{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T02:26:00Z","timestamp":1793413560204,"version":"4.5.0"},"reference-count":62,"publisher":"Zhejiang University Press","issue":"12","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J. Zhejiang Univ. Sci. B"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1631\/jzus.b2500254","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T07:12:25Z","timestamp":1768201945000},"page":"1172-1191","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Single-cell RNA-sequencing-guided reactive oxygen species-scavenging hydrogel design for regeneration of osteoporotic bone","\u57fa\u4e8e\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u6d4b\u5e8f\u5206\u6790: \u8bbe\u8ba1\u6d3b\u6027\u6c27\u6e05\u9664\u6c34\u51dd\u80f6\u53ca\u5176\u5728\u9aa8\u8d28\u758f\u677e\u6027\u9aa8\u518d\u751f\u4e2d\u7684\u5e94\u7528"],"prefix":"10.1631","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2485-2303","authenticated-orcid":false,"given":"Wei","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyi","family":"Fei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhichao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yude","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengfei","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1308-4827","authenticated-orcid":false,"given":"Fan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7159-1934","authenticated-orcid":false,"given":"Feiya","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"635","published-online":{"date-parts":[[2026,1,12]]},"reference":[{"issue":"40","key":"821_CR1","doi-asserted-by":"publisher","first-page":"27438","DOI":"10.1074\/jbc.M109.023572","volume":"284","author":"M Almeida","year":"2009","unstructured":"Almeida M, Ambrogini E, Han L, et al., 2009. Increased lipid oxidation causes oxidative stress, increased peroxisome proliferator-activated receptor-\u03b3 expression, and diminished pro-osteogenic Wnt signaling in the skeleton. J Biol Chem, 284(40):27438\u201327448. https:\/\/doi.org\/10.1074\/jbc.M109.023572","journal-title":"J Biol Chem"},{"issue":"14","key":"821_CR2","doi-asserted-by":"publisher","first-page":"2580","DOI":"10.3390\/cancers16142580","volume":"16","author":"A Amaroli","year":"2024","unstructured":"Amaroli A, Panfoli I, Bozzo M, et al., 2024. The bright side of curcumin: a narrative review of its therapeutic potential in cancer management. Cancers (Basel), 16(14):2580. https:\/\/doi.org\/10.3390\/cancers16142580","journal-title":"Cancers (Basel)"},{"key":"821_CR3","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/j.msec.2017.03.114","volume":"76","author":"AN Au-Duong","year":"2017","unstructured":"Au-Duong AN, Lee CK, 2017. Iodine-loaded metal organic framework as growth-triggered antimicrobial agent. Mater Sci Eng C, 76:477\u2013482. https:\/\/doi.org\/10.1016\/j.msec.2017.03.114","journal-title":"Mater Sci Eng C"},{"key":"821_CR4","doi-asserted-by":"publisher","first-page":"128022","DOI":"10.1016\/j.ijbiomac.2023.128022","volume":"255","author":"D Aycan","year":"2024","unstructured":"Aycan D, G\u00fcl \u0130, Yorulmaz V, et al., 2024. Gelatin microsphere-alginate hydrogel combined system for sustained and gastric targeted delivery of 5-fluorouracil. Int J Biol Macromol, 255:128022. https:\/\/doi.org\/10.1016\/j.ijbiomac.2023.128022","journal-title":"Int J Biol Macromol"},{"issue":"9","key":"821_CR5","doi-asserted-by":"publisher","first-page":"2057","DOI":"10.1002\/jbmr.2245","volume":"29","author":"KE Barbour","year":"2014","unstructured":"Barbour KE, Lui LY, Ensrud KE, et al., 2014. Inflammatory markers and risk of hip fracture in older white women: the study of osteoporotic fractures. J Bone Miner Res, 29(9): 2057\u20132064. https:\/\/doi.org\/10.1002\/jbmr.2245","journal-title":"J Bone Miner Res"},{"issue":"6","key":"821_CR6","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1007\/s00424-024-02947-8","volume":"476","author":"S Becker","year":"2024","unstructured":"Becker S, Swoboda A, Siemer H, et al., 2024. Membrane potential dynamics of C5a-stimulated neutrophil granulocytes. Pflugers Arch, 476(6):1007\u20131018. https:\/\/doi.org\/10.1007\/s00424-024-02947-8","journal-title":"Pflugers Arch"},{"key":"821_CR7","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/nature01658","volume":"423","author":"WJ Boyle","year":"2003","unstructured":"Boyle WJ, Simonet WS, Lacey DL, 2003. Osteoclast differentiation and activation. Nature, 423:337\u2013342. https:\/\/doi.org\/10.1038\/nature01658","journal-title":"Nature"},{"issue":"10","key":"821_CR8","doi-asserted-by":"publisher","first-page":"3859","DOI":"10.7150\/thno.96516","volume":"14","author":"JY Chen","year":"2024","unstructured":"Chen JY, Hao ZW, Li HK, et al., 2024. Osteoporotic osseointegration: therapeutic hallmarks and engineering strategies. Theranostics, 14(10):3859\u20133899. https:\/\/doi.org\/10.7150\/thno.96516","journal-title":"Theranostics"},{"key":"821_CR9","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1016\/j.jconrel.2025.02.031","volume":"380","author":"LF Chen","year":"2025","unstructured":"Chen LF, Wang Y, Huang XQ, et al., 2025. Maltodextrin-driven MOF nano-antibacterial system for effective targeted bacteria and enhancing photodynamic therapy in bacterial keratitis. J Control Release, 380:1164\u20131183. https:\/\/doi.org\/10.1016\/j.jconrel.2025.02.031","journal-title":"J Control Release"},{"key":"821_CR10","doi-asserted-by":"publisher","first-page":"101628","DOI":"10.1016\/j.mtbio.2025.101628","volume":"31","author":"W Chen","year":"2025","unstructured":"Chen W, Pan YF, Chu CH, et al., 2025. Microenvironment-responsive nanoparticles functionalized titanium implants mediate redox balance and immunomodulation for enhanced osseointegration. Mater Today Bio, 31:101628. https:\/\/doi.org\/10.1016\/j.mtbio.2025.101628","journal-title":"Mater Today Bio"},{"issue":"4","key":"821_CR11","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.oooo.2024.05.014","volume":"138","author":"J Cho","year":"2024","unstructured":"Cho J, Feldman G, Tomlinson R, et al., 2024. Medication-related osteonecrosis of the jaw (MRONJ) systemic review: mevalonate pathway mechanisms explored. Oral Surg Oral Med Oral Pathol Oral Radiol, 138(4):475\u2013483. https:\/\/doi.org\/10.1016\/j.oooo.2024.05.014","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"821_CR12","doi-asserted-by":"publisher","first-page":"113165","DOI":"10.1016\/j.intimp.2024.113165","volume":"142","author":"D Das","year":"2024","unstructured":"Das D, Thacker H, Priya K, et al., 2024. Complement component 5a receptor 1 and leukotriene B4 receptor 1 regulate neutrophil extracellular trap (NET) formation through Rap1a\/B-Raf\/ERK signaling pathway and their deficiency in term low birth weight newborns leads to deficient NETosis. Int Immunopharmacol, 142:113165. https:\/\/doi.org\/10.1016\/j.intimp.2024.113165","journal-title":"Int Immunopharmacol"},{"issue":"8","key":"821_CR13","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1016\/j.tem.2020.05.005","volume":"31","author":"PGFP de Oliveira","year":"2020","unstructured":"de Oliveira PGFP, Bonfante EA, Bergamo ETP, et al., 2020. Obesity\/metabolic syndrome and diabetes mellitus on peri-implantitis. Trends Endocrinol Metab, 31(8):596\u2013610. https:\/\/doi.org\/10.1016\/j.tem.2020.05.005","journal-title":"Trends Endocrinol Metab"},{"key":"821_CR14","doi-asserted-by":"publisher","first-page":"101107","DOI":"10.1016\/j.redox.2019.101107","volume":"23","author":"M Dodson","year":"2019","unstructured":"Dodson M, Castro-Portuguez R, Zhang DD, 2019. NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis. Redox Biol, 23:101107. https:\/\/doi.org\/10.1016\/j.redox.2019.101107","journal-title":"Redox Biol"},{"issue":"13","key":"821_CR15","doi-asserted-by":"publisher","first-page":"e2312081","DOI":"10.1002\/adma.202312081","volume":"36","author":"HT Guan","year":"2024","unstructured":"Guan HT, Wang W, Jiang ZC, et al., 2024. Magnetic aggregation-induced bone-targeting nanocarrier with effects of piezo1 activation and osteogenic-angiogenic coupling for osteoporotic bone repair. Adv Mater, 36(13):e2312081. https:\/\/doi.org\/10.1002\/adma.202312081","journal-title":"Adv Mater"},{"key":"821_CR16","doi-asserted-by":"publisher","first-page":"70","DOI":"10.3390\/biomedicines12010070","volume":"12","author":"QH Guo","year":"2023","unstructured":"Guo QH, Yang SS, Ni GQ, et al., 2023. The preparation and effects of organic-inorganic antioxidative biomaterials for bone repair. Biomedicines, 12:70. https:\/\/doi.org\/10.3390\/biomedicines12010070","journal-title":"Biomedicines"},{"key":"821_CR17","doi-asserted-by":"publisher","first-page":"112005","DOI":"10.1016\/j.compositesb.2024.112005","volume":"291","author":"ZY Huang","year":"2025","unstructured":"Huang ZY, Jiang XZ, Zhang LC, et al., 2025. Multifunctional manganese-based nanogels catalyze immune energy metabolism to promote bone repair. Compos B Eng, 291:112005. https:\/\/doi.org\/10.1016\/j.compositesb.2024.112005","journal-title":"Compos B Eng"},{"issue":"4","key":"821_CR18","doi-asserted-by":"publisher","first-page":"3772","DOI":"10.3390\/ijms24043772","volume":"24","author":"T Iantomasi","year":"2023","unstructured":"Iantomasi T, Romagnoli C, Palmini G, et al., 2023. Oxidative stress and inflammation in osteoporosis: molecular mechanisms involved and the relationship with microRNAs. Int J Mol Sci, 24(4):3772. https:\/\/doi.org\/10.3390\/ijms24043772","journal-title":"Int J Mol Sci"},{"issue":"6","key":"821_CR19","doi-asserted-by":"publisher","first-page":"660","DOI":"10.3390\/antiox13060660","volume":"13","author":"F Inchingolo","year":"2024","unstructured":"Inchingolo F, Inchingolo AD, Latini G, et al., 2024. The role of curcumin in oral health and diseases: a systematic review. Antioxidants (Basel), 13(6):660. https:\/\/doi.org\/10.3390\/antiox13060660","journal-title":"Antioxidants (Basel)"},{"issue":"9","key":"821_CR20","doi-asserted-by":"publisher","first-page":"13671","DOI":"10.1021\/acsanm.2c03884","volume":"5","author":"S Jung","year":"2022","unstructured":"Jung S, Chang S, Kim NE, et al., 2022. Curcumin\/zeolitic imidazolate framework-8 nanoparticle-integrated micro-needles for pH-responsive treatment of skin disorders. ACS Appl Nano Mater, 5(9):13671\u201313679. https:\/\/doi.org\/10.1021\/acsanm.2c03884","journal-title":"ACS Appl Nano Mater"},{"key":"821_CR21","doi-asserted-by":"publisher","first-page":"14061","DOI":"10.1038\/s41598-017-14444-3","volume":"7","author":"A Kovtun","year":"2017","unstructured":"Kovtun A, Bergdolt S, H\u00e4gele Y, et al., 2017. Complement receptors C5aR1 and C5aR2 act differentially during the early immune response after bone fracture but are similarly involved in bone repair. Sci Rep, 7:14061. https:\/\/doi.org\/10.1038\/s41598-017-14444-3","journal-title":"Sci Rep"},{"issue":"1","key":"821_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/s2213-8587(20)30408-3","volume":"9","author":"The Lancet Diabetes & Endocrinology","year":"2021","unstructured":"The Lancet Diabetes & Endocrinology, 2021. Osteoporosis: overlooked in men for too long. Lancet Diabetes Endocrinol, 9(1):1. https:\/\/doi.org\/10.1016\/s2213-8587(20)30408-3","journal-title":"Lancet Diabetes Endocrinol"},{"key":"821_CR23","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1007\/s42242-022-00219-x","volume":"6","author":"SH Lee","year":"2023","unstructured":"Lee SH, Lee KG, Lee J, et al., 2023. Three-dimensional kagome structures in a PCL\/HA-based hydrogel scaffold to lead slow BMP-2 release for effective bone regeneration. Bio-Des Manuf, 6:12\u201325. https:\/\/doi.org\/10.1007\/s42242-022-00219-x","journal-title":"Bio-Des Manuf"},{"issue":"35","key":"821_CR24","doi-asserted-by":"publisher","first-page":"8543","DOI":"10.1039\/D4TB00226A","volume":"12","author":"SW Li","year":"2024","unstructured":"Li SW, Lin YH, Mo CZ, et al., 2024. Application of metal-organic framework materials in regenerative medicine. J Mater Chem B, 12(35):8543\u20138576. https:\/\/doi.org\/10.1039\/d4tb00226a","journal-title":"J Mater Chem B"},{"issue":"5","key":"821_CR25","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1016\/j.drudis.2021.03.002","volume":"26","author":"X Li","year":"2021","unstructured":"Li X, Li BE, Shi Y, et al., 2021. Targeting reactive oxygen species in stem cells for bone therapy. Drug Discov Today, 26(5):1226\u20131244. https:\/\/doi.org\/10.1016\/j.drudis.2021.03.002","journal-title":"Drug Discov Today"},{"issue":"4","key":"821_CR26","doi-asserted-by":"publisher","first-page":"497","DOI":"10.33549\/physiolres.935054","volume":"72","author":"X Li","year":"2023","unstructured":"Li X, Sung P, Zhang D, et al., 2023. Curcumin in vitro neuro-protective effects are mediated by p62\/keap-1\/Nrf2 and PI3K\/AKT signaling pathway and autophagy inhibition. Physiol Res, 72(4):497\u2013510. https:\/\/doi.org\/10.33549\/physiolres.935054","journal-title":"Physiol Res"},{"key":"821_CR27","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1038\/s41413-024-00319-7","volume":"12","author":"Y Li","year":"2024","unstructured":"Li Y, Cai ZW, Ma WJ, et al., 2024. A DNA tetrahedron-based ferroptosis-suppressing nanoparticle: superior delivery of curcumin and alleviation of diabetic osteoporosis. Bone Res, 12:14. https:\/\/doi.org\/10.1038\/s41413-024-00319-7","journal-title":"Bone Res"},{"issue":"50","key":"821_CR28","doi-asserted-by":"publisher","first-page":"e2410962","DOI":"10.1002\/adma.202410962","volume":"36","author":"PH Lin","year":"2024","unstructured":"Lin PH, Qian ZY, Liu SB, et al., 2024. A single-cell RNA sequencing guided multienzymatic hydrogel design for self-regenerative repair in diabetic mandibular defects. Adv Mater, 36(50):e2410962. https:\/\/doi.org\/10.1002\/adma.202410962","journal-title":"Adv Mater"},{"issue":"41","key":"821_CR29","doi-asserted-by":"publisher","first-page":"17543","DOI":"10.1021\/jacs.0c07309","volume":"142","author":"XF Lin","year":"2020","unstructured":"Lin XF, Wang QQ, Gu CH, et al., 2020. Smart nanosacrificial layer on the bone surface prevents osteoporosis through acid-base neutralization regulated biocascade effects. J Am Chem Soc, 142(41): 17543\u201317556. https:\/\/doi.org\/10.1021\/jacs.0c07309","journal-title":"J Am Chem Soc"},{"key":"821_CR30","doi-asserted-by":"publisher","first-page":"155767","DOI":"10.1016\/j.metabol.2023.155767","volume":"152","author":"J Liu","year":"2024","unstructured":"Liu J, Bao XG, Huang J, et al., 2024. TMEM135 maintains the equilibrium of osteogenesis and adipogenesis by regulating mitochondrial dynamics. Metabolism, 152:155767. https:\/\/doi.org\/10.1016\/j.metabol.2023.155767","journal-title":"Metabolism"},{"key":"821_CR31","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1186\/s13020-024-00961-7","volume":"19","author":"XF Liu","year":"2024","unstructured":"Liu XF, Liao YT, Shao JH, et al., 2024. Angelicin improves osteoporosis in ovariectomized rats by reducing ROS production in osteoclasts through regulation of the KAT6A\/Nrf2 signalling pathway. Chin Med, 19:91. https:\/\/doi.org\/10.1186\/s13020-024-00961-7","journal-title":"Chin Med"},{"issue":"3","key":"821_CR32","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1210\/er.2009-0024","volume":"31","author":"SC Manolagas","year":"2010","unstructured":"Manolagas SC, 2010. From estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosis. Endocr Rev, 31(3):266\u2013300. https:\/\/doi.org\/10.1210\/er.2009-0024","journal-title":"Endocr Rev"},{"issue":"17","key":"821_CR33","doi-asserted-by":"publisher","first-page":"9625","DOI":"10.3390\/ijms25179625","volume":"25","author":"M Maqsood","year":"2024","unstructured":"Maqsood M, Suntharalingham S, Khan M, et al., 2024. Complement-mediated two-step NETosis: serum-induced complement activation and calcium influx generate NADPH oxidase-dependent NETs in serum-free conditions. Int J Mol Sci, 25(17):9625. https:\/\/doi.org\/10.3390\/ijms25179625","journal-title":"Int J Mol Sci"},{"key":"821_CR34","doi-asserted-by":"publisher","first-page":"103134","DOI":"10.1016\/j.redox.2024.103134","volume":"72","author":"C Morgenstern","year":"2024","unstructured":"Morgenstern C, Lastres-Becker I, Demird\u00f6\u011fen BC, et al., 2024. Biomarkers of NRF2 signalling: current status and future challenges. Redox Biol, 72:103134. https:\/\/doi.org\/10.1016\/j.redox.2024.103134","journal-title":"Redox Biol"},{"issue":"10","key":"821_CR35","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1038\/s41423-022-00902-0","volume":"19","author":"G Morris","year":"2022","unstructured":"Morris G, Gevezova M, Sarafian V, et al., 2022. Redox regulation of the immune response. Cell Mol Immunol, 19(10): 1079\u20131101. https:\/\/doi.org\/10.1038\/s41423-022-00902-0","journal-title":"Cell Mol Immunol"},{"key":"821_CR36","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.materresbull.2017.05.043","volume":"94","author":"G Nagaraju","year":"2017","unstructured":"Nagaraju G, Udayabhanu, Shivaraj, et al., 2017. Electrochemical heavy metal detection, photocatalytic, photoluminescence, biodiesel production and antibacterial activities of Ag\u2013ZnO nanomaterial. Mater Res Bull, 94:54\u201363. https:\/\/doi.org\/10.1016\/j.materresbull.2017.05.043","journal-title":"Mater Res Bull"},{"key":"821_CR37","doi-asserted-by":"publisher","first-page":"103288","DOI":"10.1016\/j.vibspec.2021.103288","volume":"116","author":"KDC Perera","year":"2021","unstructured":"Perera KDC, Weragoda GK, Haputhanthri R, et al., 2021. Study of concentration dependent curcumin interaction with serum biomolecules using ATR-FTIR spectroscopy combined with principal component analysis (PCA) and partial least square regression (PLS-R). Vib Spectrosc, 116:103288. https:\/\/doi.org\/10.1016\/j.vibspec.2021.103288","journal-title":"Vib Spectrosc"},{"issue":"11","key":"821_CR38","doi-asserted-by":"publisher","first-page":"15595","DOI":"10.18632\/aging.203124","volume":"13","author":"X Qiu","year":"2021","unstructured":"Qiu X, Liu Y, Shen H, et al., 2021. Single-cell RNA sequencing of human femoral head in vivo. Aging (Albany NY), 13(11):15595\u201315619. https:\/\/doi.org\/10.18632\/aging.203124","journal-title":"Aging (Albany NY)"},{"key":"821_CR39","doi-asserted-by":"publisher","first-page":"100835","DOI":"10.1016\/j.mtbio.2023.100835","volume":"23","author":"N Sheng","year":"2023","unstructured":"Sheng N, Xing F, Wang J, et al., 2023. Recent progress in bone-repair strategies in diabetic conditions. Mater Today Bio, 23:100835. https:\/\/doi.org\/10.1016\/j.mtbio.2023.100835","journal-title":"Mater Today Bio"},{"key":"821_CR40","doi-asserted-by":"publisher","first-page":"113820","DOI":"10.1016\/j.bcp.2020.113820","volume":"173","author":"JW Shin","year":"2020","unstructured":"Shin JW, Chun KS, Kim DH, et al., 2020. Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification. Biochem Pharmacol, 173:113820. https:\/\/doi.org\/10.1016\/j.bcp.2020.113820","journal-title":"Biochem Pharmacol"},{"key":"821_CR41","doi-asserted-by":"publisher","first-page":"121604","DOI":"10.1016\/j.biomaterials.2022.121604","volume":"286","author":"N Su","year":"2022","unstructured":"Su N, Villicana C, Yang F, 2022. Immunomodulatory strategies for bone regeneration: a review from the perspective of disease types. Biomaterials, 286:121604. https:\/\/doi.org\/10.1016\/j.biomaterials.2022.121604","journal-title":"Biomaterials"},{"key":"821_CR42","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1007\/s42242-021-00172-1","volume":"5","author":"X Sun","year":"2022","unstructured":"Sun X, Zhang X, Jiao X, et al., 2022. Injectable bioactive polymethyl methacrylate\u2013hydrogel hybrid bone cement loaded with BMP-2 to improve osteogenesis for percutaneous vertebroplasty and kyphoplasty. Bio-Des Manuf, 5: 318\u2013332. https:\/\/doi.org\/10.1007\/s42242-021-00172-1","journal-title":"Bio-Des Manuf"},{"key":"821_CR43","doi-asserted-by":"publisher","first-page":"119125","DOI":"10.1016\/j.lfs.2021.119125","volume":"270","author":"LP Tan","year":"2021","unstructured":"Tan LP, Cao ZY, Chen H, et al., 2021. Curcumin reduces apoptosis and promotes osteogenesis of human periodontal ligament stem cells under oxidative stress in vitro and in vivo. Life Sci, 270:119125. https:\/\/doi.org\/10.1016\/j.lfs.2021.119125","journal-title":"Life Sci"},{"issue":"25","key":"821_CR44","doi-asserted-by":"publisher","first-page":"2412065","DOI":"10.1002\/smll.202412065","volume":"21","author":"H Tang","year":"2025","unstructured":"Tang H, Yu YM, Zhan XX, et al., 2025. Zinc-cobalt bimetallic organic frameworks with antioxidative and osteogenic activities for periodontitis treatment. Small, 21(25):2412065. https:\/\/doi.org\/10.1002\/smll.202412065","journal-title":"Small"},{"issue":"Pt1","key":"821_CR45","doi-asserted-by":"publisher","first-page":"132542","DOI":"10.1016\/j.ijbiomac.2024.132542","volume":"271","author":"M Teimouri","year":"2024","unstructured":"Teimouri M, Mirzaee M, Nemati A, et al., 2024. Polysilses-quioxane decorated ZIF-8 as a potential pH-responsive vehicle for topical delivery and release of acyclovir and tetracycline: investigation of blood compatibility, cytotoxicity and antibacterial properties. Int J Biol Macromol, 271(Pt 1): 132542. https:\/\/doi.org\/10.1016\/j.ijbiomac.2024.132542","journal-title":"Int J Biol Macromol"},{"issue":"3","key":"821_CR46","doi-asserted-by":"publisher","first-page":"177","DOI":"10.3390\/md21030177","volume":"21","author":"SL Tomi\u0107","year":"2023","unstructured":"Tomi\u0107 SL, Babi\u0107 Radi\u0107 MM, Vukovi\u0107 JS, et al., 2023. Alginate-based hydrogels and scaffolds for biomedical applications. Mar Drugs, 21(3):177. https:\/\/doi.org\/10.3390\/md21030177","journal-title":"Mar Drugs"},{"key":"821_CR47","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1038\/s41577-019-0178-8","volume":"19","author":"M Tsukasaki","year":"2019","unstructured":"Tsukasaki M, Takayanagi H, 2019. Osteoimmunology: evolving concepts in bone-immune interactions in health and disease. Nat Rev Immunol, 19:626\u2013642. https:\/\/doi.org\/10.1038\/s41577-019-0178-8","journal-title":"Nat Rev Immunol"},{"issue":"4","key":"821_CR48","doi-asserted-by":"publisher","first-page":"109608","DOI":"10.1016\/j.isci.2024.109608","volume":"27","author":"JJ Wang","year":"2024","unstructured":"Wang JJ, Xie XY, Li H, et al., 2024. Vascular endothelial cells-derived exosomes synergize with curcumin to prevent osteoporosis development. iScience, 27(4):109608. https:\/\/doi.org\/10.1016\/j.isci.2024.109608","journal-title":"iScience"},{"key":"821_CR49","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.bbrc.2023.06.080","volume":"674","author":"LF Wang","year":"2023","unstructured":"Wang LF, Liang YJ, Zhou XH, et al., 2023. Nrf2 differentially regulates osteoclast and osteoblast differentiation for bone homeostasis. Biochem Biophys Res Commun, 674:19\u201326. https:\/\/doi.org\/10.1016\/j.bbrc.2023.06.080","journal-title":"Biochem Biophys Res Commun"},{"key":"821_CR50","doi-asserted-by":"publisher","first-page":"101501","DOI":"10.1016\/j.mtbio.2025.101501","volume":"31","author":"Y Wang","year":"2025","unstructured":"Wang Y, Sun L, Dong ZL, et al., 2025. Targeted inhibition of ferroptosis in bone marrow mesenchymal stem cells by engineered exosomes alleviates bone loss in smoking-related osteoporosis. Mater Today Bio, 31:101501. https:\/\/doi.org\/10.1016\/j.mtbio.2025.101501","journal-title":"Mater Today Bio"},{"key":"821_CR51","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1007\/s42242-024-00287-1","volume":"7","author":"Z Wang","year":"2024","unstructured":"Wang Z, Wang X, Huang Y, et al., 2024. Cav3.3-mediated endochondral ossification in a three-dimensional bioprinted GelMA hydrogel. Bio-Des Manuf, 7:983\u2013999. https:\/\/doi.org\/10.1007\/s42242-024-00287-1","journal-title":"Bio-Des Manuf"},{"issue":"6","key":"821_CR52","doi-asserted-by":"publisher","first-page":"1518","DOI":"10.1016\/j.ymthe.2020.04.003","volume":"28","author":"WB Wu","year":"2020","unstructured":"Wu WB, Xiao ZX, Chen Y, et al., 2020. CD39 produced from human GMSCs regulates the balance of osteoclasts and osteoblasts through the Wnt\/\u03b2-catenin pathway in osteoporosis. Mol Ther, 28(6):1518\u20131532. https:\/\/doi.org\/10.1016\/j.ymthe.2020.04.003","journal-title":"Mol Ther"},{"key":"821_CR53","doi-asserted-by":"publisher","first-page":"3847","DOI":"10.2147\/IJN.S451042","volume":"19","author":"XJ Yan","year":"2024","unstructured":"Yan XJ, Zhao XY, Fan MD, et al., 2024. Acidic environment-responsive metal organic framework-mediated dihydroartemisinin delivery for triggering production of reactive oxygen species in drug-resistant lung cancer. Int J Nanomedicine, 19:3847\u20133859. https:\/\/doi.org\/10.2147\/ijn.S451042","journal-title":"Int J Nanomedicine"},{"key":"821_CR54","doi-asserted-by":"publisher","first-page":"100688","DOI":"10.1016\/j.mtbio.2023.100688","volume":"20","author":"XM Yang","year":"2023","unstructured":"Yang XM, Yang XW, Luo P, et al., 2023. Novel one-pot strategy for fabrication of a pH-responsive bone-targeted drug self-frame delivery system for treatment of osteoporosis. Mater Today Bio, 20:100688. https:\/\/doi.org\/10.1016\/j.mtbio.2023.100688","journal-title":"Mater Today Bio"},{"issue":"18","key":"821_CR55","doi-asserted-by":"publisher","first-page":"2206533","DOI":"10.1002\/advs.202206533","volume":"10","author":"Z Yang","year":"2023","unstructured":"Yang Z, Zhang XW, Zhuo FF, et al., 2023. Allosteric activation of transglutaminase 2 via inducing an \u201copen\u201d conformation for osteoblast differentiation. Adv Sci (Weinh), 10(18):2206533. https:\/\/doi.org\/10.1002\/advs.202206533","journal-title":"Adv Sci (Weinh)"},{"issue":"8","key":"821_CR56","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1016\/j.molmed.2016.06.002","volume":"22","author":"B Yu","year":"2016","unstructured":"Yu B, Wang CY, 2016. Osteoporosis: the result of an \u2018aged\u2019 bone microenvironment. Trends Mol Med, 22(8):641\u2013644. https:\/\/doi.org\/10.1016\/j.molmed.2016.06.002","journal-title":"Trends Mol Med"},{"issue":"Pt1","key":"821_CR57","doi-asserted-by":"publisher","first-page":"131594","DOI":"10.1016\/j.ijbiomac.2024.131594","volume":"268","author":"FS Zhang","year":"2024","unstructured":"Zhang FS, Wu XT, Li QC, et al., 2024. Dual growth factor methacrylic alginate microgels combined with chitosan-based conduits facilitate peripheral nerve repair. Int J Biol Macromol, 268(Pt 1):131594. https:\/\/doi.org\/10.1016\/j.ijbiomac.2024.131594","journal-title":"Int J Biol Macromol"},{"issue":"6","key":"821_CR58","doi-asserted-by":"publisher","first-page":"1890","DOI":"10.1111\/jpn.14029","volume":"108","author":"JY Zhang","year":"2024","unstructured":"Zhang JY, Zhang RS, Jin SJ, et al., 2024. Curcumin, a plant polyphenol with multiple physiological functions of improving antioxidation, anti-inflammation, immunomodulation and its application in poultry production. J Anim Physiol Anim Nutr (Berl), 108(6):1890\u20131905. https:\/\/doi.org\/10.1111\/jpn.14029","journal-title":"J Anim Physiol Anim Nutr (Berl)"},{"key":"821_CR59","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/j.bioactmat.2022.04.017","volume":"19","author":"W Zhang","year":"2023","unstructured":"Zhang W, Zhou XZ, Hou WD, et al., 2023. Reversing the imbalance in bone homeostasis via sustained release of SIRT-1 agonist to promote bone healing under osteoporotic condition. Bioact Mater, 19:429\u2013443. https:\/\/doi.org\/10.1016\/j.bioactmat.2022.04.017","journal-title":"Bioact Mater"},{"issue":"6","key":"821_CR60","doi-asserted-by":"publisher","first-page":"108889","DOI":"10.1016\/j.cclet.2023.108889","volume":"35","author":"X Zhang","year":"2024","unstructured":"Zhang X, Chen JY, Pei X, et al., 2024. Drug-loading ZIF-8 for modification of microporous bone scaffold to promote vascularized bone regeneration. Chin Chem Lett, 35(6):108889. https:\/\/doi.org\/10.1016\/j.cclet.2023.108889","journal-title":"Chin Chem Lett"},{"key":"821_CR61","doi-asserted-by":"publisher","first-page":"100717","DOI":"10.1016\/j.mtbio.2023.100717","volume":"21","author":"CQ Zhao","year":"2023","unstructured":"Zhao CQ, Shu CQ, Yu JM, et al., 2023. Metal-organic frameworks functionalized biomaterials for promoting bone repair. Mater Today Bio, 21:100717. https:\/\/doi.org\/10.1016\/j.mtbio.2023.100717","journal-title":"Mater Today Bio"},{"issue":"7","key":"821_CR62","doi-asserted-by":"publisher","first-page":"e13367","DOI":"10.1111\/acel.13367","volume":"20","author":"DB Zou","year":"2021","unstructured":"Zou DB, Mou ZY, Wu WL, et al., 2021. TRIM33 protects osteoblasts from oxidative stress-induced apoptosis in osteoporosis by inhibiting FOXO3a ubiquitylation and degradation. Aging Cell, 20(7):e13367. https:\/\/doi.org\/10.1111\/acel.13367","journal-title":"Aging Cell"}],"container-title":["Journal of Zhejiang University-SCIENCE B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1631\/jzus.B2500254.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1631\/jzus.B2500254","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1631\/jzus.B2500254.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T21:02:45Z","timestamp":1768338165000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1631\/jzus.B2500254"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":62,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["821"],"URL":"https:\/\/doi.org\/10.1631\/jzus.b2500254","relation":{},"ISSN":["1673-1581","1862-1783"],"issn-type":[{"value":"1673-1581","type":"print"},{"value":"1862-1783","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"14 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Wei HU, Tianyi FEI, Zhichao LIU, Yude DING, Mengfei YU, Fan YANG, and Feiya ZHAO declare that they have no conflicts of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethics guidelines"}},{"value":"All institutional and national guidelines for the care and use of laboratory animals were followed. The study was approved by the Ethics Committee of Zhejiang Provincial People\u2019s Hospital (No. 20230526174010377463).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethics guidelines"}}]}}