{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T07:02:55Z","timestamp":1773385375116,"version":"3.50.1"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2015,3,6]],"date-time":"2015-03-06T00:00:00Z","timestamp":1425600000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background and Objective.<\/jats:title>\n                  <jats:p>Hematopoietic stem cell transplantation (HSCT) in developing countries is cost-limited. Our primary goal was to determine the cost structure for the HSCT program model developed over the last decade at our public university hospital and to assess its clinical outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Materials and Methods.<\/jats:title>\n                  <jats:p>Adults and children receiving an allogeneic hematopoietic stem cell transplant from January 2010 to February 2011 at our hematology regional reference center were included. Laboratory tests, medical procedures, chemotherapy drugs, other drugs, and hospitalization costs were scrutinized to calculate the total cost for each patient and the median cost for the procedure. Data regarding clinical evolution were incorporated into the analysis. Physician fees are not charged at the institution and therefore were not included.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results.<\/jats:title>\n                  <jats:p>Fifty patients were evaluated over a 1-year period. The total estimated cost for an allogeneic HSCT was $12,504. The two most expensive diseases to allograft were non-Hodgkin lymphoma ($11,760 \u00b1 $2,236) for the malignant group and thalassemia ($12,915 \u00b1 $5,170) for the nonmalignant group. Acute lymphoblastic leukemia ($11,053 \u00b1 2,817) and acute myeloblastic leukemia ($10,251 \u00b1 $1,538) were the most frequent indications for HSCT, with 11 cases each. Median out-of-pocket expenses were $1,605, and 1-year follow-up costs amounted to $1,640, adding up to a total cost of $15,749 for the first year. The most expensive components were drugs and laboratory tests.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion.<\/jats:title>\n                  <jats:p>Applying the cost structure described, HSCT is an affordable option for hematological patients living in a developing country.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1634\/theoncologist.2014-0218","type":"journal-article","created":{"date-parts":[[2015,3,7]],"date-time":"2015-03-07T02:43:26Z","timestamp":1425696206000},"page":"386-392","source":"Crossref","is-referenced-by-count":56,"title":["Cost Structure and Clinical Outcome of a Stem Cell Transplantation Program in a Developing Country: The Experience in Northeast Mexico"],"prefix":"10.1093","volume":"20","author":[{"given":"Jos\u00e9 Carlos","family":"Jaime-P\u00e9rez","sequence":"first","affiliation":[{"name":"Department of Hematology, Internal Medicine Division, Dr. Jos\u00e9 E. Gonz\u00e1lez University Hospital, School of Medicine of the Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Monterrey, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto Carlos","family":"Heredia-Salazar","sequence":"additional","affiliation":[{"name":"Department of Hematology, Internal Medicine Division, Dr. Jos\u00e9 E. Gonz\u00e1lez University Hospital, School of Medicine of the Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Monterrey, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga G.","family":"Cant\u00fa-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Department of Hematology, Internal Medicine Division, Dr. Jos\u00e9 E. Gonz\u00e1lez University Hospital, School of Medicine of the Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Monterrey, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Homero","family":"Guti\u00e9rrez-Aguirre","sequence":"additional","affiliation":[{"name":"Department of Hematology, Internal Medicine Division, Dr. Jos\u00e9 E. Gonz\u00e1lez University Hospital, School of Medicine of the Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Monterrey, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9sar Daniel","family":"Villarreal-Villarreal","sequence":"additional","affiliation":[{"name":"Department of Hematology, Internal Medicine Division, Dr. Jos\u00e9 E. Gonz\u00e1lez University Hospital, School of Medicine of the Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Monterrey, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Consuelo","family":"Manc\u00edas-Guerra","sequence":"additional","affiliation":[{"name":"Department of Hematology, Internal Medicine Division, Dr. Jos\u00e9 E. Gonz\u00e1lez University Hospital, School of Medicine of the Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Monterrey, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Lu\u00eds","family":"Herrera-Garza","sequence":"additional","affiliation":[{"name":"Department of Hematology, Internal Medicine Division, Dr. Jos\u00e9 E. Gonz\u00e1lez University Hospital, School of Medicine of the Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Monterrey, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"G\u00f3mez-Almaguer","sequence":"additional","affiliation":[{"name":"Department of Hematology, Internal Medicine Division, Dr. Jos\u00e9 E. Gonz\u00e1lez University Hospital, School of Medicine of the Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Monterrey, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2015,3,6]]},"reference":[{"key":"2021122309230409200_B1","first-page":"1175","article-title":"An economic evaluation of peripheral blood stem cell transplantation as an alternative to autologous bone marrow transplantation in multiple myeloma","volume":"18","author":"Duncan","year":"1996","journal-title":"Bone Marrow Transplant"},{"issue":"suppl 1","key":"2021122309230409200_B2","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/BF03165286","article-title":"The importance of lowering the costs of stem cell transplantation in developing countries","volume":"76","author":"Barr","year":"2002","journal-title":"Int J Hematol"},{"issue":"suppl 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