choi, J.H., Rhie, Y.J., Chae, H.W., Kim, J.H., Hwang, I.T., Shin, C.H., Kim, E.Y. &amp; Lee, K.H. (2018)  Design of the long-term observational cohort study with recombinant human growth hormone in Korean children: LG Growth Study.  <i>Ann. Pediatr. Endocrinol. Metab<\/i>., 23, 43-50."},{"key":"4","doi-asserted-by":"crossref","unstructured":"Cohen, P., Rogol, A.D., Deal, C.L., Saenger, P., Reiter, E.O., Ross, J.L., Chernausek, S.D., Savage, M.O. &amp; Wit, J.M.; 2007 ISS Consensus Workshop participants  (2008)  Consensus statement on the diagnosis and treatment of children with idiopathic short stature: a summary of the Growth Hormone Research Society, the Lawson Wilkins Pediatric Endocrine Society, and the European Society for Paediatric Endocrinology Workshop.  <i>J. Clin. Endocrinol. Metab<\/i>., 93, 4210-4217.","DOI":"10.1210\/jc.2008-0509"},{"key":"5","doi-asserted-by":"crossref","unstructured":"Dumas, O., Mansbach, J.M., Jartti, T., Hasegawa, K., Sullivan, A.F., Piedra, P.A. &amp; Camargo, C.A. Jr. (2016)  A clustering approach to identify severe bronchiolitis profiles in children.  <i>Thorax<\/i>, 71, 712-718.","DOI":"10.1136\/thoraxjnl-2016-208535"},{"key":"6","doi-asserted-by":"crossref","unstructured":"Fisker, S., Jorgensen, J.O. &amp; Christiansen, J.S. (1998)  Variability in growth hormone stimulation tests.  <i>Growth Horm. IGF Res.<\/i>, 8 Suppl A, 31-35.","DOI":"10.1016\/S1096-6374(98)80006-3"},{"key":"7","unstructured":"Fraley, C. &amp; Raftery, A.E. (1999)  MCLUST: software for model-based cluster analysis.  <i>J. Classif<\/i>., 16, 297-306."},{"key":"8","unstructured":"Ghigo, E., Bellone, J., Aimaretti, G., Bellone, S., Loche, S., Cappa, M., Bartolotta, E., Dammacco, F. &amp; Camanni, F. (1996)  Reliability of provocative tests to assess growth hormone secretory status. Study in 472 normally growing children.  <i>J. Clin. Endocrinol. Metab<\/i>., 81, 3323-3327."},{"key":"9","unstructured":"GH Research Society  (2000)  Consensus guidelines for the diagnosis and treatment of growth hormone (GH) deficiency in childhood and adolescence: summary statement of the GH Research Society.  <i>J. Clin. Endocrinol. Metab<\/i>., 85, 3990-3993."},{"key":"10","unstructured":"Haldar, P., Pavord, I.D., Shaw, D.E., Berry, M.A., Thomas, M., Brightling, C.E., Wardlaw, A.J. &amp; Green, R.H. (2008)  Cluster analysis and clinical asthma phenotypes.  <i>Am. J. Respir. Crit. Care Med<\/i>., 178, 218-224."},{"key":"11","doi-asserted-by":"crossref","unstructured":"Herr, M., Just, J., Nikasinovic, L., Foucault, C., Le Marec, A.M., Giordanella, J.P. &amp; Momas, I. (2012)  Risk factors and characteristics of respiratory and allergic phenotypes in early childhood.  <i>J. Allergy Clin. Immunol<\/i>., 130, 389-396 e384.","DOI":"10.1016\/j.jaci.2012.05.054"},{"key":"12","doi-asserted-by":"crossref","unstructured":"Kaplowitz, P.B., Shulman, D.I., Frane, J.W., Jacobs, J. &amp; Lippe, B. (2013)  Characteristics of children with the best and poorest first- and second-year growth during rhGH therapy: data from 25 years of the Genentech national cooperative growth study (NCGS).  <i>Int. J. Pediatr. Endocrinol<\/i>., 2013, 9.","DOI":"10.1186\/1687-9856-2013-9"},{"key":"13","doi-asserted-by":"crossref","unstructured":"Loftus, J., Lindberg, A., Aydin, F., Gomez, R., Maghnie, M., Rooman, R., Steinkamp, H., Doerr, H., Ranke, M. &amp; Camacho-Hubner, C. (2017)  Individualised growth response optimisation (iGRO) tool: an accessible and easy-to-use growth prediction system to enable treatment optimisation for children treated with growth hormone.  <i>J. Pediatr. Endocrinol. Metab<\/i>., 30, 1019-1026.","DOI":"10.1515\/jpem-2017-0120"},{"key":"14","unstructured":"Murray, P.G., Dattani, M.T. &amp; Clayton, P.E. (2016)  Controversies in the diagnosis and management of growth hormone deficiency in childhood and adolescence.  <i>Arch. Dis. Child<\/i>., 101, 96-100."},{"key":"15","doi-asserted-by":"crossref","unstructured":"Park, P. &amp; Cohen, P. (2005)  Insulin-like growth factor I (IGF-I) measurements in growth hormone (GH) therapy of idiopathic short stature (ISS).  <i>Growth Horm. IGF Res.<\/i>, 15 Suppl A, S13-20.","DOI":"10.1016\/j.ghir.2005.06.011"},{"key":"16","unstructured":"Pedicelli, S., Peschiaroli, E., Violi, E. &amp; Cianfarani, S. (2009)  Controversies in the definition and treatment of idiopathic short stature (ISS).  <i>J. Clin. Res. Pediatr. Endocrinol<\/i>., 1, 105-115."},{"key":"17","doi-asserted-by":"crossref","unstructured":"Ranke, M.B., Lindberg, A., Price, D.A., Darendeliler, F., Albertsson-Wikland, K., Wilton, P., Reiter, E.O. &amp; Board, K.I. (2007)  Age at growth hormone therapy start and first-year responsiveness to growth hormone are major determinants of height outcome in idiopathic short stature.  <i>Horm. Res<\/i>., 68, 53-62.","DOI":"10.1159\/000098707"},{"key":"18","doi-asserted-by":"crossref","unstructured":"Ranke, M.B., Lindberg, A., Tanaka, T., Camacho-Hubner, C., Dunger, D.B. &amp; Geffner, M.E. (2017)  Baseline characteristics and gender differences in prepubertal children treated with growth hormone in Europe, USA, and Japan: 25 years\u2019 KIGS(R) experience (1987-2012) and review.  <i>Horm. Res. Paediatr<\/i>., 87, 30-41.","DOI":"10.1159\/000452887"},{"key":"19","doi-asserted-by":"crossref","unstructured":"Rogol, A.D., Blethen, S.L., Sy, J.P. &amp; Veldhuis, J.D. (2003)  Do growth hormone (GH) serial sampling, insulin-like growth factor-I (IGF-I) or auxological measurements have an advantage over GH stimulation testing in predicting the linear growth response to GH therapy?  <i>Clin. Endocrinol<\/i> (<i>Oxf<\/i>)., 58, 229-237.","DOI":"10.1046\/j.1365-2265.2003.01701.x"},{"key":"20","doi-asserted-by":"crossref","unstructured":"Rosenbloom, A.L. (2000)  Physiology and disorders of the growth hormone receptor (GHR) and GH-GHR signal transduction.  <i>Endocrine<\/i>, 12, 107-119.","DOI":"10.1385\/ENDO:12:2:107"},{"key":"21","unstructured":"Siklar, Z., Kocaay, P., Camtosun, E., Isakoca, M., Hacihamdioglu, B., Savas Erdeve, S. &amp; Berberoglu, M. (2015)  The effect of recombinant growth hormone treatment in children with idiopathic short stature and low insulin-like growth factor-1 levels.  <i>J. Clin. Res. Pediatr. Endocrinol<\/i>., 7, 301-306."},{"key":"22","unstructured":"Sotos, J.F. &amp; Tokar, N.J. (2014)  Growth hormone significantly increases the adult height of children with idiopathic short stature: comparison of subgroups and benefit.  <i>Int. J. Pediatr. Endocrinol<\/i>., 2014, 15."},{"key":"23","doi-asserted-by":"crossref","unstructured":"Wagner, I.V., Paetzold, C., Gausche, R., Vogel, M., Koerner, A., Thiery, J., Arsene, C.G., Henrion, A., Guettler, B., Keller, E., Kiess, W., Pfaeffle, R. &amp; Kratzsch, J. (2014)  Clinical evidence-based cutoff limits for GH stimulation tests in children with a backup of results with reference to mass spectrometry.  <i>Eur. J. Endocrinol<\/i>., 171, 389-397.","DOI":"10.1530\/EJE-14-0165"},{"key":"24","doi-asserted-by":"crossref","unstructured":"Wikland, K.A., Kristrom, B., Rosberg, S., Svensson, B. &amp; Nierop, A.F. (2000)  Validated multivariate models predicting the growth response to GH treatment in individual short children with a broad range in GH secretion capacities.  <i>Pediatr. Res<\/i>., 48, 475-484.","DOI":"10.1203\/00006450-200010000-00010"}],"container-title":["The Tohoku Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/tjem\/248\/3\/248_193\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,27]],"date-time":"2019-07-27T03:42:11Z","timestamp":1564198931000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/tjem\/248\/3\/248_193\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.1620\/tjem.248.193","relation":{},"ISSN":["0040-8727","1349-3329"],"issn-type":[{"value":"0040-8727","type":"print"},{"value":"1349-3329","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]}}}