{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T08:52:57Z","timestamp":1770972777113,"version":"3.50.1"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2011,6,14]],"date-time":"2011-06-14T00:00:00Z","timestamp":1308009600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5 R21 CA149803-02"],"award-info":[{"award-number":["5 R21 CA149803-02"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Learning Objectives<\/jats:title><jats:p>After completing this course, the reader will be able to: Identify situations in which contralateral prophylactic mastectomy may be appropriate in breast cancer patients.Describe epidemiological data on the clinical benefits of contralateral prophylactic mastectomy for patients with breast cancer.<\/jats:p><jats:p>CME This article is available for continuing medical education credit at CME.TheOncologist.com<\/jats:p><jats:p>The use of contralateral prophylactic mastectomy (CPM) in the U.S. among patients with unilateral invasive breast cancer increased by 150% from 1993 to 2003. Although CPM has been shown to reduce the risk for developing contralateral breast cancer, there is conflicting evidence on whether or not it reduces breast cancer mortality or overall death. The increase in the CPM rate is especially concerning among women with early-stage sporadic breast cancer who have a minimal annual risk for developing contralateral breast cancer, and for many of these women the risk for distant metastatic disease outweighs the risk for contralateral breast cancer. The lack of information about the clinical value of CPM in women with sporadic breast cancer is an important public health problem. This review evaluates current data on the clinical indications for CPM and long-term patient satisfaction and psychosocial outcomes. Gaps in knowledge about the clinical value of CPM, including patient- and physician-related psychosocial factors that influence the decision-making process of CPM among women with sporadic breast cancer, are highlighted.<\/jats:p><\/jats:sec>","DOI":"10.1634\/theoncologist.2011-0022","type":"journal-article","created":{"date-parts":[[2011,6,15]],"date-time":"2011-06-15T00:35:13Z","timestamp":1308098113000},"page":"935-941","source":"Crossref","is-referenced-by-count":43,"title":["Current Knowledge on Contralateral Prophylactic Mastectomy Among Women with Sporadic Breast Cancer"],"prefix":"10.1093","volume":"16","author":[{"given":"Abenaa M.","family":"Brewster","sequence":"first","affiliation":[{"name":"a Department of Clinical Cancer Prevention, University of Texas MD Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia A.","family":"Parker","sequence":"additional","affiliation":[{"name":"b Department of Behavioral Science, University of Texas MD Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2011,6,14]]},"reference":[{"key":"2021122310000627000_B1","doi-asserted-by":"crossref","first-page":"5203","DOI":"10.1200\/JCO.2007.12.3141","article-title":"Increasing use of contralateral prophylactic mastectomy for breast cancer patients: A trend toward more aggressive surgical treatment","volume":"25","author":"Tuttle","year":"2007","journal-title":"J Clin Oncol"},{"key":"2021122310000627000_B2","first-page":"CD002748","article-title":"Prophylactic mastectomy for the prevention of breast cancer","volume":"11","author":"Lostumbo","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"2021122310000627000_B3","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1053\/ejso.1999.0711","article-title":"Clinical and histological predictors of contralateral breast cancer","volume":"25","author":"Kollias","year":"1999","journal-title":"Eur J Surg Oncol"},{"key":"2021122310000627000_B4","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1002\/1097-0142(196412)17:12<1501::AID-CNCR2820171202>3.0.CO;2-P","article-title":"Bilateral primary breast cancer: A prospective clinicopathological study","volume":"17","author":"Robbins","year":"1964","journal-title":"Cancer"},{"key":"2021122310000627000_B5","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1200\/JCO.1993.11.8.1545","article-title":"Contralateral breast cancer: Clinical characteristics and impact on prognosis","volume":"11","author":"Healey","year":"1993","journal-title":"J Clin Oncol"},{"key":"2021122310000627000_B6","first-page":"904","article-title":"Contralateral breast carcinoma: An assessment of risk and prognosis in stage I (T1N0M0) and stage II (T1N1M0) patients with 20-year follow-up","volume":"106","author":"Rosen","year":"1989","journal-title":"Surgery"},{"key":"2021122310000627000_B7","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1002\/1097-0142(19850201)55:3<643::AID-CNCR2820550328>3.0.CO;2-L","article-title":"Age at first primary as a determinant of the incidence of bilateral breast cancer. 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