{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T05:44:48Z","timestamp":1789019088512,"version":"build-2803163510"},"reference-count":28,"publisher":"Tohoku University Medical Press","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tohoku J. Exp. Med."],"published-print":{"date-parts":[[2021]]},"DOI":"10.1620\/tjem.253.125","type":"journal-article","created":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T22:13:05Z","timestamp":1613772785000},"page":"125-134","source":"Crossref","is-referenced-by-count":7,"title":["Incidence and Relapse Triggers of Childhood Idiopathic Nephrotic Syndrome between 2006 and 2016: A Population-Based Study in Fukushima, Japan"],"prefix":"10.1620","volume":"253","author":[{"given":"Yohei","family":"Kume","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Fukushima Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukihiko","family":"Kawasaki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Fukushima Medical University"},{"name":"Department of Pediatrics, Sapporo Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhide","family":"Suyama","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Fukushima Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Fukushima Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yui","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Fukushima Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Hoshino","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Fukushima Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeo","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Ohara General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Mitomo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Japanese Red Cross Society Fukushima Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruriko","family":"Nozawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Fujita General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Namai","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Ohta Nishinouchi General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Sakuma","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hoshi General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatoshi","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Jusendo Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Oda","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Iwase General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromichi","family":"Murai","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Shirakawa Kosei General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuto","family":"Kanno","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Shirakawa Kosei General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katustoshi","family":"Nagasawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Takeda General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Soma General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoshiro","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Iwaki City Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichiro","family":"Ohara","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Iwaki City Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayato","family":"Go","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Fukushima Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya","family":"Goto","sequence":"additional","affiliation":[{"name":"Center for Integrated Science and Humanities, Fukushima Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuaki","family":"Hosoya","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Fukushima Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"622","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"Abeyagunawardena, A.S., Goldblatt, D., Andrews, N. &amp; Trompeter, R.S. (2003)  Risk of relapse after meningococcal C conjugate vaccine in nephrotic syndrome.  <i>Lancet<\/i>, 362, 449-450.","DOI":"10.1016\/S0140-6736(03)14072-X"},{"key":"2","unstructured":"Abeyagunawardena, A.S., Thalgahagoda, R.S., Dissanayake, P.V., Abeyagunawardena, S., Illangasekera, Y.A., Karunadasa, U.I. &amp; Trompeter, R.S. (2017)  Short courses of daily prednisolone during upper respiratory tract infections reduce relapse frequency in childhood nephrotic syndrome.  <i>Pediatr. Nephrol.<\/i>, 32, 1377-1382."},{"key":"3","unstructured":"Alpay, H., Yildiz, N., Onar, A., Temizer, H. &amp; Oz\u00e7ay, S. (2002)  Varicella vaccination in children with steroid-sensitive nephrotic syndrome.  <i>Pediatr. Nephrol.<\/i>, 17, 181-183."},{"key":"4","unstructured":"Andersen, R.F., Thrane, N., Noergaard, K., Rytter, L., Jespersen, B. &amp; Rittig, S. (2010)  Early age at debut is a predictor of steroid-dependent and frequent relapsing nephrotic syndrome.  <i>Pediatr. Nephrol.<\/i>, 25, 1299-1304."},{"key":"5","unstructured":"Bakkum, L., Willemen, A.M., Zoetebier, L. &amp; Bouts, A.H. (2019)  A longitudinal study on the effects of psychological stress on proteinuria in childhood steroid-sensitive nephrotic syndrome.  <i>J. Psychosom. Res.<\/i>, 121, 8-13."},{"key":"6","unstructured":"Banaszak, B. &amp; Banaszak, P. (2012)  The increasing incidence of initial steroid resistance in childhood nephrotic syndrome.  <i>Pediatr. Nephrol.<\/i>, 27, 927-932."},{"key":"7","unstructured":"Banh, T.H.M., Hussain-Shamsy, N., Patel, V., Vasilevska-Ristovska, J., Borges, K., Sibbald, C., Lipszyc, D., Brooke, J., Geary, D., Langlois, V., Reddon, M., Pearl, R., Levin, L., Piekut, M., Licht, C.P.B., et al.  (2016)  Ethnic differences in incidence and outcomes of childhood nephrotic syndrome.  <i>Clin. J. Am. Soc. Nephrol.<\/i>, 11, 1760-1768."},{"key":"8","unstructured":"Chang, J.W., Tsai, H.L., Yang, L.Y. &amp; Chen, T.J. (2012)  Epidemiology and predictors of end-stage renal disease in Taiwanese children with idiopathic nephrotic syndrome.  <i>J. Epidemiol.<\/i>, 22, 517-522."},{"key":"9","unstructured":"Cuoghi, D., Venturi, P. &amp; Cheli, E. (1988)  Bee sting and relapse of nephrotic syndrome.  <i>Child Nephrol. Urol.<\/i>, 9, 82-83."},{"key":"10","unstructured":"Dossier, C., Lapidus, N., Bayer, F., Sellier-Leclerc, A.L., Boyer, O., de Pontual, L., May, A., Nathanson, S., Orzechowski, C., Simon, T., Carrat, F. &amp; Desch\u00eanes, G. (2016)  Epidemiology of idiopathic nephrotic syndrome in children: endemic or epidemic? <i>Pediatr. Nephrol.<\/i>, 31, 2299-2308."},{"key":"11","unstructured":"El Bakkali, L., Rodrigues Pereira, R., Kuik, D.J., Ket, J.C.F. &amp; van Wijk, J.A.E. (2011)  Nephrotic syndrome in The Netherlands: a population-based cohort study and a review of the literature.  <i>Pediatr. Nephrol.<\/i>, 26, 1241-1246."},{"key":"12","unstructured":"Franke, I., Aydin, M., Llamas Lopez, C.E., Kurylowicz, L., Ganschow, R., Lentze, M. &amp; Born, M. (2018)  The incidence of the nephrotic syndrome in childhood in Germany.  <i>Clin. Exp. Nephrol.<\/i>, 22, 126-132."},{"key":"13","unstructured":"Kawasaki, Y., Nakano, H., Hosoya, M., Yasumura, S., Ohira, T., Satoh, H., Suzuki, H., Sakai, A., Ohtsuru, A., Takahashi, A., Kobashi, G. &amp; Kamiya, K. (2020)  Influence of post-disaster evacuation on childhood obesity and hyperlipidemia.  <i>Pediatr. Int.<\/i>, 62, 669-676."},{"key":"14","doi-asserted-by":"crossref","unstructured":"Kikunaga, K., Ishikura, K., Terano, C., Sato, M., Komaki, F., Hamasaki, Y., Sasaki, S., Iijima, K., Yoshikawa, N., Nakanishi, K., Nakazato, H., Matsuyama, T., Ando, T., Ito, S., Honda, M., et al.  (2017)  High incidence of idiopathic nephrotic syndrome in East Asian children: a nationwide survey in Japan (JP-SHINE study).  <i>Clin. Exp. Nephrol.<\/i>, 21, 651-657.","DOI":"10.1007\/s10157-016-1319-z"},{"key":"15","doi-asserted-by":"crossref","unstructured":"Klifa, R., Toubiana, J., Michel, A., Biebuyck, N., Charbit, M., Heidet, L., Krid, S., Krug, P., Salomon, R. &amp; Boyer, O. (2019)  Influenza vaccination among children with idiopathic nephrotic syndrome: an investigation of practices.  <i>BMC Nephrol.<\/i>, 20, 65.","DOI":"10.1186\/s12882-019-1240-2"},{"key":"16","unstructured":"Krug, P., Boyer, O., Balzamo, E., Sidi, D., Lehnert, A. &amp; Niaudet, P. (2012)  Nephrotic syndrome in Kawasaki disease: a report of three cases.  <i>Pediatr. Nephrol.<\/i>, 27, 1547-1550."},{"key":"17","unstructured":"Maeda, R., Kawasaki, Y., Suzuki, S., Ohara, S., Kazuhide, S. &amp; Hosoya, M. (2018)  Relapse of nephrotic syndrome triggered by Kawasaki disease.  <i>CEN Case Rep.<\/i>, 7, 13-16."},{"key":"18","doi-asserted-by":"crossref","unstructured":"Noone, D.G., Iijima, K. &amp; Parekh, R. (2018)  Idiopathic nephrotic syndrome in children.  <i>Lancet<\/i>, 392, 61-74.","DOI":"10.1016\/S0140-6736(18)30536-1"},{"key":"19","doi-asserted-by":"crossref","unstructured":"Ono, A., Isojima, T., Yokoya, S., Kato, N., Tanaka, T., Yamagata, Z., Chida, S., Matsubara, H., Tanaka, S., Ishikuro, M., Kikuya, M., Kuriyama, S., Kure, S. &amp; Hosoya, M. (2018)  Effect of the Fukushima earthquake on weight in early childhood: a retrospective analysis.  <i>BMJ Paediatr. Open<\/i>, 2, e000229.","DOI":"10.1136\/bmjpo-2017-000229"},{"key":"20","doi-asserted-by":"crossref","unstructured":"Riar, S.S., Banh, T.H.M., Borges, K., Subbarao, P., Patel, V., Vasilevska-Ristovska, J., Chanchlani, R., Hussain-Shamsy, N., Noone, D., Hebert, D., Licht, C.P.B., Langlois, V., Pearl, R.J. &amp; Parekh, R.S. (2019)  Prevalence of asthma and allergies and risk of relapse in childhood nephrotic syndrome: insight into nephrotic syndrome cohort.  <i>J. Pediatr.<\/i>, 208, 251-257.  e251.","DOI":"10.1016\/j.jpeds.2018.12.048"},{"key":"21","doi-asserted-by":"crossref","unstructured":"Segerstrom, S.C. &amp; Miller, G.E. (2004)  Psychological stress and the human immune system: a meta-analytic study of 30 years of inquiry.  <i>Psychol. Bull.<\/i>, 130, 601-630.","DOI":"10.1037\/0033-2909.130.4.601"},{"key":"22","unstructured":"Sureshkumar, P., Hodson, E.M., Willis, N.S., Barzi, F. &amp; Craig, J.C. (2014)  Predictors of remission and relapse in idiopathic nephrotic syndrome: a prospective cohort study.  <i>Pediatr. Nephrol.<\/i>, 29, 1039-1046."},{"key":"23","unstructured":"Takahashi, S., Wada, N., Murakami, H., Funaki, S., Inagaki, T., Harada, K. &amp; Nagata, M. (2007)  Triggers of relapse in steroid-dependent and frequently relapsing nephrotic syndrome.  <i>Pediatr. Nephrol.<\/i>, 22, 232-236."},{"key":"24","unstructured":"Tasic, V. (2000)  Nephrotic syndrome in a child after a bee sting.  <i>Pediatr. Nephrol.<\/i>, 15, 245-247."},{"key":"25","unstructured":"Uwaezuoke, S.N. (2015)  Steroid-sensitive nephrotic syndrome in children: triggers of relapse and evolving hypotheses on pathogenesis.  <i>Ital. J. Pediatr.<\/i>, 41, 19."},{"key":"26","doi-asserted-by":"crossref","unstructured":"Wong, W. (2007)  Idiopathic nephrotic syndrome in New Zealand children, demographic, clinical features, initial management and outcome after twelve-month follow-up: results of a three-year national surveillance study.  <i>J. Paediatr. Child Health<\/i>, 43, 337-341.","DOI":"10.1111\/j.1440-1754.2007.01077.x"},{"key":"27","doi-asserted-by":"crossref","unstructured":"Yabe, H., Suzuki, Y., Mashiko, H., Nakayama, Y., Hisata, M., Niwa, S., Yasumura, S., Yamashita, S., Kamiya, K. &amp; Abe, M.;  Mental Health Group of the Fukushima Health Management Survey  (2014)  Psychological distress after the Great East Japan Earthquake and Fukushima Daiichi Nuclear Power Plant accident: results of a mental health and lifestyle survey through the Fukushima Health Management Survey in FY2011 and FY2012.  <i>Fukushima J. Med. Sci.<\/i>, 60, 57-67.","DOI":"10.5387\/fms.2014-1"},{"key":"28","doi-asserted-by":"crossref","unstructured":"Zhou, Y., You, H., Xin, J., Gu, Y., Lin, S. &amp; Ding, F. (2010)  Nephrotic syndrome with minimal change disease following insect bite: case report and a published work review.  <i>Nephrology <\/i>(<i>Carlton<\/i>), 15, 592.","DOI":"10.1111\/j.1440-1797.2010.01211.x"}],"container-title":["The Tohoku Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/tjem\/253\/2\/253_125\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T03:51:00Z","timestamp":1613793060000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/tjem\/253\/2\/253_125\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.1620\/tjem.253.125","relation":{},"ISSN":["0040-8727","1349-3329"],"issn-type":[{"value":"0040-8727","type":"print"},{"value":"1349-3329","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}