{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T22:20:02Z","timestamp":1793658002018,"version":"4.5.1"},"reference-count":149,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2018,12,27]],"date-time":"2018-12-27T00:00:00Z","timestamp":1545868800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title\/>\n                  <jats:p>Unintentional weight loss in patients with pancreatic cancer is highly prevalent and contributes to low therapeutic tolerance, reduced quality of life, and overall mortality. Weight loss in pancreatic cancer can be due to anorexia, malabsorption, and\/or cachexia. Proper supportive care can stabilize or reverse weight loss in patients and improve outcomes. We review the literature on supportive care relevant to pancreatic cancer patients, and offer evidence-based recommendations that include expert nutritional assessment, counseling, supportive measures to ensure adequate caloric intake, pancreatic enzyme supplementation, nutritional supplement replacement, orexigenic agents, and exercise. Pancreatic Cancer Action Network-supported initiatives will spearhead the dissemination and adoption of these best supportive care practices.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1634\/theoncologist.2018-0266","type":"journal-article","created":{"date-parts":[[2018,12,27]],"date-time":"2018-12-27T21:05:16Z","timestamp":1545944716000},"page":"691-701","source":"Crossref","is-referenced-by-count":159,"title":["Pancreas Cancer-Associated Weight Loss"],"prefix":"10.1093","volume":"24","author":[{"given":"Andrew E.","family":"Hendifar","sequence":"first","affiliation":[{"name":"Cedars-Sinai Medical Center, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Q.B.","family":"Petzel","sequence":"additional","affiliation":[{"name":"MD Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa A.","family":"Zimmers","sequence":"additional","affiliation":[{"name":"Indiana University, Simon Cancer Center, Indianapolis, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crystal S.","family":"Denlinger","sequence":"additional","affiliation":[{"name":"Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn M.","family":"Matrisian","sequence":"additional","affiliation":[{"name":"Pancreatic Cancer Action Network, Manhattan Beach, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent J.","family":"Picozzi","sequence":"additional","affiliation":[{"name":"Virginia Mason Medical Center, Seattle, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lola","family":"Rahib","sequence":"additional","affiliation":[{"name":"Pancreatic Cancer Action Network, Manhattan Beach, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the Precision Promise Consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,12,27]]},"reference":[{"key":"2021122506422154800_R1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s00520-012-1514-8","article-title":"Symptoms in advanced pancreatic cancer are of importance for energy intake","volume":"21","author":"Bye","year":"2013","journal-title":"Support Care Cancer"},{"key":"2021122506422154800_R2","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1007\/s00520-010-1011-x","article-title":"Nutritional status of patients with locally advanced pancreatic cancer: A pilot study","volume":"19","author":"Ferrucci","year":"2011","journal-title":"Support Care Cancer"},{"key":"2021122506422154800_R3","doi-asserted-by":"crossref","first-page":"17","DOI":"10.21037\/jgo.2017.11.10","article-title":"Cachexia, and not obesity, prior to pancreatic cancer diagnosis worsens survival and is 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