{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T07:36:54Z","timestamp":1783496214530,"version":"3.55.0"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2006,1,26]],"date-time":"2006-01-26T00:00:00Z","timestamp":1138233600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We hypothesized that angiogenesis can be triggered by autologous whole bone marrow stem cell transplantation. Twenty-seven patients (34 lower limbs) with Buerger's disease, who were not candidates for surgical revascularization or radiologic intervention, were enrolled in this study. Six sites of the tibia bone were fenestrated using a 2.5-mm-diameter screw under fluoroscopic guidance. Clinical status and outcome were determined using the \u201cRecommended Standards for Reports.\u201d To mobilize endothelial progenitor cells (EPCs) from bone marrow, recombinant human granulocyte colony-stimulating factor (r-HuG-CSF) was injected subcutaneously as a dose of 75 \u03bcg, preoperatively. During the follow-up period (19.1 \u00b1 3.5 months), one limb showed a markedly improved outcome (+3), and 26 limbs showed a moderately improved outcome (+2). Thirteen limbs among 17 limbs with nonhealing ulcers healed. Postoperative angiograms were obtained for 22 limbs. Two limbs showed marked (+3), five limbs moderate (+2), and nine limbs slight (+1) collateral development. However, six limbs showed no collateral development (0). Peripheral blood and bone marrow samples were analyzed for CD34 and CD133 molecules to enumerate potential EPCs, and EPC numbers were found to be increased in peripheral blood and in bone marrow after r-HuG-CSF injection. In conclusion, the transplantation of autologous whole BMCs by fenestration of the tibia bone represents a simple, safe, and effective means of inducing therapeutic angiogenesis in patients with Buerger's disease.<\/jats:p>","DOI":"10.1634\/stemcells.2005-0349","type":"journal-article","created":{"date-parts":[[2006,1,27]],"date-time":"2006-01-27T01:48:43Z","timestamp":1138326523000},"page":"1194-1200","source":"Crossref","is-referenced-by-count":44,"title":["Angiogenesis Facilitated by Autologous Whole Bone Marrow Stem Cell Transplantation for Buerger's Disease"],"prefix":"10.1093","volume":"24","author":[{"given":"Dong-Ik","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Vascular Surgery, Sungkyunkwan University School of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi-Jung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, University of Ulsan College of Medicine, Asan Institute for Life Sciences, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Hyun","family":"Joh","sequence":"additional","affiliation":[{"name":"Division of Vascular Surgery, Sungkyunkwan University School of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Wook","family":"Shin","sequence":"additional","affiliation":[{"name":"Departments of Radiology, Sungkyunkwan University School of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Soo","family":"Do","sequence":"additional","affiliation":[{"name":"Departments of Radiology, Sungkyunkwan University School of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Young","family":"Moon","sequence":"additional","affiliation":[{"name":"Division of Vascular Surgery, Sungkyunkwan University School of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na-Ri","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Vascular Surgery, Sungkyunkwan University School of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joung-Eun","family":"Lim","sequence":"additional","affiliation":[{"name":"Samsung Biomedical Research Institute, Seoul National University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ae-Kyeong","family":"Kim","sequence":"additional","affiliation":[{"name":"Samsung Biomedical Research Institute, Seoul National University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun-Seon","family":"Eo","sequence":"additional","affiliation":[{"name":"Samsung Biomedical Research Institute, Seoul National University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung-Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Hanyang University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Woo","family":"Cho","sequence":"additional","affiliation":[{"name":"School of Chemical and Biological Engineering, Seoul National University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Hye","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, University of Ulsan College of Medicine, Asan Institute for Life Sciences, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan-Jeoung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, University of Ulsan College of Medicine, Asan Institute for Life Sciences, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Sup","family":"Shim","sequence":"additional","affiliation":[{"name":"Orthopedic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2006,1,26]]},"reference":[{"key":"2021122214420305200_bib1","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1172\/JCI117018","article-title":"Therapeutic angiogenesis: A single intraarterial bolus of vascular endothelial growth factor augments revas-cularization in a rabbit ischemic hindlimb model","volume":"93","author":"Takeshita","year":"1994","journal-title":"J Clin Invest"},{"key":"2021122214420305200_bib2","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/S0140-6736(96)03361-2","article-title":"Clinical evidence of angiogensis after arterial gene transfer of phVEGF165 in patients with an ischemic 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