{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T18:07:21Z","timestamp":1764698841732,"version":"3.30.1"},"reference-count":15,"publisher":"Zhejiang University Press","issue":"11","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J. Zhejiang Univ. Sci. B"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1631\/jzus.b2300195","type":"journal-article","created":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T04:23:58Z","timestamp":1700713438000},"page":"1037-1046","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Loss-of-function of zebrafish cdt1 causes retarded body growth and underdeveloped gonads resembling human Meier-Gorlin syndrome","\u6591\u9a6c\u9c7ccdt1\u7f3a\u5931\u5bfc\u81f4\u7c7b\u4f3c\u4eba\u7c7bMeier-Gorlin\u75be\u75c5\u7684\u4f8f\u5112\u75c7\u53ca\u6027\u817a\u53d1\u80b2\u4e0d\u5168\u7efc\u5408\u5f81"],"prefix":"10.1631","volume":"24","author":[{"given":"Yinan","family":"He","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanqing","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3247-840X","authenticated-orcid":false,"given":"Li Jan","family":"Lo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"635","published-online":{"date-parts":[[2023,11,23]]},"reference":[{"issue":"S12","key":"195_CR1","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1242\/jcs.1989.Supplement_12.2","volume":"1989","author":"CE Alfa","year":"1989","unstructured":"Alfa CE, Booher R, Beach D, et al., 1989. Fission yeast cyclin: subcellular localisation and cell cycle regulation. J Cell Sci, 1989(S12):9\u201319. https:\/\/doi.org\/10.1242\/jcs.1989.supplement_12.2","journal-title":"J Cell Sci"},{"issue":"4","key":"195_CR2","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1038\/ng.776","volume":"43","author":"LS Bicknell","year":"2011","unstructured":"Bicknell LS, Walker S, Klingseisen A, et al., 2011. Mutations in ORC1, encoding the largest subunit of the origin recognition complex, cause microcephalic primordial dwarf-ism resembling Meier-Gorlin syndrome. Nat Genet, 43(4): 350\u2013355. https:\/\/doi.org\/10.1038\/ng.776","journal-title":"Nat Genet"},{"key":"195_CR3","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1186\/s13023-015-0322-x","volume":"10","author":"SA de Munnik","year":"2015","unstructured":"de Munnik SA, Hoefsloot EH, Roukema J, et al., 2015. Meier-Gorlin syndrome. Orphanet J Rare Dis, 10:114. https:\/\/doi.org\/10.1186\/s13023-015-0322-x","journal-title":"Orphanet J Rare Dis"},{"issue":"2","key":"195_CR4","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1002\/j.1460-2075.1994.tb06277.x","volume":"13","author":"JF Hofmann","year":"1994","unstructured":"Hofmann JF, Beach D, 1994. cdt1 is an essential target of the Cdc10\/Sct1 transcription factor: requirement for DNA replication and inhibition of mitosis. EMBO J, 13(2): 425\u2013434. https:\/\/doi.org\/10.1002\/j.1460-2075.1994.tb06277.x","journal-title":"EMBO J"},{"issue":"5","key":"195_CR5","doi-asserted-by":"publisher","first-page":"2449","DOI":"10.21873\/anticanres.14214","volume":"40","author":"A Kanellou","year":"2020","unstructured":"Kanellou A, Giakoumakis NN, Panagopoulos A, et al., 2020. The licensing factor Cdt1 links cell cycle progression to the DNA damage response. Anticancer Res, 40(5):2449\u20132456. https:\/\/doi.org\/10.21873\/anticanres.14214","journal-title":"Anticancer Res"},{"issue":"7751","key":"195_CR6","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1038\/s41586-019-1057-y","volume":"568","author":"ZP Ma","year":"2019","unstructured":"Ma ZP, Zhu PP, Shi H, et al., 2019. PTC-bearing mRNA elicits a genetic compensation response via Upf3a and COMPASS components. Nature, 568(7751):259\u2013263. https:\/\/doi.org\/10.1038\/s41586-019-1057-y","journal-title":"Nature"},{"issue":"6778","key":"195_CR7","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1038\/35007104","volume":"404","author":"D Maiorano","year":"2000","unstructured":"Maiorano D, Moreau J, M\u00e9chali M, 2000. XCDT1 is required for the assembly of pre-replicative complexes in Xenopus laevis. Nature, 404(6778):622\u2013625. https:\/\/doi.org\/10.1038\/35007104","journal-title":"Nature"},{"issue":"16","key":"195_CR8","doi-asserted-by":"publisher","first-page":"9234","DOI":"10.3390\/ijms23169234","volume":"23","author":"MS Nazarenko","year":"2022","unstructured":"Nazarenko MS, Viakhireva IV, Skoblov MY, et al., 2022. Meier-Gorlin syndrome: clinical misdiagnosis, genetic testing and functional analysis of ORC6 mutations and the development of a prenatal test. Int J Mol Sci, 23(16):9234. https:\/\/doi.org\/10.3390\/ijms23169234","journal-title":"Int J Mol Sci"},{"issue":"6778","key":"195_CR9","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1038\/35007110","volume":"404","author":"H Nishitani","year":"2000","unstructured":"Nishitani H, Lygerou Z, Nishimoto T, et al., 2000. The Cdt1 protein is required to license DNA for replication in fission yeast. Nature, 404(6778):625\u2013628. https:\/\/doi.org\/10.1038\/35007110","journal-title":"Nature"},{"issue":"1","key":"195_CR10","doi-asserted-by":"publisher","first-page":"2","DOI":"10.3390\/genes8010002","volume":"8","author":"PN Pozo","year":"2017","unstructured":"Pozo PN, Cook JG, 2017. Regulation and function of Cdt1; a key factor in cell proliferation and genome stability. Genes (Basel), 8(1):2. https:\/\/doi.org\/10.3390\/genes8010002","journal-title":"Genes (Basel)"},{"issue":"4","key":"195_CR11","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1016\/S1097-2765(03)00099-6","volume":"11","author":"C Vaziri","year":"2003","unstructured":"Vaziri C, Saxena S, Jeon Y, et al., 2003. A p53-dependent checkpoint pathway prevents rereplication. Mol Cell, 11(4):997\u20131008. https:\/\/doi.org\/10.1016\/s1097-2765(03)00099-6","journal-title":"Mol Cell"},{"issue":"14","key":"195_CR12","doi-asserted-by":"publisher","first-page":"1765","DOI":"10.1101\/gad.14.14.1765","volume":"14","author":"AJ Whittaker","year":"2000","unstructured":"Whittaker AJ, Royzman I, Orr-Weaver TL, 2000. Drosophila Double parked: a conserved, essential replication protein that colocalizes with the origin recognition complex and links DNA replication with mitosis and the down-regulation of S phase transcripts. Genes Dev, 14(14): 1765\u20131776. https:\/\/doi.org\/10.1101\/gad.14.14.1765","journal-title":"Genes Dev"},{"issue":"13","key":"195_CR13","doi-asserted-by":"publisher","first-page":"3517","DOI":"10.1128\/MCB.00177-09","volume":"29","author":"N Wittkopp","year":"2009","unstructured":"Wittkopp N, Huntzinger E, Weiler C, et al., 2009. Nonsensemediated mRNA decay effectors are essential for zebrafish embryonic development and survival. Mol Cell Biol, 29(13):3517\u20133528. https:\/\/doi.org\/10.1128\/MCB.00177-09","journal-title":"Mol Cell Biol"},{"issue":"5500","key":"195_CR14","doi-asserted-by":"publisher","first-page":"2309","DOI":"10.1126\/science.290.5500.2309","volume":"290","author":"JA Wohlschlegel","year":"2000","unstructured":"Wohlschlegel JA, Dwyer BT, Dhar SK, et al., 2000. Inhibition of eukaryotic DNA replication by geminin binding to Cdt1. Science, 290(5500):2309\u20132312. https:\/\/doi.org\/10.1126\/science.290.5500.2309","journal-title":"Science"},{"issue":"21","key":"195_CR15","doi-asserted-by":"publisher","first-page":"4168","DOI":"10.1093\/hmg\/ddx305","volume":"26","author":"LK Yao","year":"2017","unstructured":"Yao LK, Chen J, Wu XT, et al., 2017. Zebrafish cdc6 hypomorphic mutation causes Meier-Gorlin syndrome-like phenotype. Hum Mol Genet, 26(21):4168\u20134180. https:\/\/doi.org\/10.1093\/hmg\/ddx305","journal-title":"Hum Mol Genet"}],"container-title":["Journal of Zhejiang University-SCIENCE B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1631\/jzus.B2300195.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1631\/jzus.B2300195\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1631\/jzus.B2300195.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T01:02:09Z","timestamp":1733446929000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1631\/jzus.B2300195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":15,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["195"],"URL":"https:\/\/doi.org\/10.1631\/jzus.b2300195","relation":{},"ISSN":["1673-1581","1862-1783"],"issn-type":[{"type":"print","value":"1673-1581"},{"type":"electronic","value":"1862-1783"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"21 March 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 May 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 November 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Yinan HE, Yong WANG, Yanqing ZHU, and Li Jan LO declare that they have no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethics guidelines"}},{"value":"All animal experiments were approved by the Animal Care Committee of Zhejiang University, and all methods were performed in accordance with the Guidelines for the Care and Use of Animals for Research and Teaching at Zhejiang University (ETHICS CODE Permit No. ZJU20220031).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethics guidelines"}}]}}