{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T20:06:25Z","timestamp":1779912385264,"version":"3.53.1"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T00:00:00Z","timestamp":1553472000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"National High Technology Research and Development Program (863 Program) of China","award":["2015AA020401"],"award-info":[{"award-number":["2015AA020401"]}]},{"name":"National Key Research and Development Program of China","award":["2016YFF01400"],"award-info":[{"award-number":["2016YFF01400"]}]},{"name":"National Key Research and Development Program of China","award":["2016YFC0902400"],"award-info":[{"award-number":["2016YFC0902400"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81472676"],"award-info":[{"award-number":["81472676"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81572823"],"award-info":[{"award-number":["81572823"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81602543"],"award-info":[{"award-number":["81602543"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81602581"],"award-info":[{"award-number":["81602581"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81672839"],"award-info":[{"award-number":["81672839"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Projects from the Shanghai Science and Technology Commission","award":["14DZ1940300"],"award-info":[{"award-number":["14DZ1940300"]}]},{"name":"Projects from the Shanghai Science and Technology Commission","award":["14411970200"],"award-info":[{"award-number":["14411970200"]}]},{"name":"Projects from the Shanghai Science and Technology Commission","award":["14140902301"],"award-info":[{"award-number":["14140902301"]}]},{"name":"Resident Standardization Rraining Foundation of Zhongshan hospital","award":["2017006"],"award-info":[{"award-number":["2017006"]}]},{"name":"State Key Program of National Natural Science of China","award":["81530077"],"award-info":[{"award-number":["81530077"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Patients with intrahepatic cholangiocarcinoma (ICC) rarely present fever as the initial symptom. We aimed to identify clinical characteristics and prognostic factors for these feverish patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Subjects, Materials, and Methods<\/jats:title>\n                  <jats:p>This study retrospectively reviewed 31 patients with ICC with fever (\u226538.0\u00b0C) treated at our hospital between January 2002 and December 2014. A propensity score was used to match patients with and without fever at a ratio of 1:2.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Patients with ICC with fever had higher serum \u03b3-glutamyl transferase and carcinoembryonic antigen levels, larger tumors, poorer tumor differentiation, and worse prognosis (all p\u2009&amp;lt;\u2009.05) than those without fever. This was supported by propensity score matching (PSM) analysis. Univariate and multivariate analyses indicated that microvascular invasion, hilar lymph node metastasis, and temperature\u2009\u2265\u200938.6\u00b0C were related to prognosis. Patients with ICC with fever had higher levels of leucocytes, neutrophils, neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) in peripheral blood before and after PSM analysis. Body temperature positively correlated with leucocytes (r\u2009=\u20090.599, p\u2009&amp;lt;\u2009.001), neutrophils (r\u2009=\u20090.644, p\u2009&amp;lt;\u2009.001), NLR (r\u2009=\u20090.681, p\u2009&amp;lt;\u2009.001), and PLR (r\u2009=\u20090.457, p\u2009=\u2009.010).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Patients with ICC with fever \u226538.0\u00b0C and\u2009\u226538.6\u00b0C had poor and extremely poor prognosis, respectively. Radical surgical treatment may improve the prognosis of patients with ICC with fever &amp;lt;38.6\u00b0C. However, systemic therapy (e.g., anti-inflammatory and immune therapy) may be preferable to surgery for these patients with fever \u226538.6\u00b0C.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1634\/theoncologist.2018-0268","type":"journal-article","created":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T18:44:13Z","timestamp":1553539453000},"page":"997-1007","source":"Crossref","is-referenced-by-count":11,"title":["Clinical Characteristics and Prognostic Factors of Patients with Intrahepatic Cholangiocarcinoma with Fever: A Propensity Score Matching Analysis"],"prefix":"10.1093","volume":"24","author":[{"given":"Zi-Jun","family":"Gong","sequence":"first","affiliation":[{"name":"Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, People's Republic of China"},{"name":"Department of General Surgery, Zhongshan Hospital, Biliary 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