{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:32:50Z","timestamp":1790188370107,"version":"4.1.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2008,4,17]],"date-time":"2008-04-17T00:00:00Z","timestamp":1208390400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Adult bone marrow (BM) contains Sca-1+\/Lin\u2212\/CD45\u2212 very small embryonic-like stem cells (VSELs) that express markers of several lineages, including cardiac markers, and differentiate into cardiomyocytes in vitro. We examined whether BM-derived VSELs promote myocardial repair after a reperfused myocardial infarction (MI). Mice underwent a 30-minute coronary occlusion followed by reperfusion and received intramyocardial injection of vehicle (n= 11), 1 \u00d7 105 Sca-1+\/Lin\u2212\/CD45+ enhanced green fluorescent protein (EGFP)-labeled hematopoietic stem cells (n= 13 [cell control group]), or 1 \u00d7 104 Sca-1+\/Lin\u2212\/CD45\u2212 EGFP-labeled cells (n= 14 [VSEL-treated group]) at 48 hours after MI. At 35 days after MI, VSEL-treated mice exhibited improved global and regional left ventricular (LV) systolic function (echocardiography) and attenuated myocyte hypertrophy in surviving tissue (histology and echocardiography) compared with vehicle-treated controls. In contrast, transplantation of Sca-1+\/Lin\u2212\/CD45+ cells failed to confer any functional or structural benefits. Scattered EGFP+ myocytes and capillaries were present in the infarct region in VSEL-treated mice, but their numbers were very small. These results indicate that transplantation of a relatively small number of CD45\u2212 VSELs is sufficient to improve LV function and alleviate myocyte hypertrophy after MI, supporting the potential therapeutic utility of these cells for cardiac repair.<\/jats:p>\n               <jats:p>Disclosure of potential conflicts of interest is found at the end of this article.<\/jats:p>","DOI":"10.1634\/stemcells.2007-0715","type":"journal-article","created":{"date-parts":[[2008,4,18]],"date-time":"2008-04-18T01:07:38Z","timestamp":1208480858000},"page":"1646-1655","source":"Crossref","is-referenced-by-count":110,"title":["Transplantation of Bone Marrow-Derived Very Small Embryonic-Like Stem Cells Attenuates Left Ventricular Dysfunction and Remodeling After Myocardial Infarction"],"prefix":"10.1093","volume":"26","author":[{"given":"Buddhadeb","family":"Dawn","sequence":"first","affiliation":[{"name":"Institute of Molecular Cardiology, University of Louisville, Louisville, Kentucky, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumit","family":"Tiwari","sequence":"additional","affiliation":[{"name":"Institute of Molecular Cardiology, University of Louisville, Louisville, Kentucky, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena J.","family":"Kucia","sequence":"additional","affiliation":[{"name":"Stem Cell Biology Program, University of Louisville, Louisville, Kentucky, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa K.","family":"Zuba-Surma","sequence":"additional","affiliation":[{"name":"Stem Cell Biology Program, University of Louisville, Louisville, Kentucky, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiru","family":"Guo","sequence":"additional","affiliation":[{"name":"Institute of Molecular Cardiology, University of Louisville, Louisville, Kentucky, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santosh 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Molecular Cardiology, University of Louisville, Louisville, Kentucky, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan J.","family":"Reed","sequence":"additional","affiliation":[{"name":"Institute of Molecular Cardiology, University of Louisville, Louisville, Kentucky, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariusz Z.","family":"Ratajczak","sequence":"additional","affiliation":[{"name":"Stem Cell Biology Program, University of Louisville, Louisville, Kentucky, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Bolli","sequence":"additional","affiliation":[{"name":"Institute of Molecular Cardiology, University of Louisville, Louisville, Kentucky, 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