{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T22:05:56Z","timestamp":1775081156538,"version":"3.50.1"},"reference-count":86,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Learning Objectives<\/jats:title><jats:p>After completing this course, the reader will be able to: Discuss the association of parathyroid cancers with severe hypercalcemia and markedly elevated parathyroid hormone levels.Describe the effect of the risk factors, clinical presentation, and gene expression on diagnosis of parathyroid cancers.Analyze the probability of cure for parathyroid cancers with treatment by aggressive surgery with en bloc resection and lymph node dissection.<\/jats:p><jats:p>CME This article is available for continuing medical education credit at CME.TheOncologist.com<\/jats:p><jats:p>Parathyroid carcinoma is an indolent but ultimately life-threatening malignancy. Due to the lack of definitive diagnostic markers and overlapping clinical features of benign primary hyperparathyroidism (PHPT), this disease is often misdiagnosed as parathyroid adenoma. Therefore, a high index of suspicion preoperatively and early intraoperative recognition with en bloc surgical resection are crucial for favorable outcome. Owing to the rarity of the disease, little is known about the molecular pathogenesis of parathyroid carcinoma. Here, we review the literature to present current understanding of the disease and provide new information on gene expression and use of intraoperative parathyroid hormone (PTH) monitoring in the surgical management of this rare malignancy. Specifically, using microarray transcriptome analysis of an unequivocal case of parathyroid carcinoma and a biopsy from the same patient's normal parathyroid gland, we identify APP, CDH1, KCNJ16, and UCHL1 as differentially expressed genes in parathyroid carcinoma. Further, using case records from four cases of unequivocal parathyroid carcinoma, we compared intraoperative PTH kinetics of these patients to 475 patients with benign PHPT, and show that intraoperative PTH monitoring is accurate in predicting postoperative normocalcemia in initial en bloc operations for parathyroid carcinoma.<\/jats:p><\/jats:sec>","DOI":"10.1634\/theoncologist.2009-0185","type":"journal-article","created":{"date-parts":[[2010,1,6]],"date-time":"2010-01-06T01:43:58Z","timestamp":1262742238000},"page":"61-72","source":"Crossref","is-referenced-by-count":49,"title":["Parathyroid Carcinoma: Current Understanding and New Insights into Gene Expression and Intraoperative Parathyroid Hormone Kinetics"],"prefix":"10.1093","volume":"15","author":[{"given":"Mohamed","family":"Abdelgadir Adam","sequence":"first","affiliation":[{"name":"Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian R.","family":"Untch","sequence":"additional","affiliation":[{"name":"Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"John A.","family":"Olson","sequence":"additional","affiliation":[{"name":"Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2010,1,5]]},"reference":[{"key":"2021122207232484100_R1","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1210\/jcem.86.2.7207","article-title":"Clinical review 122: Parathyroid carcinoma","volume":"86","author":"Shane","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"2021122207232484100_R2","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1002\/(SICI)1097-0142(19990801)86:3<538::AID-CNCR25>3.0.CO;2-K","article-title":"Two hundred eighty-six cases of parathyroid carcinoma treated in the U.S. between 1985\u20131995: A National Cancer Data Base Report. The American College of Surgeons Commission on Cancer and the American Cancer Society","volume":"86","author":"Hundahl","year":"1999","journal-title":"Cancer"},{"key":"2021122207232484100_R3","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1002\/cncr.22599","article-title":"Trends in the incidence and treatment of parathyroid cancer in the United States","volume":"109","author":"Lee","year":"2007","journal-title":"Cancer"},{"key":"2021122207232484100_R4","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1210\/edrv-3-2-218","article-title":"Parathyroid carcinoma: A review of 62 patients","volume":"3","author":"Shane","year":"1982","journal-title":"Endocr Rev"},{"key":"2021122207232484100_R5","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1007\/BF02067369","article-title":"Prognostic factors in parathyroid cancer: A review of 95 cases","volume":"16","author":"Sandelin","year":"1992","journal-title":"World J Surg"},{"key":"2021122207232484100_R6","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1007\/s002689900549","article-title":"Parathyroid carcinoma: Sixteen new cases and suggestions for correct management","volume":"22","author":"Favia","year":"1998","journal-title":"World J Surg"},{"key":"2021122207232484100_R7","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1007\/BF01665308","article-title":"Diagnosis and treatment of patients with parathyroid carcinoma: An update and review","volume":"15","author":"Obara","year":"1991","journal-title":"World J Surg"},{"key":"2021122207232484100_R8","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1002\/1097-0142(197303)31:3<600::AID-CNCR2820310316>3.0.CO;2-0","article-title":"Parathyroid carcinoma. A study of 70 cases","volume":"31","author":"Schantz","year":"1973","journal-title":"Cancer"},{"key":"2021122207232484100_R9","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1097\/00000658-196904000-00022","article-title":"Parathyroid carcinoma: A collective review","volume":"169","author":"Holmes","year":"1969","journal-title":"Ann Surg"},{"key":"2021122207232484100_R10","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1097\/00005792-199207000-00002","article-title":"Parathyroid carcinoma: Clinical and pathologic features in 43 patients","volume":"71","author":"Wynne","year":"1992","journal-title":"Medicine (Baltimore)"},{"key":"2021122207232484100_R11","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1002\/hed.20049","article-title":"Parathyroid carcinoma: A 22-year experience","volume":"26","author":"Busaidy","year":"2004","journal-title":"Head Neck"},{"key":"2021122207232484100_R12","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1245\/ASO.2005.03.036","article-title":"Is parathyroid carcinoma indeed a lethal disease?","volume":"12","author":"Kleinpeter","year":"2005","journal-title":"Ann Surg Oncol"},{"key":"2021122207232484100_R13","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1046\/j.1440-1754.2002.00802.x","article-title":"Familial parathyroid carcinoma in a child","volume":"38","author":"Hamill","year":"2002","journal-title":"J Paediatr Child Health"},{"key":"2021122207232484100_R14","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1177\/1066896908315821","article-title":"Mediastinal parathyroid carcinoma with tumor implants in a child: A unique occurrence","volume":"16","author":"Righi","year":"2008","journal-title":"Int J Surg Pathol"},{"key":"2021122207232484100_R15","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1288\/00005537-198702000-00015","article-title":"Parathyroid carcinoma: Two new cases\u2014diagnosis, therapy, and treatment","volume":"97","author":"Mashburn","year":"1987","journal-title":"Laryngoscope"},{"key":"2021122207232484100_R16","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1136\/jcp.38.10.1114","article-title":"Parathyroid carcinoma associated with chronic renal failure and previous radiotherapy to the neck","volume":"38","author":"Ireland","year":"1985","journal-title":"J Clin Pathol"},{"key":"2021122207232484100_R17","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/S0039-6060(96)80101-2","article-title":"Parathyroid carcinoma in patients with chronic renal failure on maintenance hemodialysis","volume":"120","author":"Miki","year":"1996","journal-title":"Surgery"},{"key":"2021122207232484100_R18","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1007\/BF00312388","article-title":"Lung metastasis from parathyroid carcinoma causing recurrent renal hyperparathyroidism in a hemodialysis patient: Report of a case","volume":"25","author":"Tominaga","year":"1995","journal-title":"Surg Today"},{"key":"2021122207232484100_R19","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1097\/00041552-199607000-00008","article-title":"Molecular genetics of hyperparathyroid disease","volume":"5","author":"Tominaga","year":"1996","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"2021122207232484100_R20","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1111\/j.1445-2197.1994.tb02251.x","article-title":"Parathyroid carcinoma in a mediastinal sixth parathyroid gland","volume":"64","author":"Kelly","year":"1994","journal-title":"Aust N Z J Surg"},{"key":"2021122207232484100_R21","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1507\/endocrj.50.477","article-title":"Double parathyroid carcinoma","volume":"50","author":"Kameyama","year":"2003","journal-title":"Endocr J"},{"key":"2021122207232484100_R22","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/S0002-9610(85)80050-7","article-title":"Natural history of parathyroid carcinoma. Diagnosis, treatment, and results","volume":"149","author":"Wang","year":"1985","journal-title":"Am J Surg"},{"key":"2021122207232484100_R23","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1007\/BF00353773","article-title":"Clinical course of metastatic parathyroid cancer","volume":"18","author":"Sandelin","year":"1994","journal-title":"World J Surg"},{"key":"2021122207232484100_R24","first-page":"978","article-title":"Metastatic parathyroid carcinoma: Dilemmas in management","volume":"110","author":"Sandelin","year":"1991","journal-title":"Surgery"},{"key":"2021122207232484100_R25","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1056\/NEJM199403173301105","article-title":"Loss of the retinoblastoma tumor-suppressor gene in parathyroid carcinoma","volume":"330","author":"Cryns","year":"1994","journal-title":"N Engl J Med"},{"key":"2021122207232484100_R26","doi-asserted-by":"crossref","first-page":"3194","DOI":"10.1210\/jcem.81.9.8784068","article-title":"Allelic loss of the retinoblastoma tumor suppressor gene: A marker for aggressive parathyroid tumors?","volume":"81","author":"Dotzenrath","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"2021122207232484100_R27","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1046\/j.1365-2265.1996.d01-1561.x","article-title":"Loss of heterozygosity studies at the retinoblastoma and breast cancer susceptibility (BRCA2) loci in pituitary, parathyroid, pancreatic and carcinoid tumours","volume":"45","author":"Pearce","year":"1996","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2021122207232484100_R28","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1111\/j.1445-2197.1995.tb00542.x","article-title":"Inactivation of retinoblastoma gene in malignant parathyroid growths: A candidate genetic trigger?","volume":"65","author":"Subramaniam","year":"1995","journal-title":"Aust N Z J Surg"},{"key":"2021122207232484100_R29","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s002689900567","article-title":"Evaluation of retinoblastoma and Ki-67 immunostaining as diagnostic markers of benign and malignant parathyroid disease","volume":"23","author":"Farnebo","year":"1999","journal-title":"World J Surg"},{"key":"2021122207232484100_R30","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1046\/j.1365-2265.2003.01814.x","article-title":"Mutational analyses of RB and BRCA2 as candidate tumour suppressor genes in parathyroid carcinoma","volume":"59","author":"Shattuck","year":"2003","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2021122207232484100_R31","first-page":"1320","article-title":"p53 abnormalities in human parathyroid carcinoma","volume":"78","author":"Cryns","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"key":"2021122207232484100_R32","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1111\/j.1365-2265.2007.02894.x","article-title":"Identification of MEN1 and HRPT2 somatic mutations in paraffin-embedded (sporadic) parathyroid carcinomas","volume":"67","author":"Haven","year":"2007","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2021122207232484100_R33","first-page":"412","article-title":"Expression of cyclin D1 in parathyroid carcinomas, adenomas, and hyperplasias: A paraffin immunohistochemical study","volume":"12","author":"Vasef","year":"1999","journal-title":"Mod Pathol"},{"key":"2021122207232484100_R34","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1038\/sj.onc.1208274","article-title":"Parafibromin, product of the hyperparathyroidism-jaw tumor syndrome gene HRPT2, regulates cyclin D1\/PRAD1 expression","volume":"24","author":"Woodard","year":"2005","journal-title":"Oncogene"},{"key":"2021122207232484100_R35","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1136\/jmg.40.9.657","article-title":"HRPT2 mutations are associated with malignancy in sporadic parathyroid tumours","volume":"40","author":"Howell","year":"2003","journal-title":"J Med Genet"},{"key":"2021122207232484100_R36","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/ng1048","article-title":"HRPT2, encoding parafibromin, is mutated in hyperparathyroidism-jaw tumor syndrome","volume":"32","author":"Carpten","year":"2002","journal-title":"Nat Genet"},{"key":"2021122207232484100_R37","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1056\/NEJMoa031237","article-title":"Somatic and germ-line mutations of the HRPT2 gene in sporadic parathyroid carcinoma","volume":"349","author":"Shattuck","year":"2003","journal-title":"N Engl J Med"},{"key":"2021122207232484100_R38","doi-asserted-by":"crossref","first-page":"17420","DOI":"10.1073\/pnas.0710725105","article-title":"The parafibromin tumor suppressor protein inhibits cell proliferation by repression of the c-myc proto-oncogene","volume":"105","author":"Lin","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2021122207232484100_R39","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1007\/s00774-008-0032-8","article-title":"Stimulating parathyroid cell proliferation and PTH release with phosphate in organ cultures obtained from patients with primary and secondary hyperparathyroidism for a prolonged period","volume":"27","author":"Nakajima","year":"2009","journal-title":"J Bone Miner Metab"},{"key":"2021122207232484100_R40","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/s00268-005-0708-3","article-title":"Differential RNA expression profile by cDNA microarray in sporadic primary hyperparathyroidism (pHPT): Primary parathyroid hyperplasia versus adenoma","volume":"30","author":"Vel\u00e1zquez-Fern\u00e1ndez","year":"2006","journal-title":"World J Surg"},{"key":"2021122207232484100_R41","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1530\/eje.1.01864","article-title":"Distinction in gene expression profiles demonstrated in parathyroid adenomas by high-density oligoarray technology","volume":"152","author":"Forsberg","year":"2005","journal-title":"Eur J Endocrinol"},{"key":"2021122207232484100_R42","doi-asserted-by":"crossref","first-page":"7405","DOI":"10.1158\/0008-5472.CAN-04-2063","article-title":"Gene expression of parathyroid tumors: Molecular subclassification and identification of the potential malignant phenotype","volume":"64","author":"Haven","year":"2004","journal-title":"Cancer Res"},{"key":"2021122207232484100_R43","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1210\/jc.2008-1740","article-title":"Accuracy of combined protein gene product 9.5 and parafibromin markers for immunohistochemical diagnosis of parathyroid carcinoma","volume":"94","author":"Howell","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"2021122207232484100_R44","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.amjoto.2008.05.006","article-title":"Parathyroid carcinoma: Clinical presentation and management","volume":"30","author":"Schoretsanitis","year":"2009","journal-title":"Am J Otolaryngol"},{"key":"2021122207232484100_R45","first-page":"463","article-title":"Nonfunctioning parathyroid carcinoma","volume":"57","author":"Klink","year":"1991","journal-title":"Am Surg"},{"key":"2021122207232484100_R46","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1002\/1097-0142(19820115)49:2<388::AID-CNCR2820490230>3.0.CO;2-F","article-title":"Parathyroid carcinoma: A clinical study of seven cases of functioning and two cases of nonfunctioning parathyroid cancer","volume":"49","author":"Aldinger","year":"1982","journal-title":"Cancer"},{"key":"2021122207232484100_R47","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0039-6109(16)44188-5","article-title":"How to recognize and treat parathyroid carcinoma","volume":"67","author":"Fujimoto","year":"1987","journal-title":"Surg Clin North Am"},{"key":"2021122207232484100_R48","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/0002-9343(90)90346-F","article-title":"Nephrolithiasis and bone involvement in primary hyperparathyroidism","volume":"89","author":"Silverberg","year":"1990","journal-title":"Am J Med"},{"key":"2021122207232484100_R49","first-page":"458","article-title":"Case report: Clinical pathological correlations in a case of primary parathyroid carcinoma","volume":"14","author":"Laks","year":"1984","journal-title":"Ann Clin Lab Sci"},{"key":"2021122207232484100_R50","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1507\/endocrj.48.213","article-title":"Ultrasonographic features of parathyroid carcinoma","volume":"48","author":"Hara","year":"2001","journal-title":"Endocr J"},{"key":"2021122207232484100_R51","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1097\/RLU.0b013e318162dd4d","article-title":"Tc-99m pertechnetate\/sestamibi subtraction scan in a case of parathyroid carcinoma","volume":"33","author":"Singhal","year":"2008","journal-title":"Clin Nucl Med"},{"key":"2021122207232484100_R52","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1055\/s-0038-1629843","article-title":"A case of parathyroid carcinoma visualized on Tc-99m-sestamibi scintigraphy","volume":"36","author":"Aigner","year":"1997","journal-title":"Nuklearmedizin"},{"key":"2021122207232484100_R53","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/00003072-199901000-00005","article-title":"Detection of metastatic parathyroid carcinoma with Tc-99m sestamibi imaging","volume":"24","author":"Al-Sobhi","year":"1999","journal-title":"Clin Nucl Med"},{"key":"2021122207232484100_R54","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1097\/00003072-200411000-00001","article-title":"Providing optimal preoperative localization for recurrent parathyroid carcinoma: A combined parathyroid scintigraphy and computed tomography approach","volume":"29","author":"Clark","year":"2004","journal-title":"Clin Nucl Med"},{"key":"2021122207232484100_R55","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/s00423-006-0095-8","article-title":"Implantation of parathyroid carcinoma along fine needle aspiration track","volume":"391","author":"Agarwal","year":"2006","journal-title":"Langenbecks Arch Surg"},{"key":"2021122207232484100_R56","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/BF03343718","article-title":"Cutaneous spreading of parathyroid carcinoma after fine needle aspiration cytology","volume":"23","author":"Spinelli","year":"2000","journal-title":"J Endocrinol Invest"},{"key":"2021122207232484100_R57","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0960-7404(99)00037-7","article-title":"Parathyroid cancer: Biology and management","volume":"8","author":"Koea","year":"1999","journal-title":"Surg Oncol"},{"key":"2021122207232484100_R58","first-page":"704","article-title":"Carcinoma of the parathyroid gland: A 30-year experience","volume":"110","author":"Shortell","year":"1991","journal-title":"Surgery"},{"key":"2021122207232484100_R59","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1177\/014556130408300718","article-title":"Parathyroid carcinoma: A multicenter review of clinicopathologic features and treatment outcomes","volume":"83","author":"Wiseman","year":"2004","journal-title":"Ear Nose Throat J"},{"key":"2021122207232484100_R60","first-page":"906","article-title":"Parathyroid carcinoma: Features and difficulties in diagnosis and management","volume":"94","author":"Anderson","year":"1983","journal-title":"Surgery"},{"key":"2021122207232484100_R61","first-page":"154","article-title":"Parathyroid carcinoma, adenoma and hyperplasia in a case of chronic renal insufficiency on dialysis","volume":"18","author":"Berland","year":"1982","journal-title":"Clin Nephrol"},{"key":"2021122207232484100_R62","first-page":"100","article-title":"Parathyroid carcinoma secondary to prolonged hyperplasia in chronic renal failure and in coeliac disease","volume":"25","author":"Boyle","year":"1999","journal-title":"Eur J Surg Oncol"},{"key":"2021122207232484100_R63","first-page":"649","article-title":"Parathyroid carcinoma versus parathyroid adenoma in patients with profound hypercalcemia","volume":"101","author":"Levin","year":"1987","journal-title":"Surgery"},{"key":"2021122207232484100_R64","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/S0002-9610(85)80178-1","article-title":"Recurrent hyperparathyroidism due to implantation of parathyroid tissue","volume":"149","author":"Rattner","year":"1985","journal-title":"Am J Surg"},{"key":"2021122207232484100_R65","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1002\/cncr.20089","article-title":"Parathyroid carcinoma: Evaluation and interdisciplinary management","volume":"100","author":"Clayman","year":"2004","journal-title":"Cancer"},{"key":"2021122207232484100_R66","first-page":"882","article-title":"Parathyroid carcinoma: Diagnosis and clinical history","volume":"114","author":"Vetto","year":"1993","journal-title":"Surgery"},{"key":"2021122207232484100_R67","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1055\/s-2007-992155","article-title":"A case of parathyroid carcinoma with severe hungry bone syndrome and review of literature","volume":"116","author":"Rathi","year":"2008","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"2021122207232484100_R68","doi-asserted-by":"crossref","first-page":"152","DOI":"10.4158\/EP.9.2.152","article-title":"Thymic parathyroid carcinoma and postoperative hungry bone syndrome","volume":"9","author":"Chandran","year":"2003","journal-title":"Endocr Pract"},{"key":"2021122207232484100_R69","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1007\/s00268-004-7708-6","article-title":"Quick intraoperative parathyroid hormone assay: Surgical adjunct to allow limited parathyroidectomy, improve success rate, and predict outcome","volume":"28","author":"Irvin","year":"2004","journal-title":"World J Surg"},{"key":"2021122207232484100_R70","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/S0039-6060(97)90206-3","article-title":"Intraoperative parathyroid hormone monitoring during parathyroidectomy for secondary hyperparathyroidism","volume":"122","author":"Clary","year":"1997","journal-title":"Surgery"},{"key":"2021122207232484100_R71","doi-asserted-by":"crossref","first-page":"3216","DOI":"10.1245\/s10434-007-9590-6","article-title":"Intra-operative parathyroid hormone monitoring in patients with parathyroid cancer","volume":"14","author":"Sol\u00f3rzano","year":"2007","journal-title":"Ann Surg Oncol"},{"key":"2021122207232484100_R72","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.surg.2007.09.026","article-title":"Impact of 25-hydroxyvitamin D deficiency on perioperative parathyroid hormone kinetics and results in patients with primary hyperparathyroidism","volume":"142","author":"Untch","year":"2007","journal-title":"Surgery"},{"key":"2021122207232484100_R73","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1385\/EP:16:1:049","article-title":"Proposal for the histological classification of parathyroid carcinoma","volume":"16","author":"Kameyama","year":"2005","journal-title":"Endocr Pathol"},{"key":"2021122207232484100_R74","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1007\/BF01655086","article-title":"Surgical treatment of ten cases of parathyroid carcinoma: Importance of an initial en bloc tumor resection","volume":"8","author":"Fujimoto","year":"1984","journal-title":"World J Surg"},{"key":"2021122207232484100_R75","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1097\/01.pas.0000209827.39477.4f","article-title":"Loss of nuclear expression of parafibromin distinguishes parathyroid carcinomas and hyperparathyroidism-jaw tumor (HPT-JT) syndrome-related adenomas from sporadic parathyroid adenomas and hyperplasias","volume":"30","author":"Gill","year":"2006","journal-title":"Am J Surg Pathol"},{"key":"2021122207232484100_R76","first-page":"1040","article-title":"Surgical and medical management of patients with pulmonary metastasis from parathyroid carcinoma","volume":"114","author":"Obara","year":"1993","journal-title":"Surgery"},{"key":"2021122207232484100_R77","first-page":"931","article-title":"Surgical treatment of parathyroid carcinoma (review)","volume":"8","author":"Hoelting","year":"2001","journal-title":"Oncol Rep"},{"key":"2021122207232484100_R78","doi-asserted-by":"crossref","first-page":"3803","DOI":"10.1210\/jc.2007-0585","article-title":"Cinacalcet hydrochloride reduces the serum calcium concentration in inoperable parathyroid carcinoma","volume":"92","author":"Silverberg","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"2021122207232484100_R79","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1210\/jcem.83.4.4726","article-title":"Treatment of hypercalcemia secondary to parathyroid carcinoma with a novel calcimimetic agent","volume":"83","author":"Collins","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"2021122207232484100_R80","first-page":"1095","article-title":"Parathyroid carcinoma: The Lahey Clinic experience","volume":"98","author":"Cohn","year":"1985","journal-title":"Surgery"},{"key":"2021122207232484100_R81","first-page":"1132","article-title":"Parathyroid carcinoma: Biochemical and pathologic response to DTIC","volume":"96","author":"Calandra","year":"1984","journal-title":"Surgery"},{"key":"2021122207232484100_R82","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.surg.2008.08.030","article-title":"Loss of heterozygosity of selected tumor suppressor genes in parathyroid carcinoma","volume":"144","author":"Yip","year":"2008","journal-title":"Surgery"},{"key":"2021122207232484100_R83","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1002\/1097-0142(19901001)66:7<1555::AID-CNCR2820660721>3.0.CO;2-S","article-title":"Flow cytometric DNA analysis of parathyroid tumors. Implication of aneuploidy for pathologic and biologic classification","volume":"66","author":"Obara","year":"1990","journal-title":"Cancer"},{"key":"2021122207232484100_R84","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1002\/1097-0142(19900415)65:8<1789::AID-CNCR2820650820>3.0.CO;2-N","article-title":"Flow cytometric DNA analysis of parathyroid tumors with special reference to its diagnostic and prognostic value in parathyroid carcinoma","volume":"65","author":"Obara","year":"1990","journal-title":"Cancer"},{"key":"2021122207232484100_R85","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1097\/00000478-199308000-00007","article-title":"Histopathological variables and DNA cytometry in parathyroid carcinoma","volume":"17","author":"Bondeson","year":"1993","journal-title":"Am J Surg Pathol"},{"key":"2021122207232484100_R86","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1530\/EJE-08-0169","article-title":"Human chorionic gonadotropin measurements in parathyroid carcinoma","volume":"159","author":"Rubin","year":"2008","journal-title":"Eur J Endocrinol"}],"container-title":["The Oncologist"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1634\/theoncologist.2009-0185","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1634\/theoncologist.2009-0185","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/oncolo\/article-pdf\/15\/1\/61\/41842710\/oncolo_15_1_61.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/oncolo\/article-pdf\/15\/1\/61\/41842710\/oncolo_15_1_61.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T13:43:05Z","timestamp":1711114985000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/oncolo\/article\/15\/1\/61\/6399083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1,1]]},"references-count":86,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2010,1,5]]},"published-print":{"date-parts":[[2010,1,1]]}},"URL":"https:\/\/doi.org\/10.1634\/theoncologist.2009-0185","relation":{},"ISSN":["1083-7159","1549-490X"],"issn-type":[{"value":"1083-7159","type":"print"},{"value":"1549-490X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2010,1,1]]},"published":{"date-parts":[[2010,1,1]]}}}