{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T23:51:42Z","timestamp":1773186702631,"version":"3.50.1"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2012,6,18]],"date-time":"2012-06-18T00:00:00Z","timestamp":1339977600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Learning Objectives<\/jats:title>\n                  <jats:p>After completing this course, the reader will be able to: Compare the diagnostic performances of 18F-FDG PET\/CT and conventional CT with respect to their ability to detect primary tumor sites in carcinoma of unknown primary patients with extracervical metastases.Describe the rate of identification of primary tumor sites using 18F-FDG PET\/CT and conventional CT.<\/jats:p>\n                  <jats:p>CME This article is available for continuing medical education credit at CME.TheOncologist.com<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Background.<\/jats:title>\n                  <jats:p>The aim of the present study was to evaluate prospectively the diagnostic value of 18F-fluorodeoxyglucose positron emission tomography\/computed tomography (18F-FDG PET\/CT) and conventional CT regarding the ability to detect the primary tumor site in patients with extracervical metastases from carcinoma of unknown primary (CUP) site.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Patients and Methods.<\/jats:title>\n                  <jats:p>From January 2006 to December 2010, 136 newly diagnosed CUP patients with extracervical metastases underwent 18F-FDG PET\/CT.<\/jats:p>\n                  <jats:p>A standard of reference (SR) was established by a multidisciplinary team to ensure that the same set of criteria were used for classification of patients, that is, either as CUP patients or patients with a suggested primary tumor site. The independently obtained suggestions of primary tumor sites using PET\/CT and CT were correlated with the SR to reach a consensus regarding true-positive (TP), true-negative, false-negative, and false-positive results.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results.<\/jats:title>\n                  <jats:p>SR identified a primary tumor site in 66 CUP patients (48.9%). PET\/CT identified 38 TP primary tumor sites and CT identified 43 TP primary tumor sites. No statistically significant differences were observed between 18F-FDG PET\/CT and CT alone in regard to sensitivity, specificity, and accuracy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion.<\/jats:title>\n                  <jats:p>In the general CUP population with multiple extracervical metastases 18F-FDG PET\/CT does not represent a clear diagnostic advantage over CT alone regarding the ability to detect the primary tumor site.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1634\/theoncologist.2011-0449","type":"journal-article","created":{"date-parts":[[2012,6,19]],"date-time":"2012-06-19T03:51:29Z","timestamp":1340077889000},"page":"1146-1154","source":"Crossref","is-referenced-by-count":47,"title":["A Prospective Comparison of 18F-FDG PET\/CT and CT as Diagnostic Tools to Identify the Primary Tumor Site in Patients with Extracervical Carcinoma of Unknown Primary Site"],"prefix":"10.1093","volume":"17","author":[{"given":"Anne Kirstine H.","family":"M\u00f8ller","sequence":"first","affiliation":[{"name":"a Department of Oncology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annika","family":"Loft","sequence":"additional","affiliation":[{"name":"b Department of Clinical Physiology, Nuclear Medicine, and PET, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne K.","family":"Berthelsen","sequence":"additional","affiliation":[{"name":"b Department of Clinical Physiology, Nuclear Medicine, and PET, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen D.","family":"Pedersen","sequence":"additional","affiliation":[{"name":"c Department of Radiology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesper","family":"Graff","sequence":"additional","affiliation":[{"name":"e Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital Hvidovre Hospital, Copenhagen, Denmark;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte B.","family":"Christensen","sequence":"additional","affiliation":[{"name":"b Department of Clinical Physiology, Nuclear Medicine, and PET, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junia C.","family":"Costa","sequence":"additional","affiliation":[{"name":"b Department of Clinical Physiology, Nuclear Medicine, and PET, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lene T.","family":"Skovgaard","sequence":"additional","affiliation":[{"name":"f Department of Biostatistics, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Perell","sequence":"additional","affiliation":[{"name":"a Department of Oncology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bodil L.","family":"Petersen","sequence":"additional","affiliation":[{"name":"d Department of Pathology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gedske","family":"Daugaard","sequence":"additional","affiliation":[{"name":"a Department of Oncology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2012,6,18]]},"reference":[{"key":"2021122308221280400_B1","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1016\/S0959-8049(03)00547-1","article-title":"Diagnostic and therapeutic management of cancer of an unknown primary","volume":"39","author":"Pavlidis","year":"2003","journal-title":"Eur J Cancer"},{"key":"2021122308221280400_B2","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.critrevonc.2008.09.005","article-title":"Carcinoma of unknown primary (CUP)","volume":"69","author":"Pavlidis","year":"2009","journal-title":"Crit Rev Oncol Hematol"},{"issue":"suppl 10","key":"2021122308221280400_B3","doi-asserted-by":"crossref","first-page":"x177","DOI":"10.1093\/annonc\/mdl256","article-title":"Treatment of patients with specific subsets of carcinoma of an unknown primary site","volume":"17","author":"Fizazi","year":"2006","journal-title":"Ann Oncol"},{"key":"2021122308221280400_B4","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1053\/j.seminoncol.2008.10.006","article-title":"Treatment for patients with unknown primary cancer and favorable prognostic factors","volume":"36","author":"Hainsworth","year":"2009","journal-title":"Semin Oncol"},{"key":"2021122308221280400_B5","first-page":"313","volume-title":"Textbook of Medical Oncology","author":"Daugaard","year":"2009","edition":"Fourth Edition"},{"key":"2021122308221280400_B6","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1016\/j.ejca.2007.06.023","article-title":"Switching benchmarks in cancer of unknown primary: From autopsy to microarray","volume":"43","author":"Pentheroudakis","year":"2007","journal-title":"Eur J Cancer"},{"key":"2021122308221280400_B7","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.ejrad.2009.03.051","article-title":"PET\/CT for the staging and follow-up of patients with malignancies","volume":"70","author":"Poeppel","year":"2009","journal-title":"Eur J Radiol"},{"key":"2021122308221280400_B8","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1056\/NEJMoa0900043","article-title":"Preoperative staging of lung cancer with combined PET-CT","volume":"361","author":"Fischer","year":"2009","journal-title":"N Engl J Med"},{"key":"2021122308221280400_B9","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.1056\/NEJMoa022136","article-title":"Staging of non-small-cell lung cancer with integrated positron-emission tomography and computed tomography","volume":"348","author":"Lardinois","year":"2003","journal-title":"N Engl J Med"},{"key":"2021122308221280400_B10","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1002\/hed.20734","article-title":"Prospective study of 18FDG-PET in the detection and management of patients with lymph node metastases to the neck from an unknown primary tumor. Results from the DAHANCA-13 study","volume":"30","author":"Johansen","year":"2008","journal-title":"Head Neck"},{"key":"2021122308221280400_B11","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1002\/hed.21635","article-title":"Carcinoma of unknown primary in the head and neck: Comparison between positron emission tomography (PET) and PET\/CT","volume":"33","author":"Keller","year":"2011","journal-title":"Head Neck"},{"key":"2021122308221280400_B12","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.oraloncology.2008.05.010","article-title":"Utility of combined (18)F-fluorodeoxyglucose-positron emission tomography and computed tomography in patients with cervical metastases from unknown primary tumors","volume":"45","author":"Roh","year":"2009","journal-title":"Oral Oncol"},{"key":"2021122308221280400_B13","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1002\/cncr.20687","article-title":"The role of fluorodeoxyglucose positron emission tomography in cervical lymph node metastases from an unknown primary tumor","volume":"101","author":"Rusthoven","year":"2004","journal-title":"Cancer"},{"key":"2021122308221280400_B14","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1007\/s00330-008-1194-4","article-title":"Combined FDG-PET\/CT for the detection of unknown primary tumors: Systematic review and meta-analysis","volume":"19","author":"Kwee","year":"2009","journal-title":"Eur Radiol"},{"key":"2021122308221280400_B15","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1634\/theoncologist.2010-0189","article-title":"18F-FDG PET\/CT as a diagnostic tool in patients with extracervical carcinoma of unknown primary site: A literature review","volume":"16","author":"M\u00f8ller","year":"2011","journal-title":"The Oncologist"},{"issue":"suppl 6","key":"2021122308221280400_B16","doi-asserted-by":"crossref","first-page":"vi64","DOI":"10.1093\/annonc\/mdr389","article-title":"Cancers of unknown primary site: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up","volume":"22","author":"Fizazi","year":"2011","journal-title":"Ann Oncol"},{"key":"2021122308221280400_B17","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1097\/MNM.0b013e328332b340","article-title":"The value of 18F-fluorodeoxyglucose positron emission tomography\/computed tomography in carcinoma of an unknown primary: Diagnosis and follow-up","volume":"31","author":"Yapar","year":"2010","journal-title":"Nucl Med Commun"},{"key":"2021122308221280400_B18","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1148\/radiol.2341031554","article-title":"Unknown primary tumors: Detection with dual-modality PET\/CT\u2014initial experience","volume":"234","author":"Gutzeit","year":"2005","journal-title":"Radiology"},{"key":"2021122308221280400_B19","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1007\/s00259-007-0564-5","article-title":"TNM staging with FDG-PET\/CT in patients with primary head and neck cancer","volume":"34","author":"Veit-Haibach","year":"2007","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"2021122308221280400_B20","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1007\/s11547-006-0112-6","article-title":"18F-FDG PET\/CT in the assessment of carcinoma of unknown primary origin","volume":"111","author":"Ambrosini","year":"2006","journal-title":"Radiol Med"},{"key":"2021122308221280400_B21","first-page":"15","article-title":"Role of whole body positron emission tomography\/computed tomography scan with 18F-fluorodeoxyglucose in patients with biopsy proven tumor metastases from unknown primary site","volume":"50","author":"Pelosi","year":"2006","journal-title":"Q J Nucl Med Mol Imaging"},{"key":"2021122308221280400_B22","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/1756-0500-4-56","article-title":"Detection of primary sites in unknown primary tumors using FDG-PET or FDG-PET\/CT","volume":"4","author":"Park","year":"2011","journal-title":"BMC Res Notes"},{"key":"2021122308221280400_B23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/b139071","volume-title":"Multidetector-Row Computed Tomography: Scanning and Contrast Protocols","author":"Marchal","year":"2005"},{"key":"2021122308221280400_B24","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1634\/theoncologist.2009-0328","article-title":"Molecular profiling in unknown primary cancer: Accuracy of tissue of origin prediction","volume":"15","author":"Greco","year":"2010","journal-title":"The Oncologist"},{"key":"2021122308221280400_B25","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s00428-009-0867-y","article-title":"Comparison of histopathological and gene expression-based typing of cancer of unknown primary","volume":"456","author":"Morawietz","year":"2010","journal-title":"Virchows Arch"},{"key":"2021122308221280400_B26","doi-asserted-by":"crossref","first-page":"4442","DOI":"10.1200\/JCO.2007.14.4378","article-title":"Molecular profiling of carcinoma of unknown primary and correlation with clinical evaluation","volume":"26","author":"Varadhachary","year":"2008","journal-title":"J Clin Oncol"}],"container-title":["The Oncologist"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1634\/theoncologist.2011-0449","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1634\/theoncologist.2011-0449","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/oncolo\/article-pdf\/17\/9\/1146\/41859335\/oncolo_17_9_1146.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/oncolo\/article-pdf\/17\/9\/1146\/41859335\/oncolo_17_9_1146.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T21:21:14Z","timestamp":1640294474000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/oncolo\/article\/17\/9\/1146\/6401534"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,18]]},"references-count":26,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2012,6,18]]},"published-print":{"date-parts":[[2012,9,1]]}},"URL":"https:\/\/doi.org\/10.1634\/theoncologist.2011-0449","relation":{},"ISSN":["1083-7159","1549-490X"],"issn-type":[{"value":"1083-7159","type":"print"},{"value":"1549-490X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2012,9,1]]},"published":{"date-parts":[[2012,6,18]]}}}