{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:16:07Z","timestamp":1790802967479,"version":"4.1.0"},"reference-count":71,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2017,6,29]],"date-time":"2017-06-29T00:00:00Z","timestamp":1498694400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Appendiceal mucinous neoplasms (AMNs) are a rare and heterogeneous disease for which clinical management is challenging. We aim to review the literature regarding modalities of treatment to guide the management of AMNs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and Review Criteria<\/jats:title>\n                  <jats:p>We conducted a PubMed search in February 2016 for English-language publications, using the terms \u201cappendiceal,\u201d \u201cappendix,\u201d \u201ccarcinoma,\u201d \u201ccancer,\u201d \u201cmucinous,\u201d \u201ctreatment,\u201d \u201cgenes,\u201d \u201ctarget,\u201d \u201cgenomic,\u201d and terms listed in the articles' subheadings. Published reports and abstracts from the American Society of Clinical Oncology meetings were also searched.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In this review, we summarize current data and controversies in AMN classification, clinical presentation, molecular alterations, treatment outcomes with regard to cytoreductive surgery, hyperthermic intraperitoneal chemotherapy (HIPEC), and the role of systemic chemotherapy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Appendiceal mucinous neoplasms are a heterogeneous group of tumors with a rising incidence. Treatment is based on stage and histology. Low-grade tumors are treated surgically with resection of the primary site in early stage disease, or peritoneal debulking and HIPEC in patients with advanced stage disease. Treatment of high-grade tumors requires further prospective trials, and options include debulking surgery and HIPEC with or without preoperative chemotherapy. Trials evaluating novel therapies based on the molecular profiling of AMN tumors are needed to evaluate therapeutic options in patients who are not surgical candidates.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1634\/theoncologist.2017-0081","type":"journal-article","created":{"date-parts":[[2017,6,30]],"date-time":"2017-06-30T01:05:26Z","timestamp":1498784726000},"page":"1107-1116","source":"Crossref","is-referenced-by-count":216,"title":["Appendiceal Mucinous Neoplasms: Diagnosis and Management"],"prefix":"10.1093","volume":"22","author":[{"given":"Walid L.","family":"Shaib","sequence":"first","affiliation":[{"name":"Department of Hematology and Oncology, Atlanta, Georgia, USA"},{"name":"GI Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Assi","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology American University of Beirut, Beirut, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Shamseddine","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology American University of Beirut, Beirut, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olatunji B.","family":"Alese","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Atlanta, Georgia, USA"},{"name":"GI Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Charles","family":"Staley","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahar","family":"Memis","sequence":"additional","affiliation":[{"name":"Department of Pathology, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volkan","family":"Adsay","sequence":"additional","affiliation":[{"name":"Department of Pathology, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanios","family":"Bekaii-Saab","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Mayo Clinic, Phoenix, Arizona, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bassel F.","family":"El-Rayes","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Atlanta, Georgia, USA"},{"name":"GI Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,6,29]]},"reference":[{"key":"2021122508220797400_onco12190-bib-0001","doi-asserted-by":"crossref","first-page":"3307","DOI":"10.1002\/cncr.10589","article-title":"Primary malignant neoplasms of the appendix: A population-based study from the surveillance, epidemiology and end-results program, 1973\u20131998","volume":"94","author":"McCusker","year":"2002","journal-title":"Cancer"},{"key":"2021122508220797400_onco12190-bib-0002","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.ejso.2007.04.002","article-title":"Appendiceal neoplasms and pseudomyxoma peritonei: A population based study","volume":"34","author":"Smeenk","year":"2008","journal-title":"Eur J Surg Oncol"},{"key":"2021122508220797400_onco12190-bib-0003","first-page":"100","volume-title":"A Manual of Pathological Anatomy","author":"Rokitansky","year":"1855"},{"key":"2021122508220797400_onco12190-bib-0004","first-page":"549","article-title":"IX. 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