{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T16:28:25Z","timestamp":1766507305279,"version":"3.48.0"},"reference-count":46,"publisher":"Zhejiang University Press","license":[{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J. Zhejiang Univ. Sci. B"],"DOI":"10.1631\/jzus.b2500142","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T01:17:12Z","timestamp":1766452632000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Momordicine I induces ER stress and inhibits OSCC by targeting ribosomal proteins","\u82e6\u74dc\u7d20I\u901a\u8fc7\u9776\u5411\u6838\u7cd6\u4f53\u86cb\u767d\u8bf1\u5bfc\u5185\u8d28\u7f51\u5e94\u6fc0\u6291\u5236\u53e3\u8154\u9cde\u72b6\u7ec6\u80de\u764c"],"prefix":"10.1631","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9264-2929","authenticated-orcid":false,"given":"Jianlu","family":"Kong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7680-5292","authenticated-orcid":false,"given":"Ziyu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yijie","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siyi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianyi","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1131-7455","authenticated-orcid":false,"given":"Huiming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengfei","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3699-4759","authenticated-orcid":false,"given":"Yu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"635","published-online":{"date-parts":[[2025,12,22]]},"reference":[{"key":"142_CR1","doi-asserted-by":"publisher","first-page":"e43036","DOI":"10.7554\/eLife.43036","volume":"7","author":"D Acosta-Alvear","year":"2018","unstructured":"Acosta-Alvear D, Karag\u00f6z GE, Fr\u00f6hlich F, et al., 2018. The unfolded protein response and endoplasmic reticulum protein targeting machineries converge on the stress sensor IRE1. eLife, 7:e43036. https:\/\/doi.org\/10.7554\/eLife.43036","journal-title":"eLife"},{"key":"142_CR2","doi-asserted-by":"publisher","first-page":"4243","DOI":"10.1038\/s41467-022-31906-z","volume":"13","author":"M Ahn","year":"2022","unstructured":"Ahn M, W\u0142odarski T, Mitropoulou A, et al., 2022. Modulating co-translational protein folding by rational design and ribosome engineering. Nat Commun, 13:4243. https:\/\/doi.org\/10.1038\/s41467-022-31906-z","journal-title":"Nat Commun"},{"issue":"6","key":"142_CR3","doi-asserted-by":"publisher","first-page":"e1809","DOI":"10.1002\/wrna.1809","volume":"14","author":"LR Alagar Boopathy","year":"2023","unstructured":"Alagar Boopathy LR, Beadle E, Garcia-Bueno Rico A, et al., 2023. Proteostasis regulation through ribosome quality control and no-go-decay. WIREs RNA, 14(6):e1809. https:\/\/doi.org\/10.1002\/wrna.1809","journal-title":"WIREs RNA"},{"key":"142_CR4","doi-asserted-by":"publisher","first-page":"22419","DOI":"10.1038\/srep22419","volume":"6","author":"LY Bai","year":"2016","unstructured":"Bai LY, Chiu CF, Chu PC, et al., 2016. A triterpenoid from wild bitter gourd inhibits breast cancer cells. Sci Rep, 6:22419. https:\/\/doi.org\/10.1038\/srep22419","journal-title":"Sci Rep"},{"issue":"11","key":"142_CR5","first-page":"3282","volume":"48","author":"WJ Blot","year":"1988","unstructured":"Blot WJ, McLaughlin JK, Winn DM, et al., 1988. Smoking and drinking in relation to oral and pharyngeal cancer. Cancer Res, 48(11):3282\u20133287.","journal-title":"Cancer Res"},{"issue":"6","key":"142_CR6","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3322\/caac.21492","volume":"68","author":"F Bray","year":"2018","unstructured":"Bray F, Ferlay J, Soerjomataram I, et al., 2018. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 68(6):394\u2013424. https:\/\/doi.org\/10.3322\/caac.21492","journal-title":"CA Cancer J Clin"},{"key":"142_CR7","doi-asserted-by":"publisher","first-page":"117179","DOI":"10.1016\/j.carbpol.2020.117179","volume":"252","author":"F Chen","year":"2021","unstructured":"Chen F, Huang GL, Huang HL, 2021. Preparation, analysis, antioxidant activities in vivo of phosphorylated polysaccharide from Momordica charantia. Carbohydr Polym, 252:117179. https:\/\/doi.org\/10.1016\/j.carbpol.2020.117179","journal-title":"Carbohydr Polym"},{"key":"142_CR8","doi-asserted-by":"publisher","first-page":"3939714","DOI":"10.1155\/2018\/3939714","volume":"2018","author":"PY Chen","year":"2018","unstructured":"Chen PY, Shih NL, Hao WR, et al., 2018. Inhibitory effects of momordicine I on high-glucose-induced cell proliferation and collagen synthesis in rat cardiac fibroblasts. Oxid Med Cell Longev, 2018:3939714. https:\/\/doi.org\/10.1155\/2018\/3939714","journal-title":"Oxid Med Cell Longev"},{"key":"142_CR9","doi-asserted-by":"publisher","first-page":"4523","DOI":"10.2147\/CMAR.S171251","volume":"10","author":"SW Chen","year":"2018","unstructured":"Chen SW, Zhang Q, Guo ZM, et al., 2018. Trends in clinical features and survival of oral cavity cancer: fifty years of experience with 3362 consecutive cases from a single institution. Cancer Manag Res, 10:4523\u20134535. https:\/\/doi.org\/10.2147\/cmar.S171251","journal-title":"Cancer Manag Res"},{"issue":"8","key":"142_CR10","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1111\/j.1349-7006.2008.00863.x","volume":"99","author":"YJ Chen","year":"2008","unstructured":"Chen YJ, Chang JTC, Liao CT, et al., 2008. Head and neck cancer in the betel quid chewing area: recent advances in molecular carcinogenesis. Cancer Sci, 99(8):1507\u20131514. https:\/\/doi.org\/10.1111\/j.1349-7006.2008.00863.x","journal-title":"Cancer Sci"},{"issue":"9","key":"142_CR11","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1631\/jzus.B2200602","volume":"24","author":"YW Dai","year":"2023","unstructured":"Dai YW, Wu ZQ, Chen YT, et al., 2023. OCT4\u2019s role and mechanism underlying oral squamous cell carcinoma. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 24(9):796\u2013806. https:\/\/doi.org\/10.1631\/jzus.B2200602","journal-title":"J Zhejiang Univ-Sci B (Biomed & Biotechnol)"},{"key":"142_CR12","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/1475-2867-13-31","volume":"13","author":"LL Feller","year":"2013","unstructured":"Feller LL, Khammissa RR, Kramer BB, et al., 2013. Oral squamous cell carcinoma in relation to field precancerisation: pathobiology. Cancer Cell Int, 13:31. https:\/\/doi.org\/10.1186\/1475-2867-13-31","journal-title":"Cancer Cell Int"},{"issue":"10","key":"142_CR13","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1101\/gad.189951.112","volume":"26","author":"S Fumagalli","year":"2012","unstructured":"Fumagalli S, Ivanenkov VV, Teng T, et al., 2012. Suprainduction of p53 by disruption of 40S and 60S ribosome biogenesis leads to the activation of a novel G2\/M checkpoint. Genes Dev, 26(10):1028\u20131040. https:\/\/doi.org\/10.1101\/gad.189951.112","journal-title":"Genes Dev"},{"issue":"12","key":"142_CR14","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1631\/jzus.B2300200","volume":"24","author":"PF Gao","year":"2023","unstructured":"Gao PF, Zhang WT, Lin YJ, et al., 2023. Luteolin suppresses oral carcinoma 3 (OC3) cell growth and migration via modulating polo-like kinase 1 (PLK1) expression and cellular energy metabolism. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 24(12):1151\u20131158. https:\/\/doi.org\/10.1631\/jzus.B2300200","journal-title":"J Zhejiang Univ-Sci B (Biomed & Biotechnol)"},{"issue":"2","key":"142_CR15","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1111\/j.1582-4934.2009.00969.x","volume":"15","author":"XY Guo","year":"2011","unstructured":"Guo XY, Shi YQ, Gou YW, et al., 2011. Human ribosomal protein S13 promotes gastric cancer growth through down-regulating p27Kip1. J Cell Mol Med, 15(2):296\u2013306. https:\/\/doi.org\/10.1111\/j.1582-4934.2009.00969.x","journal-title":"J Cell Mol Med"},{"issue":"4","key":"142_CR16","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1177\/0022034509333371","volume":"88","author":"PT Hennessey","year":"2009","unstructured":"Hennessey PT, Westra WH, Califano JA, 2009. Human papillomavirus and head and neck squamous cell carcinoma: recent evidence and clinical implications. J Dent Res, 88(4): 300\u2013306. https:\/\/doi.org\/10.1177\/0022034509333371","journal-title":"J Dent Res"},{"issue":"6264","key":"142_CR17","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1126\/science.aad0344","volume":"350","author":"W Holtkamp","year":"2015","unstructured":"Holtkamp W, Kokic G, J\u00e4ger M, et al., 2015. Cotranslational protein folding on the ribosome monitored in real time. Science, 350(6264):1104\u20131107. https:\/\/doi.org\/10.1126\/science.aad0344","journal-title":"Science"},{"key":"142_CR18","doi-asserted-by":"publisher","first-page":"824043","DOI":"10.3389\/fonc.2022.824043","volume":"12","author":"RJ Hsu","year":"2022","unstructured":"Hsu RJ, Peng KY, Hsu WL, et al., 2022. Z-ligustilide induces c-Myc-dependent apoptosis via activation of ER-stress signaling in hypoxic oral cancer cells. Front Oncol, 12:824043. https:\/\/doi.org\/10.3389\/fonc.2022.824043","journal-title":"Front Oncol"},{"issue":"6","key":"142_CR19","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1093\/jb\/mvac010","volume":"171","author":"MK Ichikawa","year":"2022","unstructured":"Ichikawa MK, Saitoh M, 2022. Direct and indirect roles of GRWD1 in the inactivation of p53 in cancer. J Biochem, 171(6):601\u2013603. https:\/\/doi.org\/10.1093\/jb\/mvac010","journal-title":"J Biochem"},{"key":"142_CR20","doi-asserted-by":"publisher","first-page":"6131","DOI":"10.2147\/OTT.S252045","volume":"13","author":"HS Ji","year":"2020","unstructured":"Ji HS, Zhang XY, 2020. RPL38 regulates the proliferation and apoptosis of gastric cancer via miR-374b-5p\/VEGF signal pathway. Onco Targets Ther, 13:6131\u20136141. https:\/\/doi.org\/10.2147\/ott.S252045","journal-title":"Onco Targets Ther"},{"issue":"6063","key":"142_CR21","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1126\/science.1209740","volume":"334","author":"CM Kaiser","year":"2011","unstructured":"Kaiser CM, Goldman DH, Chodera JD, et al., 2011. The ribosome modulates nascent protein folding. Science, 334(6063): 1723\u20131727. https:\/\/doi.org\/10.1126\/science.1209740","journal-title":"Science"},{"key":"142_CR22","doi-asserted-by":"publisher","first-page":"482","DOI":"10.17179\/excli2023-6129","volume":"22","author":"Y Kao","year":"2023","unstructured":"Kao Y, Chou CH, Huang LC, et al., 2023. Momordicine I suppresses glioma growth by promoting apoptosis and impairing mitochondrial oxidative phosphorylation. EXCLI J, 22:482\u2013498. https:\/\/doi.org\/10.17179\/excli2023-6129","journal-title":"EXCLI J"},{"issue":"5","key":"142_CR23","doi-asserted-by":"publisher","first-page":"729","DOI":"10.3390\/foods11050729","volume":"11","author":"YT Lee","year":"2022","unstructured":"Lee YT, Pao LH, Chen CY, et al., 2022. Microwave- and ultrasound-assisted extraction of cucurbitane-type triter-penoids from Momordica charantia L. cultivars and their antiproliferative effect on SAS human oral cancer cells. Foods, 11(5):729. https:\/\/doi.org\/10.3390\/foods11050729","journal-title":"Foods"},{"issue":"1","key":"142_CR24","doi-asserted-by":"publisher","first-page":"75","DOI":"10.4196\/kjpp.2023.27.1.75","volume":"27","author":"HM Li","year":"2023","unstructured":"Li HM, Qiu YM, Xie MD, et al., 2023. Momordicine I alleviates isoproterenol-induced cardiomyocyte hypertrophy through suppression of PLA2G6 and DGK-\u03b6. Korean J Physiol Pharmacol, 27(1):75\u201384. https:\/\/doi.org\/10.4196\/kjpp.2023.27.1.75","journal-title":"Korean J Physiol Pharmacol"},{"issue":"2","key":"142_CR25","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.molcel.2019.01.043","volume":"74","author":"KX Liu","year":"2019","unstructured":"Liu KX, Maciuba K, Kaiser CM, 2019. The ribosome cooperates with a chaperone to guide multi-domain protein folding. Mol Cell, 74(2):310\u2013319.e7. https:\/\/doi.org\/10.1016\/j.molcel.2019.01.043","journal-title":"Mol Cell"},{"issue":"6141","key":"142_CR26","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1126\/science.1233606","volume":"341","author":"D Martinez Molina","year":"2013","unstructured":"Martinez Molina D, Jafari R, Ignatushchenko M, et al., 2013. Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay. Science, 341(6141):84\u201387. https:\/\/doi.org\/10.1126\/science.1233606","journal-title":"Science"},{"issue":"10","key":"142_CR27","doi-asserted-by":"publisher","first-page":"5063","DOI":"10.1002\/anie.202015962","volume":"60","author":"B Neuditschko","year":"2021","unstructured":"Neuditschko B, Legin AA, Baier D, et al., 2021. Interaction with ribosomal proteins accompanies stress induction of the anticancer metallodrug BOLD-100\/KP1339 in the endoplasmic reticulum. Angew Chem Int Ed, 60(10):5063\u20135068. https:\/\/doi.org\/10.1002\/anie.202015962","journal-title":"Angew Chem Int Ed"},{"issue":"12","key":"142_CR28","doi-asserted-by":"publisher","first-page":"5236","DOI":"10.1172\/JCI124282","volume":"129","author":"KE Oliver","year":"2019","unstructured":"Oliver KE, Rauscher R, Mijnders M, et al., 2019. Slowing ribosome velocity restores folding and function of mutant CFTR. J Clin Invest, 129(12):5236\u20135253. https:\/\/doi.org\/10.1172\/jci124282","journal-title":"J Clin Invest"},{"issue":"3\u20134","key":"142_CR29","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1016\/j.fct.2012.01.009","volume":"50","author":"P Pitchakarn","year":"2012","unstructured":"Pitchakarn P, Suzuki S, Ogawa K, et al., 2012. Kuguacin J, a triterpeniod from Momordica charantia leaf, modulates the progression of androgen-independent human prostate cancer cell line, PC3. Food Chem Toxicol, 50(3\u20134):840\u2013847. https:\/\/doi.org\/10.1016\/j.fct.2012.01.009","journal-title":"Food Chem Toxicol"},{"issue":"4","key":"142_CR30","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1007\/s11418-017-1099-0","volume":"71","author":"P Pitchakarn","year":"2017","unstructured":"Pitchakarn P, Umsumarng S, Mapoung S, et al., 2017. Kuguacin J isolated from bitter melon leaves modulates paclitaxel sensitivity in drug-resistant human ovarian cancer cells. J Nat Med, 71(4):693\u2013702. https:\/\/doi.org\/10.1007\/s11418-017-1099-0","journal-title":"J Nat Med"},{"issue":"8","key":"142_CR31","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1038\/nm.2392","volume":"17","author":"M Sasaki","year":"2011","unstructured":"Sasaki M, Kawahara K, Nishio M, et al., 2011. Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11. Nat Med, 17(8):944\u2013951. https:\/\/doi.org\/10.1038\/nm.2392","journal-title":"Nat Med"},{"key":"142_CR32","doi-asserted-by":"publisher","first-page":"3017807","DOI":"10.1155\/2022\/3017807","volume":"2022","author":"YY She","year":"2022","unstructured":"She YY, Lin JJ, Su JH, et al., 2022. 4-Carbomethoxyl-10-epigyrosanoldie E extracted from cultured soft coral Sinularia sandensis induced apoptosis and autophagy via ROS and mitochondrial dysfunction and ER stress in oral cancer cells. Oxid Med Cell Longev, 2022:3017807. https:\/\/doi.org\/10.1155\/2022\/3017807","journal-title":"Oxid Med Cell Longev"},{"issue":"2","key":"142_CR33","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.yexcr.2004.02.009","volume":"296","author":"YQ Shi","year":"2004","unstructured":"Shi YQ, Zhai HH, Wang X, et al., 2004. Ribosomal proteins S13 and L23 promote multidrug resistance in gastric cancer cells by suppressing drug-induced apoptosis. Exp Cell Res, 296(2):337\u2013346. https:\/\/doi.org\/10.1016\/j.yexcr.2004.02.009","journal-title":"Exp Cell Res"},{"key":"142_CR34","doi-asserted-by":"publisher","first-page":"12","DOI":"10.20517\/2394-4722.2020.126","volume":"7","author":"S Sur","year":"2021","unstructured":"Sur S, Ray RB, 2021. Diverse roles of bitter melon (Momordica charantia) in prevention of oral cancer. J Cancer Metastasis Treat, 7:12. https:\/\/doi.org\/10.20517\/2394-4722.2020.126","journal-title":"J Cancer Metastasis Treat"},{"issue":"6","key":"142_CR35","doi-asserted-by":"publisher","first-page":"1432","DOI":"10.3390\/cancers13061432","volume":"13","author":"S Sur","year":"2021","unstructured":"Sur S, Steele R, Isbell TS, et al., 2021. Momordicine-I, a bitter melon bioactive metabolite, displays anti-tumor activity in head and neck cancer involving c-Met and downstream signaling. Cancers, 13(6):1432. https:\/\/doi.org\/10.3390\/cancers13061432","journal-title":"Cancers"},{"issue":"5","key":"142_CR36","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1158\/1535-7163.MCT-23-0718","volume":"23","author":"S Sur","year":"2024","unstructured":"Sur S, Bhartiya P, Steele R, et al., 2024. Momordicine-I suppresses head and neck cancer growth by reprogrammimg immunosuppressive effect of the tumor-infiltrating macrophages and B lymphocytes. Mol Cancer Ther, 23(5):672\u2013682. https:\/\/doi.org\/10.1158\/1535-7163.Mct-23-0718","journal-title":"Mol Cancer Ther"},{"issue":"12","key":"142_CR37","doi-asserted-by":"publisher","first-page":"1888","DOI":"10.1038\/s41594-024-01355-x","volume":"31","author":"TE Wales","year":"2024","unstructured":"Wales TE, Pajak A, Roeselov\u00e1 A, et al., 2024. Resolving chaperone-assisted protein folding on the ribosome at the peptide level. Nat Struct Mol Biol, 31(12):1888\u20131897. https:\/\/doi.org\/10.1038\/s41594-024-01355-x","journal-title":"Nat Struct Mol Biol"},{"issue":"10","key":"142_CR38","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.2174\/187152012803833026","volume":"12","author":"H Wang","year":"2012","unstructured":"Wang H, Khor TO, Shu LM, et al., 2012. Plants vs. cancer: a review on natural phytochemicals in preventing and treating cancers and their druggability. Anticancer Agents Med Chem, 12(10):1281\u20131305. https:\/\/doi.org\/10.2174\/187152012803833026","journal-title":"Anticancer Agents Med Chem"},{"key":"142_CR39","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1038\/s41422-019-0236-6","volume":"30","author":"LH Wang","year":"2020","unstructured":"Wang LH, Xu Y, Rogers H, et al., 2020. UFMylation of RPL26 links translocation-associated quality control to endoplasmic reticulum protein homeostasis. Cell Res, 30:5\u201320. https:\/\/doi.org\/10.1038\/s41422-019-0236-6","journal-title":"Cell Res"},{"issue":"11","key":"142_CR40","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1016\/j.tibs.2019.06.008","volume":"44","author":"CA Waudby","year":"2019","unstructured":"Waudby CA, Dobson CM, Christodoulou J, 2019. Nature and regulation of protein folding on the ribosome. Trends Biochem Sci, 44(11):914\u2013926. https:\/\/doi.org\/10.1016\/j.tibs.2019.06.008","journal-title":"Trends Biochem Sci"},{"issue":"22","key":"142_CR41","doi-asserted-by":"publisher","first-page":"E4399","DOI":"10.1073\/pnas.1617873114","volume":"114","author":"F Wruck","year":"2017","unstructured":"Wruck F, Katranidis A, Nierhaus KH, et al., 2017. Translation and folding of single proteins in real time. Proc Natl Acad Sci USA, 114(22):E4399\u2013E4407. https:\/\/doi.org\/10.1073\/pnas.1617873114","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"142_CR42","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1177\/0022034514559376","volume":"94","author":"Y Xi","year":"2015","unstructured":"Xi Y, Garshott DM, Brownell AL, et al., 2015. Cantharidins induce ER stress and a terminal unfolded protein response in OSCC. J Dent Res, 94(2):320\u2013329. https:\/\/doi.org\/10.1177\/0022034514559376","journal-title":"J Dent Res"},{"key":"142_CR43","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1186\/s12951-021-00995-1","volume":"19","author":"M Yang","year":"2021","unstructured":"Yang M, Luo QQ, Chen X, et al., 2021. Bitter melon derived extracellular vesicles enhance the therapeutic effects and reduce the drug resistance of 5-fluorouracil on oral squamous cell carcinoma. J Nanobiotechnol, 19:259. https:\/\/doi.org\/10.1186\/s12951-021-00995-1","journal-title":"J Nanobiotechnol"},{"key":"142_CR44","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.phytochem.2018.10.009","volume":"157","author":"JY Yue","year":"2019","unstructured":"Yue JY, Sun YY, Xu J, et al., 2019. Cucurbitane triterpenoids from the fruit of Momordica charantia L. and their anti-hepatic fibrosis and anti-hepatoma activities. Phytochemistry, 157:21\u201327. https:\/\/doi.org\/10.1016\/j.phytochem.2018.10.009","journal-title":"Phytochemistry"},{"issue":"22","key":"142_CR45","doi-asserted-by":"publisher","first-page":"2782","DOI":"10.1038\/onc.2012.289","volume":"32","author":"X Zhang","year":"2013","unstructured":"Zhang X, Wang W, Wang H, et al., 2013. Identification of ribosomal protein S25 (RPS25)\u2013MDM2\u2013p53 regulatory feedback loop. Oncogene, 32(22):2782\u20132791. https:\/\/doi.org\/10.1038\/onc.2012.289","journal-title":"Oncogene"},{"issue":"23","key":"142_CR46","doi-asserted-by":"publisher","first-page":"8902","DOI":"10.1128\/MCB.23.23.8902-8912.2003","volume":"23","author":"YP Zhang","year":"2003","unstructured":"Zhang YP, Wolf GW, Bhat K, et al., 2003. Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway. Mol Cell Biol, 23(23):8902\u20138912. https:\/\/doi.org\/10.1128\/mcb.23.23.8902-8912.2003","journal-title":"Mol Cell Biol"}],"container-title":["Journal of Zhejiang University-SCIENCE B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1631\/jzus.B2500142.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1631\/jzus.B2500142","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1631\/jzus.B2500142.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T14:02:50Z","timestamp":1766498570000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1631\/jzus.B2500142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,22]]},"references-count":46,"alternative-id":["142"],"URL":"https:\/\/doi.org\/10.1631\/jzus.b2500142","relation":{},"ISSN":["1673-1581","1862-1783"],"issn-type":[{"type":"print","value":"1673-1581"},{"type":"electronic","value":"1862-1783"}],"subject":[],"published":{"date-parts":[[2025,12,22]]},"assertion":[{"value":"25 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Jianlu KONG, Ziyu ZHU, Yijie HU, Siyi ZHOU, Tianyi GU, Xiao SHEN, Huiming WANG, Mengfei YU, and Yu LIU declare that they have no conflicts of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethics guidelines"}},{"value":"The animal experiments were performed in accordance with the protocol approved by the Animal Care and Use Committee of Zhejiang University (ETHICS CODE: ZJU20210268). All institutional and national guidelines for the care and use of laboratory animals were followed.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethics guidelines"}}]}}