{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T05:02:19Z","timestamp":1785819739280,"version":"3.56.0"},"reference-count":18,"publisher":"Zhejiang University Press","issue":"9","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Zhejiang Univ. Sci. B"],"published-print":{"date-parts":[[2013,9]]},"DOI":"10.1631\/jzus.b1200221","type":"journal-article","created":{"date-parts":[[2013,9,7]],"date-time":"2013-09-07T02:18:00Z","timestamp":1378520280000},"page":"837-843","source":"Crossref","is-referenced-by-count":18,"title":["Influence of induced ciprofloxacin resistance on efflux pump activity of Klebsiella pneumoniae"],"prefix":"10.1631","volume":"14","author":[{"given":"Hai-qin","family":"Zhong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"635","published-online":{"date-parts":[[2013,9,8]]},"reference":[{"issue":"6","key":"3501_CR1","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1007\/s10096-010-1147-0","volume":"30","author":"S Aathithan","year":"2011","unstructured":"Aathithan, S., French, G.L., 2011. Prevalence and role of efflux pump activity in ciprofloxacin resistance in clinical isolates of Klebsiella pneumoniae. Eur. J. Clin. Microbiol. Infect. Dis., 30(6):745\u2013752. [doi:10.1007\/s10096-010-1147-0]","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"issue":"9","key":"3501_CR2","doi-asserted-by":"crossref","first-page":"3621","DOI":"10.1128\/AAC.48.9.3621-3624.2004","volume":"48","author":"R Chollet","year":"2004","unstructured":"Chollet, R., Chevalier, J., Bryskier, A., Pag\u00e8s, J.M., 2004. The AcrAB-TolC pump is involved in macrolide resistance but not in telithromycin efflux in Enterobacter aerogenes and Escherichia coli. Antimicrob. Agents Chemother., 48(9):3621\u20133624. [doi:10.1128\/AAC.48.9.3621-3624.2004]","journal-title":"Agents Chemother."},{"key":"3501_CR3","volume-title":"Performance Standards for Antimicrobial Susceptibility Testing; Twenty-second Informational Supplement","author":"CLSI ClinicalLaboratory Standards Institute","year":"2012","unstructured":"CLSI (Clinical and Laboratory Standards Institute), 2012. Performance Standards for Antimicrobial Susceptibility Testing; Twenty-second Informational Supplement. ISO M100-S22:2012, Clinical and Laboratory Standards Institute, America."},{"issue":"3","key":"3501_CR4","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.ijantimicag.2010.03.028","volume":"36","author":"R Daugelavi\u010dius","year":"2010","unstructured":"Daugelavi\u010dius, R., Buivydas, A., Sen\u010dilo, A., Bamford, D.H., 2010. Assessment of the activity of RND-type multidrug efflux pumps in Pseudomonasaeruginosa using tetraphenylphosphonium ions. Int. J. Antimicrob. Agents, 36(3):234\u2013238. [doi:10.1016\/j.ijantimicag.2010.03.028]","journal-title":"Int. J. Antimicrob. Agents"},{"issue":"2","key":"3501_CR5","doi-asserted-by":"crossref","first-page":"175","DOI":"10.4067\/S0716-10182012000200009","volume":"29","author":"LM Echeverri-Toro","year":"2012","unstructured":"Echeverri-Toro, L.M., Rueda, Z.V., Maya, W., Agudelo, Y., Ospina, S., 2012. Multidrug-resistant Klebsiella pneumoniae, predisposing factors and associated mortality in a tertiary-care hospital in Colombia. Rev. Chilena Infectol., 29(2):175\u2013182. [doi:10.4067\/S0716-10182012000200009]","journal-title":"Rev. Chilena Infectol."},{"issue":"4","key":"3501_CR6","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.jhin.2009.02.021","volume":"73","author":"ME Falagas","year":"2009","unstructured":"Falagas, M.E., Karageorgopoulos, D.E., 2009. Extended-spectrum \u03b2-lactamase-producing organisms. J. Hosp. Infect., 73(4):345\u2013354. [doi:10.1016\/j.jhin.2009.02.021]","journal-title":"J. Hosp. Infect."},{"issue":"6","key":"3501_CR7","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1128\/JCM.42.6.2701-2706.2004","volume":"42","author":"UO Hasdemir","year":"2004","unstructured":"Hasdemir, U.O., Chevalier, J., Nordmann, P., Pag\u00e8s, J.M., 2004. Detection and prevalence of active drug efflux mechanism in various multidrug-resistant Klebsiella pneumoniae strains from Turkey. J. Clin. Microbiol., 42(6):2701\u20132706. [doi:10.1128\/JCM.42.6.2701-2706.2004]","journal-title":"J. Clin. Microbiol."},{"issue":"5","key":"3501_CR8","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.ijantimicag.2005.02.006","volume":"25","author":"KL Hopkins","year":"2005","unstructured":"Hopkins, K.L., Davies, R.H., Threlfall, E.J., 2005. Mechanisms of quinolone resistance in Escherichia coli and Salmonella: recent developments. Int. J. Antimicrob. Agents, 25(5):358\u2013373. [doi:10.1016\/j.ijantimicag.2005.02.006]","journal-title":"Int. J. Antimicrob. Agents"},{"key":"3501_CR9","doi-asserted-by":"crossref","first-page":"S145","DOI":"10.1016\/S0035-9203(08)70032-4","volume":"102","author":"A Kumar","year":"2008","unstructured":"Kumar, A., Mayo, M., Trunck, L.A., Cheng, A.C., Currie, B.J., Schweizer, H.P., 2008. Expression of resistance-nodulation-cell-division efflux pumps in commonly used Burkholderia pseudomallei strains and clinical isolates from northern Australia. Trans. R. Soc. Trop. Med. Hyg., 102:S145\u2013S151. [doi:10.1016\/S0035-9203(08)70032-4]","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"issue":"12","key":"3501_CR10","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.2165\/11317030-000000000-00000","volume":"69","author":"XZ Li","year":"2009","unstructured":"Li, X.Z., Nikaido, H., 2009. Efflux-mediated drug resistance in bacteria: an update. Drugs, 69(12):1555\u20131623. [doi:10.2165\/11317030-000000000-00000]","journal-title":"Drugs"},{"issue":"7","key":"3501_CR11","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.bcp.2005.10.021","volume":"71","author":"AS Lynch","year":"2006","unstructured":"Lynch, A.S., 2006. Efflux systems in bacterial pathogens: an opportunity for therapeutic intervention? An industry view. Biochem. Pharmacol., 71(7):949\u2013956. [doi:10.1016\/j.bcp.2005.10.021]","journal-title":"Biochem. Pharmacol."},{"issue":"3","key":"3501_CR12","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1006\/scdb.2000.0247","volume":"12","author":"H Nikaido","year":"2001","unstructured":"Nikaido, H., 2001. Preventing drug access to targets: cell surface permeability barriers and active efflux in bacteria. Semin. Cell Dev. Biol., 12(3):215\u2013223. [doi:10.1006\/scdb.2000.0247]","journal-title":"Semin. Cell Dev. Biol."},{"issue":"5","key":"3501_CR13","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.bbapap.2008.12.011","volume":"1794","author":"JM Pag\u00e8s","year":"2009","unstructured":"Pag\u00e8s, J.M., Amaral, L., 2009. Mechanisms of drug efflux and strategies to combat them: challenging the efflux pump of Gram-negative bacteria. Biochim. Biophys. Acta, 1794(5): 826\u2013833. [doi:10.1016\/j.bbapap.2008.12.011]","journal-title":"Biochim. Biophys. Acta"},{"issue":"1","key":"3501_CR14","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1754-1611-3-18","volume":"3","author":"L Paix\u00e3o","year":"2009","unstructured":"Paix\u00e3o, L., Rodrigues, L., Couto, I., Martins, M., Fernandes, P., de Carvalho, C.C., Monteiro, G.A., Sansonetty, F., Amaral, L., Viveiros, M., 2009. Fluorometric determination of ethidium bromide efflux kinetics in Escherichia coli. J. Biol. Eng., 3(1):18. [doi:10.1186\/1754-1611-3-18]","journal-title":"J. Biol. Eng."},{"issue":"2","key":"3501_CR15","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s10156-010-0120-2","volume":"17","author":"JM Rodr\u00edguez-Mart\u00ednez","year":"2011","unstructured":"Rodr\u00edguez-Mart\u00ednez, J.M., Cano, M.E., Velasco, C., Mart\u00ednez-Mart\u00ednez, L., Pascual, A., 2011. Plamid-mediated quinolone resistance: an update. J. Infect. Chemother., 17(2):149\u2013182. [doi:10.1007\/s10156-010-0120-2]","journal-title":"J. Infect. Chemother."},{"issue":"5","key":"3501_CR16","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.ijantimicag.2009.04.012","volume":"34","author":"GC Schito","year":"2009","unstructured":"Schito, G.C., Naber, K.G., Botto, H., Palou, J., Mazzei, T., Gualco, L., Marchese, A., 2009. The ARESC study: an international survey on the antimicrobial resistance of pathogens involved in uncomplicated urinary tract infections. Int. J. Antimicrob. Agents, 34(5):407\u2013413. [doi:10.1016\/j.ijantimicag.2009.04.012]","journal-title":"Int. J. Antimicrob. Agents"},{"issue":"4","key":"3501_CR17","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0006-2952(00)00291-4","volume":"60","author":"F Bambeke van","year":"2000","unstructured":"van Bambeke, F., Balzi, E., Tulkens, P.M., 2000. Antibiotic efflux pumps. Biochem. Pharmacol., 60(4):457\u2013470. [doi:10.1016\/S0006-2952(00)00291-4]","journal-title":"Biochem. Pharmacol."},{"issue":"4","key":"3501_CR18","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1093\/jac\/dkq538","volume":"66","author":"CF Donk van der","year":"2011","unstructured":"van der Donk, C.F., Beisser, P.S., Hoogkamp-Korstanje, J.A., Bruggeman, C.A., Stobberingh, E.E., Antibotic Resistance Surveillance Group, 2011. A 12-year (1998\u20132009) antibiotic resistance surveillance of Klebsiella pneumoniae collected from intensive care and urology patients in 14 Dutch hospitals. J. Antimicrob. Chemother., 66(4): 855\u2013858. [doi:10.1093\/jac\/dkq538]","journal-title":"J. Antimicrob. Chemother."}],"container-title":["Journal of Zhejiang University SCIENCE B"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1631\/jzus.B1200221.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1631\/jzus.B1200221\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1631\/jzus.B1200221","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T01:00:07Z","timestamp":1559610007000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1631\/jzus.B1200221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9]]},"references-count":18,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["3501"],"URL":"https:\/\/doi.org\/10.1631\/jzus.b1200221","relation":{},"ISSN":["1673-1581","1862-1783"],"issn-type":[{"value":"1673-1581","type":"print"},{"value":"1862-1783","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9]]}}}