{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:58:37Z","timestamp":1788872317102,"version":"build-2803163510"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2014,6,20]],"date-time":"2014-06-20T00:00:00Z","timestamp":1403222400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Wolff-Toomim Fund"},{"name":"Texas Business Women Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background.<\/jats:title>\n                    <jats:p>Women with premenopausal breast cancer may face treatment-related infertility and have a higher likelihood of a BRCA mutation, which may affect their attitudes toward future childbearing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods.<\/jats:title>\n                    <jats:p>Premenopausal women were invited to participate in a questionnaire study administered before and after BRCA genetic testing. We used the Impact of Event Scale (IES) to evaluate the pre- and post-testing impact of cancer or carrying a BRCA mutation on attitudes toward future childbearing. The likelihood of pursuing prenatal diagnosis (PND) or preimplantation genetic diagnosis (PGD) was also assessed in this setting. Univariate analyses determined factors contributing to attitudes toward future childbearing and likelihood of PND or PGD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results.<\/jats:title>\n                    <jats:p>One hundred forty-eight pretesting and 114 post-testing questionnaires were completed. Women with a personal history of breast cancer had less change in IES than those with no history of breast cancer (p = .003). The 18 BRCA-positive women had a greater change in IES than the BRCA-negative women (p = .005). After testing, 31% and 24% of women would use PND and PGD, respectively. BRCA results did not significantly affect attitudes toward PND\/PGD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion.<\/jats:title>\n                    <jats:p>BRCA results and history of breast cancer affect the psychological impact on future childbearing. Intentions to undergo PND or PGD do not appear to change after disclosure of BRCA results. Additional counseling for patients who have undergone BRCA testing may be warranted to educate patients about available fertility preservation options.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1634\/theoncologist.2014-0057","type":"journal-article","created":{"date-parts":[[2014,6,21]],"date-time":"2014-06-21T03:53:39Z","timestamp":1403322819000},"page":"797-804","source":"Crossref","is-referenced-by-count":22,"title":["Breast Cancer, BRCA Mutations, and Attitudes Regarding Pregnancy and Preimplantation Genetic Diagnosis"],"prefix":"10.1093","volume":"19","author":[{"given":"Ashley H.","family":"Woodson","sequence":"first","affiliation":[{"name":"Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly I.","family":"Muse","sequence":"additional","affiliation":[{"name":"Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Jackson","sequence":"additional","affiliation":[{"name":"Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle N.","family":"Mattair","sequence":"additional","affiliation":[{"name":"Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie","family":"Schover","sequence":"additional","affiliation":[{"name":"Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terri","family":"Woodard","sequence":"additional","affiliation":[{"name":"Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie","family":"McKenzie","sequence":"additional","affiliation":[{"name":"Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard L.","family":"Theriault","sequence":"additional","affiliation":[{"name":"Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel N.","family":"Hortob\u00e1gyi","sequence":"additional","affiliation":[{"name":"Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Banu","family":"Arun","sequence":"additional","affiliation":[{"name":"Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan K.","family":"Peterson","sequence":"additional","affiliation":[{"name":"Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Profato","sequence":"additional","affiliation":[{"name":"Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer K.","family":"Litton","sequence":"additional","affiliation":[{"name":"Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,6,20]]},"reference":[{"key":"2021122309081851400_B1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3322\/caac.20138","article-title":"Cancer statistics, 2012","volume":"62","author":"Siegel","year":"2012","journal-title":"CA Cancer J Clin"},{"key":"2021122309081851400_B2","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1093\/humrep\/deg473","article-title":"Depletion of ovarian reserve in young women after treatment for cancer in childhood: Detection by anti-M\u00fcllerian hormone, inhibin B and ovarian ultrasound","volume":"18","author":"Bath","year":"2003","journal-title":"Hum Reprod"},{"key":"2021122309081851400_B3","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/0002-9378(92)91335-8","article-title":"Early menopause in long-term survivors of cancer during adolescence","volume":"166","author":"Byrne","year":"1992","journal-title":"Am J Obstet Gynecol"},{"key":"2021122309081851400_B4","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1200\/JCO.1999.17.8.2365","article-title":"Risk of menopause during the first year after breast cancer diagnosis","volume":"17","author":"Goodwin","year":"1999","journal-title":"J Clin Oncol"},{"key":"2021122309081851400_B5","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/GCO.0b013e3283517908","article-title":"Delayed childbearing: Effects on fertility and the outcome of pregnancy","volume":"24","author":"Balasch","year":"2012","journal-title":"Curr Opin Obstet Gynecol"},{"key":"2021122309081851400_B6","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.1200\/JCO.2006.06.5888","article-title":"American Society of Clinical Oncology recommendations on fertility preservation in cancer patients","volume":"24","author":"Lee","year":"2006","journal-title":"J Clin Oncol"},{"key":"2021122309081851400_B7","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1002\/pon.685","article-title":"The fertility- and menopause-related information needs of younger women with a diagnosis of breast cancer: A qualitative study","volume":"12","author":"Thewes","year":"2003","journal-title":"Psychooncology"},{"key":"2021122309081851400_B8","doi-asserted-by":"crossref","first-page":"4174","DOI":"10.1200\/JCO.2004.01.159","article-title":"Web-based survey of fertility issues in young women with breast cancer","volume":"22","author":"Partridge","year":"2004","journal-title":"J Clin Oncol"},{"key":"2021122309081851400_B9","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1002\/(SICI)1097-0142(19990815)86:4<697::AID-CNCR20>3.0.CO;2-J","article-title":"Having children after cancer. A pilot survey of survivors\u2019 attitudes and experiences","volume":"86","author":"Schover","year":"1999","journal-title":"Cancer"},{"key":"2021122309081851400_B10","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1200\/JCO.2005.01.134","article-title":"Discussions regarding reproductive health for young women with breast cancer undergoing chemotherapy","volume":"23","author":"Duffy","year":"2005","journal-title":"J Clin Oncol"},{"key":"2021122309081851400_B11","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1126\/science.7545954","article-title":"A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1","volume":"266","author":"Miki","year":"1994","journal-title":"Science"},{"key":"2021122309081851400_B12","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1158\/1055-9965.733.13.5","article-title":"Fertility intentions following testing for a BRCA1 gene mutation","volume":"13","author":"Smith","year":"2004","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"2021122309081851400_B13","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1002\/pon.1875","article-title":"The psychosocial impact of interrupted childbearing in long-term female cancer survivors","volume":"21","author":"Canada","year":"2012","journal-title":"Psychooncology"},{"key":"2021122309081851400_B14","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.soncn.2009.08.002","article-title":"Cancer and its treatment effect on young breast cancer survivors","volume":"25","author":"Camp-Sorrell","year":"2009","journal-title":"Semin Oncol Nurs"},{"key":"2021122309081851400_B15","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1034\/j.1399-0004.2002.620204.x","article-title":"Family issues in a psychoeducation group for women with a BRCA mutation","volume":"62","author":"Speice","year":"2002","journal-title":"Clin Genet"},{"key":"2021122309081851400_B16","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.cancergencyto.2005.07.011","article-title":"Patient responses to the disclosure of BRCA mutation tests in hereditary breast-ovarian cancer families","volume":"165","author":"Lynch","year":"2006","journal-title":"Cancer Genet Cytogenet"},{"key":"2021122309081851400_B17","volume-title":"Genetic disorders and the fetus: Diagnosis, prevention, and treatment","author":"Milunsky","year":"2010","edition":"6th ed"},{"key":"2021122309081851400_B18","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1093\/humrep\/13.8.2238","article-title":"Preimplantation genetic diagnosis principles and ethics","volume":"13","author":"Fasouliotis","year":"1998","journal-title":"Hum Reprod"},{"key":"2021122309081851400_B19","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.fertnstert.2012.09.028","article-title":"Mature oocyte cryopreservation: A guideline","volume":"99","author":"Practice Committees of American Society for Reproductive Medicine","year":"2013","journal-title":"Fertil Steril"},{"key":"2021122309081851400_B20","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1093\/humrep\/dep172","article-title":"Reduction of the multiple pregnancy rate in a preimplantation genetic diagnosis programme after introduction of single blastocyst transfer and cryopreservation of blastocysts biopsied on day 3","volume":"24","author":"El-Toukhy","year":"2009","journal-title":"Hum Reprod"},{"key":"2021122309081851400_B21","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1093\/humrep\/deq338","article-title":"Closed blastocyst vitrification of biopsied embryos: Evaluation of 100 consecutive warming cycles","volume":"26","author":"Van Landuyt","year":"2011","journal-title":"Hum Reprod"},{"key":"2021122309081851400_B22","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s10689-007-9171-7","article-title":"Cancer risk reduction and reproductive concerns in female BRCA1\/2 mutation carriers","volume":"7","author":"Staton","year":"2008","journal-title":"Fam Cancer"},{"key":"2021122309081851400_B23","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1093\/humrep\/dem055","article-title":"Views of BRCA gene mutation carriers on preimplantation genetic diagnosis as a reproductive option for hereditary breast and ovarian cancer","volume":"22","author":"Menon","year":"2007","journal-title":"Hum Reprod"},{"key":"2021122309081851400_B24","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1016\/j.fertnstert.2008.03.019","article-title":"Attitudes of high-risk women toward preimplantation genetic diagnosis","volume":"91","author":"Quinn","year":"2009","journal-title":"Fertil Steril"},{"key":"2021122309081851400_B25","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/gim.2011.27","article-title":"BRCA1\/2 carriers: Their childbearing plans and theoretical intentions about having preimplantation genetic diagnosis and prenatal diagnosis","volume":"14","author":"Julian-Reynier","year":"2012","journal-title":"Genet Med"},{"key":"2021122309081851400_B26","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1634\/theoncologist.2012-0236","article-title":"Fertility preservation and pregnancy in women with and without BRCA mutation-positive breast cancer","volume":"17","author":"Rodriguez-Wallberg","year":"2012","journal-title":"The Oncologist"},{"key":"2021122309081851400_B27","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1097\/00006842-197905000-00004","article-title":"Impact of Event Scale: A measure of subjective stress","volume":"41","author":"Horowitz","year":"1979","journal-title":"Psychosom Med"},{"key":"2021122309081851400_B28","volume-title":"Statistical Methods for the Analysis of Biomedical Data","author":"Woolson","year":"2000","edition":"2nd ed."},{"key":"2021122309081851400_B29","doi-asserted-by":"crossref","DOI":"10.1002\/0471722146","volume-title":"Applied Logistic Regression","author":"Hosmer","year":"2000","edition":"2nd ed."},{"key":"2021122309081851400_B30","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1037\/0278-6133.16.1.63","article-title":"Psychological responses to BRCA1 mutation testing: Preliminary findings","volume":"16","author":"Croyle","year":"1997","journal-title":"Health Psychol"},{"key":"2021122309081851400_B31","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1002\/ajmg.a.20374","article-title":"Impact of BRCA1\/2 testing and disclosure of a positive test result on women affected and unaffected with breast or ovarian cancer","volume":"124A","author":"Van Roosmalen","year":"2004","journal-title":"Am J Med Genet A"},{"key":"2021122309081851400_B32","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1037\/a0014778","article-title":"Emotional distress following genetic testing for hereditary breast and ovarian cancer: A meta-analytic review","volume":"28","author":"Hamilton","year":"2009","journal-title":"Health Psychol"},{"key":"2021122309081851400_B33","doi-asserted-by":"crossref","first-page":"3867","DOI":"10.1200\/JCO.2003.10.100","article-title":"Long-term psychological impact of carrying a BRCA1\/2 mutation and prophylactic surgery: A 5-year follow-up study","volume":"21","author":"Van Oostrom","year":"2003","journal-title":"J Clin Oncol"},{"key":"2021122309081851400_B34","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s12160-008-9060-9","article-title":"The trajectory of psychological impact in BRCA1\/2 genetic testing: Does time heal?","volume":"36","author":"Beran","year":"2008","journal-title":"Ann Behav Med"},{"key":"2021122309081851400_B35","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1136\/bmj.38343.670868.D3","article-title":"Depression and anxiety in women with early breast cancer: Five year observational cohort study","volume":"330","author":"Burgess","year":"2005","journal-title":"BMJ"},{"key":"2021122309081851400_B36","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1037\/0278-6133.18.2.159","article-title":"Concerns about breast cancer and relations to psychosocial well-being in a multiethnic sample of early-stage patients","volume":"18","author":"Spencer","year":"1999","journal-title":"Health Psychol"},{"key":"2021122309081851400_B37","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1093\/humrep\/den471","article-title":"Opinion about reproductive decision making among individuals undergoing BRCA1\/2 genetic testing in a multicentre Spanish cohort","volume":"24","author":"Fortuny","year":"2009","journal-title":"Hum Reprod"},{"key":"2021122309081851400_B38","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/ejhg.2011.146","article-title":"Attitudes to reproductive genetic testing in women who had a positive BRCA test before having children: A qualitative analysis","volume":"20","author":"Ormondroyd","year":"2012","journal-title":"Eur J Hum Genet"},{"key":"2021122309081851400_B39","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1136\/jme.29.2.90","article-title":"Is there an ethical difference between preimplantation genetic diagnosis and abortion?","volume":"29","author":"Cameron","year":"2003","journal-title":"J Med Ethics"},{"key":"2021122309081851400_B40","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1146\/annurev.genom.7.080505.115753","article-title":"Preimplantation genetic diagnosis: An overview of socio-ethical and legal considerations","volume":"7","author":"Knoppers","year":"2006","journal-title":"Annu Rev Genomics Hum Genet"},{"key":"2021122309081851400_B41","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0738-3991(98)00079-2","article-title":"Preimplantation genetic diagnosis as an alternative to amniocentesis and chorionic villus sampling: Psychosocial and ethical aspects","volume":"35","author":"Vergeer","year":"1998","journal-title":"Patient Educ Couns"},{"issue":"Suppl 2","key":"2021122309081851400_B42","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S1472-6483(10)60274-X","article-title":"Ethical, legal and social implications of prenatal and preimplantation genetic testing for cancer susceptibility","volume":"19","author":"Wang","year":"2009","journal-title":"Reprod Biomed Online"},{"key":"2021122309081851400_B43","doi-asserted-by":"crossref","first-page":"6270","DOI":"10.1002\/cncr.27695","article-title":"Incorporating information regarding preimplantation genetic diagnosis into discussions concerning testing and risk management for BRCA1\/2 mutations: A qualitative study of patient preferences","volume":"118","author":"Hurley","year":"2012","journal-title":"Cancer"}],"container-title":["The Oncologist"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1634\/theoncologist.2014-0057","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1634\/theoncologist.2014-0057","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/oncolo\/article-pdf\/19\/8\/797\/41862385\/oncolo_19_8_797.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/oncolo\/article-pdf\/19\/8\/797\/41862385\/oncolo_19_8_797.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T09:35:25Z","timestamp":1689327325000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/oncolo\/article\/19\/8\/797\/6399330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,20]]},"references-count":43,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2014,6,20]]},"published-print":{"date-parts":[[2014,8,1]]}},"URL":"https:\/\/doi.org\/10.1634\/theoncologist.2014-0057","relation":{},"ISSN":["1083-7159","1549-490X"],"issn-type":[{"value":"1083-7159","type":"print"},{"value":"1549-490X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2014,8,1]]},"published":{"date-parts":[[2014,6,20]]}}}