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Informed consent was obtained from all participants for being included in the study. Additional informed consent was obtained from all participants for whom identifying information is included in this article. All animal experiments were approved by the Institutional Animal Care and Use Committee of Peking University Health Science Center (No. PUIRB-LA2022692).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethics guidelines"}},{"value":"During the preparation of this work, the authors used ChatGPT to improve language and readability. After using this tool, the authors reviewed and edited the content as needed and take full responsibility for the content of the publication.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declaration on the use of generative AI tools"}}]}}