{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T08:43:39Z","timestamp":1792226619905,"version":"4.4.0"},"reference-count":31,"publisher":"Zhejiang University Press","issue":"5","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Zhejiang Univ. Sci. B"],"published-print":{"date-parts":[[2009,5]]},"DOI":"10.1631\/jzus.b0820248","type":"journal-article","created":{"date-parts":[[2009,5,4]],"date-time":"2009-05-04T19:01:49Z","timestamp":1241463709000},"page":"331-340","source":"Crossref","is-referenced-by-count":32,"title":["Adenovirus-mediated wild-type p53 gene transfer in combination with bronchial arterial infusion for treatment of advanced non-small-cell lung cancer, one year follow-up"],"prefix":"10.1631","volume":"10","author":[{"given":"Yong-song","family":"Guan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi","family":"La","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"635","published-online":{"date-parts":[[2009,5,2]]},"reference":[{"issue":"2","key":"2471_CR1","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3109\/07357909009017560","volume":"8","author":"J.A. Ajani","year":"1990","unstructured":"Ajani, J.A., Welch, S.R., Raber, M.N., 1990. Comprehensive criteria for assessing therapy-induced toxicity. Cancer Invest., 8(2):147\u2013159. [doi:10.3109\/07357909009017560]","journal-title":"Cancer Invest."},{"issue":"5","key":"2471_CR2","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1474-9726.2006.00228.x","volume":"5","author":"J.H. Bauer","year":"2006","unstructured":"Bauer, J.H., Helfand, S.L., 2006. New tricks of an old molecule: lifespan regulation by p53. Aging Cell, 5(5):437\u2013440. [doi:10.1111\/j.1474-9726.2006.00228.x]","journal-title":"Aging Cell"},{"issue":"23","key":"2471_CR3","first-page":"2033","volume":"83","author":"C.B. Chen","year":"2003","unstructured":"Chen, C.B., Pan, J.J., Xu, L.Y., 2003. Recombinant adenovirus-p53 agent injection combine with radiotherapy in treatment of nasopharyngeal carcinoma: a phase. II. Clinical trial. Zhonghua Yi Xue Za Zhi, 83(23):2033\u20132035 (in Chinese).","journal-title":"Zhonghua Yi Xue Za Zhi"},{"issue":"3","key":"2471_CR4","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1002\/ssu.10038","volume":"21","author":"J.C. Daniel","year":"2003","unstructured":"Daniel, J.C., Smythe, W.R., 2003. Gene therapy of lung cancer. Semin. Surg. Oncol., 21(3):196\u2013204. [doi:10.1002\/ssu.10038]","journal-title":"Semin. Surg. Oncol."},{"issue":"5","key":"2471_CR5","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1634\/theoncologist.4-5-379","volume":"4","author":"G. Frasci","year":"1999","unstructured":"Frasci, G., Panza, N., Comella, G., Pcillio, G., 1999. Is there any impact of new drugs on the outcome of advanced NSCLC? An overview of the Southern Italy Cooperative Oncology Group trials. Oncologist, 4(5):379\u2013385.","journal-title":"Oncologist"},{"issue":"9","key":"2471_CR6","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1136\/gut.2005.069237","volume":"54","author":"Y.S. Guan","year":"2005","unstructured":"Guan, Y.S., Liu, Y., Zhou, X.P., Li, X., He, Q., Sun, L., 2005. p53 gene (Gendicine) and embolization overcame recurrent hepatocellular carcinoma. Gut, 54(9):1318\u20131319. [doi:10.1136\/gut.2005.069237]","journal-title":"Gut"},{"issue":"17","key":"2471_CR7","first-page":"3551","volume":"22","author":"M. Hollstein","year":"1994","unstructured":"Hollstein, M., Rice, K., Greenblatt, M.S., Soussi, T., Fuchs, R., S\u00f8rlie, T., Hovig, E., Smith-s\u00f8rensen, B., Montesano, R., Harris, C.C., 1994. Database of p53 gene somatic mutations in human tumors and cell lines. Nucleic Acids Res., 22(17):3551\u20133555.","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"2471_CR8","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0304-3835(00)00480-8","volume":"157","author":"A. Inoue","year":"2000","unstructured":"Inoue, A., Natumi, K., Matsubrara, N., Sugawara, S., Saijo, Y., Satoh, K., Nukiwa, T., 2000. Administration of wild-type p53 adenoviral vector synergistically enhances the cytotoxicity of anti-cancer drugs in human lung cancer cells irrespective of the status of p53 gene. Cancer Lett., 157(1):105\u2013112. [doi:10.1016\/S0304-3835(00)00480-8]","journal-title":"Cancer Lett."},{"issue":"4","key":"2471_CR9","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1007\/s004320050039","volume":"126","author":"K. Junker","year":"2000","unstructured":"Junker, K., Wiethege, T., Muller, K.M., Thomas, M., 2000. p53 tumour-suppressor gene in non-small-cell lung cancer with neoadjuvant therapy. J. Cancer Res. Clin. Oncol., 126(4):238\u2013245. [doi:10.1007\/s004320050039]","journal-title":"J. Cancer Res. Clin. Oncol."},{"issue":"2","key":"2471_CR10","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1007\/s003300050670","volume":"9","author":"H.U. Kauczor","year":"1999","unstructured":"Kauczor, H.U., Schuler, M., Heussel, C.P., von Weymarn, A., Bongartz, G., Rochlitz, C., Huber, C., Thelen, M., 1999. CT-guided intratumoral gene therapy in non-small-cell lung cancer. Eur. Radiol., 9(2):292\u2013296. [doi:10.1007\/s003300050670]","journal-title":"Eur. Radiol."},{"issue":"2","key":"2471_CR11","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1080\/09553000010008540","volume":"77","author":"S. Kawabe","year":"2001","unstructured":"Kawabe, S., Munshi, A., Zumstein, L.A., Wilson, D.R., Roth, J.A., Meyn, R.E., 2001. Adenovirus-mediated wild-type p53 gene expression radiosensitizes non-small cell lung cancer cells but not normal lung fibroblasts. Int. J. Radiat. Biol., 77(2):185\u2013194. [doi:10.1080\/09553000010008540]","journal-title":"Int. J. Radiat. Biol."},{"issue":"52","key":"2471_CR12","doi-asserted-by":"crossref","first-page":"7763","DOI":"10.1038\/sj.onc.1209048","volume":"24","author":"D. Ko","year":"2005","unstructured":"Ko, D., Hawkins, L., Yu, D.C., 2005. Development of transcriptionally regulated oncolytic adenoviruses. Oncogene, 24(52):7763\u20137774. [doi:10.1038\/sj.onc.1209048]","journal-title":"Oncogene"},{"issue":"6","key":"2471_CR13","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1093\/jnci\/83.6.417","volume":"83","author":"T. Chevalier Le","year":"1991","unstructured":"Le Chevalier, T., Arriagada, R., Quoix, E., 1991. Radiotherapy alone versus combined chemotherapy and radiotherapy in non-resectable non-small cell lung cancer: first analysis of a randomized trial in 353 patients. J. Natl. Cancer Inst., 83(6):417\u2013423. [doi:10.1093\/jnci\/83.6.417]","journal-title":"J. Natl. Cancer Inst."},{"issue":"3","key":"2471_CR14","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0092-8674(00)81871-1","volume":"88","author":"A.J. Levine","year":"1997","unstructured":"Levine, A.J., 1997. p53 the cellular gatekeeper for growth and division. Cell, 88(3):323\u2013331. [doi:10.1016\/S0092-8674(00)81871-1]","journal-title":"Cell"},{"issue":"6","key":"2471_CR15","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1097\/00001622-199511000-00013","volume":"7","author":"S.W. Lowe","year":"1995","unstructured":"Lowe, S.W., 1995. Cancer gene therapy and p53. Curr. Opin. Oncol., 7(6):547\u2013553. [doi:10.1097\/00001622-199511000-00013]","journal-title":"Curr. Opin. Oncol."},{"issue":"14","key":"2471_CR16","first-page":"5055","volume":"9","author":"C. Moon","year":"2003","unstructured":"Moon, C., Oh, Y., Roth, J.A., 2003. Current status of gene therapy for lung cancer and head and neck cancer. Clin. Cancer Res., 9(14):5055\u20135067.","journal-title":"Clin. Cancer Res."},{"issue":"3","key":"2471_CR17","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1200\/JCO.2000.18.3.609","volume":"18","author":"J. Nemunaitis","year":"2000","unstructured":"Nemunaitis, J., Swisher, S.G., Timmons, T., Connors, D., Mack, M., Doerksen, L., Weill, D., Wait, J., Lawrence, D.D., Kemp, B.L., et al., 2000. Adenovirus-mediated p53 gene transfer in sequence with cisplatin to tumors of patients with non-small-cell lung cancer. J. Clin. Oncol., 18(3):609\u2013622.","journal-title":"J. Clin. Oncol."},{"issue":"9","key":"2471_CR18","first-page":"2887","volume":"7","author":"M. Nishizaki","year":"2001","unstructured":"Nishizaki, M., Meyn, R.E., Levy, L.B., Atkinson, E.N., White, R.A., Roth, J.A., Ji, L., 2001. Synergistic inhibition of human lung cancer cell growth by adenovirus-mediated wild-type p53 gene transfer in combination with docetaxel and radiation therapeutic in vitro and in vivo. Clin. Cancer Res., 7(9):2887\u20132897.","journal-title":"Clin. Cancer Res."},{"issue":"2","key":"2471_CR19","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/sj.cgt.7700096","volume":"7","author":"S. Osaki","year":"2000","unstructured":"Osaki, S., Nakanishi, Y., Takayama, K., Pei, X.H., Ueno, H., Hara, N., 2000. Alteration of drug chemosensitivity caused by the adenovirus-mediated transfer of the wild-type p53 gene in human lung cancer cells. Cancer Gene Ther., 7(2):300\u2013307. [doi:10.1038\/sj.cgt.7700096]","journal-title":"Cancer Gene Ther."},{"issue":"1","key":"2471_CR20","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3322\/canjclin.47.1.5","volume":"47","author":"S.L. Parker","year":"1997","unstructured":"Parker, S.L., Tong, T., Bolden, S., Wingo, P.A., 1997. Cancer statistics, 1997. CA Cancer J. Clin., 47(1):5\u201327. [doi:10.3322\/canjclin.47.1.5]","journal-title":"CA Cancer J. Clin."},{"issue":"9","key":"2471_CR21","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1089\/hum.2005.16.1016","volume":"16","author":"Z. Peng","year":"2005","unstructured":"Peng, Z., 2005. Current status of gendicine in China: recombinant human Ad-p53 agent for treatment of cancers. Hum. Gene. Ther., 16(9):1016\u20131027. [doi:10.1089\/hum. 2005.16.1016]","journal-title":"Hum. Gene. Ther."},{"issue":"9","key":"2471_CR22","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1038\/nm0996-985","volume":"2","author":"J.A. Roth","year":"1996","unstructured":"Roth, J.A., Nguyen, D., Lawrence, D.D., Kemp, B.L., Carrasco, C.H., Ferson, D.Z., Hong, W.K., Komaki, R., Lee, J.J., Nesbitt, J.C., et al., 1996. Retrovirus-mediated p53 gene therapy. Nat. Med., 2(9):985\u2013991. [doi:10.1038\/nm0996-985]","journal-title":"Nat. Med."},{"issue":"8","key":"2471_CR23","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1056\/NEJM199202203260805","volume":"326","author":"C. Schaake-koning","year":"1992","unstructured":"Schaake-koning, C., van den Boggert, W., Dalesio, O., Festen, J., Hoogenhout, J., van Houtte, P., Kirpatrick, A., Koolen, M., Maat, B., Nijs, A., 1992. Effects of concomitant cisplatin and radiotherapy on inoperable non-small cell lung cancer. N. Engl. J. Med., 326(8):524\u2013530.","journal-title":"N. Engl. J. Med."},{"issue":"6","key":"2471_CR24","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1200\/JCO.2001.19.6.1750","volume":"19","author":"M. Schuler","year":"2001","unstructured":"Schuler, M., Herrmann, R., de Greve, J.L., Stewart, A.K., Gatzemeier, U., Stewart, D.J., Laufman, L., Gralla, R., Kuball, J., Buhl, R., et al., 2001. Adenovirus-mediated wild-type p53 gene transfer in patients receiving chemotherapy for advanced non-small-cell lung cancer: results of a multicenter phase II study. J. Clin. Oncol., 19(6):1750\u20131758.","journal-title":"J. Clin. Oncol."},{"issue":"3","key":"2471_CR25","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S1055-3207(02)00028-5","volume":"11","author":"S.G. Swisher","year":"2002","unstructured":"Swisher, S.G., Roth, J.A., 2002. Clinical update of Ad-p53 gene therapy for lung cancer. Surg. Oncol. Clin. N. Am., 11(3):521\u2013535. [doi:10.1016\/S1055-3207(02)00028-5]","journal-title":"Surg. Oncol. Clin. N. Am."},{"issue":"9","key":"2471_CR26","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1093\/jnci\/91.9.763","volume":"91","author":"S.G. Swisher","year":"1999","unstructured":"Swisher, S.G., Roth, J.A., Nemunaitis, J., Lawrence, D.D., Kemp, B.L., Carrasco, C.H., Connors, D.G., El-naggar, A.K., Fossella, F., Glisson, B.S., et al., 1999. Adenovirus-mediated p53 gene transfer in advanced non-small-cell lung cancer. J. Natl. Cancer Inst., 91(9):763\u2013771. [doi:10.1093\/jnci\/91.9.763]","journal-title":"J. Natl. Cancer Inst."},{"issue":"1","key":"2471_CR27","first-page":"93","volume":"9","author":"S.G. Swisher","year":"2003","unstructured":"Swisher, S.G., Roth, J.A., Komaki, R., Gu, J., Lee, J.J., Hicks, M., Ro, J.Y., Hong, W.K., Merritt, J.A., Ahrar, K., et al., 2003. Induction of p53-regulated genes and tumor regression in ling cancer patients after intratumoral delivery of adenoviral p53 (INGN 201) and radiation therapy. Clin. Cancer Res., 9(1):93\u2013101.","journal-title":"Clin. Cancer Res."},{"issue":"4929","key":"2471_CR28","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1126\/science.2554494","volume":"246","author":"T. Takahashi","year":"1989","unstructured":"Takahashi, T., Nau, M.M., Chiba, I., Birrer, M.J., Rosenberg, R.K., Vinocour, M., Levitt, M., Pass, H., Gazadr, A.F., Minna, J.D., 1989. p53: a frequent target for genetic abnormalities in lung cancer. Science, 246(4929):491\u2013499. [doi:10.1126\/science.2554494]","journal-title":"Science"},{"issue":"3","key":"2471_CR29","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1093\/jnci\/92.3.205","volume":"92","author":"P. Therasse","year":"2000","unstructured":"Therasse, P., Arbuck, S.G., Eisenhauer, E.A., Wanders, J., Kaplan, R.S., Rubinstein, L., Verweij, J., van Glabbeke, M., van Oostrom, A.T., Christian, M.C., Gwyther, S.G., 2000. New guidelines to evaluate the response to treatment in solid tumor. J. Natl. Cancer Inst., 92(3):205\u2013216. [doi:10.1093\/jnci\/92.3.205]","journal-title":"J. Natl. Cancer Inst."},{"issue":"5204","key":"2471_CR30","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1126\/science.267.5204.1613-b","volume":"267","author":"B. Vogelstein","year":"1995","unstructured":"Vogelstein, B., Kinzler, K.W., 1995. Through the glass lightly. Science, 267(5204):1613. [doi:10.1126\/science.267.5204.1613-b]","journal-title":"Science"},{"issue":"2","key":"2471_CR31","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/0360-3016(95)02111-6","volume":"34","author":"G. Wang","year":"1996","unstructured":"Wang, G., Song, M., Xu, H., Fang, Y., 1996. Prospective trial of combined hyperfractionated radiotherapy and bronchial arterial infusion of chemotherapy for locally advanced non-small cell lung cancer. Int. J. Radiat Oncol. Biol. Phys., 34(2):309\u2013313.","journal-title":"Int. J. Radiat Oncol. Biol. Phys."}],"container-title":["Journal of Zhejiang University SCIENCE B"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1631\/jzus.B0820248.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1631\/jzus.B0820248\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1631\/jzus.B0820248","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T22:29:49Z","timestamp":1589754589000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1631\/jzus.B0820248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,5]]}},"alternative-id":["2471"],"URL":"https:\/\/doi.org\/10.1631\/jzus.b0820248","relation":{},"ISSN":["1673-1581","1862-1783"],"issn-type":[{"value":"1673-1581","type":"print"},{"value":"1862-1783","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,5]]}}}