{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:40:15Z","timestamp":1792802415085,"version":"4.5.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2014,2,25]],"date-time":"2014-02-25T00:00:00Z","timestamp":1393286400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"2012 American Society of Hematology Trainee Research Award","id":[{"id":"https:\/\/ror.org\/02nw48b86","id-type":"ROR","asserted-by":"crossref"}]},{"name":"2012 BC Cancer Studentship"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background.<\/jats:title>\n                    <jats:p>We examined the relationship between location of residence at the time of diagnosis of diffuse large B-cell lymphoma (DLBCL) and health outcomes in a geographically large Canadian province with publicly funded, universally available medical care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods.<\/jats:title>\n                    <jats:p>The British Columbia Cancer Registry was used to identify all patients 18\u201380 years of age diagnosed with DLBCL between January 2003 and December 2008. Home and treatment center postal codes were used to determine urban versus rural status and driving distance to access treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results.<\/jats:title>\n                    <jats:p>We identified 1,357 patients. The median age was 64 years (range: 18\u201380 years), 59% were male, 50% were stage III\/IV, 84% received chemotherapy with curative intent, and 32% received radiotherapy. There were 186 (14%) who resided in rural areas, 141 (10%) in small urban areas, 183 (14%) in medium urban areas, and 847 (62%) in large urban areas. Patient and treatment characteristics were similar regardless of location. Five-year overall survival (OS) was 62% for patients in rural areas, 44% in small urban areas, 53% in medium urban areas, and 60% in large urban areas (p = .018). In multivariate analysis, there was no difference in OS between rural and large urban area patients (hazard ratio [HR]: 1.0; 95% confidence interval [CI]: 0.7\u20131.4), although patients in small urban areas (HR: 1.4; 95% CI: 1.0\u20132.0) and medium urban areas (HR: 1.4; 95% CI: 1.0\u20131.9) had worse OS than those in large urban areas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion.<\/jats:title>\n                    <jats:p>Place of residence at diagnosis is associated with survival of patients with DLBCL in British Columbia, Canada. Rural patients have similar survival to those in large urban areas, whereas patients living in small and medium urban areas experience worse outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1634\/theoncologist.2013-0343","type":"journal-article","created":{"date-parts":[[2014,2,26]],"date-time":"2014-02-26T00:53:32Z","timestamp":1393376012000},"page":"283-290","source":"Crossref","is-referenced-by-count":30,"title":["Effect of Place of Residence and Treatment on Survival Outcomes in Patients With Diffuse Large B-Cell Lymphoma in British Columbia"],"prefix":"10.1093","volume":"19","author":[{"given":"Benny","family":"Lee","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozge","family":"Goktepe","sequence":"additional","affiliation":[{"name":"Centre for Lymphoid Cancer, British Columbia Cancer Agency, Vancouver, British Columbia, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Hay","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph M.","family":"Connors","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada;"},{"name":"Centre for Lymphoid Cancer, British Columbia Cancer Agency, Vancouver, British Columbia, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie H.","family":"Sehn","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada;"},{"name":"Centre for Lymphoid Cancer, British Columbia Cancer Agency, Vancouver, British Columbia, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry J.","family":"Savage","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada;"},{"name":"Centre for Lymphoid Cancer, British Columbia Cancer Agency, Vancouver, British Columbia, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Shenkier","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada;"},{"name":"Centre for Lymphoid Cancer, British Columbia Cancer Agency, Vancouver, British Columbia, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Klasa","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada;"},{"name":"Centre for Lymphoid Cancer, British Columbia Cancer Agency, Vancouver, British Columbia, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina","family":"Gerrie","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada;"},{"name":"Centre for Lymphoid Cancer, British Columbia Cancer Agency, Vancouver, British Columbia, Canada;"},{"name":"Leukemia\/Bone Marrow Transplantation Program of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Villa","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada;"},{"name":"Centre for Lymphoid Cancer, British Columbia Cancer Agency, Vancouver, British Columbia, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,2,25]]},"reference":[{"key":"2021122308454438700_B1","first-page":"44","article-title":"Rural-urban differences in cancer care: Results from the Lake Superior Rural Cancer Care Project","volume":"87","author":"Elliott","year":"2004","journal-title":"Minn Med"},{"key":"2021122308454438700_B2","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/BF03404068","article-title":"Effect of community population size on breast cancer screening, stage distribution, treatment use and outcomes","volume":"103","author":"Olson","year":"2012","journal-title":"Can J Public Health"},{"issue":"Suppl","key":"2021122308454438700_B3","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1002\/cncr.22016","article-title":"Colorectal cancer stage at diagnosis by socioeconomic and urban\/rural status in California, 1988-2000","volume":"107","author":"Parikh-Patel","year":"2006","journal-title":"Cancer"},{"key":"2021122308454438700_B4","doi-asserted-by":"crossref","first-page":"293","DOI":"10.5694\/j.1326-5377.2011.tb02977.x","article-title":"Urban-rural differences in prostate cancer outcomes in Australia: What has changed?","volume":"194","author":"Baade","year":"2011","journal-title":"Med J Aust"},{"key":"2021122308454438700_B5","doi-asserted-by":"crossref","first-page":"112","DOI":"10.5694\/j.1326-5377.2005.tb06609.x","article-title":"Urban-rural differences in prostate cancer mortality, radical prostatectomy and prostate-specific antigen testing in Australia","volume":"182","author":"Coory","year":"2005","journal-title":"Med J Aust"},{"key":"2021122308454438700_B6","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.breast.2010.03.032","article-title":"Variation in the management of early breast cancer in rural and metropolitan centres: Implications for the organisation of rural cancer services","volume":"19","author":"Craft","year":"2010","journal-title":"Breast"},{"key":"2021122308454438700_B7","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1111\/j.1445-2197.2006.03917.x","article-title":"Urban-rural differences in the management of screen-detected invasive breast cancer and ductal carcinoma in situ in victoria","volume":"76","author":"Kok","year":"2006","journal-title":"ANZ J Surg"},{"key":"2021122308454438700_B8","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1080\/03630242.2012.674091","article-title":"Disparities in late stage diagnosis, treatment, and breast cancer-related death by race, age, and rural residence among women in Georgia","volume":"52","author":"Markossian","year":"2012","journal-title":"Women Health"},{"key":"2021122308454438700_B9","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1002\/cncr.23229","article-title":"Geographic access to cancer care in the U.S","volume":"112","author":"Onega","year":"2008","journal-title":"Cancer"},{"key":"2021122308454438700_B10","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.clon.2010.06.006","article-title":"Utilisation of radiotherapy in rural and urban areas in British Columbia compared with evidence-based estimates of radiotherapy needs for patients with breast, prostate and lung cancer","volume":"22","author":"Tyldesley","year":"2010","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"2021122308454438700_B11","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/j.1748-0361.2011.00390.x","article-title":"Differences in late-stage diagnosis, treatment, and colorectal cancer-related death between rural and urban African Americans and whites in Georgia","volume":"28","author":"Hines","year":"2012","journal-title":"J Rural Health"},{"key":"2021122308454438700_B12","doi-asserted-by":"crossref","first-page":"5376","DOI":"10.1200\/JCO.2009.22.0038","article-title":"Survival disparities in patients with lymphoma according to place of residence and treatment provider: A population-based study","volume":"27","author":"Loberiza","year":"2009","journal-title":"J Clin Oncol"},{"key":"2021122308454438700_B13","doi-asserted-by":"crossref","first-page":"2979","DOI":"10.1182\/blood-2004-10-3863","article-title":"Association of transplant center and physician factors on mortality after hematopoietic stem cell transplantation in the United States","volume":"105","author":"Loberiza","year":"2005","journal-title":"Blood"},{"key":"2021122308454438700_B14","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1016\/j.bbmt.2007.09.006","article-title":"Disparity in survival outcome after hematopoietic stem cell transplantation for hematologic malignancies according to area of primary residence","volume":"13","author":"Rao","year":"2007","journal-title":"Biol Blood Marrow Transplant"},{"key":"2021122308454438700_B15","volume-title":"BC Cancer Agency. Communities Oncology Network","year":"2013"},{"key":"2021122308454438700_B16","volume-title":"BC Cancer Agency. BC cancer statistics","year":"2013"},{"key":"2021122308454438700_B17","volume-title":"Statistics Canada. Postal code conversion file (PCCF)","year":"2013"},{"key":"2021122308454438700_B18","volume-title":"Definitions of \u201crural.\u201d","author":"Statistics Canada","year":"2013"},{"key":"2021122308454438700_B19","volume-title":"Income and taxation: Neighbourhood income and demographics, 2006","author":"BCStats","year":"2013"},{"key":"2021122308454438700_B20","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/BF02888350","article-title":"Likelihood and the Bayes procedure","volume":"31","author":"Akaike","year":"1980","journal-title":"Trabajos de Estadistica Y de Investigacion Operativa"},{"key":"2021122308454438700_B21","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/01621459.1958.10501452","article-title":"Nonparametric estimation from incomplete observations","volume":"53","author":"Kaplan","year":"1958","journal-title":"J Am Stat Assoc"},{"key":"2021122308454438700_B22","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1200\/JCO.1996.14.3.925","article-title":"Adults and children with small non-cleaved-cell lymphoma have a similar excellent outcome when treated with the same chemotherapy regimen","volume":"14","author":"Magrath","year":"1996","journal-title":"J Clin Oncol"},{"key":"2021122308454438700_B23","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1038\/bmt.2009.332","article-title":"Does location matter? Rural vs urban outcomes after blood and marrow transplantation in a population-based Canadian cohort","volume":"45","author":"Paulson","year":"2010","journal-title":"Bone Marrow Transplant"},{"key":"2021122308454438700_B24","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.bbmt.2009.10.028","article-title":"Outcomes of hematologic malignancies after unrelated donor hematopoietic cell transplantation according to place of residence","volume":"16","author":"Loberiza","year":"2010","journal-title":"Biol Blood Marrow Transplant"}],"container-title":["The Oncologist"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pericles-gcp.literatumonline.com\/doi\/pdf\/10.1634\/theoncologist.2013-0343","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pericles-gcp.literatumonline.com\/doi\/full-xml\/10.1634\/theoncologist.2013-0343","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/oncolo\/article-pdf\/19\/3\/283\/41861209\/oncolo_19_3_283.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/oncolo\/article-pdf\/19\/3\/283\/41861209\/oncolo_19_3_283.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T20:25:42Z","timestamp":1640291142000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/oncolo\/article\/19\/3\/283\/6399295"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,25]]},"references-count":24,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,2,25]]},"published-print":{"date-parts":[[2014,3,1]]}},"URL":"https:\/\/doi.org\/10.1634\/theoncologist.2013-0343","relation":{},"ISSN":["1083-7159","1549-490X"],"issn-type":[{"value":"1083-7159","type":"print"},{"value":"1549-490X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2014,3,1]]},"published":{"date-parts":[[2014,2,25]]}}}