{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:11:00Z","timestamp":1791875460872,"version":"4.3.4"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2014,2,25]],"date-time":"2014-02-25T00:00:00Z","timestamp":1393286400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Geriatric Oncologic Unit"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose.<\/jats:title>\n                    <jats:p>To assess solid cancer treatment feasibility in older patients<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods.<\/jats:title>\n                    <jats:p>Between 2007 and 2010, 385 consecutive elderly patients (mean age: 78.9 \u00b1 5.4 years; 47.8% males) with solid malignancies referred to two geriatric oncology clinics were included prospectively. We recorded feasibility of first-line chemotherapy (planned number of cycles in patients without metastases and three to six cycles depending on tumor site in patients with metastases), surgery (patient alive 30 days after successfully performed planned surgical procedure), radiotherapy (planned dose delivered), and hormonal therapy (planned drug dose given), and we recorded overall 1-year survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results.<\/jats:title>\n                    <jats:p>Main tumor sites were colorectal (28.6%), breast (23.1%), and prostate (10.9%), and 47% of patients had metastases. Planned cancer treatment was feasible in 65.7% of patients with metastases; this proportion was 59.0% for chemotherapy, 82.6% for surgery, 100% for radiotherapy, and 85.2% for hormonal therapy. In the group without metastases, feasibility proportions were 86.8% overall, 72.4% for chemotherapy, 95.7% for surgery, 96.4% for radiotherapy, and 97.9% for hormonal therapy. Factors independently associated with chemotherapy feasibility were good functional status defined as Eastern Cooperative Oncology Group performance status &amp;lt;2 (p &amp;lt; .0001) or activities of daily living &amp;gt;5 (p = .01), normal mobility defined as no difficulty walking (p = .01) or no fall risk (p = .007), and higher creatinine clearance (p = .04).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion.<\/jats:title>\n                    <jats:p>Feasibility rates were considerably lower for chemotherapy than for surgery, radiotherapy, and hormonal therapy. Therefore, utilization of limited geriatric oncology resources may be optimized by preferential referral of elderly cancer patients initially considered for chemotherapy to geriatric oncology clinics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1634\/theoncologist.2013-0351","type":"journal-article","created":{"date-parts":[[2014,2,26]],"date-time":"2014-02-26T00:53:32Z","timestamp":1393376012000},"page":"275-282","source":"Crossref","is-referenced-by-count":36,"title":["Assessment of Solid Cancer Treatment Feasibility in Older Patients: A Prospective Cohort Study"],"prefix":"10.1093","volume":"19","author":[{"given":"Marie","family":"Laurent","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris Est, Facult\u00e9 de M\u00e9decine, LIC, EA4393 Cr\u00e9teil, France;"},{"name":"D\u00e9partement de M\u00e9decine Interne et G\u00e9riatrie, Unit\u00e9 de Coordination d'Onco-G\u00e9riatrie (UCOG-Sud Val de Marne), Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Paillaud","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Est, Facult\u00e9 de M\u00e9decine, LIC, EA4393 Cr\u00e9teil, France;"},{"name":"D\u00e9partement de M\u00e9decine Interne et G\u00e9riatrie, Unit\u00e9 de Coordination d'Onco-G\u00e9riatrie (UCOG-Sud Val de Marne), Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Tournigand","sequence":"additional","affiliation":[{"name":"Service d'Oncologie M\u00e9dicale, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Caillet","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Est, Facult\u00e9 de M\u00e9decine, LIC, EA4393 Cr\u00e9teil, France;"},{"name":"D\u00e9partement de M\u00e9decine Interne et G\u00e9riatrie, Unit\u00e9 de Coordination d'Onco-G\u00e9riatrie (UCOG-Sud Val de Marne), Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"Le Thuaut","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Est, Facult\u00e9 de M\u00e9decine, LIC, EA4393 Cr\u00e9teil, France;"},{"name":"Service de Sant\u00e9 Publique, Cr\u00e9teil, France"},{"name":"Unit\u00e9 de Recherche Clinique, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-L\u00e9on","family":"Lagrange","sequence":"additional","affiliation":[{"name":"Service de Radioth\u00e9rapie, H\u00f4pital Henri-Mondor, Cr\u00e9teil, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Beauchet","sequence":"additional","affiliation":[{"name":"Centre hospitalier universitaire, D\u00e9partement de Neuroscience, Division M\u00e9decine g\u00e9riatrique Angers, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Vincent","sequence":"additional","affiliation":[{"name":"AP-HP H\u00f4pital Paul Brousse, Service de soins de suite polyvalents, Villejuif, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muriel","family":"Carvahlo-Verlinde","sequence":"additional","affiliation":[{"name":"Service de Pharmacie, AP-HP, H\u00f4pital Henri-Mondor, Cr\u00e9teil, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Culine","sequence":"additional","affiliation":[{"name":"AP-HP, H\u00f4pital Saint-Louis, Service d'Oncologie M\u00e9dicale, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Bastuji-Garin","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Est, Facult\u00e9 de M\u00e9decine, LIC, EA4393 Cr\u00e9teil, France;"},{"name":"Service de Sant\u00e9 Publique, Cr\u00e9teil, 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