{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:49:21Z","timestamp":1790912961795,"version":"4.1.0"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2013,5,30]],"date-time":"2013-05-30T00:00:00Z","timestamp":1369872000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1NRO10162\u201301A1"],"award-info":[{"award-number":["RO1NRO10162\u201301A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1CA122292\u201301"],"award-info":[{"award-number":["RO1CA122292\u201301"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1CA124481\u201301"],"award-info":[{"award-number":["RO1CA124481\u201301"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007313","name":"MD Anderson Cancer Center","doi-asserted-by":"publisher","award":["CA016672"],"award-info":[{"award-number":["CA016672"]}],"id":[{"id":"10.13039\/100007313","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction.<\/jats:title>\n                  <jats:p>The factors associated with successful opioid discontinuation after cancer treatment are not well-known. We determined the proportion of patients with advanced head and neck cancer who continued using opioids 3 months after the completion of radiation therapy with or without chemotherapy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods.<\/jats:title>\n                  <jats:p>We included 70 patients with head and neck cancer referred to our institution's supportive care center between January 1, 2008, and December 31, 2010. Patients who no longer used opioids 3 months after the completion of radiation therapy were classified as stoppers; patients who continued using opioids were considered nonstoppers. We compared demographics, cancer-related characteristics, alcoholism, substance abuse history, use of psychoactive drugs, and opioid-related factors between stoppers and nonstoppers.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results.<\/jats:title>\n                  <jats:p>In all, 44 of 70 patients (63%) and 23 of 70 patients (33%) continued opioids 3 months and 6 months after the completion of radiation therapy, respectively. A total of 18 of 44 nonstoppers (41%) and 3 of 26 stoppers (12%) were positive for alcoholism based on the CAGE questionnaire (i.e., Cut down, Annoying, Guilty, Eye opener; odds ratio: 5.3). Demographic and clinical characteristics did not differ between stoppers and nonstoppers. The median duration of any type of opioid use of CAGE-positive patients was significantly longer than that of CAGE-negative patients (median: 261 days vs. 93 days; hazard ratio: 2.5).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion.<\/jats:title>\n                  <jats:p>CAGE positivity is a risk factor for opioid use beyond 3 months after the completion of radiation therapy and for duration of opioid treatment. Routine CAGE screening and meticulous follow-up are needed for these patients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1634\/theoncologist.2013-0001","type":"journal-article","created":{"date-parts":[[2013,5,31]],"date-time":"2013-05-31T05:29:13Z","timestamp":1369978153000},"page":"768-774","source":"Crossref","is-referenced-by-count":71,"title":["Predictors of Long-Term Opioid Treatment Among Patients Who Receive Chemoradiation for Head and Neck Cancer"],"prefix":"10.1093","volume":"18","author":[{"given":"Jung Hye","family":"Kwon","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Kangdong Sacred Heart Hospital, Hallym University, Seoul, Republic of Korea;"},{"name":"Department of Palliative Care and Rehabilitation Medicine, MD Anderson Cancer Center, The University of Texas, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Hui","sequence":"additional","affiliation":[{"name":"Department of Palliative Care and Rehabilitation Medicine, MD Anderson Cancer Center, The University of Texas, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Chisholm","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, MD Anderson Cancer Center, The University of Texas, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Bruera","sequence":"additional","affiliation":[{"name":"Department of Palliative Care and Rehabilitation Medicine, MD Anderson Cancer Center, The University of Texas, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,5,30]]},"reference":[{"key":"2021122308335055000_B1","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/ncponc0750","article-title":"The chemoradiation paradigm in head and neck cancer","volume":"4","author":"Seiwert","year":"2008","journal-title":"Nat Clin Pract Oncol"},{"key":"2021122308335055000_B2","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0167-8140(02)00404-8","article-title":"Mucositis incidence, severity and associated outcomes in patients with head and neck cancer receiving radiotherapy with or without chemotherapy: A systematic literature review","volume":"66","author":"Trotti","year":"2003","journal-title":"Radiother Oncol"},{"key":"2021122308335055000_B3","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.ijrobp.2007.03.010","article-title":"Effects of prolongation of overall treatment time due to unplanned interruptions during radiotherapy of different tumor sites and practical methods for compensation","volume":"68","author":"Bese","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"2021122308335055000_B4","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0360-3016(97)00716-5","article-title":"Similar decreases in local tumor control are calculated for treatment protraction and for interruptions in the radiotherapy of carcinoma of the larynx in four centers","volume":"40","author":"Robertson","year":"1998","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"2021122308335055000_B5","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.radonc.2011.09.016","article-title":"Multicenter phase II study of an opioid-based pain control program for head and neck cancer patients receiving chemoradiotherapy","volume":"101","author":"Zenda","year":"2011","journal-title":"Radiother Oncol"},{"key":"2021122308335055000_B6","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1007\/s005200050256","article-title":"Low-energy He\/Ne laser in the prevention of radiation-induced mucositis. 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