{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T08:01:40Z","timestamp":1768550500739,"version":"3.49.0"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We present the case of a 25-year-old woman with a history of weakness, weight loss, anemia, and elevated liver enzymes. Outpatient diagnostic evaluation, including abdominal ultrasound and endoscopies, revealed no conclusive explanation for the clinical picture and the patient was admitted to our clinic. Because of the hepatosplenomegaly together with the elevated liver enzymes, one of our differential diagnoses was that of liver disease. To clarify this, we performed a minilaparoscopy, which showed multiple diffuse distributed spots of livid color without clear margins distributed all over both liver lobes. A biopsy taken from these areas revealed the diagnosis of peliosis hepatis with irregular and diffusely enlarged hepatic sinusoids with an irregular structure. Peliosis hepatis is associated with numerous infectious and neoplastic diseases, but also occurs as a result of toxic liver damage. Further evaluation of our patient with an x-ray and a computed tomography (CT) scan revealed a mediastinal mass and a CT-guided biopsy showed classical Hodgkin\u2019s lymphoma. After completing further screening, a definitive diagnosis of Hodgkin\u2019s lymphoma stage II\/N\/B (Ann-Arbor) was established and chemotherapy according to the German Hodgkin\u2019s study group protocol with bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone (the BEACOPP regimen) was initiated. After the first chemotherapy cycle, the patient\u2019s symptoms and laboratory values improved rapidly. Taken together, we present the case of a patient with peliosis hepatis as an uncommon manifestation of Hodgkin\u2019s lymphoma. Despite an extensive literature search, we could not find any case of peliosis hepatis associated with a de novo diagnosis of classical Hodgkin\u2019s disease.<\/jats:p>","DOI":"10.1634\/theoncologist.2009-0215","type":"journal-article","created":{"date-parts":[[2009,11,5]],"date-time":"2009-11-05T01:45:25Z","timestamp":1257385525000},"page":"1088-1094","source":"Crossref","is-referenced-by-count":20,"title":["First Reported Case of Disease: Peliosis Hepatis as Cardinal Symptom of Hodgkin\u2019s Lymphoma"],"prefix":"10.1093","volume":"14","author":[{"given":"Alexander","family":"Kleger","sequence":"first","affiliation":[{"name":"Department of Internal Medicine I, University Medical Centre Ulm, Centre for Internal Medicine, Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Bommer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, University Medical Centre Ulm, Centre for Internal Medicine, Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Kunze","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, University Medical Centre Ulm, Centre for Internal Medicine, Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jochen","family":"Klaus","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, University Medical Centre Ulm, Centre for Internal Medicine, Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Leithaeuser","sequence":"additional","affiliation":[{"name":"Department of Pathology, University Medical Centre Ulm, Centre for Internal Medicine, Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Wegener","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Medical Centre Ulm, Centre for Internal Medicine, Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido","family":"Adler","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, University Medical Centre Ulm, Centre for Internal Medicine, Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nektarios","family":"Dikopoulos","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, University Medical Centre Ulm, Centre for Internal Medicine, Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2009,11,4]]},"reference":[{"key":"2021122207132418400_R1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.3348\/kjr.2007.8.1.64","article-title":"Peliosis hepatis with hemorrhagic necrosis and rupture: A case report with emphasis on the multi-detector CT findings","volume":"8","author":"Kim","year":"2007","journal-title":"Korean J Radiol"},{"key":"2021122207132418400_R2","doi-asserted-by":"crossref","first-page":"e106","DOI":"10.3324\/haematol.11343","article-title":"Peliosis hepatis following treatment with androgen-steroids in patients with bone marrow failure syndromes","volume":"92","author":"Tsirigotis","year":"2007","journal-title":"Haematologica"},{"key":"2021122207132418400_R3","first-page":"385","article-title":"Peliosis hepatis; report of two cases","volume":"67","author":"Young","year":"1953","journal-title":"Am Rev Tuberc"},{"key":"2021122207132418400_R4","first-page":"572","article-title":"Generalized peliosis hepatis and cirrhosis after long-term use of oral contraceptives","volume":"83","author":"Erpecum","year":"1988","journal-title":"Am J Gastroenterol"},{"key":"2021122207132418400_R5","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1056\/NEJM199712253372603","article-title":"Molecular epidemiology of bartonella infections in patients with bacillary angiomatosis-peliosis","volume":"337","author":"Koehler","year":"1997","journal-title":"N Engl J Med"},{"key":"2021122207132418400_R6","first-page":"628","article-title":"Peliosis hepatis in Hodgkin\u2019s disease: An infrequent association","volume":"85","author":"Bhaskar","year":"1990","journal-title":"Am J Gastroenterol"},{"key":"2021122207132418400_R7","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1097\/00004836-200209000-00012","article-title":"Macroscopic and microscopic findings of livers in malignant hematologic disorders, biopsied under peritoneoscopy","volume":"35","author":"Iwai","year":"2002","journal-title":"J Clin Gastroenterol"},{"key":"2021122207132418400_R8","first-page":"205","article-title":"[Peliosis hepatis\u2014report of a case associated with cancer of the pancreas]","volume":"25","author":"Godoy","year":"1979","journal-title":"AMB Rev Assoc Med Bras"},{"key":"2021122207132418400_R9","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1111\/j.1440-1746.2006.03172.x","article-title":"Peliosis hepatis in a living related liver transplantation donor candidate","volume":"21","author":"Testa","year":"2006","journal-title":"J Gastroenterol Hepatol"},{"key":"2021122207132418400_R10","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1097\/00000441-200601000-00015","article-title":"Abdominal Castleman disease with mixed histopathology in a patient with iron deficiency anemia, growth retardation and peliosis hepatis","volume":"331","author":"Saritas","year":"2006","journal-title":"Am J Med Sci"},{"key":"2021122207132418400_R11","first-page":"428","article-title":"[Focal peliosis of the adult liver in combination with glycogenosis type I (v.Gierke). A case report and review of the recent literature]","volume":"30","author":"Eising","year":"1990","journal-title":"Radiologe"},{"key":"2021122207132418400_R12","first-page":"149","article-title":"A rare clinical entity misdiagnosed as a tumor: Peliosis hepatis","volume":"13","author":"Atila","year":"2007","journal-title":"Ulus Travma Acil Cerrahi Derg"},{"key":"2021122207132418400_R13","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1007\/s00535-003-1268-7","article-title":"Peliosis hepatis during postpartum period: Successful embolization of hepatic artery","volume":"39","author":"Omori","year":"2004","journal-title":"J Gastroenterol"},{"key":"2021122207132418400_R14","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1155\/2000\/94813","article-title":"Peliosis hepatis with intrahepatic hemorrhage: Successful embolization of the hepatic artery","volume":"11","author":"O\u2019Riordan","year":"2000","journal-title":"HPB Surg"},{"key":"2021122207132418400_R15","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1097\/00007611-200093060-00020","article-title":"Peliosis hepatis after treatment with 2-chloro-3\u2032-deoxyadenosine","volume":"93","author":"Gushiken","year":"2000","journal-title":"South Med J"},{"key":"2021122207132418400_R16","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.forsciint.2004.05.010","article-title":"Pathology of peliosis","volume":"149","author":"Tsokos","year":"2005","journal-title":"Forensic Sci Int"}],"container-title":["The Oncologist"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1634\/theoncologist.2009-0215","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1634\/theoncologist.2009-0215","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/oncolo\/article-pdf\/14\/11\/1088\/41842242\/oncolo_14_11_1088.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/oncolo\/article-pdf\/14\/11\/1088\/41842242\/oncolo_14_11_1088.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T07:32:38Z","timestamp":1640158358000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/oncolo\/article\/14\/11\/1088\/6398797"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11,1]]},"references-count":16,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2009,11,4]]},"published-print":{"date-parts":[[2009,11,1]]}},"URL":"https:\/\/doi.org\/10.1634\/theoncologist.2009-0215","relation":{},"ISSN":["1083-7159","1549-490X"],"issn-type":[{"value":"1083-7159","type":"print"},{"value":"1549-490X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2009,11,1]]},"published":{"date-parts":[[2009,11,1]]}}}