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In contrast, we show herein that striatal neuroblasts are generated without decline at least for 4 months after stroke in adult rats. Neuroblasts formed early or late after stroke either differentiate into mature neurons, which survive for several months, or die through caspase-mediated apoptosis. The directed migration of the new neurons toward the ischemic damage is regulated by stromal cell-derived factor-1\u03b1 and its receptor CXCR4. These results show that endogenous neural stem cells continuously supply the injured adult brain with new neurons, which suggests novel self-repair strategies to improve recovery after stroke.<\/jats:p>","DOI":"10.1634\/stemcells.2005-0281","type":"journal-article","created":{"date-parts":[[2005,10,6]],"date-time":"2005-10-06T20:33:30Z","timestamp":1128630810000},"page":"739-747","source":"Crossref","is-referenced-by-count":600,"title":["Persistent Production of Neurons from Adult Brain Stem Cells During Recovery after Stroke"],"prefix":"10.1093","volume":"24","author":[{"given":"P\u00e4r","family":"Thored","sequence":"first","affiliation":[{"name":"Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund, Sweden"},{"name":"Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, Lund, 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