{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:28:34Z","timestamp":1791275314303,"version":"4.1.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2006,4,1]],"date-time":"2006-04-01T00:00:00Z","timestamp":1143849600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Mesenchymal stem cells (MSCs) have been shown to migrate to various tissues. There is little information on the fate and potential therapeutic efficacy of the reinfusion of MSCs following total body irradiation (TBI). We addressed this question using human MSC (hMSCs) infused to nonobese diabetic\/ severe combined immunodeficient (NOD\/SCID) mice submitted to TBI. Further, we tested the impact of additional local irradiation (ALI) superimposed to TBI, as a model of accidental irradiation. NOD\/SCID mice were transplanted with hM-SCs. Group 1 was not irradiated before receiving hMSC infusion. Group 2 received only TBI at a dose of 3.5 Gy, group 3 received local irradiation to the abdomen at a dose of 4.5 Gy in addition to TBI, and group 4 received local irradiation to the leg at 26.5 Gy in addition to TBI. Fifteen days after irradiation, quantitative and spatial distribution of the hMSCs were studied. Histological analysis of mouse tissues confirmed the presence of radio-induced lesions in the irradiated fields. Following their infusion into nonirradiated animals, hMSCs homed at a very low level to various tissues (lung, bone marrow, and muscles) and no significant engraftment was found in other organs. TBI induced an increase of engraftment levels of hMSCs in the brain, heart, bone marrow, and muscles. Abdominal irradiation (AI) as compared with leg irradiation (LI) increased hMSC engraftment in the exposed area (the gut, liver, and spleen). Hind LI as compared with AI increased hMSC engraftment in the exposed area (skin, quadriceps, and muscles). An increase of hMSC engraftment in organs outside the fields of the ALI was also observed. Conversely, following LI, hMSC engraftment was increased in the brain as compared with AI. This study shows that engraftment of hMSCs in NOD\/ SCID mice with significantly increased in response to tissue injuries following TBI with or without ALI. ALI induced an increase of the level of engraftment at sites outside the local irradiation field, thus suggesting a distant (abscopal) effect of radiation damage. This work supports the use of MSCs to repair damaged normal tissues following accidental irradiation and possibly in patients submitted to radiotherapy.<\/jats:p>","DOI":"10.1634\/stemcells.2005-0260","type":"journal-article","created":{"date-parts":[[2005,12,8]],"date-time":"2005-12-08T21:09:36Z","timestamp":1134076176000},"page":"1020-1029","source":"Crossref","is-referenced-by-count":337,"title":["Local Irradiation Not Only Induces Homing of Human Mesenchymal Stem Cells at Exposed Sites but Promotes Their Widespread Engraftment to Multiple Organs: A Study of Their Quantitative Distribution After Irradiation Damage"],"prefix":"10.1093","volume":"24","author":[{"given":"Sabine","family":"Fran\u00e7ois","sequence":"first","affiliation":[{"name":"Laboratoire de Th\u00e9rapie Cellulaire et Radioprotection Accidentelle, Institut de Radioprotection et de S\u00fbret\u00e9 Nucl\u00e9aire, Fontenay aux Roses CEDEX, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morad","family":"Bensidhoum","sequence":"additional","affiliation":[{"name":"EA 1638, Laboratoire de Th\u00e9rapie Cellulaire et Radioprotection Accidentelle, Facult\u00e9 de M\u00e9decine Saint Antoine, Universit\u00e9 Paris VI Pierre et Marie Curie, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moubarak","family":"Mouiseddine","sequence":"additional","affiliation":[{"name":"Laboratoire de Th\u00e9rapie Cellulaire et Radioprotection Accidentelle, Institut de Radioprotection et de S\u00fbret\u00e9 Nucl\u00e9aire, Fontenay aux Roses CEDEX, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christelle","family":"Mazurier","sequence":"additional","affiliation":[{"name":"EA 1638, Laboratoire de Th\u00e9rapie Cellulaire et Radioprotection Accidentelle, Facult\u00e9 de M\u00e9decine Saint Antoine, Universit\u00e9 Paris VI Pierre et Marie Curie, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9n\u00e9dicte","family":"Allenet","sequence":"additional","affiliation":[{"name":"Laboratoire de Th\u00e9rapie Cellulaire et Radioprotection Accidentelle, Institut de Radioprotection et de S\u00fbret\u00e9 Nucl\u00e9aire, Fontenay aux Roses CEDEX, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Semont","sequence":"additional","affiliation":[{"name":"Laboratoire de Th\u00e9rapie Cellulaire et Radioprotection Accidentelle, Institut de Radioprotection et de S\u00fbret\u00e9 Nucl\u00e9aire, Fontenay aux Roses CEDEX, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Frick","sequence":"additional","affiliation":[{"name":"Laboratoire de Th\u00e9rapie Cellulaire et Radioprotection Accidentelle, Institut de Radioprotection et de S\u00fbret\u00e9 Nucl\u00e9aire, Fontenay aux Roses CEDEX, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amandine","family":"Sach\u00e9","sequence":"additional","affiliation":[{"name":"Laboratoire de Th\u00e9rapie Cellulaire et Radioprotection Accidentelle, Institut de Radioprotection et de S\u00fbret\u00e9 Nucl\u00e9aire, Fontenay aux Roses CEDEX, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Bouchet","sequence":"additional","affiliation":[{"name":"EA 1638, Laboratoire de Th\u00e9rapie Cellulaire et Radioprotection Accidentelle, Facult\u00e9 de M\u00e9decine Saint Antoine, Universit\u00e9 Paris VI Pierre et Marie Curie, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Thierry","sequence":"additional","affiliation":[{"name":"Laboratoire de Th\u00e9rapie Cellulaire et Radioprotection Accidentelle, Institut de Radioprotection et de S\u00fbret\u00e9 Nucl\u00e9aire, Fontenay aux Roses CEDEX, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Gourmelon","sequence":"additional","affiliation":[{"name":"Laboratoire de Th\u00e9rapie Cellulaire et Radioprotection Accidentelle, Institut de Radioprotection et de S\u00fbret\u00e9 Nucl\u00e9aire, Fontenay aux Roses CEDEX, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert-Claude","family":"Gorin","sequence":"additional","affiliation":[{"name":"EA 1638, Laboratoire de Th\u00e9rapie Cellulaire et Radioprotection Accidentelle, Facult\u00e9 de M\u00e9decine Saint Antoine, Universit\u00e9 Paris VI Pierre et Marie Curie, Paris, France"},{"name":"Service d'H\u00e9matologie et de Th\u00e9rapie cellulaire, H\u00f4pital Saint Antoine, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Chapel","sequence":"additional","affiliation":[{"name":"Laboratoire de Th\u00e9rapie Cellulaire et Radioprotection Accidentelle, Institut de Radioprotection et de S\u00fbret\u00e9 Nucl\u00e9aire, Fontenay aux Roses CEDEX, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,1,2]]},"reference":[{"key":"2021122214280134800_bib1","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/S0301-472X(00)00482-3","article-title":"Mesenchymal stem cells: Biology and potential clinical uses","volume":"28","author":"Deans","year":"2000","journal-title":"Exp Hematol"},{"key":"2021122214280134800_bib2","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1126\/science.284.5411.143","article-title":"Multilineage potential of adult human mesenchymal stem cells","volume":"284","author":"Pittenger","year":"1999","journal-title":"Science"},{"key":"2021122214280134800_bib3","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jamcollsurg.2004.05.059","article-title":"Chemokine induced migration of human mesenchymal stem cells: A strategy for directing cardiac repair","volume":"199","author":"Bolno","year":"2004","journal-title":"J Am Coll Surg"},{"key":"2021122214280134800_bib4","doi-asserted-by":"crossref","first-page":"555","DOI":"10.3727\/000000003108747154","article-title":"Human cord blood-derived mesenchymal stem cells home and survive in the marrow of immunodeficient mice after systemic infusion","volume":"12","author":"Erices","year":"2003","journal-title":"Cell Transplant"},{"key":"2021122214280134800_bib5","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.bcmd.2003.09.018","article-title":"A large animal noninjury model for study of human stem cell plasticity","volume":"32","author":"Almeida-Porada","year":"2004","journal-title":"Blood Cells Mol Dis"},{"key":"2021122214280134800_bib6","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1097\/01.TP.0000128334.93343.B3","article-title":"Dynamic of distribution of human bone marrow-derived mesenchymal stem cells after transplantation into adult unconditioned mice","volume":"78","author":"Allers","year":"2004","journal-title":"Transplantation"},{"key":"2021122214280134800_bib7","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.1182\/blood-2003-04-1121","article-title":"Homing of in vitro expanded Stro-1\u2212 or Stro-1+ human mesenchymal stem cells into the NOD\/SCID mouse and their role in supporting human CD34 cell engraftment","volume":"103","author":"Bensidhoum","year":"2004","journal-title":"Blood"},{"key":"2021122214280134800_bib8","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.1182\/blood-2002-06-1830","article-title":"Mesenchymal stem cells distribute to a wide range of tissues after systemic infusion into nonhuman primates","volume":"101","author":"Devine","year":"2003","journal-title":"Blood"},{"key":"2021122214280134800_bib9","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/6529","article-title":"Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta","volume":"5","author":"Horwitz","year":"1999","journal-title":"Nat Med"},{"key":"2021122214280134800_bib10","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1089\/10430349950016870","article-title":"Multipotential marrow stromal cells transduced to produce L-DOPA: Engraftment in a rat model of Parkinson disease","volume":"10","author":"Schwarz","year":"1999","journal-title":"Hum Gene Ther"},{"key":"2021122214280134800_bib11","doi-asserted-by":"crossref","first-page":"3001","DOI":"10.1097\/00001756-200009110-00035","article-title":"Spinal cord injury in rat: Treatment with bone marrow stromal cell transplantation","volume":"11","author":"Chopp","year":"2000","journal-title":"Neuroreport"},{"key":"2021122214280134800_bib12","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1212\/WNL.59.4.514","article-title":"Human marrow stromal cell therapy for stroke in rat: Neurotrophins and functional recovery","volume":"59","author":"Li","year":"2002","journal-title":"Neurology"},{"key":"2021122214280134800_bib13","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1172\/JCI14862","article-title":"Intracerebral transplantation of mesenchymal stem cells into acid sphingomyelinase-deficient mice delays the onset of neurological abnormalities and extends their life span","volume":"109","author":"Jin","year":"2002","journal-title":"J Clin Invest"},{"key":"2021122214280134800_bib14","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0002-9440(10)64212-5","article-title":"Kinetics of liver repopulation after bone marrow transplantation","volume":"161","author":"Wang","year":"2002","journal-title":"Am J Pathol"},{"key":"2021122214280134800_bib15","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1182\/blood-2005-02-0572","article-title":"Human mesenchymal stem cells xenografted directly to rat liver are differentiated into human hepatocytes without fusion","volume":"106","author":"Sato","year":"2005","journal-title":"Blood"},{"key":"2021122214280134800_bib16","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nature00870","article-title":"Pluripotency of mesenchymal stem cells derived from adult marrow","volume":"418","author":"Jiang","year":"2002","journal-title":"Nature"},{"key":"2021122214280134800_bib17","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.biocel.2003.11.001","article-title":"Mesenchymal stem cells: Clinical applications and biological characterization","volume":"36","author":"Barry","year":"2004","journal-title":"Int J Biochem Cell Biol"},{"key":"2021122214280134800_bib18","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1126\/science.279.5356.1528","article-title":"Muscle regeneration by bone marrow-derived myogenic progenitors","volume":"279","author":"Ferrari","year":"1998","journal-title":"Science"},{"key":"2021122214280134800_bib19","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1161\/hc0102.101442","article-title":"Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart","volume":"105","author":"Toma","year":"2002","journal-title":"Circulation"},{"key":"2021122214280134800_bib20","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1161\/01.RES.0000135902.99383.6f","article-title":"Mesenchymal stem cells and their potential as cardiac therapeutics","volume":"95","author":"Pittenger","year":"2004","journal-title":"Circ Res"},{"key":"2021122214280134800_bib21","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.ymthe.2004.09.020","article-title":"Mesenchymal stem cells that produce neurotrophic factors reduce ischemic damage in the rat middle cerebral artery occlusion model","volume":"11","author":"Kurozumi","year":"2005","journal-title":"Mol Ther"},{"key":"2021122214280134800_bib22","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1161\/01.CIR.0000151812.86142.45","article-title":"Mesenchymal stem cells differentiate into an endothelial phenotype, enhance vascular density, and improve heart function in a canine chronic ischemia model","volume":"111","author":"Silva","year":"2005","journal-title":"Circulation"},{"key":"2021122214280134800_bib23","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.exphem.2004.02.010","article-title":"Studies of the route of administration and role of conditioning with radiation on unrelated allogeneic mismatched mesenchymal stem cell engraftment in a nonhuman primate model","volume":"32","author":"Mahmud","year":"2004","journal-title":"Exp Hematol"},{"key":"2021122214280134800_bib24","doi-asserted-by":"crossref","first-page":"3300","DOI":"10.1161\/01.CIR.0000147780.30124.CF","article-title":"Stromal cell-derived factor-1alpha plays a critical role in stem cell recruitment to the heart after myocardial infarction but is not sufficient to induce homing in the absence of injury","volume":"110","author":"Abbott","year":"2004","journal-title":"Circulation"},{"key":"2021122214280134800_bib25","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1634\/stemcells.22-3-405","article-title":"Functional expression of HGF and HGF receptor\/c-met in adult human mesenchymal stem cells suggests a role in cell mobilization, tissue repair, and wound healing","volume":"22","author":"Neuss","year":"2004","journal-title":"Stem Cells"},{"key":"2021122214280134800_bib26","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/S0301-472X(02)00883-4","article-title":"Current understanding of stem cell mobilization: The roles of chemokines, proteolytic enzymes, adhesion molecules, cytokines, and stromal cells","volume":"30","author":"Lapidot","year":"2002","journal-title":"Exp Hematol"},{"key":"2021122214280134800_bib27","doi-asserted-by":"crossref","first-page":"3722","DOI":"10.1182\/blood-2002-07-2104","article-title":"Bone marrow mesenchymal stem cells inhibit the response of na\u00efve antigen specific T-cells to their cognate peptide","volume":"101","author":"Krampera","year":"2003","journal-title":"Blood"},{"key":"2021122214280134800_bib28","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/j.jtcvs.2003.07.037","article-title":"Xenoreactivity and engraftment of human mesenchymal stem cells transplanted into infarcted rat myocardium","volume":"127","author":"Grinnemo","year":"2004","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2021122214280134800_bib29","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1101\/gr.6.10.986","article-title":"Real time quantitative PCR","volume":"6","author":"Heid","year":"1996","journal-title":"Genome Res"},{"key":"2021122214280134800_bib30","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1159\/000080341","article-title":"Characterization and expression analysis of mesenchymal stem cells from human bone marrow and adipose tissue","volume":"14","author":"Lee","year":"2004","journal-title":"Cell Physiol Biochem"},{"key":"2021122214280134800_bib31","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1161\/01.CIR.0000124062.31102.57","article-title":"Local delivery of marrow-derived stromal cells augments collateral perfusion through paracrine mechanisms","volume":"109","author":"Kinnaird","year":"2004","journal-title":"Circulation"},{"key":"2021122214280134800_bib32","doi-asserted-by":"crossref","first-page":"1919\u20131925; discussion 1926","DOI":"10.1016\/S0003-4975(02)03517-8","article-title":"Mesenchymal stem cell implantation in a swine myocardial infarct model: Engraftment and functional effects","volume":"73","author":"Shake","year":"2002","journal-title":"Ann Thorac Surg"},{"key":"2021122214280134800_bib33","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.regpep.2003.09.005","article-title":"Autologous mesenchymal stem cell transplantation induce VEGF and neovascularization in ischemic myocardium","volume":"117","author":"Tang","year":"2004","journal-title":"Regul Pept"},{"key":"2021122214280134800_bib34","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1159\/000047856","article-title":"The dynamic in vivo distribution of bone marrow-derived mesenchymal stem cells after infusion","volume":"169","author":"Gao","year":"2001","journal-title":"Cells Tissues Organs"},{"key":"2021122214280134800_bib35","doi-asserted-by":"crossref","first-page":"8407","DOI":"10.1073\/pnas.1432929100","article-title":"Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects","volume":"100","author":"Ortiz","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2021122214280134800_bib36","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.yexcr.2004.07.017","article-title":"Signals from damaged but not undamaged skeletal muscle induce myogenic differentiation of rat bone-marrow-derived mesenchymal stem cells","volume":"300","author":"Santa Maria","year":"2004","journal-title":"Exp Cell Res"},{"key":"2021122214280134800_bib37","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1016\/S0003-4975(02)03952-8","article-title":"Significant improvement of heart function by cotransplantation of human mesenchymal stem cells and fetal cardiomyocytes in postinfarcted pigs","volume":"74","author":"Min","year":"2002","journal-title":"Ann Thorac Surg"},{"key":"2021122214280134800_bib38","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S1010-7940(03)00325-7","article-title":"Mobilization and homing of bone marrow stromal cells in myocardial infarction","volume":"24","author":"Bittira","year":"2003","journal-title":"Eur J Cardiothorac Surg"},{"key":"2021122214280134800_bib39","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0301-472X(02)00869-X","article-title":"Multipotent progenitor cells can be isolated from postnatal murine bone marrow, muscle, and brain","volume":"30","author":"Jiang","year":"2002","journal-title":"Exp Hematol"},{"key":"2021122214280134800_bib40","doi-asserted-by":"crossref","first-page":"405","DOI":"10.3727\/000000004783983765","article-title":"Transplanted mesenchymal stem cells are effective for skin regeneration in acute cutaneous wounds","volume":"13","author":"Satoh","year":"2004","journal-title":"Cell Transplant"},{"key":"2021122214280134800_bib41","first-page":"1035","article-title":"Mesenchymal stem cells contribute to the renal repair of acute tubular epithelial injury","volume":"14","author":"Herrera","year":"2004","journal-title":"Int J Mol Med"},{"key":"2021122214280134800_bib42","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1667\/RR3164","article-title":"Combinations of cytokines promote survival of mice and limit acute radiation damage in concert with amelioration of vascular damage","volume":"161","author":"Van der Meeren","year":"2004","journal-title":"Radiat Res"},{"key":"2021122214280134800_bib43","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1056\/NEJM200107123450203","article-title":"Neointimal and tubulointerstitial infiltration by recipient mesenchymal cells in chronic renal-allograft rejection","volume":"345","author":"Grimm","year":"2001","journal-title":"N Engl J Med"},{"key":"2021122214280134800_bib44","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1002\/jgm.452","article-title":"Mesenchymal stem cells home to injured tissues when co-infused with haematopoetic cells to treat a radiation-induced multi-organ failure syndrome","volume":"5","author":"Chapel","year":"2003","journal-title":"J Gene Med"}],"container-title":["Stem Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1634%2Fstemcells.2005-0260","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1634\/stemcells.2005-0260","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1634\/stemcells.2005-0260","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/stmcls\/article-pdf\/24\/4\/1020\/41879596\/stmcls_24_4_1020.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/stmcls\/article-pdf\/24\/4\/1020\/41879596\/stmcls_24_4_1020.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T21:50:18Z","timestamp":1642542618000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/stmcls\/article\/24\/4\/1020-1029\/6400573"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4,1]]},"references-count":44,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2009,1,2]]},"published-print":{"date-parts":[[2006,4,1]]}},"URL":"https:\/\/doi.org\/10.1634\/stemcells.2005-0260","relation":{},"ISSN":["1066-5099","1549-4918"],"issn-type":[{"value":"1066-5099","type":"print"},{"value":"1549-4918","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2006,4,1]]},"published":{"date-parts":[[2006,4,1]]}}}