{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T12:58:03Z","timestamp":1780318683842,"version":"3.54.1"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2011,9,30]],"date-time":"2011-09-30T00:00:00Z","timestamp":1317340800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1NR010162\u201301A1"],"award-info":[{"award-number":["RO1NR010162\u201301A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1CA1222292.01"],"award-info":[{"award-number":["RO1CA1222292.01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1CA124481\u201301"],"award-info":[{"award-number":["RO1CA124481\u201301"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","award":["PEP-08\u2013299-01-PC1"],"award-info":[{"award-number":["PEP-08\u2013299-01-PC1"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background.<\/jats:title><jats:p>Vitamin D deficiency in noncancer patients is associated with symptoms of fatigue, muscle weakness, and depression. These symptoms are common among advanced cancer patients. We investigated the prevalence of low serum vitamin D levels in cancer patients with fatigue or poor appetite and their association with symptom burden and other correctable endocrine abnormalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>This was a retrospective review of 100 consecutive cancer patients with appetite or fatigue scores of \u22654 of 10 referred to a supportive care clinic. We investigated serum levels of 25(OH) vitamin D, cortisol, thyroid-stimulating hormone, and bioavailable testosterone. Symptoms were measured by the Edmonton Symptom Assessment Scale. Serum 25(OH) vitamin D &amp;lt;20 ng\/mL was considered deficient; \u226520 ng\/mL and &amp;lt;30 ng\/mL were considered insufficient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Patients were predominantly male (68%) and white (66%), with a median age of 60 years (range, 27\u201391 years). Gastrointestinal (30%) and lung (22%) cancers were predominant. Forty-seven patients (47%) were vitamin D deficient and 70 (70%) were insufficient. Thirteen of 70 patients (19%) with vitamin D insufficiency were on supplementation. Vitamin D deficiency was more common among nonwhites (82% versus 36%) and females. No significant association was found between vitamin D and symptoms. Hypogonadic males had a significantly lower mean 25(OH) vitamin D level than eugonadic males.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions.<\/jats:title><jats:p>Low vitamin D levels were highly prevalent among advanced cancer patients with cachexia or fatigue. Vitamin D deficiency was more frequent among nonwhite and female patients. Vitamin D levels were also significantly lower in male patients with hypogonadism.<\/jats:p><\/jats:sec>","DOI":"10.1634\/theoncologist.2011-0151","type":"journal-article","created":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T01:06:05Z","timestamp":1317431165000},"page":"1637-1641","source":"Crossref","is-referenced-by-count":60,"title":["Preliminary Report: Vitamin D Deficiency in Advanced Cancer Patients with Symptoms of Fatigue or Anorexia"],"prefix":"10.1093","volume":"16","author":[{"given":"Rony","family":"Dev","sequence":"first","affiliation":[{"name":"a Department of Palliative Care and Rehabilitation Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Egidio","family":"Del Fabbro","sequence":"additional","affiliation":[{"name":"a Department of Palliative Care and Rehabilitation Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary G.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"c Departments of Cancer Biology and Epidemiology and Prevention, Wake Forest University Health Sciences, Winston-Salem, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Hui","sequence":"additional","affiliation":[{"name":"a Department of Palliative Care and Rehabilitation Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shana L.","family":"Palla","sequence":"additional","affiliation":[{"name":"b Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noah","family":"Gutierrez","sequence":"additional","affiliation":[{"name":"a Department of Palliative Care and Rehabilitation Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Bruera","sequence":"additional","affiliation":[{"name":"a Department of Palliative Care and Rehabilitation Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,9,30]]},"reference":[{"key":"2021122304050654400_B1","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1111\/j.1756-185X.2010.01561.x","article-title":"Association between nonspecific skeletal pain and vitamin D deficiency","volume":"13","author":"Heidari","year":"2010","journal-title":"Int J Rheum Dis"},{"key":"2021122304050654400_B2","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.mam.2005.01.005","article-title":"Vitamin D in the aging musculoskeletal system: An authentic strength preserving hormone","volume":"26","author":"Montero-Odasso","year":"2005","journal-title":"Mol Aspects Med"},{"key":"2021122304050654400_B3","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.amjopharm.2010.02.004","article-title":"Extraskeletal effects of vitamin D in older adults: Cardiovascular disease, mortality, mood, and cognition","volume":"8","author":"Barnard","year":"2010","journal-title":"Am J Geriatr Pharmacother"},{"key":"2021122304050654400_B4","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1007\/s00520-005-0899-z","article-title":"Symptom clustering in advanced cancer","volume":"14","author":"Walsh","year":"2006","journal-title":"Support Care Cancer"},{"key":"2021122304050654400_B5","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1002\/(SICI)1097-0142(20000501)88:9<2164::AID-CNCR24>3.0.CO;2-5","article-title":"Validation of the Edmonton Symptom Assessment Scale","volume":"88","author":"Chang","year":"2000","journal-title":"Cancer"},{"key":"2021122304050654400_B6","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1056\/NEJMra070553","article-title":"Vitamin D deficiency","volume":"357","author":"Holick","year":"2007","journal-title":"N Engl J Med"},{"key":"2021122304050654400_B7","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1210\/jc.2006-1864","article-title":"Position statement: Utility, limitations, and pitfalls in measuring testosterone: An Endocrine Society position statement","volume":"92","author":"Rosner","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"2021122304050654400_B8","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1530\/EJE-08-0601","article-title":"Investigation, treatment and monitoring of late-onset hypogonadism in males: ISA, ISSAM, EAU, EAA and ASA recommendations","volume":"159","author":"Wang","year":"2008","journal-title":"Eur J Endocrinol"},{"key":"2021122304050654400_B9","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s00384-008-0593-y","article-title":"Chemotherapy is linked to severe vitamin D deficiency in patients with colorectal cancer","volume":"24","author":"Fakih","year":"2009","journal-title":"Int J Colorectal Dis"},{"key":"2021122304050654400_B10","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1093\/ajcn\/88.1.133","article-title":"Vitamin D insufficiency in a multiethnic cohort of breast cancer survivors","volume":"88","author":"Neuhouser","year":"2008","journal-title":"Am J Clin Nutr"},{"key":"2021122304050654400_B11","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1007\/s00520-011-1117-9","article-title":"Vitamin D depletion: Of clinical significance in advanced cancer?","volume":"19","author":"Stone","year":"2011","journal-title":"Support Care Cancer"},{"key":"2021122304050654400_B12","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/1475-2891-9-60","article-title":"Impact of oral vitamin D supplementation on serum 25-hydroxyvitamin D levels in oncology","volume":"9","author":"Vashi","year":"2010","journal-title":"Nutr J"},{"key":"2021122304050654400_B13","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.nutres.2010.12.001","article-title":"Prevalence and correlates of vitamin D deficiency in US adults","volume":"31","author":"Forrest","year":"2011","journal-title":"Nutr Res"},{"key":"2021122304050654400_B14","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1093\/ageing\/afq159","article-title":"Prevention and treatment of vitamin D deficiency in Dutch psychogeratric nursing home residents by weekly half-body UVB exposure after showering: A pilot study","volume":"40","author":"Chel","year":"2011","journal-title":"Age Ageing"},{"key":"2021122304050654400_B15","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1359\/jbmr.1998.13.8.1238","article-title":"Ultraviolet irradiation corrects vitamin D deficiency and suppresses secondary hyperparathyroidism in the elderly","volume":"13","author":"Chel","year":"1998","journal-title":"J Bone Miner Res"},{"key":"2021122304050654400_B16","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S0140-6736(78)92760-5","article-title":"Response of plasma-25-hydroxyvitamin D to ultraviolet irradiation in long-stay geriatric patients","volume":"2","author":"Corless","year":"1978","journal-title":"Lancet"},{"key":"2021122304050654400_B17","article-title":"Does increased sunlight exposure work as a strategy to improve vitamin D status in the elderly: A cluster randomised controlled trial","author":"Sambrook","year":"2011","journal-title":"Osteoporos Int"},{"key":"2021122304050654400_B18","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1200\/JCO.2006.07.5358","article-title":"Circulating 25-hydroxyvitamin D levels predict survival in early-stage non-small cell lung cancer patients","volume":"25","author":"Zhou","year":"2007","journal-title":"J Clin Oncol"},{"key":"2021122304050654400_B19","doi-asserted-by":"crossref","first-page":"3757","DOI":"10.1200\/JCO.2008.20.0725","article-title":"Prognostic effects of 25-hydroxyvitamin D levels in early breast cancer","volume":"27","author":"Goodwin","year":"2009","journal-title":"J Clin Oncol"},{"key":"2021122304050654400_B20","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/sj.bjc.6604865","article-title":"Association between serum 25(OH)D and death from prostate cancer","volume":"100","author":"Tretli","year":"2009","journal-title":"Br J Cancer"},{"key":"2021122304050654400_B21","doi-asserted-by":"crossref","first-page":"5596","DOI":"10.1200\/JCO.2008.18.0406","article-title":"Circulating 25-hydroxyvitamin D, VDR polymorphisms, and survival in advanced non-small-cell lung cancer","volume":"26","author":"Heist","year":"2008","journal-title":"J Clin Oncol"},{"key":"2021122304050654400_B22","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/j.1365-2265.2009.03777.x","article-title":"Association of vitamin D status with serum androgen levels in men","volume":"73","author":"Wehr","year":"2010","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2021122304050654400_B23","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1055\/s-0030-1269854","article-title":"Effect of vitamin D supplementation on testosterone levels in men","volume":"43","author":"Pilz","year":"2011","journal-title":"Horm Metab Res"},{"key":"2021122304050654400_B24","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1002\/cncr.20028","article-title":"Symptomatic hypogonadism in male survivors of cancer with chronic exposure to opioids","volume":"15:100","author":"Rajagopal","year":"2004","journal-title":"Cancer"},{"key":"2021122304050654400_B25","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.physbeh.2010.03.011","article-title":"Hypothalamic mechanisms in cachexia","volume":"100","author":"Grossberg","year":"2010","journal-title":"Physiol Behav"},{"key":"2021122304050654400_B26","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1017\/S0007114509992017","article-title":"Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient\u2014a randomised, placebo-controlled trial","volume":"103","author":"Hurst","year":"2010","journal-title":"Br J Nutr"},{"key":"2021122304050654400_B27","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ejheart.2006.04.006","article-title":"The effect of testosterone on insulin sensitivity in men with heart failure","volume":"9","author":"Malkin","year":"2007","journal-title":"Eur J Heart Fail"},{"key":"2021122304050654400_B28","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1097\/MCO.0b013e32832a7902","article-title":"Systemic inflammation, nutritional status and survival in patients with cancer","volume":"12","author":"McMillan","year":"2009","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"2021122304050654400_B29","article-title":"Vitamin D deficiency in an Australian inpatient hospice population","author":"To","year":"2010","journal-title":"J Pain Symptom Manage"},{"key":"2021122304050654400_B30","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1111\/j.1532-5415.2010.03142.x","article-title":"A randomized controlled trial of the effects of vitamin D on muscle strength and mobility in older women with vitamin D insufficiency","volume":"58","author":"Zhu","year":"2010","journal-title":"J Am Geriatr Soc"},{"key":"2021122304050654400_B31","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/j.1532-5415.2007.01048.x","article-title":"A higher dose of vitamin D reduces the risk of falls in nursing home residents: A randomized, multiple-dose study","volume":"55","author":"Broe","year":"2007","journal-title":"J Am Geriatr Soc"},{"key":"2021122304050654400_B32","first-page":"424","article-title":"Effect of cholecalciferol plus calcium on falling in ambulatory older men and women: A 3-year randomized controlled trial","volume":"166","author":"Bischoff-Ferrari","year":"2006","journal-title":"Arch Intern Med"},{"key":"2021122304050654400_B33","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1111\/j.1532-5415.2005.00468.x","article-title":"Should older people in residential care receive vitamin D to prevent falls? Results of a randomized trial","volume":"53","author":"Flicker","year":"2005","journal-title":"J Am Geriatr Soc"},{"key":"2021122304050654400_B34","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1001\/jama.2010.594","article-title":"Annual high-dose oral vitamin D and falls and fractures in older women: A randomized controlled trial","volume":"303","author":"Sanders","year":"2010","journal-title":"JAMA"},{"key":"2021122304050654400_B35","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1007\/s00198-008-0573-7","article-title":"Additive benefit of higher testosterone levels and vitamin D plus calcium supplementation in regard to fall risk reduction among older men and women","volume":"19","author":"Bischoff-Ferrari","year":"2008","journal-title":"Osteoporos Int"},{"key":"2021122304050654400_B36","doi-asserted-by":"crossref","first-page":"R104","DOI":"10.1186\/cc10120","article-title":"Short-term effects of high-dose oral vitamin D3 in critically ill vitamin D deficient patients: A randomized, double-blind, placebo-controlled pilot study","volume":"15","author":"Amrein","year":"2011","journal-title":"Crit Care"}],"container-title":["The Oncologist"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1634\/theoncologist.2011-0151","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1634\/theoncologist.2011-0151","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/oncolo\/article-pdf\/16\/11\/1637\/41856137\/oncolo_16_11_1637.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/oncolo\/article-pdf\/16\/11\/1637\/41856137\/oncolo_16_11_1637.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,13]],"date-time":"2024-04-13T04:05:31Z","timestamp":1712981131000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/oncolo\/article\/16\/11\/1637\/6400829"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,30]]},"references-count":36,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2011,9,30]]},"published-print":{"date-parts":[[2011,11,1]]}},"URL":"https:\/\/doi.org\/10.1634\/theoncologist.2011-0151","relation":{},"ISSN":["1083-7159","1549-490X"],"issn-type":[{"value":"1083-7159","type":"print"},{"value":"1549-490X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2011,11,1]]},"published":{"date-parts":[[2011,9,30]]}}}