{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T03:17:02Z","timestamp":1789615022167,"version":"build-2803163510"},"reference-count":137,"publisher":"Zhejiang University Press","issue":"4","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J. Zhejiang Univ. Sci. B"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1631\/jzus.b2100977","type":"journal-article","created":{"date-parts":[[2022,4,16]],"date-time":"2022-04-16T15:02:42Z","timestamp":1650121362000},"page":"265-285","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["Molecular pathogenesis of acetaminophen-induced liver injury and its treatment options","\u5bf9\u4e59\u9170\u6c28\u57fa\u915a\u8bf1\u5bfc\u7684\u809d\u635f\u4f24\u7684\u5206\u5b50\u53d1\u75c5\u673a\u5236\u53ca\u6cbb\u7597\u7b56\u7565"],"prefix":"10.1631","volume":"23","author":[{"given":"Xiaopeng","family":"Cai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiqiang","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5340-4856","authenticated-orcid":false,"given":"Jingwen","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0848-1502","authenticated-orcid":false,"given":"Zhi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"635","published-online":{"date-parts":[[2022,4,16]]},"reference":[{"issue":"12","key":"595_CR1","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1177\/0960327118774902","volume":"37","author":"JY Akakpo","year":"2018","unstructured":"Akakpo JY, Ramachandran A, Kandel SE, et al., 2018. 4-Methylpyrazole protects against acetaminophen hepatotoxicity in mice and in primary human hepatocytes. Hum Exp Toxicol, 37(12):1310\u20131322. https:\/\/doi.org\/10.1177\/0960327118774902","journal-title":"Hum Exp Toxicol"},{"issue":"11","key":"595_CR2","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1080\/17425255.2020.1817896","volume":"16","author":"JY Akakpo","year":"2020","unstructured":"Akakpo JY, Ramachandran A, Jaeschke H, 2020. Novel strategies for the treatment of acetaminophen hepatotoxicity. Expert Opin Drug Metab Toxicol, 16(11):1039\u20131050. https:\/\/doi.org\/10.1080\/17425255.2020.1817896","journal-title":"Expert Opin Drug Metab Toxicol"},{"issue":"2","key":"595_CR3","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1002\/hep.25657","volume":"56","author":"CG Antoniades","year":"2012","unstructured":"Antoniades CG, Quaglia A, Taams LS, et al., 2012. Source and characterization of hepatic macrophages in acetaminophen-induced acute liver failure in humans. Hepatology, 56(2): 735\u2013746. https:\/\/doi.org\/10.1002\/hep.25657","journal-title":"Hepatology"},{"issue":"3","key":"595_CR4","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.2353\/ajpath.2009.080976","volume":"175","author":"U Apte","year":"2009","unstructured":"Apte U, Singh S, Zeng G, et al., 2009. Beta-catenin activation promotes liver regeneration after acetaminophen-induced injury. Am J Pathol, 175(3):1056\u20131065. https:\/\/doi.org\/10.2353\/ajpath.2009.080976","journal-title":"Am J Pathol"},{"key":"595_CR5","doi-asserted-by":"publisher","first-page":"2068","DOI":"10.1038\/s41467-017-01970-x","volume":"8","author":"L Barbier-Torres","year":"2017","unstructured":"Barbier-Torres L, Iruzubieta P, Fern\u00e1ndez-Ramos D, et al., 2017. The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury. Nat Commun, 8:2068. https:\/\/doi.org\/10.1038\/s41467-017-01970-x","journal-title":"Nat Commun"},{"issue":"5","key":"595_CR6","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1111\/j.1478-3231.2010.02219.x","volume":"30","author":"PA Berry","year":"2010","unstructured":"Berry PA, Antoniades CG, Hussain MJ, et al., 2010. Admission levels and early changes in serum interleukin-10 are predictive of poor outcome in acute liver failure and decompensated cirrhosis. Liver Int, 30(5):733\u2013740. https:\/\/doi.org\/10.1111\/j.1478-3231.2010.02219.x","journal-title":"Liver Int"},{"issue":"4","key":"595_CR7","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1016\/j.ajpath.2018.12.006","volume":"189","author":"B Bhushan","year":"2019","unstructured":"Bhushan B, Apte U, 2019. Liver regeneration after acetaminophen hepatotoxicity: mechanisms and therapeutic opportunities. Am J Pathol, 189(4):719\u2013729. https:\/\/doi.org\/10.1016\/j.ajpath.2018.12.006","journal-title":"Am J Pathol"},{"issue":"11","key":"595_CR8","doi-asserted-by":"publisher","first-page":"3013","DOI":"10.1016\/j.ajpath.2014.07.019","volume":"184","author":"B Bhushan","year":"2014","unstructured":"Bhushan B, Walesky C, Manley M, et al., 2014. Pro-regenerative signaling after acetaminophen-induced acute liver injury in mice identified using a novel incremental dose model. Am J Pathol, 184(11):3013\u20133025. https:\/\/doi.org\/10.1016\/j.ajpath.2014.07.019","journal-title":"Am J Pathol"},{"issue":"2","key":"595_CR9","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1093\/toxsci\/kfw213","volume":"155","author":"B Bhushan","year":"2017","unstructured":"Bhushan B, Chavan H, Borude P, et al., 2017a. Dual role of epidermal growth factor receptor in liver injury and regeneration after acetaminophen overdose in mice. Toxicol Sci, 155(2):363\u2013378. https:\/\/doi.org\/10.1093\/toxsci\/kfw213","journal-title":"Toxicol Sci"},{"issue":"3","key":"595_CR10","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1016\/j.ajpath.2016.11.014","volume":"187","author":"B Bhushan","year":"2017","unstructured":"Bhushan B, Poudel S, Manley MW, et al., 2017b. Inhibition of glycogen synthase kinase 3 accelerated liver regeneration after acetaminophen-induced hepatotoxicity in mice. Am J Pathol, 187(3):543\u2013552. https:\/\/doi.org\/10.1016\/j.ajpath.2016.11.014","journal-title":"Am J Pathol"},{"issue":"10","key":"595_CR11","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1111\/j.1478-3231.2006.01342.x","volume":"26","author":"M Bilzer","year":"2006","unstructured":"Bilzer M, Roggel F, Gerbes AL, 2006. Role of kupffer cells in host defense and liver disease. Liver Int, 26(10): 1175\u20131186. https:\/\/doi.org\/10.1111\/j.1478-3231.2006.01342.x","journal-title":"Liver Int"},{"issue":"454","key":"595_CR12","doi-asserted-by":"publisher","first-page":"eaan1230","DOI":"10.1126\/scitranslmed.aan1230","volume":"10","author":"TG Bird","year":"2018","unstructured":"Bird TG, M\u00fcller M, Boulter L, et al., 2018. TGF\u03b2 inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence. Sci Transl Med, 10(454): eaan1230. https:\/\/doi.org\/10.1126\/scitranslmed.aan1230","journal-title":"Sci Transl Med"},{"issue":"1","key":"595_CR13","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1006\/taap.1995.1125","volume":"133","author":"ME Blazka","year":"1995","unstructured":"Blazka ME, Wilmer JL, Holladay SD, et al., 1995. Role of proinflammatory cytokines in acetaminophen hepatotoxicity. Toxicol Appl Pharmacol, 133(1):43\u201352. https:\/\/doi.org\/10.1006\/taap.1995.1125","journal-title":"Toxicol Appl Pharmacol"},{"issue":"4","key":"595_CR14","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1002\/hep.510270418","volume":"27","author":"F Boess","year":"1998","unstructured":"Boess F, Bopst M, Althaus R, et al., 1998. Acetaminophen hepatotoxicity in tumor necrosis factor\/lymphotoxin-\u03b1 gene knockout mice. Hepatology, 27(4): 1021\u20131029. https:\/\/doi.org\/10.1002\/hep.510270418","journal-title":"Hepatology"},{"issue":"20","key":"595_CR15","doi-asserted-by":"publisher","first-page":"5551","DOI":"10.1093\/emboj\/cdg516","volume":"22","author":"T Bonaldi","year":"2003","unstructured":"Bonaldi T, Talamo F, Scaffidi P, et al., 2003. Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion. EMBO J, 22(20):5551\u20135560. https:\/\/doi.org\/10.1093\/emboj\/cdg516","journal-title":"EMBO J"},{"issue":"6","key":"595_CR16","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.1016\/j.ajpath.2018.03.006","volume":"188","author":"P Borude","year":"2018","unstructured":"Borude P, Bhushan B, Gunewardena S, et al., 2018. Pleiotropic role of p53 in injury and liver regeneration after acetaminophen overdose. Am J Pathol, 188(6):1406\u20131418. https:\/\/doi.org\/10.1016\/j.ajpath.2018.03.006","journal-title":"Am J Pathol"},{"issue":"2","key":"595_CR17","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1053\/jhep.2002.30956","volume":"35","author":"M Bourdi","year":"2002","unstructured":"Bourdi M, Masubuchi Y, Reilly TP, et al., 2002. Protection against acetaminophen-induced liver injury and lethality by interleukin 10: role of inducible nitric oxide synthase. Hepatology, 35(2):289\u2013298. https:\/\/doi.org\/10.1053\/jhep.2002.30956","journal-title":"Hepatology"},{"issue":"5","key":"595_CR18","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.1074\/mcp.M114.044305","volume":"14","author":"R Bruderer","year":"2015","unstructured":"Bruderer R, Bernhardt OM, Gandhi T, et al., 2015. Extending the limits of quantitative proteome profiling with data-independent acquisition and application to acetaminophen-treated three-dimensional liver microtissues. Mol Cell Proteomics, 14(5): 1400\u20131410. https:\/\/doi.org\/10.1074\/mcp.M114.044305","journal-title":"Mol Cell Proteomics"},{"issue":"3","key":"595_CR19","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1002\/hep.27201","volume":"60","author":"CC Cai","year":"2014","unstructured":"Cai CC, Huang H, Whelan S, et al., 2014. Benzyl alcohol attenuates acetaminophen-induced acute liver injury in a Toll-like receptor-4-dependent pattern in mice. Hepatology, 60(3):990\u20131002. https:\/\/doi.org\/10.1002\/hep.27201","journal-title":"Hepatology"},{"issue":"4","key":"595_CR20","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1016\/j.cld.2012.08.002","volume":"16","author":"AI Cederbaum","year":"2012","unstructured":"Cederbaum AI, 2012. Alcohol metabolism. Clin Liver Dis, 16(4):667\u2013685. https:\/\/doi.org\/10.1016\/j.cld.2012.08.002","journal-title":"Clin Liver Dis"},{"key":"595_CR21","doi-asserted-by":"publisher","first-page":"313","DOI":"10.3389\/fphar.2020.00313","volume":"11","author":"L Chang","year":"2020","unstructured":"Chang L, Xu DW, Zhu JJ, et al., 2020. Herbal therapy for the treatment of acetaminophen-associated liver injury: recent advances and future perspectives. Front Pharmacol, 11:313. https:\/\/doi.org\/10.3389\/fphar.2020.00313","journal-title":"Front Pharmacol"},{"issue":"3","key":"595_CR22","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1038\/labinvest.2016.130","volume":"97","author":"WJ Chang","year":"2017","unstructured":"Chang WJ, Song LJ, Chang XJ, et al., 2017. Early activated hepatic stellate cell-derived paracrine molecules modulate acute liver injury and regeneration. Lab Invest, 97(3): 318\u2013328. https:\/\/doi.org\/10.1038\/labinvest.2016.130","journal-title":"Lab Invest"},{"issue":"2","key":"595_CR23","doi-asserted-by":"publisher","first-page":"Cd003328","DOI":"10.1002\/14651858.CD003328.pub3","volume":"2","author":"AL Chiew","year":"2018","unstructured":"Chiew AL, Gluud C, Brok J, et al., 2018. Interventions for paracetamol (acetaminophen) overdose. Cochrane Database Syst Rev, 2(2):Cd003328. https:\/\/doi.org\/10.1002\/14651858.CD003328.pub3","journal-title":"Cochrane Database Syst Rev"},{"issue":"5","key":"595_CR24","doi-asserted-by":"publisher","first-page":"G959","DOI":"10.1152\/ajpgi.00219.2003","volume":"285","author":"H Chiu","year":"2003","unstructured":"Chiu H, Gardner CR, Dambach DM, et al., 2003. Role of p55 tumor necrosis factor receptor 1 in acetaminophen-induced antioxidant defense. Am J Physiol Gastrointest Liver Physiol, 285(5):G959\u2013G966. https:\/\/doi.org\/10.1152\/ajpgi.00219.2003","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"595_CR25","doi-asserted-by":"publisher","first-page":"105102","DOI":"10.1016\/j.phrs.2020.105102","volume":"161","author":"A Chowdhury","year":"2020","unstructured":"Chowdhury A, Nabila J, Adelusi Temitope I, et al., 2020. Current etiological comprehension and therapeutic targets of acetaminophen-induced hepatotoxicity. Pharmacol Res, 161:105102. https:\/\/doi.org\/10.1016\/j.phrs.2020.105102","journal-title":"Pharmacol Res"},{"issue":"1","key":"595_CR26","first-page":"54","volume":"238","author":"GB Corcoran","year":"1986","unstructured":"Corcoran GB, Wong BK, 1986. Role of glutathione in prevention of acetaminophen-induced hepatotoxicity by N-acetyl-l-cysteine in vivo: studies with N-acetyl-d-cysteine in mice. J Pharmacol Exp Ther, 238(1):54\u201361.","journal-title":"J Pharmacol Exp Ther"},{"issue":"2","key":"595_CR27","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1124\/jpet.105.088898","volume":"315","author":"C Cover","year":"2005","unstructured":"Cover C, Mansouri A, Knight TR, et al., 2005. Peroxynitrite-induced mitochondrial and endonuclease-mediated nuclear DNA damage in acetaminophen hepatotoxicity. J Pharmacol Exp Ther, 315(2):879\u2013887. https:\/\/doi.org\/10.1124\/jpet.105.088898","journal-title":"J Pharmacol Exp Ther"},{"issue":"1","key":"595_CR28","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.taap.2006.04.010","volume":"216","author":"C Cover","year":"2006","unstructured":"Cover C, Liu J, Farhood A, et al., 2006. Pathophysiological role of the acute inflammatory response during acetaminophen hepatotoxicity. Toxicol Appl Pharmacol, 216(1):98\u2013107. https:\/\/doi.org\/10.1016\/j.taap.2006.04.010","journal-title":"Toxicol Appl Pharmacol"},{"issue":"5","key":"595_CR29","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1073\/pnas.81.5.1327","volume":"81","author":"DC Dahlin","year":"1984","unstructured":"Dahlin DC, Miwa GT, Lu AY, et al., 1984. N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen. Proc Natl Acad Sci USA, 81(5):1327\u20131331. https:\/\/doi.org\/10.1073\/pnas.8L5.1327","journal-title":"Proc Natl Acad Sci USA"},{"issue":"5","key":"595_CR30","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1053\/jhep.2002.33162","volume":"35","author":"DM Dambach","year":"2002","unstructured":"Dambach DM, Watson LM, Gray KR, et al., 2002. Role of CCR2 in macrophage migration into the liver during acetaminophen-induced hepatotoxicity in the mouse. Hepatology, 35(5):1093\u20131103. https:\/\/doi.org\/10.1053\/jhep.2002.33162","journal-title":"Hepatology"},{"issue":"5","key":"595_CR31","doi-asserted-by":"publisher","first-page":"e0154375","DOI":"10.1371\/journal.pone.0154375","volume":"11","author":"Y Ding","year":"2016","unstructured":"Ding Y, Li Q, Xu Y, et al., 2016. Attenuating oxidative stress by paeonol protected against acetaminophen-induced hepatotoxicity in mice. PLoS ONE, 11(5):e0154375. https:\/\/doi.org\/10.1371\/journal.pone.0154375","journal-title":"PLoS ONE"},{"issue":"1","key":"595_CR32","doi-asserted-by":"publisher","first-page":"G102","DOI":"10.1152\/ajpgi.00575.2005","volume":"291","author":"B Donahower","year":"2006","unstructured":"Donahower B, McCullough SS, Kurten R, et al., 2006. Vascular endothelial growth factor and hepatocyte regeneration in acetaminophen toxicity. Am J Physiol Gastrointest Liver Physiol, 291(1):G102\u2013G109. https:\/\/doi.org\/10.1152\/ajpgi.00575.2005","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"1","key":"595_CR33","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1124\/jpet.109.163840","volume":"334","author":"BC Donahower","year":"2010","unstructured":"Donahower BC, McCullough SS, Hennings L, et al., 2010. Human recombinant vascular endothelial growth factor reduces necrosis and enhances hepatocyte regeneration in a mouse model of acetaminophen toxicity. J Pharmacol Exp Ther, 334(1):33\u201343. https:\/\/doi.org\/10.1124\/jpet.109.163840","journal-title":"J Pharmacol Exp Ther"},{"issue":"2","key":"595_CR34","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.bbrc.2012.10.029","volume":"428","author":"I Downs","year":"2012","unstructured":"Downs I, Aw TY, Liu JF, et al., 2012. V\u03b114iNKT cell deficiency prevents acetaminophen-induced acute liver failure by enhancing hepatic glutathione and altering APAP metabolism. Biochem Biophys Res Commun, 428(2):245\u2013251. https:\/\/doi.org\/10.1016\/j.bbrc.2012.10.029","journal-title":"Biochem Biophys Res Commun"},{"key":"595_CR35","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.redox.2016.10.001","volume":"10","author":"K Du","year":"2016","unstructured":"Du K, Ramachandran A, Jaeschke H, 2016. Oxidative stress during acetaminophen hepatotoxicity: sources, pathophysiological role and therapeutic potential. Redox Biol, 10: 148\u2013156. https:\/\/doi.org\/10.1016\/j.redox.2016.10.001","journal-title":"Redox Biol"},{"key":"595_CR36","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.fct.2017.08.020","volume":"108","author":"K Du","year":"2017","unstructured":"Du K, Ramachandran A, McGill MR, et al., 2017a. Induction of mitochondrial biogenesis protects against acetaminophen hepatotoxicity. Food Chem Toxicol, 108:339\u2013350. https:\/\/doi.org\/10.1016\/j.fct2017.08.020","journal-title":"Food Chem Toxicol"},{"issue":"2","key":"595_CR37","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1007\/s00204-016-1692-0","volume":"91","author":"K Du","year":"2017","unstructured":"Du K, Farhood A, Jaeschke H, 2017b. Mitochondria-targeted antioxidant Mito-Tempo protects against acetaminophen hepatotoxicity. Arch Toxicol, 91(2):761\u2013773. https:\/\/doi.org\/10.1007\/s00204-016-1692-0","journal-title":"Arch Toxicol"},{"issue":"12","key":"595_CR38","doi-asserted-by":"publisher","first-page":"1960","DOI":"10.1136\/gutjnl-2013-306294","volume":"63","author":"J Ehling","year":"2014","unstructured":"Ehling J, Bartneck M, Wei X, et al., 2014. CCL2-dependent infiltrating macrophages promote angiogenesis in progressive liver fibrosis. Gut, 63(12):1960\u20131971. https:\/\/doi.org\/10.1136\/gutjnl-2013-306294","journal-title":"Gut"},{"issue":"12","key":"595_CR39","doi-asserted-by":"publisher","first-page":"1982","DOI":"10.1124\/dmd.114.059535","volume":"42","author":"XM Fan","year":"2014","unstructured":"Fan XM, Jiang YM, Wang Y, et al., 2014. Wuzhi tablet (Schisandra sphenanthera extract) protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of NRF2-ARE and p53\/p21 pathways. Drug Metab Dispos, 42(12):1982\u20131990. https:\/\/doi.org\/10.1124\/dmd.114.059535","journal-title":"Drug Metab Dispos"},{"issue":"5","key":"595_CR40","doi-asserted-by":"publisher","first-page":"1943","DOI":"10.1159\/000493655","volume":"49","author":"XY Fan","year":"2018","unstructured":"Fan XY, Wang LD, Huang JB, et al., 2018. Pterostilbene reduces acetaminophen-induced liver injury by activating the Nrf2 antioxidative defense system via the AMPK\/AKT\/GSK3\u03b2 pathway. Cell Physiol Biochem, 49(5):1943\u20131958. https:\/\/doi.org\/10.1159\/000493655","journal-title":"Cell Physiol Biochem"},{"issue":"5","key":"595_CR41","doi-asserted-by":"publisher","first-page":"2512","DOI":"10.4049\/jimmunol.1400588","volume":"193","author":"DC Feng","year":"2014","unstructured":"Feng DC, Wang Y, Wang H, et al., 2014. Acute and chronic effects of IL-22 on acetaminophen-induced liver injury. J Immunol, 193(5):2512\u20132518. https:\/\/doi.org\/10.4049\/jimmunol.1400588","journal-title":"J Immunol"},{"issue":"1","key":"595_CR42","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.jss.2012.11.051","volume":"180","author":"JE Fisher","year":"2013","unstructured":"Fisher JE, Mckenzie TJ, Lillegard JB, et al., 2013. Role of Kupffer cells and Toll-like receptor 4 in acetaminophen-induced acute liver failure. J Surg Res, 180(1): 147\u2013155. https:\/\/doi.org\/10.1016\/j.jss.2012.11.051","journal-title":"J Surg Res"},{"key":"595_CR43","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1016\/j.biopha.2018.08.082","volume":"107","author":"CL Fu","year":"2018","unstructured":"Fu CL, Liu Y, Leng J, et al., 2018. Platycodin D protects acetaminophen-induced hepatotoxicity by inhibiting hepatocyte MAPK pathway and apoptosis in C57BL\/6J mice. Biomed Pharmacother, 107:867\u2013877. https:\/\/doi.org\/10.1016\/j.biopha.2018.08.082","journal-title":"Biomed Pharmacother"},{"issue":"6","key":"595_CR44","doi-asserted-by":"publisher","first-page":"2105","DOI":"10.1002\/hep.30954","volume":"71","author":"RY Gao","year":"2020","unstructured":"Gao RY, Wang M, Liu QH, et al., 2020. Hypoxia-inducible factor-2\u03b1 reprograms liver macrophages to protect against acute liver injury through the production of interleukin-6. Hepatology, 71(6):2105\u20132117. https:\/\/doi.org\/10.1002\/hep.30954","journal-title":"Hepatology"},{"issue":"1","key":"595_CR45","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.jhep.2018.02.024","volume":"69","author":"SH Gong","year":"2018","unstructured":"Gong SH, Lan T, Zeng LY, et al., 2018. Gut microbiota mediates diurnal variation of acetaminophen induced acute liver injury in mice. J Hepatol, 69(1):51\u201359. https:\/\/doi.org\/10.1016\/j.jhep.2018.02.024","journal-title":"J Hepatol"},{"issue":"4","key":"595_CR46","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/j.ccc.2012.07.006","volume":"28","author":"MJ Hodgman","year":"2012","unstructured":"Hodgman MJ, Garrard AR, 2012. A review of acetaminophen poisoning. Crit Care Clin, 28(4):499\u2013516. https:\/\/doi.org\/10.1016\/j.ccc.2012.07.006","journal-title":"Crit Care Clin"},{"issue":"6","key":"595_CR47","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1189\/jlb.0308173","volume":"84","author":"MP Holt","year":"2008","unstructured":"Holt MP, Cheng LL, Ju C, 2008. Identification and characterization of infiltrating macrophages in acetaminophen-induced liver injury. Leukoc Biol, 84(6):1410\u20131421. https:\/\/doi.org\/10.1189\/jlb.0308173","journal-title":"Leukoc Biol"},{"issue":"9","key":"595_CR48","doi-asserted-by":"publisher","first-page":"e44880","DOI":"10.1371\/journal.pone.0044880","volume":"7","author":"HS Hou","year":"2012","unstructured":"Hou HS, Liao CL, Sytwu HK, et al., 2012. Deficiency of interleukin-15 enhances susceptibility to acetaminophen-induced liver injury in mice. PLoS ONE, 7(9):e44880. https:\/\/doi.org\/10.1371\/journal.pone.0044880","journal-title":"PLoS ONE"},{"issue":"1","key":"595_CR49","doi-asserted-by":"publisher","first-page":"G45","DOI":"10.1152\/ajpgi.00024.2008","volume":"295","author":"B Hu","year":"2008","unstructured":"Hu B, Colletti LM, 2008. Stem cell factor and c-kit are involved in hepatic recovery after acetaminophen-induced liver injury in mice. Am Physiol Gastrointest Liver Physiol, 295(1):G45\u2013G53. https:\/\/doi.org\/10.1152\/ajpgi.00024.2008","journal-title":"Am Physiol Gastrointest Liver Physiol"},{"issue":"1","key":"595_CR50","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1093\/toxsci\/kfv319","volume":"150","author":"JT Hu","year":"2016","unstructured":"Hu JT, Ramshesh VK, McGill MR, et al., 2016a. Low dose acetaminophen induces reversible mitochondrial dysfunction associated with transient c-Jun N-terminal kinase activation in mouse liver. Toxicol Sci, 150(1):204\u2013215. https:\/\/doi.org\/10.1093\/toxsci\/kfv319","journal-title":"Toxicol Sci"},{"key":"595_CR51","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1016\/j.freeradbiomed.2016.06.024","volume":"97","author":"JT Hu","year":"2016","unstructured":"Hu JT, Kholmukhamedov A, Lindsey CC, et al., 2016b. Translocation of iron from lysosomes to mitochondria during acetaminophen-induced hepatocellular injury: protection by starch-desferal and minocycline. Free Radic Biol Med, 97:418\u2013426. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2016.06.024","journal-title":"Free Radic Biol Med"},{"key":"595_CR52","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.freeradbiomed.2017.02.028","volume":"106","author":"Y Huo","year":"2017","unstructured":"Huo Y, Yin S, Yan M, et al., 2017. Protective role of p53 in acetaminophen hepatotoxicity. Free Radic Biol Med, 106: 111\u2013117. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2017.02.028","journal-title":"Free Radic Biol Med"},{"issue":"4","key":"595_CR53","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1007\/s00535-011-0500-0","volume":"47","author":"Y Igusa","year":"2012","unstructured":"Igusa Y, Yamashina S, Izumi K, et al., 2012. Loss of autophagy promotes murine acetaminophen hepatotoxicity. J Gastroenterol, 47(4):433\u2013443. https:\/\/doi.org\/10.1007\/s00535-011-0500-0","journal-title":"J Gastroenterol"},{"issue":"2","key":"595_CR54","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1172\/jci35958","volume":"119","author":"AB Imaeda","year":"2009","unstructured":"Imaeda AB, Watanabe A, Sohail MA, et al., 2009. Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome. J Clin Invest, 119(2):305\u2013314. https:\/\/doi.org\/10.1172\/jci35958","journal-title":"J Clin Invest"},{"issue":"10","key":"595_CR55","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1096\/fj.02-0046com","volume":"16","author":"Y Ishida","year":"2002","unstructured":"Ishida Y, Kondo T, Ohshima T, et al., 2002. A pivotal involvement of IFN-\u03b3 in the pathogenesis of acetaminophen-induced acute liver injury. FASEB J, 16(10):1227\u20131236. https:\/\/doi.org\/10.1096\/fj.02-0046com","journal-title":"FASEB J"},{"issue":"1","key":"595_CR56","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1189\/jlb.0403152","volume":"75","author":"Y Ishida","year":"2004","unstructured":"Ishida Y, Kondo T, Tsuneyama K, et al., 2004. The pathogenic roles of tumor necrosis factor receptor p55 in acetaminophen-induced liver injury in mice. J Leukoc Biol, 75(1):59\u201367. https:\/\/doi.org\/10.1189\/jlb.0403152","journal-title":"J Leukoc Biol"},{"issue":"6","key":"595_CR57","doi-asserted-by":"publisher","first-page":"1588","DOI":"10.1002\/hep.21549","volume":"45","author":"H Jaeschke","year":"2007","unstructured":"Jaeschke H, Liu J, 2007. Neutrophil depletion protects against murine acetaminophen hepatotoxicity: another perspective. Hepatology, 45(6):1588\u20131589. https:\/\/doi.org\/10.1002\/hep.21549","journal-title":"Hepatology"},{"key":"595_CR58","doi-asserted-by":"publisher","first-page":"111240","DOI":"10.1016\/j.fct.2020.111240","volume":"138","author":"H Jaeschke","year":"2020","unstructured":"Jaeschke H, Ramachandran A, 2020. Mechanisms and pathophysiological significance of sterile inflammation during acetaminophen hepatotoxicity. Food Chem Toxicol, 138: 111240. https:\/\/doi.org\/10.1016\/j.fct.2020.111240","journal-title":"Food Chem Toxicol"},{"issue":"1","key":"595_CR59","doi-asserted-by":"publisher","first-page":"88","DOI":"10.3109\/03602532.2011.602688","volume":"44","author":"H Jaeschke","year":"2012","unstructured":"Jaeschke H, McGill MR, Ramachandran A, 2012. Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity. Drug Metab Rev, 44(1):88\u2013106. https:\/\/doi.org\/10.3109\/03602532.2011.602688","journal-title":"Drug Metab Rev"},{"issue":"3","key":"595_CR60","doi-asserted-by":"publisher","first-page":"153","DOI":"10.14218\/jcth.2014.00014","volume":"2","author":"H Jaeschke","year":"2014","unstructured":"Jaeschke H, Xie YC, McGill MR, 2014. Acetaminophen-induced liver injury: from animal models to humans. J Clin Transl Hepatol, 2(3):153\u2013161. https:\/\/doi.org\/10.14218\/jcth.2014.00014","journal-title":"J Clin Transl Hepatol"},{"issue":"2","key":"595_CR61","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1093\/toxsci\/kfaa002","volume":"174","author":"H Jaeschke","year":"2020","unstructured":"Jaeschke H, Akakpo JY, Umbaugh DS, et al., 2020. Novel therapeutic approaches against acetaminophen-induced liver injury and acute liver failure. Toxicol Sci, 174(2): 159\u2013167. https:\/\/doi.org\/10.1093\/toxsci\/kfaa002","journal-title":"Toxicol Sci"},{"issue":"4","key":"595_CR62","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1016\/j.bbrc.2003.08.085","volume":"309","author":"LP James","year":"2003","unstructured":"James LP, Lamps LW, McCullough S, et al., 2003. Interleukin 6 and hepatocyte regeneration in acetaminophen toxicity in the mouse. Biochem Biophys Res Commun, 309(4): 857\u2013863. https:\/\/doi.org\/10.1016\/j.bbrc.2003.08.085","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"595_CR63","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1111\/j.1742-7843.2005.pto_97102.x","volume":"97","author":"LP James","year":"2005","unstructured":"James LP, Kurten RC, Lamps LW, et al., 2005. Tumour necrosis factor receptor 1 and hepatocyte regeneration in acetaminophen toxicity: a kinetic study of proliferating cell nuclear antigen and cytokine expression. Basic Clin Pharmacol Toxicol, 97(1):8\u201314. https:\/\/doi.org\/10.1111\/j.1742-7843.2005.pto_97102.x","journal-title":"Basic Clin Pharmacol Toxicol"},{"issue":"1","key":"595_CR64","first-page":"195","volume":"187","author":"DJ Jollow","year":"1973","unstructured":"Jollow DJ, Mitchell JR, Potter WZ, et al., 1973. Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo. J Pharmacol Exp Ther, 187(1): 195\u2013202.","journal-title":"J Pharmacol Exp Ther"},{"key":"595_CR65","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1016\/j.fct.2018.12.012","volume":"123","author":"KY Kang","year":"2019","unstructured":"Kang KY, Shin JK, Lee SM, 2019. Pterostilbene protects against acetaminophen-induced liver injury by restoring impaired autophagic flux. Food Chem Toxicol, 123:536\u2013545. https:\/\/doi.org\/10.1016\/jfct2018.12.012","journal-title":"Food Chem Toxicol"},{"issue":"29","key":"595_CR66","doi-asserted-by":"publisher","first-page":"10396","DOI":"10.1073\/pnas.1410104111","volume":"111","author":"J Karch","year":"2014","unstructured":"Karch J, Molkentin JD, 2014. Identifying the components of the elusive mitochondrial permeability transition pore. Proc Natl Acad Sci USA, 111(29):10396\u201310397. https:\/\/doi.org\/10.1073\/pnas.1410104111","journal-title":"Proc Natl Acad Sci USA"},{"issue":"12","key":"595_CR67","doi-asserted-by":"publisher","first-page":"4078","DOI":"10.4049\/jimmunol.1700587","volume":"199","author":"D Kleinschmidt","year":"2017","unstructured":"Kleinschmidt D, Giannou AD, McGee HM, et al., 2017. A protective function of IL-22BP in ischemia reperfusion and acetaminophen-induced liver injury. J Immunol, 199(12):4078\u20134090. https:\/\/doi.org\/10.4049\/jimmunol.1700587","journal-title":"J Immunol"},{"issue":"6","key":"595_CR68","doi-asserted-by":"publisher","first-page":"1939","DOI":"10.1172\/JCI40124","volume":"120","author":"H Kono","year":"2010","unstructured":"Kono H, Chen CJ, Ontiveros F, et al., 2010. Uric acid promotes an acute inflammatory response to sterile cell death in mice. J Clin Invest, 120(6):1939\u20131949. https:\/\/doi.org\/10.1172\/jci40124","journal-title":"J Clin Invest"},{"issue":"6","key":"595_CR69","doi-asserted-by":"publisher","first-page":"331","DOI":"10.3978\/j.issn.2304-3881.2014.11.01","volume":"3","author":"O Krenkel","year":"2014","unstructured":"Krenkel O, Mossanen JC, Tacke F, 2014. Immune mechanisms in acetaminophen-induced acute liver failure. Hepatobiliary Surg Nutr, 3(6):331\u2013343. https:\/\/doi.org\/10.3978\/j.issn.2304-3881.2014.11.01","journal-title":"Hepatobiliary Surg Nutr"},{"issue":"7","key":"595_CR70","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1038\/nrm4007","volume":"16","author":"F Kruiswijk","year":"2015","unstructured":"Kruiswijk F, Labuschagne CF, Vousden KH, 2015. p53 in survival, death and metabolic health: a lifeguard with a licence to kill. Nat Rev Mol Cell Biol, 16(7):393\u2013405. https:\/\/doi.org\/10.1038\/nrm4007","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"5","key":"595_CR71","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1053\/j.gastro.2012.09.008","volume":"143","author":"P Kubes","year":"2012","unstructured":"Kubes P, Mehal WZ, 2012. Sterile inflammation in the liver. Gastroenterology, 143(5): 1158\u20131172. https:\/\/doi.org\/10.1053\/j.gastro.2012.09.008","journal-title":"Gastroenterology"},{"issue":"2","key":"595_CR72","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1093\/toxsci\/54.2.509","volume":"54","author":"JA Lawson","year":"2000","unstructured":"Lawson JA, Farhood A, Hopper RD, et al., 2000. The hepatic inflammatory response after acetaminophen overdose: role of neutrophils. Toxicol Sci, 54(2):509\u2013516. https:\/\/doi.org\/10.1093\/toxsci\/54.2.509","journal-title":"Toxicol Sci"},{"key":"595_CR73","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.toxlet.2018.04.021","volume":"292","author":"HC Lee","year":"2018","unstructured":"Lee HC, Liao CC, Day YJ, et al., 2018. IL-17 deficiency attenuates acetaminophen-induced hepatotoxicity in mice. Toxicol Lett, 292:20\u201330. https:\/\/doi.org\/10.1016\/j.toxlet.2018.04.021","journal-title":"Toxicol Lett"},{"issue":"8","key":"595_CR74","first-page":"5170","volume":"11","author":"HC Lee","year":"2019","unstructured":"Lee HC, Yu HP, Liao CC, et al., 2019. Escin protects against acetaminophen-induced liver injury in mice via attenuating inflammatory response and inhibiting ERK signaling pathway. Am J Transl Res, 11(8):5170\u20135182.","journal-title":"Am J Transl Res"},{"issue":"1","key":"595_CR75","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1002\/hep.27385","volume":"61","author":"KK Lee","year":"2015","unstructured":"Lee KK, Imaizumi N, Chamberland SR, et al., 2015. Targeting mitochondria with methylene blue protects mice against acetaminophen-induced liver injury. Hepatology, 61(1):326\u2013336. https:\/\/doi.org\/10.1002\/hep.27385","journal-title":"Hepatology"},{"issue":"3","key":"595_CR76","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/S0016-5085(98)70160-X","volume":"115","author":"JJ Lemasters","year":"1998","unstructured":"Lemasters JJ, 1998. The mitochondrial permeability transition: from biochemical curiosity to pathophysiological mechanism. Gastroenterology, 115(3):783\u2013786. https:\/\/doi.org\/10.1016\/s0016-5085(98)70160-x","journal-title":"Gastroenterology"},{"issue":"1","key":"595_CR77","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1142\/S0192415X17500082","volume":"45","author":"CC Liao","year":"2017","unstructured":"Liao CC, Day YJ, Lee HC, et al., 2017. ERK signaling pathway plays a key role in baicalin protection against acetaminophen-induced liver injury. Am J Chin Med, 45(1): 105\u2013121. https:\/\/doi.org\/10.1142\/s0192415x17500082","journal-title":"Am J Chin Med"},{"issue":"9","key":"595_CR78","first-page":"5597","volume":"12","author":"FC Liu","year":"2020","unstructured":"Liu FC, Yu HP, Chou AH, et al., 2020. Corilagin reduces acetaminophen-induced hepatotoxicity through MAPK and NF-\u03b1B signaling pathway in a mouse model. Am J Transl Res, 12(9):5597\u20135607.","journal-title":"Am J Transl Res"},{"issue":"6","key":"595_CR79","doi-asserted-by":"publisher","first-page":"1760","DOI":"10.1053\/j.gastro.2004.08.053","volume":"127","author":"ZX Liu","year":"2004","unstructured":"Liu ZX, Govindarajan S, Kaplowitz N, 2004. Innate immune system plays a critical role in determining the progression and severity of acetaminophen hepatotoxicity. Gastroenterology, 127(6):1760\u20131774. https:\/\/doi.org\/10.1053\/j.gastro.2004.08.053","journal-title":"Gastroenterology"},{"issue":"10","key":"595_CR80","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1096\/fasebj.13.10.1169","volume":"13","author":"SC Lu","year":"1999","unstructured":"Lu SC, 1999. Regulation of hepatic glutathione synthesis: current concepts and controversies. FASEB J, 13(10): 1169\u20131183. https:\/\/doi.org\/10.1096\/fasebj.13.10.1169","journal-title":"FASEB J"},{"issue":"5","key":"595_CR81","doi-asserted-by":"publisher","first-page":"1971","DOI":"10.1002\/hep.25801","volume":"56","author":"PE Marques","year":"2012","unstructured":"Marques PE, Amaral SS, Pires DA, et al., 2012. Chemokines and mitochondrial products activate neutrophils to amplify organ injury during mouse acute liver failure. Hepatology, 56(5):1971\u20131982. https:\/\/doi.org\/10.1002\/hep.25801","journal-title":"Hepatology"},{"issue":"4","key":"595_CR82","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1002\/hep.26134","volume":"57","author":"BV Martin-Murphy","year":"2013","unstructured":"Martin-Murphy BV, Kominsky DJ, Orlicky DJ, et al., 2013. Increased susceptibility of natural killer T-cell-deficient mice to acetaminophen-induced liver injury. Hepatology, 57(4):1575\u20131584. https:\/\/doi.org\/10.1002\/hep.26134","journal-title":"Hepatology"},{"issue":"1","key":"595_CR83","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1002\/hep.510300104","volume":"30","author":"SL Michael","year":"1999","unstructured":"Michael SL, Pumford NR, Mayeux PR, et al., 1999. Pretreatment of mice with macrophage inactivators decreases acetaminophen hepatotoxicity and the formation of reactive oxygen and nitrogen species. Hepatology, 30(1):186\u2013195. https:\/\/doi.org\/10.1002\/hep.510300104","journal-title":"Hepatology"},{"issue":"2","key":"595_CR84","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1002\/jcp.21172","volume":"213","author":"GK Michalopoulos","year":"2007","unstructured":"Michalopoulos GK, 2007. Liver regeneration. J Cell Physiol, 213(2):286\u2013300. https:\/\/doi.org\/10.1002\/jcp.21172","journal-title":"J Cell Physiol"},{"issue":"15","key":"595_CR85","doi-asserted-by":"publisher","first-page":"4170","DOI":"10.7150\/thno.25798","volume":"8","author":"RD Mo","year":"2018","unstructured":"Mo RD, Lai RT, Lu J, et al., 2018. Enhanced autophagy contributes to protective effects of IL-22 against acetaminophen-induced liver injury. Theranostics, 8(15):4170\u20134180. https:\/\/doi.org\/10.7150\/thno.25798","journal-title":"Theranostics"},{"key":"595_CR86","doi-asserted-by":"publisher","first-page":"453","DOI":"10.3389\/fphar.2018.00453","volume":"9","author":"A Moles","year":"2018","unstructured":"Moles A, Torres S, Baulies A, et al., 2018. Mitochondrial-lysosomal axis in acetaminophen hepatotoxicity. Front Pharmacol, 9:453. https:\/\/doi.org\/10.3389\/fphar.2018.00453","journal-title":"Front Pharmacol"},{"issue":"7","key":"595_CR87","doi-asserted-by":"publisher","first-page":"532","DOI":"10.3109\/15563650.2013.816853","volume":"51","author":"JK Moore","year":"2013","unstructured":"Moore JK, Craig DG, Pryde EA, et al., 2013. Persistently elevated troponin I in paracetamol hepatotoxicity: association with liver injury, organ failure, and outcome. Clin Toxicol, 51(7):532\u2013539. https:\/\/doi.org\/10.3109\/15563650.2013.816853","journal-title":"Clin Toxicol"},{"issue":"2","key":"595_CR88","doi-asserted-by":"publisher","first-page":"254","DOI":"10.4161\/auto.5528","volume":"4","author":"MN Moore","year":"2008","unstructured":"Moore MN, 2008. Autophagy as a second level protective process in conferring resistance to environmentally-induced oxidative stress. Autophagy, 4(2):254\u2013256. https:\/\/doi.org\/10.4161\/auto.5528","journal-title":"Autophagy"},{"issue":"1","key":"595_CR89","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1002\/hep.24690","volume":"55","author":"HM Ni","year":"2012","unstructured":"Ni HM, Bockus A, Boggess N, et al., 2012. Activation of autophagy protects against acetaminophen-induced hepatotoxicity. Hepatology, 55(1):222\u2013232. https:\/\/doi.org\/10.1002\/hep.24690","journal-title":"Hepatology"},{"issue":"3","key":"595_CR90","doi-asserted-by":"publisher","first-page":"e153","DOI":"10.1038\/ctg.2016.13","volume":"7","author":"SJ Patel","year":"2016","unstructured":"Patel SJ, Luther J, Bohr S, et al., 2016. A novel resolvin-based strategy for limiting acetaminophen hepatotoxicity. Clin Transl Gastroenterol, 7(3):e153. https:\/\/doi.org\/10.1038\/ctg.2016.13","journal-title":"Clin Transl Gastroenterol"},{"issue":"2","key":"595_CR91","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1055\/s-0039-1679919","volume":"39","author":"A Ramachandran","year":"2019","unstructured":"Ramachandran A, Jaeschke H, 2019. Acetaminophen hepatotoxicity. Semin Liver Dis, 39(2):221\u2013234. https:\/\/doi.org\/10.1055\/s-0039-1679919","journal-title":"Semin Liver Dis"},{"issue":"2","key":"595_CR92","doi-asserted-by":"publisher","first-page":"156","DOI":"10.3109\/10715762.2010.520319","volume":"45","author":"A Ramachandran","year":"2011","unstructured":"Ramachandran A, Lebofsky M, Baines CP, et al., 2011. Cyclophilin D deficiency protects against acetaminophen-induced oxidant stress and liver injury. Free Radic Res, 45(2):156\u2013164. https:\/\/doi.org\/10.3109\/10715762.2010.520319","journal-title":"Free Radic Res"},{"issue":"7","key":"595_CR93","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1080\/15563650.2019.1676899","volume":"58","author":"R Rasamison","year":"2020","unstructured":"Rasamison R, Besson H, Berleur MP, et al., 2020. Analysis of fomepizole safety based on a 16-year post-marketing experience in france. Clin Toxicol, 58(7):742\u2013747. https:\/\/doi.org\/10.1080\/15563650.2019.1676899","journal-title":"Clin Toxicol"},{"issue":"11","key":"595_CR94","doi-asserted-by":"publisher","first-page":"724","DOI":"10.7326\/M15-2211","volume":"164","author":"A Reuben","year":"2016","unstructured":"Reuben A, Tillman H, Fontana RJ, et al., 2016. Outcomes in adults with acute liver failure between 1998 and 2013: an observational cohort study. Ann Intern Med, 164(11): 724\u2013732. https:\/\/doi.org\/10.7326\/m15-2211","journal-title":"Ann Intern Med"},{"issue":"7","key":"595_CR95","doi-asserted-by":"publisher","first-page":"9257","DOI":"10.3390\/molecules19079257","volume":"19","author":"TP Rezende","year":"2014","unstructured":"Rezende TP, do A. Corr\u00eaa JO, Aarestrup BJV, et al., 2014. Protective effects of Baccharis dracunculifolia leaves extract against carbon tetrachloride- and acetaminophen-induced hepatotoxicity in experimental animals. Molecules, 19(7):9257\u20139272. https:\/\/doi.org\/10.3390\/molecules19079257","journal-title":"Molecules"},{"issue":"1","key":"595_CR96","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1021\/tx2003992","volume":"25","author":"PM Ryan","year":"2012","unstructured":"Ryan PM, Bourdi M, Korrapati MC, et al., 2012. Endogenous interleukin-4 regulates glutathione synthesis following acetaminophen-induced liver injury in mice. Chem Res Toxicol, 25(1):83\u201393. https:\/\/doi.org\/10.1021\/tx2003992","journal-title":"Chem Res Toxicol"},{"issue":"12","key":"595_CR97","doi-asserted-by":"publisher","first-page":"2830","DOI":"10.1080\/13880209.2016.1185633","volume":"54","author":"SS Saeedi Saravi","year":"2016","unstructured":"Saeedi Saravi SS, Hasanvand A, Shahkarami K, et al., 2016. The protective potential of metformin against acetaminophen-induced hepatotoxicity in BALB\/C mice. Pharm Biol, 54(12):2830\u20132837. https:\/\/doi.org\/10.1080\/13880209.2016.1185633","journal-title":"Pharm Biol"},{"issue":"1","key":"595_CR98","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1002\/hep.23267","volume":"51","author":"C Saito","year":"2010","unstructured":"Saito C, Zwingmann C, Jaeschke H, 2010. Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and N-acetylcysteine. Hepatology, 51(1):246\u2013254. https:\/\/doi.org\/10.1002\/hep.23267","journal-title":"Hepatology"},{"issue":"4","key":"595_CR99","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1016\/j.ajpath.2012.12.010","volume":"182","author":"P Scheiermann","year":"2013","unstructured":"Scheiermann P, Bachmann M, Goren I, et al., 2013. Application of interleukin-22 mediates protection in experimental acetaminophen-induced acute liver injury. Am J Pathol, 182(4):1107\u20131113. https:\/\/doi.org\/10.1016\/j.ajpath.2012.12.010","journal-title":"Am J Pathol"},{"issue":"4","key":"595_CR100","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1053\/jhep.2002.32148","volume":"35","author":"LE Schmidt","year":"2002","unstructured":"Schmidt LE, Dalhoff K, Poulsen HE, 2002. Acute versus chronic alcohol consumption in acetaminophen-induced hepatotoxicity. Hepatology, 35(4):876\u2013882. https:\/\/doi.org\/10.1053\/jhep.2002.32148","journal-title":"Hepatology"},{"issue":"4","key":"595_CR101","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1016\/j.jcmgh.2020.11.002","volume":"11","author":"KM Schneider","year":"2021","unstructured":"Schneider KM, Elfers C, Ghallab A, et al., 2021. Intestinal dysbiosis amplifies acetaminophen-induced acute liver injury. Cell Mol Gastroenterol Hepatol, 11(4):909\u2013933. https:\/\/doi.org\/10.1016\/jocmgh.2020.11.002","journal-title":"Cell Mol Gastroenterol Hepatol"},{"issue":"3","key":"595_CR102","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1113\/jphysiol.2011.219691","volume":"590","author":"E Seki","year":"2012","unstructured":"Seki E, Schnabl B, 2012. Role of innate immunity and the microbiota in liver fibrosis: crosstalk between the liver and gut. J Physiol, 590(3):447\u2013458. https:\/\/doi.org\/10.1113\/jphysiol.201L219691","journal-title":"J Physiol"},{"issue":"5","key":"595_CR103","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1124\/mol.112.079863","volume":"82","author":"M Sharma","year":"2012","unstructured":"Sharma M, Gadang V, Jaeschke A, 2012. Critical role for mixed-lineage kinase 3 in acetaminophen-induced hepatotoxicity. Mol Pharmacol, 82(5): 1001\u20131007. https:\/\/doi.org\/10.1124\/mol.112.079863","journal-title":"Mol Pharmacol"},{"key":"595_CR104","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.trsl.2018.02.003","volume":"196","author":"XX Shi","year":"2018","unstructured":"Shi XX, Bai HY, Zhao M, et al., 2018. Treatment of acetaminophen-induced liver injury with exogenous mitochondria in mice. Transl Res, 196:31\u201341. https:\/\/doi.org\/10.1016\/j.trsl.2018.02.003","journal-title":"Transl Res"},{"issue":"11","key":"595_CR105","doi-asserted-by":"publisher","first-page":"8244","DOI":"10.1074\/jbc.M109.054999","volume":"285","author":"M Shinohara","year":"2010","unstructured":"Shinohara M, Ybanez MD, Win S, et al., 2010. Silencing glycogen synthase kinase-3\u03b2 inhibits acetaminophen hepatotoxicity and attenuates JNK activation and loss of glutamate cysteine ligase and myeloid cell leukemia sequence 1. J Biol Chem, 285(11):8244\u20138255. https:\/\/doi.org\/10.1074\/jbc.M109.054999","journal-title":"J Biol Chem"},{"issue":"4","key":"595_CR106","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1002\/(SICI)1096-9896(200003)190:4<489::AID-PATH534>3.0.CO;2-V","volume":"190","author":"KJ Simpson","year":"2000","unstructured":"Simpson KJ, Lukacs NW, McGregor AH, et al., 2000. Inhibition of tumour necrosis factor alpha does not prevent experimental paracetamol-induced hepatic necrosis. J Pathol, 190(4):489\u2013494. https:\/\/doi.org\/10.1002\/(SICI)1096-9896(200003)190:4<489::AID-PATH534>3.0.CO;2-V","journal-title":"J Pathol"},{"issue":"24","key":"595_CR107","doi-asserted-by":"publisher","first-page":"1557","DOI":"10.1056\/NEJM198812153192401","volume":"319","author":"MJ Smilkstein","year":"1988","unstructured":"Smilkstein MJ, Knapp GL, Kulig KW, et al., 1988. Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. N Engl J Med, 319(24):1557\u20131562. https:\/\/doi.org\/10.1056\/nejm198812153192401","journal-title":"N Engl J Med"},{"issue":"3","key":"595_CR108","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1002\/hep.27266","volume":"60","author":"J Soeda","year":"2014","unstructured":"Soeda J, Mouralidarane A, Ray S, et al., 2014. The beta-adrenoceptor agonist isoproterenol rescues acetaminophen-injured livers through increasing progenitor numbers by Wnt in mice. Hepatology, 60(3):1023\u20131034. https:\/\/doi.org\/10.1002\/hep.27266","journal-title":"Hepatology"},{"issue":"6","key":"595_CR109","doi-asserted-by":"publisher","first-page":"2397","DOI":"10.1002\/hep.29759","volume":"67","author":"Y Sun","year":"2018","unstructured":"Sun Y, Li TY, Song L, et al., 2018. Liver-specific deficiency of unc-51 like kinase 1 and 2 protects mice from acetaminophen-induced liver injury. Hepatology, 67(6):2397\u20132413. https:\/\/doi.org\/10.1002\/hep.29759","journal-title":"Hepatology"},{"issue":"6","key":"595_CR110","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1142\/S0192415X14500876","volume":"42","author":"YH Tien","year":"2014","unstructured":"Tien YH, Chen BH, Wang Hsu GS, et al., 2014. Hepatoprotective and anti-oxidant activities of Glossogyne tenuifolia against acetaminophen-induced hepatotoxicity in mice. Am J Chin Med, 42(6): 1385\u20131398. https:\/\/doi.org\/10.1142\/s0192415x14500876","journal-title":"Am J Chin Med"},{"issue":"17","key":"595_CR111","doi-asserted-by":"publisher","first-page":"9814","DOI":"10.1016\/S0021-9258(18)81731-8","volume":"264","author":"MA Tirmenstein","year":"1989","unstructured":"Tirmenstein MA, Nelson SD, 1989. Subcellular binding and effects on calcium homeostasis produced by acetaminophen and a nonhepatotoxic regioisomer, 3\u2032-hydroxyacetanilide. in mouse liver. J Biol Chem, 264(17):9814\u20139819. https:\/\/doi.org\/10.1016\/S0021-9258(18)81731-8","journal-title":"J Biol Chem"},{"issue":"2","key":"595_CR112","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1053\/j.gastro.2019.04.023","volume":"157","author":"S Torres","year":"2019","unstructured":"Torres S, Baulies A, Insausti-Urkia N, et al., 2019. Endoplasmic reticulum stress-induced upregulation of STARD1 promotes acetaminophen-induced acute liver failure. Gastroenterology, 157(2):552\u2013568. https:\/\/doi.org\/10.1053\/j.gastro.2019.04.023","journal-title":"Gastroenterology"},{"issue":"7","key":"595_CR113","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.1016\/j.freeradbiomed.2007.12.036","volume":"44","author":"J Trnka","year":"2008","unstructured":"Trnka J, Blaikie FH, Smith RAJ, et al., 2008. A mitochondriatargeted nitroxide is reduced to its hydroxylamine by ubiquinol in mitochondria. Free Radic Biol Med, 44(7): 1406\u20131419. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2007.12.036","journal-title":"Free Radic Biol Med"},{"issue":"3","key":"595_CR114","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1016\/j.jhep.2013.04.024","volume":"59","author":"D Uzi","year":"2013","unstructured":"Uzi D, Barda L, Scaiewicz V, et al., 2013. CHOP is a critical regulator of acetaminophen-induced hepatotoxicity. J Hepatol, 59(3):495\u2013503. https:\/\/doi.org\/10.1016\/j.jhep.2013.04.024","journal-title":"J Hepatol"},{"issue":"2","key":"595_CR115","doi-asserted-by":"publisher","first-page":"164","DOI":"10.3109\/00498254.2016.1166533","volume":"47","author":"V Walker","year":"2017","unstructured":"Walker V, Mills GA, Anderson ME, et al., 2017. The acetaminophen metabolite N-acetyl-p-benzoquinone imine (NAPQI) inhibits glutathione synthetase in vitro; a clue to the mechanism of 5-oxoprolinuric acidosis? Xenobiotica, 47(2):164\u2013175. https:\/\/doi.org\/10.3109\/00498254.2016.1166533","journal-title":"Xenobiotica"},{"issue":"1","key":"595_CR116","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1002\/hep.25982","volume":"57","author":"XF Wang","year":"2013","unstructured":"Wang XF, Sun R, Wei HM, et al., 2013. High-mobility group box 1 (HMGB1)-Toll-like receptor (TLR)4-interleukin (IL)-23-IL-17A axis in drug-induced damage-associated lethal hepatitis: interaction of \u03b3\u03b4 T cells with macrophages. Hepatology, 57(1):373\u2013384. https:\/\/doi.org\/10.1002\/hep.25982","journal-title":"Hepatology"},{"issue":"12","key":"595_CR117","doi-asserted-by":"publisher","first-page":"4050","DOI":"10.3390\/ijms19124050","volume":"19","author":"YQ Wang","year":"2018","unstructured":"Wang YQ, Wei JG, Tu MJ, et al., 2018. Fucoidan alleviates acetaminophen-induced hepatotoxicity via oxidative stress inhibition and Nrf2 translocation. Int J Mol Sci, 19(12):4050. https:\/\/doi.org\/10.3390\/ijms19124050","journal-title":"Int J Mol Sci"},{"issue":"1","key":"595_CR118","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1111\/j.1553-2712.2007.00019.x","volume":"15","author":"WS Waring","year":"2008","unstructured":"Waring WS, Stephen AF, Malkowska AM, et al., 2008. Acute ethanol coingestion confers a lower risk of hepatotoxicity after deliberate acetaminophen overdose. Acad Emerg Med, 15(1):54\u201358. https:\/\/doi.org\/10.1111\/j.1553-2712.2007.00019.x","journal-title":"Acad Emerg Med"},{"issue":"9","key":"595_CR119","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.1111\/j.1478-3231.2010.02284.x","volume":"30","author":"CD Williams","year":"2010","unstructured":"Williams CD, Bajt ML, Farhood A, et al., 2010. Acetaminophen-induced hepatic neutrophil accumulation and inflammatory liver injury in CD18-deficient mice. Liver Int, 30(9): 1280\u20131292. https:\/\/doi.org\/10.1111\/j.1478-3231.2010.02284.x","journal-title":"Liver Int"},{"issue":"2","key":"595_CR120","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.taap.2014.01.004","volume":"275","author":"CD Williams","year":"2014","unstructured":"Williams CD, Bajt ML, Sharpe MR, et al., 2014. Neutrophil activation during acetaminophen hepatotoxicity and repair in mice and humans. Toxicol Appl Pharmacol, 275(2): 122\u2013133. https:\/\/doi.org\/10.1016\/j.taap.2014.01.004","journal-title":"Toxicol Appl Pharmacol"},{"issue":"6","key":"595_CR121","doi-asserted-by":"publisher","first-page":"1987","DOI":"10.1002\/hep.28486","volume":"63","author":"S Win","year":"2016","unstructured":"Win S, Than TA, Min RWM, et al., 2016. c-Jun N-terminal kinase mediates mouse liver injury through a novel Sab (SH3BP5)-dependent pathway leading to inactivation of intramitochondrial Src. Hepatology, 63(6):1987\u20132003. https:\/\/doi.org\/10.1002\/hep.28486","journal-title":"Hepatology"},{"issue":"12","key":"595_CR122","doi-asserted-by":"publisher","first-page":"5278","DOI":"10.1172\/JCI128289","volume":"129","author":"S Win","year":"2019","unstructured":"Win S, Min RWM, Chen CQ, et al., 2019. Expression of mitochondrial membrane-linked SAB determines severity of sex-dependent acute liver injury. J Clin Invest, 129(12): 5278\u20135293. https:\/\/doi.org\/10.1172\/jci128289","journal-title":"J Clin Invest"},{"issue":"5","key":"595_CR123","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1007\/s40495-018-0147-0","volume":"4","author":"BL Woolbright","year":"2018","unstructured":"Woolbright BL, Jaeschke H, 2018. Mechanisms of inflammatory liver injury and drug-induced hepatotoxicity. Curr Pharmacol Rep, 4(5):346\u2013357. https:\/\/doi.org\/10.1007\/s40495-018-0147-0","journal-title":"Curr Pharmacol Rep"},{"issue":"10","key":"595_CR124","doi-asserted-by":"publisher","first-page":"2420","DOI":"10.3390\/molecules23102420","volume":"23","author":"KC Wu","year":"2018","unstructured":"Wu KC, Ho YL, Kuo YH, et al., 2018. Hepatoprotective effect of Ugonin M, a Helminthostachys zeylanica constituent, on acetaminophen-induced acute liver injury in mice. Molecules, 23(10):2420. https:\/\/doi.org\/10.3390\/molecules23102420","journal-title":"Molecules"},{"issue":"10","key":"595_CR125","doi-asserted-by":"publisher","first-page":"921","DOI":"10.3109\/00498254.2015.1026426","volume":"45","author":"YC Xie","year":"2015","unstructured":"Xie YC, McGill MR, Cook SF, et al., 2015. Time course of acetaminophen-protein adducts and acetaminophen metabolites in circulation of overdose patients and in HepaRG cells. Xenobiotica, 45(10):921\u2013929. https:\/\/doi.org\/10.3109\/00498254.2015.1026426","journal-title":"Xenobiotica"},{"issue":"5","key":"595_CR126","doi-asserted-by":"publisher","first-page":"2626","DOI":"10.4049\/jimmunol.1003930","volume":"187","author":"J Xu","year":"2011","unstructured":"Xu J, Zhang XM, Monestier M, et al., 2011. Extracellular histones are mediators of death through TLR2 and TLR4 in mouse fatal liver injury. J Immunol, 187(5):2626\u20132631. https:\/\/doi.org\/10.4049\/jimmunol.1003930","journal-title":"J Immunol"},{"issue":"1","key":"595_CR127","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1002\/hep.24018","volume":"53","author":"AW Yan","year":"2011","unstructured":"Yan AW, Fouts DE, Brandl J, et al., 2011. Enteric dysbiosis associated with a mouse model of alcoholic liver disease. Hepatology, 53(1):96\u2013105. https:\/\/doi.org\/10.1002\/hep.24018","journal-title":"Hepatology"},{"key":"595_CR128","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.redox.2018.04.019","volume":"17","author":"MZ Yan","year":"2018","unstructured":"Yan MZ, Huo YZ, Yin ST, et al., 2018. Mechanisms of acetaminophen-induced liver injury and its implications for therapeutic interventions. Redox Biol, 17:274\u2013283. https:\/\/doi.org\/10.1016\/j.redox.2018.04.019","journal-title":"Redox Biol"},{"issue":"2","key":"595_CR129","doi-asserted-by":"publisher","first-page":"R55","DOI":"10.1186\/cc7782","volume":"13","author":"RK Yang","year":"2009","unstructured":"Yang RK, Miki K, He X, et al., 2009. Prolonged treatment with N-acetylcystine delays liver recovery from acetaminophen hepatotoxicity. Crit Care, 13(2):R55. https:\/\/doi.org\/10.1186\/cc7782","journal-title":"Crit Care"},{"key":"595_CR130","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1186\/1471-230X-11-125","volume":"11","author":"RK Yang","year":"2011","unstructured":"Yang RK, Zhang ST, Kajander H, et al., 2011. Ringer\u2019s lactate improves liver recovery in a murine model of acetaminophen toxicity. BMC Gastroenterol, 11:125. https:\/\/doi.org\/10.1186\/1471-230x-11-125","journal-title":"BMC Gastroenterol"},{"key":"595_CR131","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/1471-230X-12-45","volume":"12","author":"RK Yang","year":"2012","unstructured":"Yang RK, Zhang ST, Cotoia A, et al., 2012. High mobility group B1 impairs hepatocyte regeneration in acetaminophen hepatotoxicity. BMC Gastroenterol, 12:45. https:\/\/doi.org\/10.1186\/1471-230x-12-45","journal-title":"BMC Gastroenterol"},{"key":"595_CR132","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1038\/s41467-019-09046-8","volume":"10","author":"WT Yang","year":"2019","unstructured":"Yang WT, Tao YD, Wu Y, et al., 2019. Neutrophils promote the development of reparative macrophages mediated by ROS to orchestrate liver repair. Nat Commun, 10:1076. https:\/\/doi.org\/10.1038\/s41467-019-09046-8","journal-title":"Nat Commun"},{"issue":"5","key":"595_CR133","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1021\/tx600349f","volume":"20","author":"SB Yee","year":"2007","unstructured":"Yee SB, Bourdi M, Masson MJ, et al., 2007. Hepatoprotective role of endogenous interleukin-13 in a murine model of acetaminophen-induced liver disease. Chem Res Toxicol, 20(5):734\u2013744. https:\/\/doi.org\/10.1021\/tx600349f","journal-title":"Chem Res Toxicol"},{"issue":"7456","key":"595_CR134","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1038\/nature12347","volume":"499","author":"S Yoshimoto","year":"2013","unstructured":"Yoshimoto S, Loo TM, Atarashi K, et al., 2013. Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome. Nature, 499(7456):97\u2013101. https:\/\/doi.org\/10.1038\/nature12347","journal-title":"Nature"},{"issue":"11","key":"595_CR135","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1038\/cmi.2017.22","volume":"15","author":"C Zhang","year":"2018","unstructured":"Zhang C, Feng J, Du J, et al., 2018. Macrophage-derived IL-1\u03b1 promotes sterile inflammation in a mouse model of acetaminophen hepatotoxicity. Cell Mol Immunol, 15(11):973\u2013982. https:\/\/doi.org\/10.1038\/cmi.2017.22","journal-title":"Cell Mol Immunol"},{"key":"595_CR136","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.intimp.2017.01.028","volume":"45","author":"JY Zhang","year":"2017","unstructured":"Zhang JY, Zhang SM, Bi JB, et al., 2017. Astaxanthin pretreatment attenuates acetaminophen-induced liver injury in mice. Int Immunopharmacol, 45:26\u201333. https:\/\/doi.org\/10.1016\/j.intimp.2017.01.028","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"595_CR137","doi-asserted-by":"publisher","first-page":"344","DOI":"10.4049\/jimmunol.1400574","volume":"193","author":"E Zigmond","year":"2014","unstructured":"Zigmond E, Samia-Grinberg S, Pasmanik-Chor M, et al., 2014. Infiltrating monocyte-derived macrophages and resident Kupffer cells display different ontogeny and functions in acute liver injury. J Immunol, 193(1):344\u2013353. https:\/\/doi.org\/10.4049\/jimmunol.1400574","journal-title":"J Immunol"}],"container-title":["Journal of Zhejiang University-SCIENCE B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1631\/jzus.B2100977.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1631\/jzus.B2100977\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1631\/jzus.B2100977.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,17]],"date-time":"2022-04-17T14:03:21Z","timestamp":1650204201000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1631\/jzus.B2100977"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":137,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["595"],"URL":"https:\/\/doi.org\/10.1631\/jzus.b2100977","relation":{},"ISSN":["1673-1581","1862-1783"],"issn-type":[{"value":"1673-1581","type":"print"},{"value":"1862-1783","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"28 November 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 December 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 April 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}