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Evidence on the relation of each to cancer is summarized, including esophageal, thyroid, colon, renal, liver, melanoma, multiple myeloma, rectum, gallbladder, leukemia, lymphoma, and prostate in men; and postmenopausal breast and endometrium in women. Different mechanisms drive etiologic pathways for these cancers. Weight loss, particularly among postmenopausal women, reduces risk for breast cancer. Among cancer patients, data are less robust, but we note a long history of poor outcomes after breast cancer among obese women. While evidence on obesity and outcomes for other cancers is mixed, growing evidence points to benefits of physical activity for breast and colon cancers. Dosing of chemotherapy and radiation therapy among obese patients is discussed and the impact on therapy-related toxicity is noted. Guidelines for counseling patients for weight loss and increased physical activity are presented and supported by strong evidence that increased physical activity leads to improved quality of life among cancer survivors. The \u201cFive A's\u201d model guides clinicians through a counseling session: assess, advise, agree, assist, arrange. The burden of obesity on society continues to increase and warrants closer attention by clinicians for both cancer prevention and improved outcomes after diagnosis.<\/jats:p>","DOI":"10.1634\/theoncologist.2009-0285","type":"journal-article","created":{"date-parts":[[2010,5,27]],"date-time":"2010-05-27T20:46:34Z","timestamp":1274993194000},"page":"556-565","source":"Crossref","is-referenced-by-count":624,"title":["Obesity and Cancer"],"prefix":"10.1093","volume":"15","author":[{"given":"Kathleen Y.","family":"Wolin","sequence":"first","affiliation":[{"name":"a Department of Surgery, Washington University School of Medicine, St. Louis, Missouri, USA"},{"name":"b Alvin J. Siteman Cancer Center, Barnes Jewish Hospital, and Washington University School of Medicine, St. Louis, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Carson","sequence":"additional","affiliation":[{"name":"b Alvin J. Siteman Cancer Center, Barnes Jewish Hospital, and Washington University School of Medicine, St. Louis, Missouri, USA"},{"name":"c Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham A.","family":"Colditz","sequence":"additional","affiliation":[{"name":"a Department of Surgery, Washington University School of Medicine, St. Louis, Missouri, USA"},{"name":"b Alvin J. Siteman Cancer Center, Barnes Jewish Hospital, and Washington University School of Medicine, St. Louis, Missouri, USA"},{"name":"c Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,5,27]]},"reference":[{"key":"2021122207520553700_R1","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1056\/NEJMoa021423","article-title":"Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults","volume":"348","author":"Calle","year":"2003","journal-title":"N Engl J Med"},{"key":"2021122207520553700_R2","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1001\/jama.288.14.1723","article-title":"Prevalence and trends in obesity among US adults, 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