{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T03:14:40Z","timestamp":1770693280535,"version":"3.49.0"},"reference-count":59,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2016,2,17]],"date-time":"2016-02-17T00:00:00Z","timestamp":1455667200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Mentored Research Scholar Grant","award":["MRSG-07-001-01-CCE"],"award-info":[{"award-number":["MRSG-07-001-01-CCE"]}]},{"DOI":"10.13039\/100007313","name":"MD Anderson Cancer Center","doi-asserted-by":"publisher","award":["CA 016672"],"award-info":[{"award-number":["CA 016672"]}],"id":[{"id":"10.13039\/100007313","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","award":["RSG-11-170-01-PCSM"],"award-info":[{"award-number":["RSG-11-170-01-PCSM"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective.<\/jats:title>\n                  <jats:p>Advanced cancer patients frequently experience debilitating symptoms that occur in clusters, but few pharmacological studies have targeted symptom clusters. Our objective was to examine the effects of dexamethasone on symptom clusters in patients with advanced cancer.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods.<\/jats:title>\n                  <jats:p>We reviewed the data from a previous randomized clinical trial to determine the effects of dexamethasone on cancer symptoms. Symptom clusters were identified according to baseline symptoms by using principal component analysis. Correlations and change in the severity of symptom clusters were analyzed after study treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results.<\/jats:title>\n                  <jats:p>A total of 114 participants were included in this study. Three clusters were identified: fatigue\/anorexia-cachexia\/depression (FAD), sleep\/anxiety\/drowsiness (SAD), and pain\/dyspnea (PD). Changes in severity of FAD and PD significantly correlated over time (at baseline, day 8, and day 15). The FAD cluster was associated with significant improvement in severity at day 8 and day 15, whereas no significant change was observed with the SAD cluster or PD cluster after dexamethasone treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion.<\/jats:title>\n                  <jats:p>The results of this preliminary study suggest significant correlation over time and improvement in the FAD cluster at day 8 and day 15 after treatment with dexamethasone. These findings suggest that fatigue, anorexia-cachexia, and depression may share a common pathophysiologic basis. Further studies are needed to investigate this cluster and target anti-inflammatory therapies.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1634\/theoncologist.2014-0260","type":"journal-article","created":{"date-parts":[[2016,2,18]],"date-time":"2016-02-18T01:22:30Z","timestamp":1455758550000},"page":"384-390","source":"Crossref","is-referenced-by-count":29,"title":["Effects of Dexamethasone and Placebo on Symptom Clusters in Advanced Cancer Patients: A Preliminary Report"],"prefix":"10.1093","volume":"21","author":[{"given":"Sriram","family":"Yennurajalingam","sequence":"first","affiliation":[{"name":"a Department of Palliative Care and Rehabilitation Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet L.","family":"Williams","sequence":"additional","affiliation":[{"name":"a Department of Palliative Care and Rehabilitation Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary","family":"Chisholm","sequence":"additional","affiliation":[{"name":"b Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Bruera","sequence":"additional","affiliation":[{"name":"a Department of Palliative Care and Rehabilitation Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2016,2,17]]},"reference":[{"key":"2021122703521313100_B1","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.jpainsymman.2006.10.015","article-title":"Symptom prevalence in patients with incurable cancer: A systematic review","volume":"34","author":"Teunissen","year":"2007","journal-title":"J Pain Symptom Manage"},{"key":"2021122703521313100_B2","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jpainsymman.2010.03.017","article-title":"Impact of a palliative care consultation team on cancer-related symptoms in advanced cancer patients referred to an outpatient supportive care clinic","volume":"41","author":"Yennurajalingam","year":"2011","journal-title":"J Pain Symptom Manage"},{"key":"2021122703521313100_B3","first-page":"465","article-title":"Symptom clusters and their effect on the functional status of patients with cancer","volume":"28","author":"Dodd","year":"2001","journal-title":"Oncol Nurs Forum"},{"key":"2021122703521313100_B4","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1046\/j.1365-2648.2001.01697.x","article-title":"Advancing the science of symptom management","volume":"33","author":"Dodd","year":"2001","journal-title":"J Adv Nurs"},{"key":"2021122703521313100_B5","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s00520-001-0318-z","article-title":"Symptoms and prognosis in advanced cancer","volume":"10","author":"Walsh","year":"2002","journal-title":"Support Care Cancer"},{"key":"2021122703521313100_B6","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.critrevonc.2012.02.011","article-title":"Symptoms tell it all: A systematic review of the value of symptom assessment to predict survival in advanced cancer patients","volume":"84","author":"Trajkovic-Vidakovic","year":"2012","journal-title":"Crit Rev Oncol Hematol"},{"key":"2021122703521313100_B7","doi-asserted-by":"crossref","first-page":"448","DOI":"10.6004\/jnccn.2008.0036","article-title":"Fatigue is the most important symptom for advanced cancer patients who have had chemotherapy","volume":"6","author":"Butt","year":"2008","journal-title":"J Natl Compr Canc Netw"},{"key":"2021122703521313100_B8","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/pon.1412","article-title":"Pre-treatment symptom cluster in breast cancer patients is associated with worse sleep, fatigue and depression during chemotherapy","volume":"18","author":"Liu","year":"2009","journal-title":"Psychooncology"},{"key":"2021122703521313100_B9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jpainsymman.2010.10.261","article-title":"Pain, depression, and fatigue as a symptom cluster in advanced cancer","volume":"42","author":"Laird","year":"2011","journal-title":"J Pain Symptom Manage"},{"key":"2021122703521313100_B10","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.jpainsymman.2015.07.013","article-title":"Symptom clusters in advanced cancer patients: An empirical comparison of statistical methods and the impact on quality of life","volume":"51","author":"Dong","year":"2016","journal-title":"J Pain Symptom Manage"},{"key":"2021122703521313100_B11","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1200\/JCO.2011.39.2381","article-title":"Prospective, observational study of pain and analgesic prescribing in medical oncology outpatients with breast, colorectal, lung, or prostate cancer","volume":"30","author":"Fisch","year":"2012","journal-title":"J Clin Oncol"},{"key":"2021122703521313100_B12","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1001\/jama.297.3.295","article-title":"Palliative management of fatigue at the close of life: \u201cIt feels like my body is just worn out.\u201d","volume":"297","author":"Yennurajalingam","year":"2007","journal-title":"JAMA"},{"key":"2021122703521313100_B13","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1517\/14656566.2012.734297","article-title":"Current pharmacotherapy options for cancer anorexia and cachexia","volume":"13","author":"Macci\u00f2","year":"2012","journal-title":"Expert Opin Pharmacother"},{"key":"2021122703521313100_B14","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.ejon.2010.01.026","article-title":"Depression in advanced cancer","volume":"14","author":"Irving","year":"2010","journal-title":"Eur J Oncol Nurs"},{"key":"2021122703521313100_B15","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1097\/SPC.0b013e32835c7d88","article-title":"Update on interventions focused on symptom clusters: What has been tried and what have we learned?","volume":"7","author":"Berger","year":"2013","journal-title":"Curr Opin Support Palliat Care"},{"key":"2021122703521313100_B16","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/j.bbi.2008.05.004","article-title":"Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia","volume":"22","author":"Hutchinson","year":"2008","journal-title":"Brain Behav Immun"},{"key":"2021122703521313100_B17","doi-asserted-by":"crossref","first-page":"2919","DOI":"10.1002\/cncr.11382","article-title":"Are the symptoms of cancer and cancer treatment due to a shared biologic mechanism? A cytokine-immunologic model of cancer symptoms","volume":"97","author":"Cleeland","year":"2003","journal-title":"Cancer"},{"key":"2021122703521313100_B18","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.soncn.2007.01.008","article-title":"Is there a biological basis for the clustering of symptoms?","volume":"23","author":"Miaskowski","year":"2007","journal-title":"Semin Oncol Nurs"},{"key":"2021122703521313100_B19","doi-asserted-by":"crossref","first-page":"3517","DOI":"10.1200\/JCO.2011.36.1154","article-title":"Inflammation and behavioral symptoms after breast cancer treatment: do fatigue, depression, and sleep disturbance share a common underlying mechanism?","volume":"29","author":"Bower","year":"2011","journal-title":"J Clin Oncol"},{"key":"2021122703521313100_B20","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1200\/JCO.2007.10.7805","article-title":"Neuroendocrine-immune mechanisms of behavioral comorbidities in patients with cancer","volume":"26","author":"Miller","year":"2008","journal-title":"J Clin Oncol"},{"key":"2021122703521313100_B21","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/nrc2507","article-title":"Cytokines and their relationship to the symptoms and outcome of cancer","volume":"8","author":"Seruga","year":"2008","journal-title":"Nat Rev Cancer"},{"issue":"suppl 1","key":"2021122703521313100_B22","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.metabol.2005.01.011","article-title":"Depression, cytokines, and glial function","volume":"54","author":"Miller","year":"2005","journal-title":"Metabolism"},{"key":"2021122703521313100_B23","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jneuroim.2010.08.013","article-title":"The neuro-immune balance in neuropathic pain: Involvement of inflammatory immune cells, immune-like glial cells and cytokines","volume":"229","author":"Austin","year":"2010","journal-title":"J Neuroimmunol"},{"key":"2021122703521313100_B24","doi-asserted-by":"crossref","first-page":"7710","DOI":"10.1073\/pnas.96.14.7710","article-title":"Implications of immune-to-brain communication for sickness and pain","volume":"96","author":"Watkins","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"2021122703521313100_B25","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.cmet.2012.06.011","article-title":"Cancer cachexia: Mediators, signaling, and metabolic pathways","volume":"16","author":"Fearon","year":"2012","journal-title":"Cell Metab"},{"key":"2021122703521313100_B26","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/mp.2008.58","article-title":"Interferon-alpha effects on diurnal hypothalamic-pituitary-adrenal axis activity: Relationship with proinflammatory cytokines and behavior","volume":"15","author":"Raison","year":"2010","journal-title":"Mol Psychiatry"},{"key":"2021122703521313100_B27","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.bbi.2006.09.006","article-title":"Twenty years of research on cytokine-induced sickness behavior","volume":"21","author":"Dantzer","year":"2007","journal-title":"Brain Behav Immun"},{"key":"2021122703521313100_B28","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.neulet.2003.12.007","article-title":"Recent findings on how proinflammatory cytokines cause pain: peripheral mechanisms in inflammatory and neuropathic hyperalgesia","volume":"361","author":"Sommer","year":"2004","journal-title":"Neurosci Lett"},{"key":"2021122703521313100_B29","doi-asserted-by":"crossref","first-page":"6005","DOI":"10.1002\/cncr.27613","article-title":"Inflammation and fatigue dimensions in advanced cancer patients and cancer survivors: an explorative study","volume":"118","author":"De Raaf","year":"2012","journal-title":"Cancer"},{"key":"2021122703521313100_B30","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1634\/theoncologist.2013-0120","article-title":"The systemic inflammatory response and its relationship to pain and other symptoms in advanced cancer","volume":"18","author":"Laird","year":"2013","journal-title":"The Oncologist"},{"key":"2021122703521313100_B31","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1007\/s00520-015-2763-0","article-title":"The biology of cancer-related fatigue: A review of the literature","volume":"23","author":"Saligan","year":"2015","journal-title":"Support Care Cancer"},{"key":"2021122703521313100_B32","first-page":"751","article-title":"Action of oral methylprednisolone in terminal cancer patients: A prospective randomized double-blind study","volume":"69","author":"Bruera","year":"1985","journal-title":"Cancer Treat Rep"},{"key":"2021122703521313100_B33","doi-asserted-by":"crossref","first-page":"3076","DOI":"10.1200\/JCO.2012.44.4661","article-title":"Reduction of cancer-related fatigue with dexamethasone: A double-blind, randomized, placebo-controlled trial in patients with advanced cancer","volume":"31","author":"Yennurajalingam","year":"2013","journal-title":"J Clin Oncol"},{"key":"2021122703521313100_B34","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1002\/1097-0142(197406)33:6<1607::AID-CNCR2820330620>3.0.CO;2-V","article-title":"Corticosteroid therapy of preterminal gastrointestinal cancer","volume":"33","author":"Moertel","year":"1974","journal-title":"Cancer"},{"key":"2021122703521313100_B35","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1016\/0277-5379(89)90353-2","article-title":"Effect of methylprednisolone sodium succinate on quality of life in preterminal cancer patients: A placebo-controlled, multicenter study. The Methylprednisolone Preterminal Cancer Study Group","volume":"25","author":"Della Cuna","year":"1989","journal-title":"Eur J Cancer Clin Oncol"},{"key":"2021122703521313100_B36","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1080\/02841860500401167","article-title":"The use of corticosteroids in Swedish palliative care","volume":"45","author":"Lundstr\u00f6m","year":"2006","journal-title":"Acta Oncol"},{"issue":"suppl","key":"2021122703521313100_B37","doi-asserted-by":"crossref","first-page":"9002a","DOI":"10.1200\/jco.2012.30.15_suppl.9002","article-title":"Dexamethasone (DM) for cancer-related fatigue: A double-blinded, randomized, placebo-controlled trial","author":"Yennurajalingam","year":"2012","journal-title":"J Clin Oncol"},{"key":"2021122703521313100_B38","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0304-3959(83)90143-4","article-title":"Development of the Wisconsin Brief Pain Questionnaire to assess pain in cancer and other diseases","volume":"17","author":"Daut","year":"1983","journal-title":"Pain"},{"key":"2021122703521313100_B39","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.jpainsymman.2010.05.008","article-title":"Using confirmatory factor analysis to evaluate construct validity of the Brief Pain Inventory (BPI)","volume":"41","author":"Atkinson","year":"2011","journal-title":"J Pain Symptom Manage"},{"key":"2021122703521313100_B40","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/j.1526-4637.2009.00774.x","article-title":"The Brief Pain Inventory and its \u201cpain at its worst in the last 24 hours\u201d item: clinical trial endpoint considerations","volume":"11","author":"Atkinson","year":"2010","journal-title":"Pain Med"},{"key":"2021122703521313100_B41","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1200\/JCO.1993.11.3.570","article-title":"The Functional Assessment of Cancer Therapy scale: Development and validation of the general measure","volume":"11","author":"Cella","year":"1993","journal-title":"J Clin Oncol"},{"key":"2021122703521313100_B42","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S0885-3924(02)00529-8","article-title":"Combining anchor and distribution-based methods to derive minimal clinically important differences on the Functional Assessment of Cancer Therapy (FACT) anemia and fatigue scales","volume":"24","author":"Cella","year":"2002","journal-title":"J Pain Symptom Manage"},{"key":"2021122703521313100_B43","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/S0022-3999(00)00102-1","article-title":"Construct validation of the hospital anxiety and depression scale with clinical populations","volume":"48","author":"Johnston","year":"2000","journal-title":"J Psychosom Res"},{"key":"2021122703521313100_B44","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0163-8343(93)90099-A","article-title":"Screening for depression and anxiety in cancer patients using the Hospital Anxiety and Depression Scale","volume":"15","author":"Carroll","year":"1993","journal-title":"Gen Hosp Psychiatry"},{"key":"2021122703521313100_B45","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jpainsymman.2005.05.015","article-title":"Symptom cluster research: conceptual, design, measurement, and analysis issues","volume":"31","author":"Barsevick","year":"2006","journal-title":"J Pain Symptom Manage"},{"key":"2021122703521313100_B46","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1007\/s00520-009-0577-7","article-title":"Symptom clusters in patients with advanced cancers","volume":"17","author":"Cheung","year":"2009","journal-title":"Support Care Cancer"},{"key":"2021122703521313100_B47","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1017\/S1478951512000879","article-title":"Consistency of symptom clusters among advanced cancer patients seen at an outpatient supportive care clinic in a tertiary cancer center","volume":"11","author":"Yennurajalingam","year":"2013","journal-title":"Palliat Support Care"},{"key":"2021122703521313100_B48","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1007\/s00520-007-0241-z","article-title":"Symptom clusters in cancer patients with bone metastases","volume":"15","author":"Chow","year":"2007","journal-title":"Support Care Cancer"},{"key":"2021122703521313100_B49","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1093\/biomet\/52.3-4.591","article-title":"An analysis of variance test for normality (complete samples)","volume":"52","author":"Shapiro","year":"1965","journal-title":"Biometrika"},{"key":"2021122703521313100_B50","doi-asserted-by":"crossref","first-page":"3299","DOI":"10.1200\/JCO.1999.17.10.3299","article-title":"Randomized comparison of megestrol acetate versus dexamethasone versus fluoxymesterone for the treatment of cancer anorexia\/cachexia","volume":"17","author":"Loprinzi","year":"1999","journal-title":"J Clin Oncol"},{"key":"2021122703521313100_B51","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1136\/bmj.288.6410.27","article-title":"Prednisolone as an appetite stimulant in patients with cancer","volume":"288","author":"Wilcox","year":"1984","journal-title":"Br Med J (Clin Res Ed)"},{"key":"2021122703521313100_B52","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1200\/JCO.2013.54.3926","article-title":"Efficacy of methylprednisolone on pain, fatigue, and appetite loss in patients with advanced cancer using opioids: A randomized, placebo-controlled, double-blind trial","volume":"32","author":"Paulsen","year":"2014","journal-title":"J Clin Oncol"},{"key":"2021122703521313100_B53","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/pon.3422","article-title":"Depression, cytokines, and pancreatic cancer","volume":"23","author":"Breitbart","year":"2014","journal-title":"Psychooncology"},{"key":"2021122703521313100_B54","doi-asserted-by":"crossref","first-page":"4820","DOI":"10.1200\/JCO.2007.14.1978","article-title":"Interleukin-6, cortisol, and depressive symptoms in ovarian cancer patients","volume":"26","author":"Lutgendorf","year":"2008","journal-title":"J Clin Oncol"},{"key":"2021122703521313100_B55","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jpainsymman.2012.06.019","article-title":"Do corticosteroids provide analgesic effects in cancer patients? A systematic literature review","volume":"46","author":"Paulsen","year":"2013","journal-title":"J Pain Symptom Manage"},{"key":"2021122703521313100_B56","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1007\/s00520-001-0333-0","article-title":"Dexamethasone treatment in patients with brain metastases and primary brain tumors: Do the benefits outweigh the side-effects?","volume":"10","author":"Hempen","year":"2002","journal-title":"Support Care Cancer"},{"key":"2021122703521313100_B57","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.jpainsymman.2010.04.024","article-title":"Managing symptoms in patients with advanced lung cancer during radiotherapy: Results of a psychoeducational randomized controlled trial","volume":"41","author":"Chan","year":"2011","journal-title":"J Pain Symptom Manage"},{"key":"2021122703521313100_B58","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jpainsymman.2011.03.026","article-title":"Effects of methylphenidate on fatigue and depression: A randomized, double-blind, placebo-controlled trial","volume":"43","author":"Kerr","year":"2012","journal-title":"J Pain Symptom Manage"},{"key":"2021122703521313100_B59","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1089\/jpm.2012.0146","article-title":"The role of thalidomide and placebo for the treatment of cancer-related anorexia-cachexia symptoms: Results of a double-blind placebo-controlled randomized study","volume":"15","author":"Yennurajalingam","year":"2012","journal-title":"J Palliat Med"}],"container-title":["The Oncologist"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1634\/theoncologist.2014-0260","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1634\/theoncologist.2014-0260","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/oncolo\/article-pdf\/21\/3\/384\/41927387\/oncolo_21_3_384.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/oncolo\/article-pdf\/21\/3\/384\/41927387\/oncolo_21_3_384.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,27]],"date-time":"2021-12-27T03:54:04Z","timestamp":1640577244000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/oncolo\/article\/21\/3\/384\/6401352"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,17]]},"references-count":59,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2016,2,17]]},"published-print":{"date-parts":[[2016,3,1]]}},"URL":"https:\/\/doi.org\/10.1634\/theoncologist.2014-0260","relation":{},"ISSN":["1083-7159","1549-490X"],"issn-type":[{"value":"1083-7159","type":"print"},{"value":"1549-490X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2016,3,1]]},"published":{"date-parts":[[2016,2,17]]}}}