{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T08:32:47Z","timestamp":1791102767644,"version":"4.1.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2007,10,11]],"date-time":"2007-10-11T00:00:00Z","timestamp":1192060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The identification of mesenchymal stem cell (MSC) sources that are easily obtainable is of utmost importance. Several studies have shown that MSCs could be isolated from umbilical cord (UC) units. However, the presence of MSCs in umbilical cord blood (UCB) is controversial. A possible explanation for the low efficiency of MSCs from UCB is the use of different culture conditions by independent studies. Here, we compared the efficiency in obtaining MSCs from unrelated paired UCB and UC samples harvested from the same donors. Samples were processed simultaneously, under the same culture conditions. Although MSCs from blood were obtained from only 1 of the 10 samples, we were able to isolate large amounts of multipotent MSCs from all UC samples, which were able to originate different cell lineages. Since the routine procedure in UC banks has been to store the blood and discard other tissues, such as the cord and\/or placenta, we believe our results are of immediate clinical value. Furthermore, the possibility of originating different cell lines from the UC of neonates born with genetic defects may provide new cellular research models for understanding human malformations and genetic disorders, as well as the possibility of testing the effects of different therapeutic drugs.<\/jats:p>\n               <jats:p>Disclosure of potential conflicts of interest is found at the end of this article.<\/jats:p>","DOI":"10.1634\/stemcells.2007-0381","type":"journal-article","created":{"date-parts":[[2007,10,13]],"date-time":"2007-10-13T00:13:16Z","timestamp":1192234396000},"page":"146-150","source":"Crossref","is-referenced-by-count":296,"title":["Multipotent Stem Cells from Umbilical Cord: Cord Is Richer than Blood!"],"prefix":"10.1093","volume":"26","author":[{"given":"Mariane","family":"Secco","sequence":"first","affiliation":[{"name":"Human Genome Research Center, Department of Genetic and Evolutive Biology, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eder","family":"Zucconi","sequence":"additional","affiliation":[{"name":"Human Genome Research Center, Department of Genetic and Evolutive Biology, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natassia M.","family":"Vieira","sequence":"additional","affiliation":[{"name":"Human Genome Research Center, Department of Genetic and Evolutive Biology, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana L.Q.","family":"Foga\u00e7a","sequence":"additional","affiliation":[{"name":"Human Genome Research Center, Department of Genetic and Evolutive Biology, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Cerqueira","sequence":"additional","affiliation":[{"name":"Human Genome Research Center, Department of Genetic and Evolutive Biology, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Denise F.","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Human Genome Research Center, Department of Genetic and Evolutive Biology, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Jazedje","sequence":"additional","affiliation":[{"name":"Human Genome Research Center, Department of Genetic and Evolutive Biology, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oswaldo K.","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery, Federal University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alysson R.","family":"Muotri","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayana","family":"Zatz","sequence":"additional","affiliation":[{"name":"Human Genome Research Center, Department of Genetic and Evolutive Biology, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2007,10,11]]},"reference":[{"key":"2022011314153812600_bib1","doi-asserted-by":"crossref","first-page":"4279","DOI":"10.1091\/mbc.e02-02-0105","article-title":"Human adipose tissue is a source of multipotent stem cells","volume":"13","author":"Zuk","year":"2002","journal-title":"Mol Biol Cell"},{"key":"2022011314153812600_bib2","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1634\/stemcells.22-4-617","article-title":"Skeletal myogenic differentiation of mesenchymal stem cells isolated from human umbilical cord blood","volume":"22","author":"Gang","year":"2004","journal-title":"Stem Cells"},{"key":"2022011314153812600_bib3","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1634\/stemcells.2006-0286","article-title":"Biology of the stem cells in human umbilical cord stroma: In situ and in vitro surveys","volume":"25","author":"Karahuseyinoglu","year":"2007","journal-title":"Stem Cells"},{"key":"2022011314153812600_bib4","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1634\/stemcells.2005-0342","article-title":"Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue","volume":"24","author":"Kern","year":"2006","journal-title":"Stem Cells"},{"key":"2022011314153812600_bib5","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1089\/107632701300062859","article-title":"Multilineage cells from human adipose tissue: Implication for cell-based therapies","volume":"7","author":"Zuk","year":"2001","journal-title":"Tissue Eng"},{"key":"2022011314153812600_bib6","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1177\/154405910208100806","article-title":"Stem cell properties of human dental pulp stem cells","volume":"81","author":"Gronthos","year":"2002","journal-title":"J Dent Res"},{"key":"2022011314153812600_bib7","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nature00870","article-title":"Pluripotency of mesenchymal stem cells derived from adult marrow","volume":"418","author":"Jiang","year":"2002","journal-title":"Nature"},{"key":"2022011314153812600_bib8","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1182\/blood-2003-05-1670","article-title":"Isolation of multipotent mesenchymal stem cells from umbilical cord blood","volume":"103","author":"Lee","year":"2004","journal-title":"Blood"},{"key":"2022011314153812600_bib9","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1634\/stemcells.2004-0098","article-title":"Isolation of multipotent cells from human term placenta","volume":"23","author":"Yen","year":"2005","journal-title":"Stem Cells"},{"key":"2022011314153812600_bib10","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/nbt1274","article-title":"Isolation of amniotic stem cell lines with potential for therapy","volume":"25","author":"De Coppi","year":"2007","journal-title":"Nat Biotechnol"},{"key":"2022011314153812600_bib11","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1002\/jcb.1174","article-title":"Age-related decline in the osteogenic potential of human bone marrow cells cultured in three-dimensional collagen sponges","volume":"82","author":"Mueller","year":"2001","journal-title":"J Cell Biochem"},{"key":"2022011314153812600_bib12","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.bone.2003.07.005","article-title":"Aging is associated with decreased maximal life span and accelerated senescence of bone marrow stromal cells","volume":"33","author":"Stenderup","year":"2003","journal-title":"Bone"},{"key":"2022011314153812600_bib13","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1080\/1042819031000077016","article-title":"Hematopoietic stem-cell transplantation using umbilical-cord blood","volume":"44","author":"Cohena","year":"2003","journal-title":"Leuk Lymphoma"},{"key":"2022011314153812600_bib14","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1080\/10428190500421013","article-title":"The efficacy of unrelated cord blood transplantation for adult myelodysplastic syndrome","volume":"47","author":"Ooi","year":"2006","journal-title":"Leuk Lymphoma"},{"key":"2022011314153812600_bib15","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1056\/NEJM200106143442402","article-title":"Hematopoietic engraftment and survival in adult recipients of umbilical-cord blood from unrelated donors","volume":"344","author":"Laughlin","year":"2001","journal-title":"N Engl J Med"},{"key":"2022011314153812600_bib16","doi-asserted-by":"crossref","first-page":"e296","DOI":"10.1542\/peds.2006-1009","article-title":"First report of autologous cord blood transplantation in the treatment of a child with leukemia","volume":"119","author":"Hayani","year":"2007","journal-title":"Pediatrics"},{"key":"2022011314153812600_bib17","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1046\/j.1365-2141.2000.01986.x","article-title":"Mesenchymal progenitor cells in human umbilical cord blood","volume":"109","author":"Erices","year":"2000","journal-title":"Br J Haematol"},{"key":"2022011314153812600_bib18","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1053\/bbmt.2001.v7.pm11760145","article-title":"Multilineage differentiation activity by cells isolated from umbilical cord blood: Expression of bone, fat and neural markers","volume":"7","author":"Goodwin","year":"2001","journal-title":"Biol Blood Marrow Transplant"},{"key":"2022011314153812600_bib19","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1634\/stemcells.22-4-625","article-title":"Critical parameters for the isolation of mesenchymal stem cells from umbilical cord blood","volume":"22","author":"Bieback","year":"2004","journal-title":"Stem Cells"},{"key":"2022011314153812600_bib20","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1634\/stemcells.21-1-105","article-title":"Searching for alternative sources of postnatal human mesenchymal stem cells: Candidate MSC-like cells from umbilical cord","volume":"21","author":"Romanov","year":"2003","journal-title":"Stem Cells"},{"key":"2022011314153812600_bib21","first-page":"1099","article-title":"Isolation of human mesenchymal stem cells: Bone marrow versus umbilical cord blood","volume":"86","author":"Mareschi","year":"2001","journal-title":"Haematologica"},{"key":"2022011314153812600_bib22","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1046\/j.1365-2141.2003.04284.x","article-title":"Adult bone marrow is a rich source of human mesenchymal \u2018stem\u2019 cells but umbilical cord and mobilized adult blood are not","volume":"121","author":"Wexler","year":"2003","journal-title":"Br J Haematol"},{"key":"2022011314153812600_bib23","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1634\/stemcells.2004-0013","article-title":"Mesenchymal stem cells in the Wharton's jelly of the human umbilical cord","volume":"22","author":"Wang","year":"2004","journal-title":"Stem Cells"},{"key":"2022011314153812600_bib24","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1634\/stemcells.2004-0166","article-title":"Human umbilical cord perivascular (HUCPV) cells: A source of mesenchymal progenitors","volume":"23","author":"Sarugaser","year":"2005","journal-title":"Stem Cells"},{"key":"2022011314153812600_bib25","doi-asserted-by":"crossref","DOI":"10.1634\/stemcells.2007-0417","article-title":"Concise review: Human umbilical cord stroma with regard to the source of fetus-derived stem cells","author":"Can","year":"2007","journal-title":"Stem Cells"},{"key":"2022011314153812600_bib26","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1634\/stemcells.2004-0330","article-title":"Mesenchymal stem cells derived from CD133-positive cells in mobilized peripheral blood and cord blood: Proliferation, Oct4 expression, and plasticity","volume":"23","author":"Tondreau","year":"2005","journal-title":"Stem Cells"},{"key":"2022011314153812600_bib27","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1634\/stemcells.2005-0053","article-title":"Conversion of human umbilical cord mesenchymal stem cells in Wharton's jelly to dopaminergic neurons in vitro: Potential therapeutic application for Parkinsonism","volume":"24","author":"Fu","year":"2006","journal-title":"Stem Cells"},{"key":"2022011314153812600_bib28","first-page":"1089","article-title":"CD105(+) cells from Wharton's jelly show in vitro and in vivo myogenic differentiative potential","volume":"18","author":"Conconi","year":"2006","journal-title":"Int J Mol Med"},{"key":"2022011314153812600_bib29","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1634\/stemcells.21-1-50","article-title":"Matrix cells from Wharton's jelly form neurons and glia","volume":"21","author":"Mitchell","year":"2003","journal-title":"Stem Cells"},{"key":"2022011314153812600_bib30","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1634\/stemcells.2005-0330","article-title":"Human umbilical cord matrix stem cells: Preliminary characterization and effect of transplantation in a rodent model of Parkinson's disease","volume":"24","author":"Weiss","year":"2006","journal-title":"Stem Cells"},{"key":"2022011314153812600_bib31","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/sj.bmt.1700890","article-title":"Detection of stromal cells in peripheral blood progenitor cell collections from breast cancer patients","volume":"20","author":"Fernandez","year":"1997","journal-title":"Bone Marrow Transplant"},{"key":"2022011314153812600_bib32","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1186\/ar130","article-title":"Mesenchymal precursor cells in the blood of normal individuals","volume":"2","author":"Zvaifler","year":"2000","journal-title":"Arthritis Res"},{"key":"2022011314153812600_bib33","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1242\/jcs.02932","article-title":"Mesenchymal stem cells reside in virtually all post-natal organs and tissues","volume":"119","author":"da Silva Meirelles","year":"2006","journal-title":"J Cell Sci"},{"key":"2022011314153812600_bib34","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1634\/stemcells.2004-0024","article-title":"Comparison of gene expression of umbilical cord vein and bone marrow-derived mesenchymal stem cells","volume":"22","author":"Panepucci","year":"2004","journal-title":"Stem Cells"}],"container-title":["Stem Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1634%2Fstemcells.2007-0381","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1634\/stemcells.2007-0381","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1634\/stemcells.2007-0381","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/stmcls\/article-pdf\/26\/1\/146\/41941261\/stmcls_26_1_146.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/stmcls\/article-pdf\/26\/1\/146\/41941261\/stmcls_26_1_146.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T02:54:18Z","timestamp":1642560858000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/stmcls\/article\/26\/1\/146-150\/6401882"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10,11]]},"references-count":34,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2007,10,11]]},"published-print":{"date-parts":[[2008,1,1]]}},"URL":"https:\/\/doi.org\/10.1634\/stemcells.2007-0381","relation":{},"ISSN":["1066-5099","1549-4918"],"issn-type":[{"value":"1066-5099","type":"print"},{"value":"1549-4918","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2008,1,1]]},"published":{"date-parts":[[2007,10,11]]}}}