{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:05:36Z","timestamp":1791115536320,"version":"4.1.0"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2007,10,11]],"date-time":"2007-10-11T00:00:00Z","timestamp":1192060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Bone marrow-derived mesenchymal stem cells (MSCs) have shown great promise for cardiac repair. However, poor viability of transplanted MSCs within the ischemic heart has limited their therapeutic potential. Our previous studies have documented that hypoxia and serum deprivation (hypoxia\/SD), induced MSCs apoptosis through the mitochondrial apoptotic pathway. Since serum lysophosphatidic acid (LPA) levels are known to be significantly elevated after acute myocardial infarction and that LPA enhanced survival of other cell systems, we embarked on determining whether LPA protects MSCs against hypoxia\/SD-induced apoptosis. We have also investigated the potential mechanism(s) that may mediate such actions of LPA. All experiments were carried out on rat bone marrow MSCs. Apoptosis was induced by exposure of cells to hypoxia\/SD in a sealed GENbox hypoxic chamber. Effects of LPA were investigated in the absence and presence of inhibitors that target either Giproteins, the mitogen activated protein kinases ERK1\/2, or phosphoinositide 3-kinase (PI3K). The data obtained showed that hypoxia\/SD-induced apoptosis was significantly attenuated by LPA through Gi-coupled LPA1 receptors linked to the downstream ERK1\/2 and PI3K\/Akt signaling pathways that function in parallel. Additional studies have demonstrated that hypoxia\/SD-induced activation of mitochondrial dysfunction was virtually abolished by LPA treatment and that inhibition of the LPA1 receptor, Gi proteins, the PI3K\/Akt pathway, or ERKs effectively reversed this protective action of LPA. Taken together, our findings indicate that LPA is a novel, potent survival factor for MSCs and this may prove to be of considerable therapeutic significance in terms of exploiting MSC-based therapy in the infracted myocardium.<\/jats:p><jats:p>Disclosure of potential conflicts of interest is found at the end of this article.<\/jats:p>","DOI":"10.1634\/stemcells.2007-0098","type":"journal-article","created":{"date-parts":[[2007,10,13]],"date-time":"2007-10-13T00:13:16Z","timestamp":1192234396000},"page":"135-145","source":"Crossref","is-referenced-by-count":93,"title":["Lysophosphatidic Acid Protects Mesenchymal Stem Cells Against Hypoxia and Serum Deprivation-Induced Apoptosis"],"prefix":"10.1093","volume":"26","author":[{"given":"Jinghai","family":"Chen","sequence":"first","affiliation":[{"name":"Research Center for Cardiovascular Regenerative Medicine, The Ministry of Health of China, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anwar R.","family":"Baydoun","sequence":"additional","affiliation":[{"name":"University of Hertfordshire, Faculty of Health and Human Sciences, School of Life Sciences, College Lane, Hatfield, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruixia","family":"Xu","sequence":"additional","affiliation":[{"name":"Research Center for Cardiovascular Regenerative Medicine, The Ministry of Health of China, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linzi","family":"Deng","sequence":"additional","affiliation":[{"name":"Research Center for Cardiovascular Regenerative Medicine, The Ministry of Health of China, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuebin","family":"Liu","sequence":"additional","affiliation":[{"name":"Research Center for Cardiovascular Regenerative Medicine, The Ministry of Health of China, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiquan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Research Center for Cardiovascular Regenerative Medicine, The Ministry of Health of China, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linhui","family":"Shi","sequence":"additional","affiliation":[{"name":"Research Center for Cardiovascular Regenerative Medicine, The Ministry of Health of China, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangfeng","family":"Cong","sequence":"additional","affiliation":[{"name":"Research Center for Cardiovascular Regenerative Medicine, The Ministry of Health of China, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengshou","family":"Hu","sequence":"additional","affiliation":[{"name":"Research Center for Cardiovascular Regenerative Medicine, The Ministry of Health of China, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Chen","sequence":"additional","affiliation":[{"name":"Research Center for Cardiovascular Regenerative Medicine, The Ministry of Health of China, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2007,10,11]]},"reference":[{"key":"2022011314145594500_bib1","doi-asserted-by":"crossref","first-page":"4857","DOI":"10.1073\/pnas.92.11.4857","article-title":"Cultured adherent cells from marrow can serve as long-lasting precursor cells for bone, cartilage, and lung in irradiated mice","volume":"92","author":"Pereira","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2022011314145594500_bib2","doi-asserted-by":"crossref","first-page":"3908","DOI":"10.1073\/pnas.95.7.3908","article-title":"Engraftment and migration of human bone marrow stromal cells implanted in the brains of albino rats\u2013similarities to astrocyte grafts","volume":"95","author":"Azizi","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2022011314145594500_bib3","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1046\/j.1432-0436.2001.680411.x","article-title":"Brain from bone: efficient \u201cmeta-differentiation\u201d of marrow stroma-derived mature osteoblasts to neurons with Noggin or a demethylating agent","volume":"68","author":"Kohyama","year":"2001","journal-title":"Differentiation"},{"key":"2022011314145594500_bib4","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1126\/science.279.5356.1528","article-title":"Muscle regeneration by bone marrow-derived myogenic progenitors","volume":"279","author":"Ferrari","year":"1998","journal-title":"Science"},{"key":"2022011314145594500_bib5","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1172\/JCI5298","article-title":"Cardiomyocytes can be generated from marrow stromal cells in vitro","volume":"103","author":"Makino","year":"1999","journal-title":"J Clin Invest"},{"key":"2022011314145594500_bib6","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1161\/hc0102.101442","article-title":"Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart","volume":"105","author":"Toma","year":"2002","journal-title":"Circulation"},{"key":"2022011314145594500_bib7","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1016\/S0003-4975(02)03517-8","article-title":"Mesenchymal stem cell implantation in a swine myocardial infarct model: Engraftment and functional effects","volume":"73","author":"Shake","year":"2002","journal-title":"Ann Thorac Surg"},{"key":"2022011314145594500_bib8","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1161\/01.RES.0000218272.18669.6e","article-title":"Stem cells as a source of regenerative cardiomyocytes","volume":"98","author":"Fukuda","year":"2006","journal-title":"Circ Res"},{"key":"2022011314145594500_bib9","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1196\/annals.1299.126","article-title":"Molecular mechanisms for cardiovascular stem cell apoptosis and growth in the hearts with atherosclerotic coronary disease and ischemic heart failure","volume":"1010","author":"Geng","year":"2003","journal-title":"Ann N Y Acad Sci"},{"key":"2022011314145594500_bib10","doi-asserted-by":"crossref","first-page":"31639","DOI":"10.1074\/jbc.M204104200","article-title":"Importance of FADD signaling in serum deprivation- and hypoxia-induced cardiomyocyte apoptosis","volume":"277","author":"Chao","year":"2002","journal-title":"J Biol Chem"},{"key":"2022011314145594500_bib11","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0014-5793(03)00029-2","article-title":"H9c2 cardiac myoblasts undergo apoptosis in a model of ischemia consisting of serum deprivation and hypoxia: Inhibition by PMA","volume":"536","author":"Bonavita","year":"2003","journal-title":"FEBS Lett"},{"key":"2022011314145594500_bib12","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1634\/stemcells.2005-0121","article-title":"Hypoxia and serum deprivation-induced apoptosis in mesenchymal stem cells","volume":"24","author":"Zhu","year":"2006","journal-title":"Stem Cells"},{"key":"2022011314145594500_bib13","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1046\/j.1471-4159.1998.70010066.x","article-title":"Lysophosphatidic acid induces necrosis and apoptosis in hippocampal neurons","volume":"70","author":"Holtsberg","year":"1998","journal-title":"J Neurochem"},{"key":"2022011314145594500_bib14","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S1388-1981(01)00084-1","article-title":"Dual effects of lysophosphatidic acid on human airway smooth muscle cell proliferation and survival","volume":"1531","author":"Ediger","year":"2001","journal-title":"Biochim Biophys Acta"},{"key":"2022011314145594500_bib15","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1042\/bj3590227","article-title":"Lysophosphatidic acid promotes phorbol-ester-induced apoptosis in TF-1 cells by interfering with adhesion","volume":"359","author":"Lai","year":"2001","journal-title":"Biochem J"},{"key":"2022011314145594500_bib16","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1006\/jmcc.2001.1429","article-title":"The lysophospholipids sphingosine-1-phosphate and lysophosphatidic acid enhance survival during hypoxia in neonatal rat cardiac myocytes","volume":"33","author":"Karliner","year":"2001","journal-title":"J Mol Cell Cardiol"},{"key":"2022011314145594500_bib17","doi-asserted-by":"crossref","first-page":"G821","DOI":"10.1152\/ajpgi.00406.2002","article-title":"LPA protects intestinal epithelial cells from apoptosis by inhibiting the mitochondrial pathway","volume":"284","author":"Deng","year":"2003","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"2022011314145594500_bib18","doi-asserted-by":"crossref","first-page":"9498","DOI":"10.1074\/jbc.M410455200","article-title":"Lysophosphatidic acid (LPA) protects primary chronic lymphocytic leukemia cells from apoptosis through LPA receptor activation of the antiapoptotic protein AKT\/PKB","volume":"280","author":"Hu","year":"2005","journal-title":"J Biol Chem"},{"key":"2022011314145594500_bib19","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1042\/bj3520135","article-title":"Lysophosphatidic acid prevents apoptosis in fibroblasts via G (i)-protein-mediated activation of mitogen-activated protein kinase","volume":"352","author":"Fang","year":"2000","journal-title":"Biochem J"},{"key":"2022011314145594500_bib20","doi-asserted-by":"crossref","first-page":"5233","DOI":"10.1073\/pnas.96.9.5233","article-title":"Schwann cell survival mediated by the signaling phospholipid lysophosphatidic acid","volume":"96","author":"Weiner","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2022011314145594500_bib21","first-page":"F575","article-title":"Lysophosphatidic acid: a novel growth and survival factor for renal proximal tubular cells","volume":"273","author":"Levine","year":"1997","journal-title":"Am J Physiol"},{"key":"2022011314145594500_bib22","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1172\/JCI1002","article-title":"Lysophosphatidic acid is a major serum noncytokine survival factor for murine macrophages which acts via the phosphatidylinositol 3-kinase signaling pathway","volume":"102","author":"Koh","year":"1998","journal-title":"J Clin Invest"},{"key":"2022011314145594500_bib23","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/j.bbrc.2005.08.011","article-title":"Lysophosphatidic acid mediates pleiotropic responses in skeletal muscle cells","volume":"335","author":"Jean-Baptiste","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"2022011314145594500_bib24","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.4049\/jimmunol.162.4.2049","article-title":"Lysophosphatidic acid and sphingosine 1-phosphate protection of T cells from apoptosis in association with suppression of Bax","volume":"162","author":"Goetzl","year":"1999","journal-title":"J Immunol"},{"key":"2022011314145594500_bib25","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.semcdb.2004.05.005","article-title":"Cell surface receptors in lysophospholipid signaling","volume":"15","author":"Anliker","year":"2004","journal-title":"Semin Cell Dev Biol"},{"key":"2022011314145594500_bib26","doi-asserted-by":"crossref","first-page":"25600","DOI":"10.1074\/jbc.M302648200","article-title":"Identification of p2y9\/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family","volume":"278","author":"Noguchi","year":"2003","journal-title":"J Biol Chem"},{"key":"2022011314145594500_bib27","doi-asserted-by":"crossref","first-page":"23589","DOI":"10.1074\/jbc.M603670200","article-title":"GPR92 as a new G12\/13- and Gq-coupled lysophosphatidic acid receptor that increases cAMP, LPA5","volume":"281","author":"Lee","year":"2006","journal-title":"J Biol Chem"},{"key":"2022011314145594500_bib28","doi-asserted-by":"crossref","first-page":"20555","DOI":"10.1074\/jbc.R400013200","article-title":"Lysophospholipid G protein-coupled receptors","volume":"279","author":"Anliker","year":"2004","journal-title":"J Biol Chem"},{"key":"2022011314145594500_bib29","first-page":"1307","article-title":"Peptide and lipid growth factors decrease cis-diamminedichloroplatinum-induced cell death in human ovarian cancer cells","volume":"2","author":"Frankel","year":"1996","journal-title":"Clin Cancer Res"},{"key":"2022011314145594500_bib30","doi-asserted-by":"crossref","first-page":"9585","DOI":"10.1074\/jbc.M213244200","article-title":"Lysophosphatidic acid promotes survival and differentiation of rat Schwann cells","volume":"278","author":"Li","year":"2003","journal-title":"J Biol Chem"},{"key":"2022011314145594500_bib31","doi-asserted-by":"crossref","first-page":"C2010","DOI":"10.1152\/ajpcell.00077.2001","article-title":"Enhancement of survival by LPA via Erk1\/Erk2 and PI 3-kinase\/Akt pathways in a murine hepatocyte cell line","volume":"281","author":"Sautin","year":"2001","journal-title":"Am J Physiol Cell Physiol"},{"key":"2022011314145594500_bib32","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1111\/j.1440-1681.2006.04432.x","article-title":"Growth inhibition of mesenchymal stem cells by aspirin: involvement of the WNT\/\u03b2-catenin signal pathway","volume":"33","author":"Wang","year":"2006","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"2022011314145594500_bib33","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.cellsig.2005.06.012","article-title":"Role of heterotrimeric G-proteins in lysophosphatidic acid-mediated neurite retraction by RhoA-dependent and -independent mechanisms in N1E-115 cells","volume":"18","author":"Couvillon","year":"2006","journal-title":"Cell Signal"},{"key":"2022011314145594500_bib34","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.yjmcc.2003.12.010","article-title":"Lysophosphatidic acid induces hypertrophy of neonatal cardiac myocytes via activation of Gi and Rho","volume":"36","author":"Hilal-Dandan","year":"2004","journal-title":"J Mol Cell Cardiol"},{"key":"2022011314145594500_bib35","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0014-5793(95)00478-R","article-title":"Lysophosphatidic acid-induced activation of protein Ser\/Thr kinases in cultured rat 3Y1 fibroblasts. Possible involvement in rho p21-mediated signaling","volume":"366","author":"Kumagai","year":"1995","journal-title":"FEBS Lett"},{"key":"2022011314145594500_bib36","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/glia.10297","article-title":"Characterization of lysophosphatidic acid and sphingosine-1-phosphate-mediated signal transduction in rat cortical oligodendrocytes","volume":"45","author":"Yu","year":"2004","journal-title":"Glia"},{"key":"2022011314145594500_bib37","doi-asserted-by":"crossref","first-page":"4737","DOI":"10.1016\/j.febslet.2006.07.061","article-title":"Specific receptor subtype mediation of LPA-induced dual effects in cardiac fibroblasts","volume":"580","author":"Chen","year":"2006","journal-title":"FEBS Lett"},{"key":"2022011314145594500_bib38","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/S0026-895X(24)12305-X","article-title":"Short-chain phosphatidates are subtype-selective antagonists of lysophosphatidic acid receptors","volume":"60","author":"Fischer","year":"2001","journal-title":"Mol Pharmacol"},{"key":"2022011314145594500_bib39","doi-asserted-by":"crossref","first-page":"10344","DOI":"10.1073\/pnas.181177898","article-title":"Mobilized bone marrow cells repair the infarcted heart, improving function and survival","volume":"98","author":"Orlic","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2022011314145594500_bib40","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1038\/nm912","article-title":"Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts","volume":"9","author":"Mangi","year":"2003","journal-title":"Nat Med"},{"key":"2022011314145594500_bib41","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S0022-5223(03)00118-1","article-title":"Transcoronary implantation of bone marrow stromal cells ameliorates cardiac function after myocardial infarction","volume":"126","author":"Saito","year":"2003","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2022011314145594500_bib42","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1067\/mtc.2001.116317","article-title":"The coronary delivery of marrow stromal cells for myocardial regeneration: pathophysiologic and therapeutic implications","volume":"122","author":"Wang","year":"2001","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2022011314145594500_bib43","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1080\/00365510310003265","article-title":"Serum lysophosphatidic acid concentrations measured by dot immunogold filtration assay in patients with acute myocardial infarction","volume":"63","author":"Chen","year":"2003","journal-title":"Scand J Clin Lab Invest"},{"key":"2022011314145594500_bib44","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/S0163-7827(03)00035-3","article-title":"Molecular mechanisms of lysophosphatidic acid action","volume":"42","author":"Tigyi","year":"2003","journal-title":"Prog Lipid Res"},{"key":"2022011314145594500_bib45","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.semcdb.2004.05.003","article-title":"Biology of LPA in health and disease","volume":"15","author":"Sengupta","year":"2004","journal-title":"Semin Cell Dev Biol"},{"key":"2022011314145594500_bib46","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/S1388-1981(02)00330-X","article-title":"Lysophosphatidic acid as a novel cell survival\/apoptotic factor","volume":"1585","author":"Ye","year":"2002","journal-title":"Biochim Biophys Acta"},{"key":"2022011314145594500_bib47","first-page":"1073","article-title":"The human lipid phosphate phosphatase-3 decreases the growth, survival, and tumorigenesis of ovarian cancer cells: validation of the lysophosphatidic acid signaling cascade as a target for therapy in ovarian cancer","volume":"63","author":"Tanyi","year":"2003","journal-title":"Cancer Res"},{"key":"2022011314145594500_bib48","doi-asserted-by":"crossref","first-page":"32516","DOI":"10.1074\/jbc.M203864200","article-title":"Role for 18:1 lysophosphatidic acid as an autocrine mediator in prostate cancer cells","volume":"277","author":"Xie","year":"2002","journal-title":"J Biol Chem"},{"key":"2022011314145594500_bib49","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s11745-999-332-5","article-title":"Abnormal serum lysophospholipids in multiple myeloma patients","volume":"34","author":"Sasagawa","year":"1999","journal-title":"Lipids"},{"key":"2022011314145594500_bib50","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/S0014-5793(97)00411-0","article-title":"Lysophosphatidic acid as a phospholipid mediator: pathways of synthesis","volume":"410","author":"Gaits","year":"1997","journal-title":"FEBS Lett"},{"key":"2022011314145594500_bib51","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1006\/dbio.2000.9930","article-title":"Lysophosphatidic acid (LPA) is a novel extracellular regulator of cortical neuroblast morphology","volume":"228","author":"Fukushima","year":"2000","journal-title":"Dev Biol"},{"key":"2022011314145594500_bib52","doi-asserted-by":"crossref","first-page":"7069","DOI":"10.1523\/JNEUROSCI.21-18-07069.2001","article-title":"Regulation of Schwann cell morphology and adhesion by receptor-mediated lysophosphatidic acid signaling","volume":"21","author":"Weiner","year":"2001","journal-title":"J Neurosci"},{"key":"2022011314145594500_bib53","doi-asserted-by":"crossref","first-page":"13384","DOI":"10.1073\/pnas.97.24.13384","article-title":"Requirement for the lpA1 lysophosphatidic acid receptor gene in normal suckling behavior","volume":"97","author":"Contos","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2022011314145594500_bib54","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1023\/A:1013517013069","article-title":"Phosphoinositol 3 kinase inhibitor, LY294002 increases bcl-2 protein and inhibits okadaic acid-induced apoptosis in Bcl-2 expressing renal epithelial cells","volume":"7","author":"Carbott","year":"2002","journal-title":"Apoptosis"},{"key":"2022011314145594500_bib55","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1016\/j.cellsig.2007.04.001","article-title":"Pertussis toxin promotes macrophage survival through inhibition of acid sphingomyelinase and activation of the phosphoinositide 3-kinase\/protein kinase B pathway","volume":"19","author":"Wang","year":"2007","journal-title":"Cell Signal"},{"key":"2022011314145594500_bib56","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1074\/jbc.274.1.522","article-title":"Proinflammatory macrophage-activating properties of the novel phospholipid diacylglycerol pyrophosphate","volume":"274","author":"Balboa","year":"1999","journal-title":"J Biol Chem"}],"container-title":["Stem Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1634%2Fstemcells.2007-0098","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1634\/stemcells.2007-0098","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1634\/stemcells.2007-0098","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/stmcls\/article-pdf\/26\/1\/135\/41941173\/stmcls_26_1_135.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/stmcls\/article-pdf\/26\/1\/135\/41941173\/stmcls_26_1_135.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T16:59:15Z","timestamp":1737478755000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/stmcls\/article\/26\/1\/135-145\/6401855"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10,11]]},"references-count":56,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2007,10,11]]},"published-print":{"date-parts":[[2008,1,1]]}},"URL":"https:\/\/doi.org\/10.1634\/stemcells.2007-0098","relation":{},"ISSN":["1066-5099","1549-4918"],"issn-type":[{"value":"1066-5099","type":"print"},{"value":"1549-4918","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2008,1,1]]},"published":{"date-parts":[[2007,10,11]]}}}