{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T07:14:59Z","timestamp":1793344499176,"version":"4.5.0"},"reference-count":75,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Learning Objectives<\/jats:title>\n                    <jats:p>After completing this course, the reader will be able to: Discuss the basic epidemiology of pediatric CNS GCTs.Perform the diagnostic workup and full evaluation that is necessary when evaluating a patient with a suspected CNS GCT.Select among the different therapeutic alternatives employed in treating children with a CNS GCT.<\/jats:p>\n                    <jats:p>CME This article is available for continuing medical education credit at CME.TheOncologist.com<\/jats:p>\n                    <jats:p>Central nervous system (CNS) germ cell tumors (GCTs) represent approximately 3% of primary pediatric brain tumors and encompass a wide pathologic spectrum. CNS GCTs are most commonly located in the pineal and suprasellar regions of the brain and can be divided into major groups including germinomas and nongerminomatous GCTs (NGGCTs), with teratomas often considered a separate category. The clinical presentation varies by location and size, and it frequently includes endocrine abnormalities, visual changes, and signs of increased intracranial pressure. Neuroimaging studies cannot differentiate GCTs from other tumors, and therefore, the diagnosis usually requires histologic confirmation. The rare exceptions are the cases where characteristic elevations of tumor markers, including alpha-fetoprotein and\/or \u03b2-human chorionic gonadotropin are documented in the serum and\/or cerebrospinal fluid. In these cases, the imaging findings along with the tumor marker elevation may be diagnostic in themselves without the need for tissue confirmation.<\/jats:p>\n                    <jats:p>Treatment and prognosis differ greatly between groups. Germinomas have a superior prognosis than NGGCTs. Five-year overall survival rates &amp;gt;90% were reported initially with the use of craniospinal irradiation. More recently, the use of chemotherapy in addition to radiation therapy has afforded the ability to decrease the dose and volume of radiation therapy without affecting survival rates. NGGCTs are less radiosensitive than germinomas, but the use of adjuvant chemotherapy has improved survival rates in this group as well. The standard management for CNS GCTs remains controversial. Treatment regimens aimed to improve progression-free and overall survival times are ongoing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1634\/theoncologist.2008-0037","type":"journal-article","created":{"date-parts":[[2008,6,27]],"date-time":"2008-06-27T11:38:21Z","timestamp":1214566701000},"page":"690-699","source":"Crossref","is-referenced-by-count":371,"title":["Pediatric Central Nervous System Germ Cell Tumors: A Review"],"prefix":"10.1093","volume":"13","author":[{"given":"Maria E.","family":"Echevarr\u00eda","sequence":"first","affiliation":[{"name":"Division of Neuro-Oncology, Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Children's Memorial Hospital, Chicago, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Fangusaro","sequence":"additional","affiliation":[{"name":"Division of Neuro-Oncology, Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Children's Memorial Hospital, Chicago, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stewart","family":"Goldman","sequence":"additional","affiliation":[{"name":"Division of Neuro-Oncology, Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Children's Memorial Hospital, Chicago, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2008,6,1]]},"reference":[{"key":"2021122208463423700_R1","first-page":"13","author":"Kaatsch","year":"2003"},{"key":"2021122208463423700_R2","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3171\/jns.1985.63.2.0155","article-title":"Intracranial germ-cell tumors: Natural history and pathogenesis","volume":"63","author":"Jennings","year":"1985","journal-title":"J Neurosurg"},{"key":"2021122208463423700_R3","doi-asserted-by":"crossref","first-page":"654","DOI":"10.3171\/jns.1983.58.5.0654","article-title":"Diagnosis and management of pineal 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