{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T17:24:45Z","timestamp":1780334685715,"version":"3.54.1"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2010,5,19]],"date-time":"2010-05-19T00:00:00Z","timestamp":1274227200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Learning Objectives<\/jats:title>\n                  <jats:p>After completing this couse, the reader will be able to: Apply presymptomatic gene testing to family members with familial renal cancer in order to facilitate earlier diagnosis and treatment for this population.Use genetic testing for timely detection of familial renal cancer in carriers to enable earlier use and increased efficacy of VEGF and mTOR pathway inhibiting drugs.<\/jats:p>\n                  <jats:p>CME This article is available for continuing medical education credit at CME.TheOncologist.com.<\/jats:p>\n                  <jats:p>We discuss recent advances in the diagnosis and management of renal cell cancer (RCC) given the enhanced molecular genetics knowledge in this area. A number of hereditary renal cancer syndromes have been described, including von Hippel-Lindau disease, Birt-Hogg-Dub\u00e9 syndrome, hereditary leiomyomatosis\/RCC syndrome, and hereditary papillary renal cancer. Early molecular diagnosis now facilitates the management and prevention of RCC in families. Recommendations for screening in families are discussed.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1634\/theoncologist.2010-0023","type":"journal-article","created":{"date-parts":[[2010,5,20]],"date-time":"2010-05-20T01:09:54Z","timestamp":1274317794000},"page":"532-538","source":"Crossref","is-referenced-by-count":16,"title":["Advances in the Genetics of Familial Renal Cancer"],"prefix":"10.1093","volume":"15","author":[{"given":"Patrick J.","family":"Morrison","sequence":"first","affiliation":[{"name":"a Regional Medical Genetics Centre, Belfast City Hospital, Belfast, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deirdre E.","family":"Donnelly","sequence":"additional","affiliation":[{"name":"a Regional Medical Genetics Centre, Belfast City Hospital, Belfast, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Brew","family":"Atkinson","sequence":"additional","affiliation":[{"name":"b Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander P.","family":"Maxwell","sequence":"additional","affiliation":[{"name":"c Regional Nephrology Centre, Belfast City Hospital, Belfast, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,5,19]]},"reference":[{"key":"2021122207271802200_R1","volume-title":"What Are the Key Statistics for Kidney Cancer?","author":"American Cancer Society"},{"key":"2021122207271802200_R2","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1016\/S0140-6736(03)13643-4","article-title":"von Hippel-Lindau 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