{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T11:32:48Z","timestamp":1779103968400,"version":"3.51.4"},"reference-count":25,"publisher":"Zhejiang University Press","issue":"8","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J. Zhejiang Univ. Sci. B"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1631\/jzus.b2300181","type":"journal-article","created":{"date-parts":[[2023,8,15]],"date-time":"2023-08-15T02:01:44Z","timestamp":1692064904000},"page":"711-722","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Composite B-cell and T-cell lymphomas: clinical, pathological, and molecular features of three cases and literature review","\u4e09\u4f8b\u590d\u5408\u6027B\u7ec6\u80de\u548cT\u7ec6\u80de\u6dcb\u5df4\u7624\u60a3\u8005\u7684\u4e34\u5e8a\u3001 \u75c5\u7406\u548c\u5206\u5b50\u5b66\u7279\u5f81\u7684\u5206\u6790\u53ca\u6587\u732e\u56de\u987e"],"prefix":"10.1631","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5618-920X","authenticated-orcid":false,"given":"Xueli","family":"Jin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xibin","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianggui","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panpan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boxiao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9215-1708","authenticated-orcid":false,"given":"Yun","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5548-3156","authenticated-orcid":false,"given":"Fengbo","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"635","published-online":{"date-parts":[[2023,8,15]]},"reference":[{"issue":"7","key":"723_CR1","doi-asserted-by":"publisher","first-page":"1722","DOI":"10.1111\/j.1349-7006.2010.01569.x","volume":"101","author":"K Amara","year":"2010","unstructured":"Amara K, Ziadi S, Hachana M, et al., 2010. DNA methyltransferase DNMT3b protein overexpression as a prognostic factor in patients with diffuse large B-cell lymphomas. Cancer Sci, 101(7):1722\u20131730. https:\/\/doi.org\/10.1111\/j.1349-7006.2010.01569.x","journal-title":"Cancer Sci"},{"issue":"9","key":"723_CR2","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1097\/PAS.0b013e3180339f18","volume":"31","author":"O Balagu\u00e9","year":"2007","unstructured":"Balagu\u00e9 O, Mart\u00ednez A, Colomo L, et al., 2007. Epstein-Barr virus negative clonal plasma cell proliferations and lymphomas in peripheral T-cell lymphomas: a phenomenon with distinctive clinicopathologic features. Am J Surg Pathol, 31(9):1310\u20131322. https:\/\/doi.org\/10.1097\/PAS.0b013e3180339f18","journal-title":"Am J Surg Pathol"},{"issue":"6","key":"723_CR3","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1016\/j.jmoldx.2018.06.002","volume":"20","author":"SM Chun","year":"2018","unstructured":"Chun SM, Sung CO, Jeon H, et al., 2018. Next-generation sequencing using S1 nuclease for poor-quality formalin-fixed, paraffin-embedded tumor specimens. J Mol Diagn, 20(6):802\u2013811. https:\/\/doi.org\/10.1016\/j.jmoldx.2018.06.002","journal-title":"J Mol Diagn"},{"issue":"8401","key":"723_CR4","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/S0140-6736(84)92566-2","volume":"324","author":"ML Cleary","year":"1984","unstructured":"Cleary ML, Sklar J, 1984. Lymphoproliferative disorders in cardiac transplant recipients are multiclonal lymphomas. Lancet, 324(8401):489\u2013493. https:\/\/doi.org\/10.1016\/s0140-6736(84)92566-2","journal-title":"Lancet"},{"issue":"1","key":"723_CR5","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1056\/NEJMc1111708","volume":"366","author":"L Couronn\u00e9","year":"2012","unstructured":"Couronn\u00e9 L, Bastard C, Bernard OA, 2012. TET2 and DNMT3A mutations in human T-cell lymphoma. N Engl J Med, 366(1):95\u201396. https:\/\/doi.org\/10.1056\/NEJMc1111708","journal-title":"N Engl J Med"},{"key":"723_CR6","first-page":"554","volume-title":"Pitfalls in the diagnosis of lymphoma and leukemia from the pathologist\u2019s point of view","author":"R Custer","year":"1954","unstructured":"Custer R, 1954. Pitfalls in the diagnosis of lymphoma and leukemia from the pathologist\u2019s point of view. Proceeding of the Second National Cancer Conference. American Cancer Society, New York, p.554\u2013557."},{"issue":"1","key":"723_CR7","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1182\/blood.V70.1.287.287","volume":"70","author":"E Hu","year":"1987","unstructured":"Hu E, Weiss LM, Warnke R, et al., 1987. Non-Hodgkin\u2019s lymphoma containing both B and T cell clones. Blood, 70(1):287\u2013292. https:\/\/doi.org\/10.1182\/blood.V70.1.287.287","journal-title":"Blood"},{"issue":"5","key":"723_CR8","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1177\/002215540104900509","volume":"49","author":"U K\u00e4mmerer","year":"2001","unstructured":"K\u00e4mmerer U, Kapp M, Gassel AM, et al., 2001. A new rapid immunohistochemical staining technique using the EnVision antibody complex. J Histochem Cytochem, 49(5):623\u2013630. https:\/\/doi.org\/10.1177\/002215540104900509","journal-title":"J Histochem Cytochem"},{"issue":"3","key":"723_CR9","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1002\/1097-0142(197709)40:3<959::AID-CNCR2820400302>3.0.CO;2-3","volume":"40","author":"H Kim","year":"1977","unstructured":"Kim H, Hendrickson MR, Dorfman RF, 1977. Composite lymphoma. Cancer, 40(3):959\u2013976. https:\/\/doi.org\/10.1002\/1097-0142(197709)40:3<959::aidcncr2820400302>3.0.co;2-3","journal-title":"Cancer"},{"issue":"10","key":"723_CR10","doi-asserted-by":"publisher","first-page":"e435","DOI":"10.1016\/S1470-2045(14)70153-6","volume":"15","author":"R K\u00fcppers","year":"2014","unstructured":"K\u00fcppers R, D\u00fchrsen U, Hansmann ML, 2014. Pathogenesis, diagnosis, and treatment of composite lymphomas. Lancet Oncol, 15(10):e435\u2013e446. https:\/\/doi.org\/10.1016\/S1470-2045(14)70153-6","journal-title":"Lancet Oncol"},{"issue":"8","key":"723_CR11","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1631\/jzus.B2200016","volume":"23","author":"C Luo","year":"2022","unstructured":"Luo C, Yu T, Young KH, et al., 2022. HDAC inhibitor chidamide synergizes with venetoclax to inhibit the growth of diffuse large B-cell lymphoma via down-regulation of MYC, BCL2, and TP53 expression. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 23(8):666\u2013681. https:\/\/doi.org\/10.1631\/jzus.B2200016","journal-title":"J Zhejiang Univ-Sci B (Biomed & Biotechnol)"},{"issue":"9","key":"723_CR12","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1182\/blood-2013-10-531509","volume":"123","author":"O Odejide","year":"2014","unstructured":"Odejide O, Weigert O, Lane AA, et al., 2014. A targeted mutational landscape of angioimmunoblastic T-cell lymphoma. Blood, 123(9):1293\u20131296. https:\/\/doi.org\/10.1182\/blood-2013-10-531509","journal-title":"Blood"},{"issue":"13","key":"723_CR13","doi-asserted-by":"publisher","first-page":"3352","DOI":"10.3390\/cancers13133352","volume":"13","author":"A Onaindia","year":"2021","unstructured":"Onaindia A, Santiago-Quispe N, Iglesias-Martinez E, et al., 2021. Molecular update and evolving classification of large B-cell lymphoma. Cancers, 13(13):3352. https:\/\/doi.org\/10.3390\/cancers13133352","journal-title":"Cancers"},{"issue":"4","key":"723_CR14","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1002\/1097-0142(195607\/08)9:4<792::AID-CNCR2820090429>3.0.CO;2-B","volume":"9","author":"H Rappaport","year":"1956","unstructured":"Rappaport H, Winter WJ, Hicks EB, 1956. Follicular lymphoma. A re-evaluation of its position in the scheme of malignant lymphoma based on a survey of 253 cases. Cancer, 9(4):792\u2013821. https:\/\/doi.org\/10.1002\/1097-0142(195607\/08)9:4<792:aidcncr2820090429>3.0.co;2-b","journal-title":"Cancer"},{"issue":"10","key":"723_CR15","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1111\/j.1440-1827.2012.02858.x","volume":"62","author":"N Suefuji","year":"2012","unstructured":"Suefuji N, Niino D, Arakawa F, et al., 2012. Clinicopathological analysis of a composite lymphoma containing both T- and B-cell lymphomas. Pathol Int, 62(10):690\u2013698. https:\/\/doi.org\/10.1111\/j.1440-1827.2012.02858.x","journal-title":"Pathol Int"},{"key":"723_CR16","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.humpath.2017.11.017","volume":"76","author":"J Tanaka","year":"2018","unstructured":"Tanaka J, Su P, Luedke C, et al., 2018. Composite lymphoma of follicular B-cell and peripheral T-cell types with distinct zone distribution in a 75-year-old male patient: a case study. Hum Pathol, 76:110\u2013116. https:\/\/doi.org\/10.1016\/j.humpath.2017.11.017","journal-title":"Hum Pathol"},{"issue":"9","key":"723_CR17","doi-asserted-by":"publisher","first-page":"1376","DOI":"10.5858\/2000-124-1376-AUVOCL","volume":"124","author":"S Thirumala","year":"2000","unstructured":"Thirumala S, Esposito M, Fuchs A, 2000. An unusual variant of composite lymphoma: a short case report and review of the literature. Arch Pathol Lab Med, 124(9):1376\u20131378. https:\/\/doi.org\/10.5858\/2000-124-1376-AUVOCL","journal-title":"Arch Pathol Lab Med"},{"issue":"6","key":"723_CR18","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1097\/PAS.0000000000001646","volume":"45","author":"M Trimech","year":"2021","unstructured":"Trimech M, Letourneau A, Missiaglia E, et al., 2021. Angioimmunoblastic T-cell lymphoma and chronic lymphocytic leukemia\/small lymphocytic lymphoma: a novel form of composite lymphoma potentially mimicking Richter syndrome. Am J Surg Pathol, 45(6):773\u2013786. https:\/\/doi.org\/10.1097\/PAS.0000000000001646","journal-title":"Am J Surg Pathol"},{"issue":"4","key":"723_CR19","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1016\/j.humpath.2013.11.008","volume":"45","author":"ED Wang","year":"2014","unstructured":"Wang ED, Papavassiliou P, Wang AR, et al., 2014. Composite lymphoid neoplasm of B-cell and T-cell origins: a pathologic study of 14 cases. Hum Pathol, 45(4):768\u2013784. https:\/\/doi.org\/10.1016\/j.humpath.2013.11.008","journal-title":"Hum Pathol"},{"issue":"4","key":"723_CR20","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1016\/j.humpath.2012.09.014","volume":"44","author":"NA Whitling","year":"2013","unstructured":"Whitling NA, Shanesmith RP, Jacob L, et al., 2013. Composite lymphoma of mycosis fungoides and cutaneous small B-cell lymphoma in a 73-year-old male patient. Hum Pathol, 44(4):670\u2013675. https:\/\/doi.org\/10.1016\/j.humpath.2012.09.014","journal-title":"Hum Pathol"},{"issue":"4","key":"723_CR21","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1093\/ajcp\/81.4.526","volume":"81","author":"JA Wolfe","year":"1984","unstructured":"Wolfe JA, Borowitz MJ, 1984. Composite lymphoma: a unique case with two immunologically distinct B-cell neoplasms. Am J Clin Pathol, 81(4):526\u2013529. https:\/\/doi.org\/10.1093\/ajcp\/81.4.526","journal-title":"Am J Clin Pathol"},{"key":"723_CR22","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/s40164-020-00188-w","volume":"9","author":"CQ Xie","year":"2020","unstructured":"Xie CQ, Li X, Zeng H, et al., 2020. Molecular insights into pathogenesis and targeted therapy of peripheral T cell lymphoma. Exp Hematol Oncol, 9:30. https:\/\/doi.org\/10.1186\/s40164-020-00188-w","journal-title":"Exp Hematol Oncol"},{"issue":"6","key":"723_CR23","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1309\/VD2D-98ME-MB3F-WH34","volume":"118","author":"Y Xu","year":"2002","unstructured":"Xu Y, McKenna RW, Hoang MP, et al., 2002. Composite angioimmunoblastic T-cell lymphoma and diffuse large B-cell lymphoma: a case report and review of the literature. Am J Clin Pathol, 118(6):848\u2013854. https:\/\/doi.org\/10.1309\/VD2D-98ME-MB3F-WH34","journal-title":"Am J Clin Pathol"},{"issue":"3","key":"723_CR24","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1309\/6UTX-GVC0-12ND-JJEU","volume":"117","author":"A Zettl","year":"2002","unstructured":"Zettl A, Lee SS, R\u00fcdiger T, et al., 2002. Epstein-Barr virus-associated B-cell lymphoproliferative disorders in angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma, unspecified. Am J Clin Pathol, 117(3):368\u2013379. https:\/\/doi.org\/10.1309\/6UTX-GVC0-12ND-JJEU","journal-title":"Am J Clin Pathol"},{"key":"723_CR25","doi-asserted-by":"publisher","first-page":"1610653","DOI":"10.3389\/pore.2022.1610653","volume":"28","author":"B Zhang","year":"2022","unstructured":"Zhang B, Zhang YY, Li Q, et al., 2022. Case report: chronic lymphocytic leukemia\/small lymphocytic lymphoma and monomorphic epitheliotropic intestinal T-cell lymphoma: a composite lymphoma. Pathol Oncol Res, 28:1610653. https:\/\/doi.org\/10.3389\/pore.2022.1610653","journal-title":"Pathol Oncol Res"}],"container-title":["Journal of Zhejiang University-SCIENCE B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1631\/jzus.B2300181.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1631\/jzus.B2300181\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1631\/jzus.B2300181.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,15]],"date-time":"2023-08-15T02:02:17Z","timestamp":1692064937000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1631\/jzus.B2300181"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":25,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["723"],"URL":"https:\/\/doi.org\/10.1631\/jzus.b2300181","relation":{},"ISSN":["1673-1581","1862-1783"],"issn-type":[{"value":"1673-1581","type":"print"},{"value":"1862-1783","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"16 March 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 April 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 August 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Xueli JIN, Hui LIU, Jing Li, Xibin XIAO, Xianggui YUAN, Panpan CHEN, Boxiao CHEN, Yun LIANG, and Fengbo HUANG declare that they have no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethics guidelines"}},{"value":"All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2013. The study was approved by the ethical committee of the Second Affiliated Hospital, School of Medicine, Zhejiang University (No. 2023 (0227)). Informed consent was obtained from all patients for being included in the study. Additional informed consent was obtained from all patients for whom identifying information is included in this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethics guidelines"}}]}}